LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Protein of unknown function (DUF2946), putative
Species:
Leishmania mexicana
UniProt:
E9B6Q1_LEIMU
TriTrypDb:
Length:
836

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 3
NetGPI no yes: 0, no: 3
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6Q1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6Q1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 153 157 PF00656 0.652
CLV_NRD_NRD_1 134 136 PF00675 0.500
CLV_NRD_NRD_1 140 142 PF00675 0.532
CLV_NRD_NRD_1 161 163 PF00675 0.589
CLV_NRD_NRD_1 176 178 PF00675 0.398
CLV_NRD_NRD_1 249 251 PF00675 0.408
CLV_NRD_NRD_1 273 275 PF00675 0.452
CLV_NRD_NRD_1 28 30 PF00675 0.445
CLV_NRD_NRD_1 352 354 PF00675 0.340
CLV_NRD_NRD_1 369 371 PF00675 0.341
CLV_NRD_NRD_1 373 375 PF00675 0.326
CLV_NRD_NRD_1 383 385 PF00675 0.265
CLV_NRD_NRD_1 403 405 PF00675 0.449
CLV_NRD_NRD_1 415 417 PF00675 0.502
CLV_NRD_NRD_1 504 506 PF00675 0.297
CLV_NRD_NRD_1 537 539 PF00675 0.370
CLV_NRD_NRD_1 544 546 PF00675 0.368
CLV_NRD_NRD_1 584 586 PF00675 0.362
CLV_NRD_NRD_1 614 616 PF00675 0.490
CLV_NRD_NRD_1 627 629 PF00675 0.359
CLV_NRD_NRD_1 655 657 PF00675 0.596
CLV_NRD_NRD_1 724 726 PF00675 0.532
CLV_NRD_NRD_1 773 775 PF00675 0.339
CLV_NRD_NRD_1 796 798 PF00675 0.336
CLV_NRD_NRD_1 802 804 PF00675 0.308
CLV_NRD_NRD_1 810 812 PF00675 0.328
CLV_PCSK_FUR_1 625 629 PF00082 0.351
CLV_PCSK_FUR_1 653 657 PF00082 0.669
CLV_PCSK_KEX2_1 134 136 PF00082 0.429
CLV_PCSK_KEX2_1 161 163 PF00082 0.587
CLV_PCSK_KEX2_1 176 178 PF00082 0.396
CLV_PCSK_KEX2_1 249 251 PF00082 0.406
CLV_PCSK_KEX2_1 273 275 PF00082 0.562
CLV_PCSK_KEX2_1 28 30 PF00082 0.437
CLV_PCSK_KEX2_1 351 353 PF00082 0.346
CLV_PCSK_KEX2_1 369 371 PF00082 0.319
CLV_PCSK_KEX2_1 373 375 PF00082 0.326
CLV_PCSK_KEX2_1 383 385 PF00082 0.265
CLV_PCSK_KEX2_1 415 417 PF00082 0.515
CLV_PCSK_KEX2_1 504 506 PF00082 0.297
CLV_PCSK_KEX2_1 537 539 PF00082 0.374
CLV_PCSK_KEX2_1 544 546 PF00082 0.374
CLV_PCSK_KEX2_1 584 586 PF00082 0.362
CLV_PCSK_KEX2_1 614 616 PF00082 0.358
CLV_PCSK_KEX2_1 627 629 PF00082 0.366
CLV_PCSK_KEX2_1 655 657 PF00082 0.596
CLV_PCSK_KEX2_1 659 661 PF00082 0.628
CLV_PCSK_KEX2_1 724 726 PF00082 0.532
CLV_PCSK_KEX2_1 773 775 PF00082 0.339
CLV_PCSK_KEX2_1 796 798 PF00082 0.334
CLV_PCSK_KEX2_1 802 804 PF00082 0.306
CLV_PCSK_KEX2_1 809 811 PF00082 0.331
CLV_PCSK_PC1ET2_1 351 353 PF00082 0.373
CLV_PCSK_PC1ET2_1 659 661 PF00082 0.529
CLV_PCSK_PC7_1 369 375 PF00082 0.351
CLV_PCSK_PC7_1 500 506 PF00082 0.339
CLV_PCSK_PC7_1 623 629 PF00082 0.388
CLV_PCSK_PC7_1 655 661 PF00082 0.529
CLV_PCSK_PC7_1 720 726 PF00082 0.516
CLV_PCSK_SKI1_1 202 206 PF00082 0.425
CLV_PCSK_SKI1_1 225 229 PF00082 0.404
CLV_PCSK_SKI1_1 274 278 PF00082 0.529
CLV_PCSK_SKI1_1 330 334 PF00082 0.322
CLV_PCSK_SKI1_1 352 356 PF00082 0.341
CLV_PCSK_SKI1_1 369 373 PF00082 0.321
CLV_PCSK_SKI1_1 392 396 PF00082 0.239
CLV_PCSK_SKI1_1 404 408 PF00082 0.536
CLV_PCSK_SKI1_1 415 419 PF00082 0.506
CLV_PCSK_SKI1_1 428 432 PF00082 0.474
CLV_PCSK_SKI1_1 435 439 PF00082 0.503
CLV_PCSK_SKI1_1 443 447 PF00082 0.543
CLV_PCSK_SKI1_1 500 504 PF00082 0.265
CLV_PCSK_SKI1_1 505 509 PF00082 0.265
CLV_PCSK_SKI1_1 545 549 PF00082 0.379
CLV_PCSK_SKI1_1 594 598 PF00082 0.395
CLV_PCSK_SKI1_1 62 66 PF00082 0.444
CLV_PCSK_SKI1_1 660 664 PF00082 0.527
CLV_PCSK_SKI1_1 689 693 PF00082 0.502
CLV_PCSK_SKI1_1 720 724 PF00082 0.516
CLV_PCSK_SKI1_1 821 825 PF00082 0.396
DEG_APCC_DBOX_1 273 281 PF00400 0.648
DEG_APCC_DBOX_1 403 411 PF00400 0.347
DEG_APCC_DBOX_1 499 507 PF00400 0.265
DEG_APCC_DBOX_1 630 638 PF00400 0.605
DEG_Nend_UBRbox_1 1 4 PF02207 0.638
DEG_ODPH_VHL_1 813 825 PF01847 0.549
DEG_SPOP_SBC_1 39 43 PF00917 0.616
DOC_CKS1_1 211 216 PF01111 0.686
DOC_CKS1_1 217 222 PF01111 0.628
DOC_CYCLIN_RxL_1 222 230 PF00134 0.551
DOC_CYCLIN_RxL_1 340 348 PF00134 0.540
DOC_CYCLIN_RxL_1 366 376 PF00134 0.629
DOC_CYCLIN_RxL_1 653 664 PF00134 0.327
DOC_CYCLIN_yClb5_NLxxxL_5 225 231 PF00134 0.588
DOC_MAPK_gen_1 319 328 PF00069 0.616
DOC_MAPK_gen_1 333 342 PF00069 0.517
DOC_MAPK_gen_1 351 361 PF00069 0.538
DOC_MAPK_gen_1 383 389 PF00069 0.303
DOC_MAPK_gen_1 581 591 PF00069 0.553
DOC_MAPK_gen_1 598 607 PF00069 0.481
DOC_MAPK_gen_1 653 663 PF00069 0.327
DOC_MAPK_gen_1 693 703 PF00069 0.330
DOC_MAPK_gen_1 784 793 PF00069 0.491
DOC_MAPK_gen_1 824 834 PF00069 0.629
DOC_MAPK_MEF2A_6 319 328 PF00069 0.524
DOC_MAPK_MEF2A_6 696 703 PF00069 0.309
DOC_MAPK_MEF2A_6 786 795 PF00069 0.484
DOC_MAPK_MEF2A_6 827 836 PF00069 0.636
DOC_PP1_RVXF_1 784 790 PF00149 0.511
DOC_PP4_FxxP_1 204 207 PF00568 0.643
DOC_PP4_FxxP_1 37 40 PF00568 0.656
DOC_USP7_MATH_1 115 119 PF00917 0.554
DOC_USP7_MATH_1 179 183 PF00917 0.815
DOC_USP7_MATH_1 291 295 PF00917 0.679
DOC_USP7_MATH_1 484 488 PF00917 0.434
DOC_USP7_MATH_1 571 575 PF00917 0.637
DOC_USP7_MATH_1 69 73 PF00917 0.643
DOC_WW_Pin1_4 169 174 PF00397 0.681
DOC_WW_Pin1_4 210 215 PF00397 0.684
DOC_WW_Pin1_4 216 221 PF00397 0.636
DOC_WW_Pin1_4 265 270 PF00397 0.644
DOC_WW_Pin1_4 30 35 PF00397 0.719
DOC_WW_Pin1_4 40 45 PF00397 0.640
DOC_WW_Pin1_4 49 54 PF00397 0.610
DOC_WW_Pin1_4 827 832 PF00397 0.579
LIG_14-3-3_CanoR_1 161 171 PF00244 0.680
LIG_14-3-3_CanoR_1 176 185 PF00244 0.597
LIG_14-3-3_CanoR_1 253 261 PF00244 0.639
LIG_14-3-3_CanoR_1 273 280 PF00244 0.610
LIG_14-3-3_CanoR_1 295 299 PF00244 0.639
LIG_14-3-3_CanoR_1 319 325 PF00244 0.667
LIG_14-3-3_CanoR_1 335 341 PF00244 0.491
LIG_14-3-3_CanoR_1 35 40 PF00244 0.642
LIG_14-3-3_CanoR_1 362 366 PF00244 0.515
LIG_14-3-3_CanoR_1 373 381 PF00244 0.543
LIG_14-3-3_CanoR_1 384 390 PF00244 0.228
LIG_14-3-3_CanoR_1 408 418 PF00244 0.276
LIG_14-3-3_CanoR_1 435 440 PF00244 0.337
LIG_14-3-3_CanoR_1 461 467 PF00244 0.337
LIG_14-3-3_CanoR_1 511 519 PF00244 0.575
LIG_14-3-3_CanoR_1 537 546 PF00244 0.532
LIG_14-3-3_CanoR_1 696 702 PF00244 0.371
LIG_14-3-3_CanoR_1 809 814 PF00244 0.563
LIG_14-3-3_CanoR_1 827 831 PF00244 0.572
LIG_Actin_WH2_2 317 332 PF00022 0.566
LIG_CaM_IQ_9 378 394 PF13499 0.388
LIG_eIF4E_1 366 372 PF01652 0.548
LIG_FHA_1 105 111 PF00498 0.588
LIG_FHA_1 163 169 PF00498 0.727
LIG_FHA_1 194 200 PF00498 0.718
LIG_FHA_1 211 217 PF00498 0.714
LIG_FHA_1 222 228 PF00498 0.613
LIG_FHA_1 337 343 PF00498 0.540
LIG_FHA_1 389 395 PF00498 0.241
LIG_FHA_1 489 495 PF00498 0.217
LIG_FHA_1 698 704 PF00498 0.354
LIG_FHA_1 763 769 PF00498 0.265
LIG_FHA_2 179 185 PF00498 0.639
LIG_FHA_2 463 469 PF00498 0.369
LIG_FHA_2 759 765 PF00498 0.265
LIG_GBD_Chelix_1 588 596 PF00786 0.335
LIG_LIR_Apic_2 201 207 PF02991 0.645
LIG_LIR_Nem_3 360 366 PF02991 0.557
LIG_LIR_Nem_3 412 417 PF02991 0.436
LIG_LIR_Nem_3 618 622 PF02991 0.523
LIG_LYPXL_SIV_4 684 692 PF13949 0.270
LIG_MYND_1 203 207 PF01753 0.624
LIG_PDZ_Class_2 831 836 PF00595 0.610
LIG_Pex14_1 433 437 PF04695 0.337
LIG_Pex14_2 228 232 PF04695 0.538
LIG_SH2_CRK 638 642 PF00017 0.196
LIG_SH2_NCK_1 447 451 PF00017 0.339
LIG_SH2_SRC 638 641 PF00017 0.265
LIG_SH2_STAP1 363 367 PF00017 0.495
LIG_SH2_STAP1 638 642 PF00017 0.303
LIG_SH2_STAT3 365 368 PF00017 0.603
LIG_SH2_STAT3 527 530 PF00017 0.565
LIG_SH2_STAT5 366 369 PF00017 0.528
LIG_SH2_STAT5 527 530 PF00017 0.533
LIG_SH2_STAT5 640 643 PF00017 0.197
LIG_SH2_STAT5 757 760 PF00017 0.265
LIG_SH3_3 200 206 PF00018 0.645
LIG_SH3_3 208 214 PF00018 0.656
LIG_SH3_3 302 308 PF00018 0.659
LIG_SH3_3 573 579 PF00018 0.568
LIG_SH3_3 812 818 PF00018 0.638
LIG_SUMO_SIM_anti_2 322 328 PF11976 0.538
LIG_SUMO_SIM_anti_2 475 481 PF11976 0.381
LIG_SUMO_SIM_par_1 489 495 PF11976 0.188
LIG_TRAF2_1 125 128 PF00917 0.608
LIG_UBA3_1 326 333 PF00899 0.411
LIG_WRC_WIRS_1 434 439 PF05994 0.333
MOD_CDK_SPK_2 30 35 PF00069 0.582
MOD_CDK_SPK_2 40 45 PF00069 0.582
MOD_CDK_SPxxK_3 169 176 PF00069 0.548
MOD_CK1_1 104 110 PF00069 0.574
MOD_CK1_1 178 184 PF00069 0.776
MOD_CK1_1 193 199 PF00069 0.476
MOD_CK1_1 268 274 PF00069 0.624
MOD_CK1_1 282 288 PF00069 0.530
MOD_CK1_1 293 299 PF00069 0.503
MOD_CK1_1 300 306 PF00069 0.559
MOD_CK1_1 322 328 PF00069 0.433
MOD_CK1_1 376 382 PF00069 0.355
MOD_CK1_1 38 44 PF00069 0.557
MOD_CK1_1 388 394 PF00069 0.196
MOD_CK1_1 697 703 PF00069 0.411
MOD_CK1_1 72 78 PF00069 0.687
MOD_CK1_1 80 86 PF00069 0.591
MOD_CK1_1 830 836 PF00069 0.457
MOD_CK2_1 122 128 PF00069 0.597
MOD_CK2_1 178 184 PF00069 0.557
MOD_CK2_1 462 468 PF00069 0.452
MOD_CK2_1 55 61 PF00069 0.567
MOD_CK2_1 550 556 PF00069 0.501
MOD_CK2_1 571 577 PF00069 0.511
MOD_CK2_1 758 764 PF00069 0.265
MOD_DYRK1A_RPxSP_1 827 831 PF00069 0.427
MOD_GlcNHglycan 177 180 PF01048 0.629
MOD_GlcNHglycan 181 184 PF01048 0.630
MOD_GlcNHglycan 23 26 PF01048 0.535
MOD_GlcNHglycan 285 288 PF01048 0.508
MOD_GlcNHglycan 299 302 PF01048 0.700
MOD_GlcNHglycan 37 40 PF01048 0.618
MOD_GlcNHglycan 486 489 PF01048 0.542
MOD_GlcNHglycan 58 61 PF01048 0.513
MOD_GlcNHglycan 601 604 PF01048 0.487
MOD_GlcNHglycan 83 86 PF01048 0.610
MOD_GSK3_1 146 153 PF00069 0.582
MOD_GSK3_1 160 167 PF00069 0.638
MOD_GSK3_1 175 182 PF00069 0.512
MOD_GSK3_1 264 271 PF00069 0.624
MOD_GSK3_1 278 285 PF00069 0.576
MOD_GSK3_1 290 297 PF00069 0.618
MOD_GSK3_1 35 42 PF00069 0.619
MOD_GSK3_1 45 52 PF00069 0.544
MOD_GSK3_1 484 491 PF00069 0.544
MOD_GSK3_1 697 704 PF00069 0.365
MOD_GSK3_1 71 78 PF00069 0.661
MOD_GSK3_1 758 765 PF00069 0.265
MOD_GSK3_1 826 833 PF00069 0.506
MOD_LATS_1 160 166 PF00433 0.493
MOD_N-GLC_1 253 258 PF02516 0.535
MOD_NEK2_1 227 232 PF00069 0.603
MOD_NEK2_1 283 288 PF00069 0.707
MOD_NEK2_1 361 366 PF00069 0.358
MOD_NEK2_1 400 405 PF00069 0.352
MOD_NEK2_1 446 451 PF00069 0.444
MOD_NEK2_1 453 458 PF00069 0.444
MOD_NEK2_1 55 60 PF00069 0.572
MOD_NEK2_1 661 666 PF00069 0.394
MOD_NEK2_1 694 699 PF00069 0.345
MOD_NEK2_1 730 735 PF00069 0.436
MOD_NEK2_1 825 830 PF00069 0.430
MOD_NEK2_2 115 120 PF00069 0.429
MOD_NEK2_2 336 341 PF00069 0.407
MOD_PIKK_1 423 429 PF00454 0.344
MOD_PIKK_1 448 454 PF00454 0.432
MOD_PIKK_1 95 101 PF00454 0.484
MOD_PKA_1 161 167 PF00069 0.597
MOD_PKA_1 373 379 PF00069 0.421
MOD_PKA_1 809 815 PF00069 0.479
MOD_PKA_2 160 166 PF00069 0.565
MOD_PKA_2 175 181 PF00069 0.485
MOD_PKA_2 252 258 PF00069 0.546
MOD_PKA_2 272 278 PF00069 0.499
MOD_PKA_2 291 297 PF00069 0.608
MOD_PKA_2 320 326 PF00069 0.487
MOD_PKA_2 361 367 PF00069 0.369
MOD_PKA_2 373 379 PF00069 0.422
MOD_PKA_2 385 391 PF00069 0.221
MOD_PKA_2 484 490 PF00069 0.435
MOD_PKA_2 697 703 PF00069 0.542
MOD_PKA_2 75 81 PF00069 0.541
MOD_PKA_2 798 804 PF00069 0.472
MOD_PKA_2 809 815 PF00069 0.395
MOD_PKA_2 826 832 PF00069 0.499
MOD_PKB_1 716 724 PF00069 0.357
MOD_Plk_1 193 199 PF00069 0.528
MOD_Plk_1 376 382 PF00069 0.355
MOD_Plk_1 718 724 PF00069 0.355
MOD_Plk_4 106 112 PF00069 0.473
MOD_Plk_4 227 233 PF00069 0.511
MOD_Plk_4 322 328 PF00069 0.433
MOD_Plk_4 336 342 PF00069 0.408
MOD_Plk_4 361 367 PF00069 0.354
MOD_Plk_4 376 382 PF00069 0.389
MOD_Plk_4 385 391 PF00069 0.256
MOD_Plk_4 462 468 PF00069 0.452
MOD_Plk_4 488 494 PF00069 0.303
MOD_Plk_4 571 577 PF00069 0.511
MOD_Plk_4 587 593 PF00069 0.401
MOD_Plk_4 830 836 PF00069 0.471
MOD_ProDKin_1 169 175 PF00069 0.607
MOD_ProDKin_1 210 216 PF00069 0.613
MOD_ProDKin_1 265 271 PF00069 0.548
MOD_ProDKin_1 30 36 PF00069 0.655
MOD_ProDKin_1 40 46 PF00069 0.548
MOD_ProDKin_1 49 55 PF00069 0.506
MOD_ProDKin_1 827 833 PF00069 0.463
TRG_DiLeu_BaEn_1 194 199 PF01217 0.528
TRG_DiLeu_BaEn_1 475 480 PF01217 0.468
TRG_DiLeu_BaEn_2 60 66 PF01217 0.493
TRG_DiLeu_BaLyEn_6 367 372 PF01217 0.420
TRG_DiLeu_BaLyEn_6 413 418 PF01217 0.325
TRG_DiLeu_BaLyEn_6 497 502 PF01217 0.303
TRG_DiLeu_BaLyEn_6 657 662 PF01217 0.348
TRG_ENDOCYTIC_2 638 641 PF00928 0.228
TRG_ER_diArg_1 133 135 PF00400 0.464
TRG_ER_diArg_1 175 177 PF00400 0.555
TRG_ER_diArg_1 249 251 PF00400 0.459
TRG_ER_diArg_1 28 30 PF00400 0.545
TRG_ER_diArg_1 369 371 PF00400 0.571
TRG_ER_diArg_1 372 374 PF00400 0.353
TRG_ER_diArg_1 383 385 PF00400 0.265
TRG_ER_diArg_1 414 416 PF00400 0.452
TRG_ER_diArg_1 457 460 PF00400 0.617
TRG_ER_diArg_1 503 505 PF00400 0.351
TRG_ER_diArg_1 510 513 PF00400 0.408
TRG_ER_diArg_1 536 538 PF00400 0.458
TRG_ER_diArg_1 544 546 PF00400 0.459
TRG_ER_diArg_1 551 554 PF00400 0.397
TRG_ER_diArg_1 559 562 PF00400 0.535
TRG_ER_diArg_1 583 585 PF00400 0.439
TRG_ER_diArg_1 613 615 PF00400 0.389
TRG_ER_diArg_1 622 625 PF00400 0.379
TRG_ER_diArg_1 653 656 PF00400 0.473
TRG_ER_diArg_1 658 661 PF00400 0.526
TRG_ER_diArg_1 695 698 PF00400 0.414
TRG_ER_diArg_1 723 725 PF00400 0.338
TRG_ER_diArg_1 772 774 PF00400 0.416
TRG_ER_diArg_1 784 787 PF00400 0.403
TRG_ER_diArg_1 795 797 PF00400 0.523
TRG_ER_diArg_1 808 811 PF00400 0.377
TRG_NLS_MonoExtN_4 655 662 PF00514 0.394
TRG_Pf-PMV_PEXEL_1 120 124 PF00026 0.479
TRG_Pf-PMV_PEXEL_1 343 348 PF00026 0.409
TRG_Pf-PMV_PEXEL_1 353 357 PF00026 0.406
TRG_Pf-PMV_PEXEL_1 415 419 PF00026 0.454
TRG_Pf-PMV_PEXEL_1 821 826 PF00026 0.460

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HUY9 Leptomonas seymouri 42% 98%
A4HN44 Leishmania braziliensis 72% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS