LeishMANIAdb
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E3 ubiquitin-protein ligase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
E3 ubiquitin-protein ligase
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B6R8_LEIMU
TriTrypDb:
LmxM.34.3900
Length:
341

Annotations

LeishMANIAdb annotations

A conserved tail-anchored protein of unclear function. Kinetoplastid-specicic protein

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 2
GO:0016020 membrane 2 1

Expansion

Sequence features

E9B6R8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6R8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 216 222 PF00089 0.455
CLV_NRD_NRD_1 160 162 PF00675 0.495
CLV_NRD_NRD_1 238 240 PF00675 0.477
CLV_NRD_NRD_1 321 323 PF00675 0.449
CLV_PCSK_KEX2_1 100 102 PF00082 0.400
CLV_PCSK_KEX2_1 160 162 PF00082 0.490
CLV_PCSK_KEX2_1 238 240 PF00082 0.460
CLV_PCSK_KEX2_1 321 323 PF00082 0.423
CLV_PCSK_KEX2_1 70 72 PF00082 0.434
CLV_PCSK_KEX2_1 75 77 PF00082 0.407
CLV_PCSK_KEX2_1 90 92 PF00082 0.254
CLV_PCSK_PC1ET2_1 100 102 PF00082 0.475
CLV_PCSK_PC1ET2_1 238 240 PF00082 0.460
CLV_PCSK_PC1ET2_1 70 72 PF00082 0.434
CLV_PCSK_PC1ET2_1 75 77 PF00082 0.407
CLV_PCSK_PC1ET2_1 90 92 PF00082 0.254
CLV_PCSK_PC7_1 71 77 PF00082 0.406
CLV_PCSK_SKI1_1 161 165 PF00082 0.402
CLV_PCSK_SKI1_1 260 264 PF00082 0.376
CLV_PCSK_SKI1_1 266 270 PF00082 0.388
CLV_PCSK_SKI1_1 70 74 PF00082 0.411
CLV_PCSK_SKI1_1 75 79 PF00082 0.397
CLV_PCSK_SKI1_1 90 94 PF00082 0.258
DEG_Nend_UBRbox_3 1 3 PF02207 0.663
DOC_ANK_TNKS_1 274 281 PF00023 0.583
DOC_CDC14_PxL_1 189 197 PF14671 0.468
DOC_MAPK_gen_1 217 226 PF00069 0.650
DOC_MAPK_JIP1_4 281 287 PF00069 0.639
DOC_MAPK_MEF2A_6 194 202 PF00069 0.594
DOC_PP1_RVXF_1 73 80 PF00149 0.605
DOC_PP4_FxxP_1 245 248 PF00568 0.684
DOC_USP7_UBL2_3 12 16 PF12436 0.724
DOC_WW_Pin1_4 239 244 PF00397 0.678
LIG_14-3-3_CanoR_1 101 108 PF00244 0.630
LIG_14-3-3_CanoR_1 160 168 PF00244 0.633
LIG_14-3-3_CanoR_1 208 216 PF00244 0.717
LIG_14-3-3_CanoR_1 219 225 PF00244 0.696
LIG_14-3-3_CanoR_1 239 243 PF00244 0.729
LIG_14-3-3_CanoR_1 76 80 PF00244 0.588
LIG_BRCT_BRCA1_1 241 245 PF00533 0.739
LIG_deltaCOP1_diTrp_1 300 310 PF00928 0.609
LIG_Dynein_DLC8_1 40 46 PF01221 0.667
LIG_eIF4E_1 63 69 PF01652 0.716
LIG_FHA_1 117 123 PF00498 0.671
LIG_FHA_1 131 137 PF00498 0.597
LIG_FHA_1 184 190 PF00498 0.483
LIG_FHA_1 208 214 PF00498 0.636
LIG_FHA_1 23 29 PF00498 0.716
LIG_FHA_2 239 245 PF00498 0.667
LIG_FHA_2 35 41 PF00498 0.627
LIG_FHA_2 76 82 PF00498 0.586
LIG_LIR_Apic_2 231 237 PF02991 0.644
LIG_LIR_Apic_2 242 248 PF02991 0.614
LIG_LIR_Gen_1 102 113 PF02991 0.434
LIG_LIR_Gen_1 300 306 PF02991 0.612
LIG_LIR_Gen_1 82 93 PF02991 0.611
LIG_LIR_Nem_3 102 108 PF02991 0.444
LIG_LIR_Nem_3 18 24 PF02991 0.626
LIG_LIR_Nem_3 223 229 PF02991 0.738
LIG_LIR_Nem_3 30 35 PF02991 0.599
LIG_LIR_Nem_3 300 304 PF02991 0.638
LIG_LIR_Nem_3 308 313 PF02991 0.606
LIG_LIR_Nem_3 318 323 PF02991 0.396
LIG_LIR_Nem_3 82 88 PF02991 0.583
LIG_NRBOX 184 190 PF00104 0.452
LIG_PDZ_Class_3 336 341 PF00595 0.406
LIG_Pex14_1 324 328 PF04695 0.328
LIG_Pex14_2 164 168 PF04695 0.587
LIG_Pex14_2 263 267 PF04695 0.584
LIG_Pex14_2 320 324 PF04695 0.377
LIG_Pex14_2 326 330 PF04695 0.356
LIG_REV1ctd_RIR_1 29 37 PF16727 0.695
LIG_SH2_STAP1 229 233 PF00017 0.689
LIG_SH2_STAP1 24 28 PF00017 0.691
LIG_SH2_STAT5 24 27 PF00017 0.631
LIG_SH2_STAT5 284 287 PF00017 0.591
LIG_SH2_STAT5 85 88 PF00017 0.621
LIG_SH3_3 110 116 PF00018 0.608
LIG_SH3_3 119 125 PF00018 0.650
LIG_SH3_3 273 279 PF00018 0.558
LIG_SUMO_SIM_par_1 331 337 PF11976 0.328
LIG_TRAF2_1 180 183 PF00917 0.559
LIG_TRAF2_1 50 53 PF00917 0.761
LIG_UBA3_1 68 75 PF00899 0.704
LIG_ULM_U2AF65_1 70 75 PF00076 0.613
LIG_WRC_WIRS_1 184 189 PF05994 0.563
LIG_WRC_WIRS_1 85 90 PF05994 0.625
MOD_CK1_1 106 112 PF00069 0.579
MOD_CK1_1 132 138 PF00069 0.607
MOD_CK1_1 228 234 PF00069 0.746
MOD_CK1_1 34 40 PF00069 0.726
MOD_CK2_1 177 183 PF00069 0.552
MOD_CK2_1 305 311 PF00069 0.690
MOD_CK2_1 35 41 PF00069 0.729
MOD_CK2_1 75 81 PF00069 0.594
MOD_CMANNOS 324 327 PF00535 0.328
MOD_GlcNHglycan 161 164 PF01048 0.426
MOD_GlcNHglycan 169 172 PF01048 0.419
MOD_GlcNHglycan 179 182 PF01048 0.309
MOD_GlcNHglycan 255 258 PF01048 0.378
MOD_GlcNHglycan 260 263 PF01048 0.363
MOD_GSK3_1 116 123 PF00069 0.572
MOD_GSK3_1 130 137 PF00069 0.681
MOD_GSK3_1 155 162 PF00069 0.706
MOD_GSK3_1 183 190 PF00069 0.568
MOD_GSK3_1 225 232 PF00069 0.739
MOD_GSK3_1 31 38 PF00069 0.737
MOD_GSK3_1 99 106 PF00069 0.614
MOD_N-GLC_1 53 58 PF02516 0.515
MOD_N-GLC_1 94 99 PF02516 0.430
MOD_NEK2_1 187 192 PF00069 0.551
MOD_NEK2_1 258 263 PF00069 0.579
MOD_NEK2_1 31 36 PF00069 0.712
MOD_NEK2_1 99 104 PF00069 0.672
MOD_PIKK_1 41 47 PF00454 0.759
MOD_PKA_1 100 106 PF00069 0.637
MOD_PKA_1 238 244 PF00069 0.692
MOD_PKA_1 75 81 PF00069 0.597
MOD_PKA_2 100 106 PF00069 0.637
MOD_PKA_2 159 165 PF00069 0.696
MOD_PKA_2 207 213 PF00069 0.646
MOD_PKA_2 238 244 PF00069 0.685
MOD_PKA_2 35 41 PF00069 0.695
MOD_PKA_2 75 81 PF00069 0.597
MOD_Plk_1 127 133 PF00069 0.627
MOD_Plk_1 229 235 PF00069 0.644
MOD_Plk_1 83 89 PF00069 0.628
MOD_Plk_1 94 100 PF00069 0.605
MOD_Plk_4 183 189 PF00069 0.565
MOD_Plk_4 229 235 PF00069 0.655
MOD_Plk_4 94 100 PF00069 0.645
MOD_ProDKin_1 239 245 PF00069 0.675
MOD_SUMO_for_1 50 53 PF00179 0.706
MOD_SUMO_rev_2 143 149 PF00179 0.751
MOD_SUMO_rev_2 286 292 PF00179 0.618
MOD_SUMO_rev_2 34 44 PF00179 0.603
TRG_DiLeu_BaEn_1 64 69 PF01217 0.734
TRG_DiLeu_BaEn_2 182 188 PF01217 0.553
TRG_DiLeu_BaEn_2 249 255 PF01217 0.652
TRG_ENDOCYTIC_2 265 268 PF00928 0.582
TRG_ENDOCYTIC_2 284 287 PF00928 0.507
TRG_ENDOCYTIC_2 301 304 PF00928 0.545
TRG_ENDOCYTIC_2 85 88 PF00928 0.572
TRG_ER_diArg_1 216 219 PF00400 0.678
TRG_ER_diArg_1 320 322 PF00400 0.449
TRG_NLS_MonoExtN_4 237 242 PF00514 0.697
TRG_Pf-PMV_PEXEL_1 57 61 PF00026 0.524
TRG_Pf-PMV_PEXEL_1 91 96 PF00026 0.398

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HTX3 Leptomonas seymouri 75% 95%
A0A0S4J079 Bodo saltans 50% 95%
A0A1X0P567 Trypanosomatidae 60% 96%
A0A3Q8IJD6 Leishmania donovani 96% 100%
A0A422N430 Trypanosoma rangeli 56% 96%
A4HN61 Leishmania braziliensis 86% 100%
A4IBS8 Leishmania infantum 96% 100%
C9ZYU4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 96%
E9AFL4 Leishmania major 94% 100%
V5BCU0 Trypanosoma cruzi 57% 96%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS