Membrane-associated protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Enriched in surface-labeled proteome protein 9, putative

Species:

Leishmania mexicana

UniProt:

E9B6Q5_LEIMU

TriTrypDb:

LmxM.34.3770

Length:

643

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 4, no: 4
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005739	mitochondrion	5	1
GO:0005768	endosome	7	1
GO:0020023	kinetoplast	2	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1

Expansion

Sequence features

E9B6Q5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6Q5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.305
CLV_C14_Caspase3-7	209	213	PF00656	0.283
CLV_MEL_PAP_1	330	336	PF00089	0.429
CLV_NRD_NRD_1	384	386	PF00675	0.663
CLV_NRD_NRD_1	395	397	PF00675	0.482
CLV_NRD_NRD_1	547	549	PF00675	0.647
CLV_PCSK_KEX2_1	384	386	PF00082	0.504
CLV_PCSK_KEX2_1	395	397	PF00082	0.502
CLV_PCSK_KEX2_1	547	549	PF00082	0.647
CLV_PCSK_SKI1_1	385	389	PF00082	0.636
CLV_PCSK_SKI1_1	49	53	PF00082	0.513
CLV_PCSK_SKI1_1	574	578	PF00082	0.638
DEG_APCC_KENBOX_2	78	82	PF00400	0.316
DEG_SPOP_SBC_1	185	189	PF00917	0.301
DEG_SPOP_SBC_1	286	290	PF00917	0.495
DEG_SPOP_SBC_1	405	409	PF00917	0.308
DEG_SPOP_SBC_1	455	459	PF00917	0.341
DOC_CYCLIN_yCln2_LP_2	139	145	PF00134	0.320
DOC_CYCLIN_yCln2_LP_2	175	181	PF00134	0.410
DOC_MAPK_gen_1	251	260	PF00069	0.436
DOC_MAPK_gen_1	333	341	PF00069	0.224
DOC_MAPK_MEF2A_6	37	46	PF00069	0.265
DOC_MAPK_MEF2A_6	79	88	PF00069	0.331
DOC_PP1_RVXF_1	442	448	PF00149	0.273
DOC_PP2B_LxvP_1	175	178	PF13499	0.342
DOC_PP4_FxxP_1	370	373	PF00568	0.375
DOC_SPAK_OSR1_1	68	72	PF12202	0.316
DOC_USP7_MATH_1	144	148	PF00917	0.328
DOC_USP7_MATH_1	272	276	PF00917	0.508
DOC_USP7_MATH_1	286	290	PF00917	0.447
DOC_USP7_MATH_1	405	409	PF00917	0.308
DOC_WW_Pin1_4	138	143	PF00397	0.305
DOC_WW_Pin1_4	199	204	PF00397	0.312
DOC_WW_Pin1_4	237	242	PF00397	0.317
DOC_WW_Pin1_4	312	317	PF00397	0.441
DOC_WW_Pin1_4	412	417	PF00397	0.380
LIG_14-3-3_CanoR_1	153	158	PF00244	0.390
LIG_14-3-3_CanoR_1	3	12	PF00244	0.491
LIG_14-3-3_CanoR_1	333	343	PF00244	0.348
LIG_14-3-3_CanoR_1	396	402	PF00244	0.307
LIG_14-3-3_CanoR_1	406	412	PF00244	0.326
LIG_14-3-3_CanoR_1	444	448	PF00244	0.274
LIG_14-3-3_CanoR_1	478	482	PF00244	0.344
LIG_14-3-3_CanoR_1	49	54	PF00244	0.374
LIG_14-3-3_CanoR_1	547	554	PF00244	0.262
LIG_14-3-3_CanoR_1	61	71	PF00244	0.435
LIG_14-3-3_CanoR_1	617	621	PF00244	0.536
LIG_AP2alpha_1	303	307	PF02296	0.253
LIG_APCC_ABBA_1	84	89	PF00400	0.375
LIG_BRCT_BRCA1_1	160	164	PF00533	0.257
LIG_BRCT_BRCA1_1	337	341	PF00533	0.394
LIG_Clathr_ClatBox_1	196	200	PF01394	0.419
LIG_Clathr_ClatBox_1	41	45	PF01394	0.358
LIG_deltaCOP1_diTrp_1	352	360	PF00928	0.339
LIG_eIF4E_1	191	197	PF01652	0.261
LIG_FHA_1	117	123	PF00498	0.249
LIG_FHA_1	150	156	PF00498	0.289
LIG_FHA_1	163	169	PF00498	0.258
LIG_FHA_1	398	404	PF00498	0.382
LIG_FHA_1	438	444	PF00498	0.341
LIG_FHA_1	461	467	PF00498	0.475
LIG_FHA_1	538	544	PF00498	0.287
LIG_FHA_1	575	581	PF00498	0.370
LIG_FHA_1	617	623	PF00498	0.591
LIG_FHA_1	634	640	PF00498	0.752
LIG_FHA_1	9	15	PF00498	0.429
LIG_FHA_1	97	103	PF00498	0.356
LIG_FHA_2	207	213	PF00498	0.304
LIG_FHA_2	297	303	PF00498	0.265
LIG_FHA_2	50	56	PF00498	0.389
LIG_GBD_Chelix_1	131	139	PF00786	0.472
LIG_Integrin_RGD_1	37	39	PF01839	0.513
LIG_LIR_Apic_2	368	373	PF02991	0.364
LIG_LIR_Apic_2	538	544	PF02991	0.344
LIG_LIR_Apic_2	549	554	PF02991	0.330
LIG_LIR_Gen_1	223	231	PF02991	0.330
LIG_LIR_Gen_1	308	319	PF02991	0.331
LIG_LIR_Gen_1	329	339	PF02991	0.262
LIG_LIR_Gen_1	357	366	PF02991	0.393
LIG_LIR_Gen_1	400	405	PF02991	0.262
LIG_LIR_Gen_1	470	481	PF02991	0.322
LIG_LIR_Gen_1	532	541	PF02991	0.349
LIG_LIR_LC3C_4	310	314	PF02991	0.205
LIG_LIR_Nem_3	170	175	PF02991	0.369
LIG_LIR_Nem_3	188	194	PF02991	0.265
LIG_LIR_Nem_3	223	227	PF02991	0.288
LIG_LIR_Nem_3	308	314	PF02991	0.303
LIG_LIR_Nem_3	320	324	PF02991	0.351
LIG_LIR_Nem_3	326	331	PF02991	0.358
LIG_LIR_Nem_3	470	476	PF02991	0.332
LIG_LIR_Nem_3	532	536	PF02991	0.293
LIG_LIR_Nem_3	540	545	PF02991	0.255
LIG_Pex14_2	222	226	PF04695	0.342
LIG_Pex14_2	303	307	PF04695	0.296
LIG_Pex14_2	317	321	PF04695	0.323
LIG_PTB_Apo_2	216	223	PF02174	0.351
LIG_SH2_CRK	172	176	PF00017	0.419
LIG_SH2_CRK	473	477	PF00017	0.362
LIG_SH2_CRK	501	505	PF00017	0.313
LIG_SH2_CRK	551	555	PF00017	0.443
LIG_SH2_CRK	573	577	PF00017	0.397
LIG_SH2_GRB2like	101	104	PF00017	0.322
LIG_SH2_NCK_1	298	302	PF00017	0.322
LIG_SH2_NCK_1	551	555	PF00017	0.443
LIG_SH2_SRC	101	104	PF00017	0.322
LIG_SH2_STAP1	181	185	PF00017	0.278
LIG_SH2_STAP1	328	332	PF00017	0.285
LIG_SH2_STAP1	351	355	PF00017	0.291
LIG_SH2_STAP1	401	405	PF00017	0.336
LIG_SH2_STAP1	473	477	PF00017	0.318
LIG_SH2_STAP1	537	541	PF00017	0.292
LIG_SH2_STAT3	160	163	PF00017	0.302
LIG_SH2_STAT5	101	104	PF00017	0.268
LIG_SH2_STAT5	298	301	PF00017	0.362
LIG_SH2_STAT5	386	389	PF00017	0.313
LIG_SH2_STAT5	454	457	PF00017	0.430
LIG_SH2_STAT5	525	528	PF00017	0.360
LIG_SH2_STAT5	535	538	PF00017	0.246
LIG_SH2_STAT5	541	544	PF00017	0.264
LIG_SH2_STAT5	545	548	PF00017	0.262
LIG_SH2_STAT5	87	90	PF00017	0.316
LIG_SH2_STAT5	96	99	PF00017	0.276
LIG_SH3_1	298	304	PF00018	0.312
LIG_SH3_3	255	261	PF00018	0.435
LIG_SH3_3	298	304	PF00018	0.305
LIG_SH3_3	310	316	PF00018	0.263
LIG_SH3_3	413	419	PF00018	0.328
LIG_SH3_3	492	498	PF00018	0.332
LIG_SH3_3	597	603	PF00018	0.294
LIG_SH3_3	79	85	PF00018	0.372
LIG_SUMO_SIM_anti_2	43	48	PF11976	0.350
LIG_SUMO_SIM_par_1	10	15	PF11976	0.553
LIG_SUMO_SIM_par_1	164	171	PF11976	0.235
LIG_SUMO_SIM_par_1	20	25	PF11976	0.520
LIG_SUMO_SIM_par_1	202	207	PF11976	0.339
LIG_TYR_ITSM	187	194	PF00017	0.277
LIG_Vh1_VBS_1	1	19	PF01044	0.376
LIG_WRC_WIRS_1	221	226	PF05994	0.392
LIG_WRC_WIRS_1	566	571	PF05994	0.451
MOD_CDC14_SPxK_1	315	318	PF00782	0.298
MOD_CDK_SPxK_1	312	318	PF00069	0.284
MOD_CK1_1	134	140	PF00069	0.378
MOD_CK1_1	147	153	PF00069	0.352
MOD_CK1_1	158	164	PF00069	0.288
MOD_CK1_1	229	235	PF00069	0.520
MOD_CK1_1	237	243	PF00069	0.446
MOD_CK1_1	275	281	PF00069	0.608
MOD_CK1_1	288	294	PF00069	0.608
MOD_CK1_1	335	341	PF00069	0.337
MOD_CK1_1	407	413	PF00069	0.474
MOD_CK1_1	459	465	PF00069	0.678
MOD_CK1_1	468	474	PF00069	0.560
MOD_CK1_1	54	60	PF00069	0.549
MOD_CK1_1	565	571	PF00069	0.457
MOD_CK1_1	593	599	PF00069	0.279
MOD_CK1_1	62	68	PF00069	0.425
MOD_CK1_1	72	78	PF00069	0.448
MOD_CK2_1	122	128	PF00069	0.419
MOD_CK2_1	296	302	PF00069	0.594
MOD_CK2_1	49	55	PF00069	0.406
MOD_GlcNHglycan	160	163	PF01048	0.326
MOD_GlcNHglycan	181	184	PF01048	0.297
MOD_GlcNHglycan	28	31	PF01048	0.601
MOD_GlcNHglycan	283	286	PF01048	0.524
MOD_GlcNHglycan	290	293	PF01048	0.671
MOD_GlcNHglycan	467	470	PF01048	0.536
MOD_GlcNHglycan	49	52	PF01048	0.498
MOD_GlcNHglycan	5	8	PF01048	0.610
MOD_GlcNHglycan	512	515	PF01048	0.339
MOD_GlcNHglycan	577	580	PF01048	0.407
MOD_GlcNHglycan	595	598	PF01048	0.253
MOD_GlcNHglycan	64	67	PF01048	0.352
MOD_GlcNHglycan	71	74	PF01048	0.418
MOD_GSK3_1	102	109	PF00069	0.345
MOD_GSK3_1	134	141	PF00069	0.362
MOD_GSK3_1	143	150	PF00069	0.405
MOD_GSK3_1	158	165	PF00069	0.375
MOD_GSK3_1	186	193	PF00069	0.385
MOD_GSK3_1	202	209	PF00069	0.361
MOD_GSK3_1	22	29	PF00069	0.485
MOD_GSK3_1	222	229	PF00069	0.305
MOD_GSK3_1	271	278	PF00069	0.609
MOD_GSK3_1	281	288	PF00069	0.566
MOD_GSK3_1	3	10	PF00069	0.634
MOD_GSK3_1	361	368	PF00069	0.426
MOD_GSK3_1	414	421	PF00069	0.528
MOD_GSK3_1	455	462	PF00069	0.454
MOD_GSK3_1	467	474	PF00069	0.509
MOD_GSK3_1	47	54	PF00069	0.575
MOD_GSK3_1	575	582	PF00069	0.451
MOD_GSK3_1	71	78	PF00069	0.604
MOD_N-GLC_1	102	107	PF02516	0.486
MOD_N-GLC_1	158	163	PF02516	0.413
MOD_N-GLC_1	229	234	PF02516	0.465
MOD_N-GLC_1	242	247	PF02516	0.482
MOD_N-GLC_1	281	286	PF02516	0.454
MOD_N-GLC_1	296	301	PF02516	0.363
MOD_N-GLC_1	424	429	PF02516	0.452
MOD_N-GLC_1	471	476	PF02516	0.411
MOD_N-GLC_1	59	64	PF02516	0.550
MOD_N-GLC_1	628	633	PF02516	0.500
MOD_N-GLC_2	218	220	PF02516	0.406
MOD_N-GLC_2	392	394	PF02516	0.370
MOD_NEK2_1	1	6	PF00069	0.518
MOD_NEK2_1	12	17	PF00069	0.394
MOD_NEK2_1	131	136	PF00069	0.351
MOD_NEK2_1	164	169	PF00069	0.249
MOD_NEK2_1	186	191	PF00069	0.370
MOD_NEK2_1	22	27	PF00069	0.423
MOD_NEK2_1	222	227	PF00069	0.406
MOD_NEK2_1	280	285	PF00069	0.452
MOD_NEK2_1	287	292	PF00069	0.440
MOD_NEK2_1	307	312	PF00069	0.389
MOD_NEK2_1	317	322	PF00069	0.374
MOD_NEK2_1	334	339	PF00069	0.251
MOD_NEK2_1	404	409	PF00069	0.473
MOD_NEK2_1	479	484	PF00069	0.429
MOD_NEK2_1	590	595	PF00069	0.372
MOD_NEK2_1	69	74	PF00069	0.418
MOD_NEK2_2	424	429	PF00069	0.452
MOD_PIKK_1	437	443	PF00454	0.321
MOD_PK_1	153	159	PF00069	0.295
MOD_PK_1	190	196	PF00069	0.296
MOD_PKA_2	147	153	PF00069	0.313
MOD_PKA_2	2	8	PF00069	0.590
MOD_PKA_2	275	281	PF00069	0.536
MOD_PKA_2	332	338	PF00069	0.457
MOD_PKA_2	405	411	PF00069	0.362
MOD_PKA_2	443	449	PF00069	0.374
MOD_PKA_2	477	483	PF00069	0.418
MOD_PKA_2	546	552	PF00069	0.266
MOD_PKA_2	616	622	PF00069	0.483
MOD_Plk_1	206	212	PF00069	0.396
MOD_Plk_1	243	249	PF00069	0.471
MOD_Plk_1	296	302	PF00069	0.448
MOD_Plk_1	424	430	PF00069	0.449
MOD_Plk_1	455	461	PF00069	0.612
MOD_Plk_1	471	477	PF00069	0.353
MOD_Plk_1	531	537	PF00069	0.374
MOD_Plk_1	59	65	PF00069	0.530
MOD_Plk_2-3	106	112	PF00069	0.342
MOD_Plk_4	131	137	PF00069	0.449
MOD_Plk_4	14	20	PF00069	0.513
MOD_Plk_4	275	281	PF00069	0.551
MOD_Plk_4	307	313	PF00069	0.404
MOD_Plk_4	317	323	PF00069	0.378
MOD_Plk_4	326	332	PF00069	0.297
MOD_Plk_4	361	367	PF00069	0.364
MOD_Plk_4	407	413	PF00069	0.336
MOD_Plk_4	418	424	PF00069	0.323
MOD_Plk_4	443	449	PF00069	0.382
MOD_Plk_4	456	462	PF00069	0.523
MOD_Plk_4	54	60	PF00069	0.522
MOD_Plk_4	579	585	PF00069	0.345
MOD_ProDKin_1	138	144	PF00069	0.366
MOD_ProDKin_1	199	205	PF00069	0.365
MOD_ProDKin_1	237	243	PF00069	0.384
MOD_ProDKin_1	312	318	PF00069	0.557
MOD_ProDKin_1	412	418	PF00069	0.468
MOD_SUMO_rev_2	106	116	PF00179	0.327
TRG_DiLeu_BaEn_2	537	543	PF01217	0.309
TRG_ENDOCYTIC_2	172	175	PF00928	0.419
TRG_ENDOCYTIC_2	191	194	PF00928	0.283
TRG_ENDOCYTIC_2	331	334	PF00928	0.548
TRG_ENDOCYTIC_2	401	404	PF00928	0.396
TRG_ENDOCYTIC_2	473	476	PF00928	0.453
TRG_ENDOCYTIC_2	573	576	PF00928	0.495
TRG_ER_diArg_1	383	385	PF00400	0.321
TRG_ER_diArg_1	395	397	PF00400	0.288
TRG_ER_diArg_1	546	548	PF00400	0.529
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	90	95	PF00026	0.382

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IH70	Leptomonas seymouri	46%	100%
A0A1X0NCX6	Trypanosomatidae	31%	100%
A0A3S5H803	Leishmania donovani	82%	99%
A4HN48	Leishmania braziliensis	62%	100%
A4IBR6	Leishmania infantum	81%	99%
C9ZYV7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AFK1	Leishmania major	79%	100%