CULLIN_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cullin family, putative

Species:

Leishmania mexicana

UniProt:

E9B6Q3_LEIMU

TriTrypDb:

LmxM.34.3750

Length:

563

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6Q3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6Q3

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	6
GO:0006511	ubiquitin-dependent protein catabolic process	7	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009056	catabolic process	2	6
GO:0009057	macromolecule catabolic process	4	6
GO:0009987	cellular process	1	6
GO:0019538	protein metabolic process	3	6
GO:0019941	modification-dependent protein catabolic process	6	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043632	modification-dependent macromolecule catabolic process	5	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0044248	cellular catabolic process	3	6
GO:0044260	obsolete cellular macromolecule metabolic process	3	6
GO:0044265	obsolete cellular macromolecule catabolic process	4	6
GO:0051603	proteolysis involved in protein catabolic process	5	6
GO:0071704	organic substance metabolic process	2	6
GO:1901564	organonitrogen compound metabolic process	3	6
GO:1901575	organic substance catabolic process	3	6
GO:0007049	cell cycle	2	4
GO:0051301	cell division	2	4

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0005515	protein binding	2	6
GO:0019899	enzyme binding	3	6
GO:0031625	ubiquitin protein ligase binding	5	6
GO:0044389	ubiquitin-like protein ligase binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	353	357	PF00656	0.506
CLV_C14_Caspase3-7	61	65	PF00656	0.414
CLV_NRD_NRD_1	147	149	PF00675	0.421
CLV_NRD_NRD_1	219	221	PF00675	0.554
CLV_NRD_NRD_1	277	279	PF00675	0.228
CLV_NRD_NRD_1	50	52	PF00675	0.381
CLV_PCSK_KEX2_1	146	148	PF00082	0.428
CLV_PCSK_KEX2_1	219	221	PF00082	0.520
CLV_PCSK_KEX2_1	277	279	PF00082	0.228
CLV_PCSK_KEX2_1	363	365	PF00082	0.242
CLV_PCSK_KEX2_1	49	51	PF00082	0.378
CLV_PCSK_PC1ET2_1	363	365	PF00082	0.242
CLV_PCSK_SKI1_1	211	215	PF00082	0.388
CLV_PCSK_SKI1_1	219	223	PF00082	0.384
CLV_PCSK_SKI1_1	255	259	PF00082	0.227
CLV_PCSK_SKI1_1	363	367	PF00082	0.259
CLV_PCSK_SKI1_1	40	44	PF00082	0.525
CLV_PCSK_SKI1_1	503	507	PF00082	0.465
CLV_PCSK_SKI1_1	93	97	PF00082	0.383
CLV_Separin_Metazoa	26	30	PF03568	0.586
CLV_Separin_Metazoa	539	543	PF03568	0.527
DEG_APCC_DBOX_1	210	218	PF00400	0.389
DEG_SPOP_SBC_1	514	518	PF00917	0.558
DOC_ANK_TNKS_1	5	12	PF00023	0.746
DOC_CDC14_PxL_1	371	379	PF14671	0.542
DOC_CKS1_1	77	82	PF01111	0.579
DOC_CYCLIN_RxL_1	206	216	PF00134	0.392
DOC_CYCLIN_RxL_1	90	98	PF00134	0.532
DOC_MAPK_gen_1	204	212	PF00069	0.517
DOC_MAPK_MEF2A_6	106	115	PF00069	0.376
DOC_MAPK_MEF2A_6	206	214	PF00069	0.405
DOC_MAPK_MEF2A_6	448	455	PF00069	0.542
DOC_USP7_MATH_1	18	22	PF00917	0.678
DOC_USP7_MATH_1	310	314	PF00917	0.508
DOC_USP7_MATH_1	514	518	PF00917	0.538
DOC_USP7_MATH_1	519	523	PF00917	0.500
DOC_USP7_UBL2_3	387	391	PF12436	0.542
DOC_USP7_UBL2_3	525	529	PF12436	0.562
DOC_WW_Pin1_4	242	247	PF00397	0.542
DOC_WW_Pin1_4	306	311	PF00397	0.542
DOC_WW_Pin1_4	326	331	PF00397	0.542
DOC_WW_Pin1_4	421	426	PF00397	0.464
DOC_WW_Pin1_4	447	452	PF00397	0.506
DOC_WW_Pin1_4	76	81	PF00397	0.501
LIG_14-3-3_CanoR_1	370	374	PF00244	0.542
LIG_14-3-3_CanoR_1	419	425	PF00244	0.542
LIG_14-3-3_CanoR_1	503	509	PF00244	0.532
LIG_14-3-3_CanoR_1	512	520	PF00244	0.403
LIG_BIR_III_2	17	21	PF00653	0.696
LIG_BIR_III_4	190	194	PF00653	0.711
LIG_BRCT_BRCA1_1	131	135	PF00533	0.397
LIG_BRCT_BRCA1_1	183	187	PF00533	0.722
LIG_BRCT_BRCA1_1	471	475	PF00533	0.552
LIG_CaM_IQ_9	270	286	PF13499	0.442
LIG_CSL_BTD_1	321	324	PF09270	0.542
LIG_CSL_BTD_1	372	375	PF09270	0.542
LIG_FHA_1	105	111	PF00498	0.357
LIG_FHA_1	458	464	PF00498	0.527
LIG_FHA_1	504	510	PF00498	0.412
LIG_FHA_1	84	90	PF00498	0.540
LIG_FHA_2	103	109	PF00498	0.411
LIG_FHA_2	242	248	PF00498	0.428
LIG_FHA_2	259	265	PF00498	0.511
LIG_FHA_2	383	389	PF00498	0.480
LIG_LIR_Gen_1	224	234	PF02991	0.368
LIG_LIR_Gen_1	472	483	PF02991	0.701
LIG_LIR_Gen_1	53	63	PF02991	0.381
LIG_LIR_Nem_3	320	325	PF02991	0.420
LIG_LIR_Nem_3	360	365	PF02991	0.506
LIG_LIR_Nem_3	53	59	PF02991	0.373
LIG_MYND_3	66	70	PF01753	0.523
LIG_NRBOX	38	44	PF00104	0.388
LIG_PCNA_yPIPBox_3	529	541	PF02747	0.550
LIG_Pex14_2	121	125	PF04695	0.482
LIG_Rb_pABgroove_1	399	407	PF01858	0.542
LIG_RPA_C_Fungi	272	284	PF08784	0.442
LIG_SH2_CRK	362	366	PF00017	0.366
LIG_SH2_CRK	558	562	PF00017	0.475
LIG_SH2_NCK_1	558	562	PF00017	0.563
LIG_SH2_STAT3	74	77	PF00017	0.541
LIG_SH2_STAT5	74	77	PF00017	0.491
LIG_SH3_2	7	12	PF14604	0.743
LIG_SH3_3	156	162	PF00018	0.578
LIG_SH3_3	165	171	PF00018	0.515
LIG_SH3_3	393	399	PF00018	0.442
LIG_SH3_3	4	10	PF00018	0.732
LIG_SH3_3	452	458	PF00018	0.418
LIG_SUMO_SIM_anti_2	107	115	PF11976	0.382
LIG_SUMO_SIM_anti_2	313	318	PF11976	0.355
LIG_SUMO_SIM_anti_2	536	543	PF11976	0.526
LIG_SUMO_SIM_par_1	40	46	PF11976	0.381
LIG_SUMO_SIM_par_1	400	406	PF11976	0.405
LIG_SUMO_SIM_par_1	548	554	PF11976	0.556
LIG_SxIP_EBH_1	210	220	PF03271	0.554
LIG_TRAF2_1	245	248	PF00917	0.302
LIG_TRAF2_1	350	353	PF00917	0.442
LIG_TRAF2_1	483	486	PF00917	0.743
LIG_TRFH_1	558	562	PF08558	0.563
LIG_WRC_WIRS_1	541	546	PF05994	0.532
MOD_CK1_1	136	142	PF00069	0.518
MOD_CK1_1	21	27	PF00069	0.585
MOD_CK1_1	298	304	PF00069	0.379
MOD_CK1_1	315	321	PF00069	0.315
MOD_CK1_1	468	474	PF00069	0.510
MOD_CK2_1	241	247	PF00069	0.283
MOD_CK2_1	75	81	PF00069	0.559
MOD_GlcNHglycan	303	306	PF01048	0.442
MOD_GlcNHglycan	335	338	PF01048	0.408
MOD_GlcNHglycan	471	474	PF01048	0.598
MOD_GlcNHglycan	484	489	PF01048	0.705
MOD_GlcNHglycan	81	84	PF01048	0.531
MOD_GSK3_1	129	136	PF00069	0.414
MOD_GSK3_1	171	178	PF00069	0.646
MOD_GSK3_1	18	25	PF00069	0.608
MOD_GSK3_1	273	280	PF00069	0.302
MOD_GSK3_1	293	300	PF00069	0.396
MOD_GSK3_1	306	313	PF00069	0.337
MOD_GSK3_1	369	376	PF00069	0.376
MOD_GSK3_1	387	394	PF00069	0.142
MOD_GSK3_1	415	422	PF00069	0.405
MOD_GSK3_1	457	464	PF00069	0.418
MOD_GSK3_1	465	472	PF00069	0.475
MOD_GSK3_1	504	511	PF00069	0.554
MOD_GSK3_1	515	522	PF00069	0.466
MOD_GSK3_1	75	82	PF00069	0.545
MOD_NEK2_1	114	119	PF00069	0.329
MOD_NEK2_1	213	218	PF00069	0.417
MOD_NEK2_1	258	263	PF00069	0.442
MOD_NEK2_1	273	278	PF00069	0.355
MOD_NEK2_1	287	292	PF00069	0.355
MOD_NEK2_1	295	300	PF00069	0.428
MOD_NEK2_1	317	322	PF00069	0.291
MOD_NEK2_1	382	387	PF00069	0.327
MOD_NEK2_1	405	410	PF00069	0.274
MOD_NEK2_1	43	48	PF00069	0.361
MOD_NEK2_1	465	470	PF00069	0.506
MOD_NEK2_1	504	509	PF00069	0.473
MOD_NEK2_1	530	535	PF00069	0.521
MOD_NEK2_1	540	545	PF00069	0.322
MOD_NEK2_1	88	93	PF00069	0.385
MOD_NEK2_1	95	100	PF00069	0.379
MOD_PIKK_1	171	177	PF00454	0.687
MOD_PIKK_1	19	25	PF00454	0.656
MOD_PIKK_1	277	283	PF00454	0.392
MOD_PIKK_1	293	299	PF00454	0.223
MOD_PIKK_1	382	388	PF00454	0.336
MOD_PKA_1	277	283	PF00069	0.302
MOD_PKA_2	277	283	PF00069	0.302
MOD_PKA_2	293	299	PF00069	0.302
MOD_PKA_2	369	375	PF00069	0.413
MOD_PKA_2	5	11	PF00069	0.743
MOD_Plk_1	128	134	PF00069	0.425
MOD_Plk_1	405	411	PF00069	0.319
MOD_Plk_4	129	135	PF00069	0.410
MOD_Plk_4	312	318	PF00069	0.370
MOD_Plk_4	369	375	PF00069	0.401
MOD_Plk_4	391	397	PF00069	0.301
MOD_Plk_4	400	406	PF00069	0.262
MOD_Plk_4	504	510	PF00069	0.446
MOD_ProDKin_1	242	248	PF00069	0.442
MOD_ProDKin_1	306	312	PF00069	0.442
MOD_ProDKin_1	326	332	PF00069	0.442
MOD_ProDKin_1	421	427	PF00069	0.333
MOD_ProDKin_1	447	453	PF00069	0.392
MOD_ProDKin_1	76	82	PF00069	0.503
MOD_SUMO_for_1	84	87	PF00179	0.547
TRG_DiLeu_BaEn_1	496	501	PF01217	0.601
TRG_DiLeu_BaEn_4	353	359	PF01217	0.442
TRG_DiLeu_BaLyEn_6	37	42	PF01217	0.534
TRG_ENDOCYTIC_2	226	229	PF00928	0.287
TRG_ENDOCYTIC_2	362	365	PF00928	0.325
TRG_ER_diArg_1	145	148	PF00400	0.547
TRG_ER_diArg_1	218	220	PF00400	0.559
TRG_ER_diArg_1	277	279	PF00400	0.294
TRG_ER_diArg_1	49	51	PF00400	0.416
TRG_NES_CRM1_1	539	554	PF08389	0.448
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	277	281	PF00026	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J0P6	Bodo saltans	35%	68%
A0A1X0P5D0	Trypanosomatidae	43%	73%
A0A422MYM3	Trypanosoma rangeli	42%	72%
C9ZYV9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	73%
Q874R3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	83%
Q8BZQ7	Mus musculus	25%	67%
Q9UJX6	Homo sapiens	24%	68%
V5BTC2	Trypanosoma cruzi	43%	73%