t-SNARE coiled-coil homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B6Q0_LEIMU

TriTrypDb:

LmxM.34.3720

Length:

440

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B6Q0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6Q0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	225	229	PF00656	0.613
CLV_C14_Caspase3-7	26	30	PF00656	0.382
CLV_C14_Caspase3-7	68	72	PF00656	0.609
CLV_NRD_NRD_1	184	186	PF00675	0.540
CLV_NRD_NRD_1	258	260	PF00675	0.499
CLV_NRD_NRD_1	276	278	PF00675	0.498
CLV_NRD_NRD_1	345	347	PF00675	0.507
CLV_NRD_NRD_1	438	440	PF00675	0.755
CLV_NRD_NRD_1	85	87	PF00675	0.479
CLV_PCSK_KEX2_1	128	130	PF00082	0.704
CLV_PCSK_KEX2_1	184	186	PF00082	0.543
CLV_PCSK_KEX2_1	258	260	PF00082	0.499
CLV_PCSK_KEX2_1	276	278	PF00082	0.498
CLV_PCSK_KEX2_1	85	87	PF00082	0.481
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.704
CLV_PCSK_SKI1_1	169	173	PF00082	0.539
CLV_PCSK_SKI1_1	243	247	PF00082	0.521
CLV_PCSK_SKI1_1	300	304	PF00082	0.610
CLV_PCSK_SKI1_1	347	351	PF00082	0.512
CLV_PCSK_SKI1_1	391	395	PF00082	0.596
CLV_Separin_Metazoa	338	342	PF03568	0.567
DEG_Nend_UBRbox_2	1	3	PF02207	0.724
DOC_MAPK_gen_1	166	174	PF00069	0.508
DOC_MAPK_gen_1	184	191	PF00069	0.476
DOC_MAPK_gen_1	346	352	PF00069	0.497
DOC_MAPK_gen_1	391	399	PF00069	0.473
DOC_MAPK_MEF2A_6	391	399	PF00069	0.315
DOC_PP1_RVXF_1	127	134	PF00149	0.680
DOC_USP7_MATH_1	305	309	PF00917	0.605
DOC_USP7_MATH_1	386	390	PF00917	0.312
LIG_Actin_WH2_2	66	83	PF00022	0.485
LIG_CaM_IQ_9	363	379	PF13499	0.448
LIG_CaM_IQ_9	73	88	PF13499	0.508
LIG_FHA_1	16	22	PF00498	0.617
LIG_FHA_1	280	286	PF00498	0.598
LIG_FHA_1	327	333	PF00498	0.479
LIG_FHA_2	109	115	PF00498	0.556
LIG_FHA_2	223	229	PF00498	0.596
LIG_LIR_Gen_1	130	141	PF02991	0.607
LIG_LIR_Gen_1	186	194	PF02991	0.585
LIG_LIR_Nem_3	130	136	PF02991	0.626
LIG_LIR_Nem_3	186	191	PF02991	0.546
LIG_LIR_Nem_3	322	327	PF02991	0.494
LIG_LIR_Nem_3	328	333	PF02991	0.459
LIG_Rb_LxCxE_1	233	252	PF01857	0.614
LIG_RPA_C_Plants	75	86	PF08784	0.327
LIG_SH2_CRK	188	192	PF00017	0.518
LIG_SH2_PTP2	324	327	PF00017	0.573
LIG_SH2_SRC	324	327	PF00017	0.573
LIG_SH2_STAP1	24	28	PF00017	0.493
LIG_SH2_STAT5	324	327	PF00017	0.515
LIG_SH3_3	55	61	PF00018	0.397
LIG_SUMO_SIM_par_1	170	175	PF11976	0.595
LIG_SUMO_SIM_par_1	348	353	PF11976	0.507
LIG_TRAF2_1	10	13	PF00917	0.577
LIG_TRAF2_1	20	23	PF00917	0.548
LIG_TRAF2_1	308	311	PF00917	0.598
LIG_TRAF2_1	60	63	PF00917	0.531
LIG_TRAF2_1	95	98	PF00917	0.584
LIG_UBA3_1	349	354	PF00899	0.516
LIG_WRC_WIRS_1	327	332	PF05994	0.619
MOD_CK1_1	152	158	PF00069	0.594
MOD_CK1_1	160	166	PF00069	0.609
MOD_CK1_1	227	233	PF00069	0.556
MOD_CK2_1	108	114	PF00069	0.621
MOD_CK2_1	131	137	PF00069	0.565
MOD_CK2_1	144	150	PF00069	0.414
MOD_CK2_1	227	233	PF00069	0.580
MOD_CK2_1	238	244	PF00069	0.618
MOD_CK2_1	281	287	PF00069	0.532
MOD_CK2_1	305	311	PF00069	0.614
MOD_CK2_1	403	409	PF00069	0.357
MOD_Cter_Amidation	126	129	PF01082	0.695
MOD_GlcNHglycan	174	177	PF01048	0.622
MOD_GlcNHglycan	300	303	PF01048	0.567
MOD_GlcNHglycan	305	308	PF01048	0.570
MOD_GlcNHglycan	384	387	PF01048	0.609
MOD_GlcNHglycan	435	438	PF01048	0.731
MOD_GSK3_1	144	151	PF00069	0.589
MOD_GSK3_1	152	159	PF00069	0.612
MOD_GSK3_1	222	229	PF00069	0.609
MOD_GSK3_1	23	30	PF00069	0.539
MOD_GSK3_1	277	284	PF00069	0.512
MOD_GSK3_1	353	360	PF00069	0.579
MOD_GSK3_1	382	389	PF00069	0.554
MOD_N-GLC_1	108	113	PF02516	0.438
MOD_N-GLC_2	193	195	PF02516	0.598
MOD_NEK2_1	108	113	PF00069	0.513
MOD_NEK2_1	119	124	PF00069	0.545
MOD_NEK2_1	148	153	PF00069	0.453
MOD_NEK2_1	167	172	PF00069	0.606
MOD_NEK2_1	205	210	PF00069	0.489
MOD_NEK2_1	339	344	PF00069	0.541
MOD_NEK2_1	411	416	PF00069	0.517
MOD_NEK2_2	326	331	PF00069	0.614
MOD_NEK2_2	386	391	PF00069	0.539
MOD_PIKK_1	403	409	PF00454	0.429
MOD_PKA_2	15	21	PF00069	0.642
MOD_PKA_2	183	189	PF00069	0.553
MOD_PKA_2	411	417	PF00069	0.577
MOD_Plk_1	144	150	PF00069	0.523
MOD_Plk_1	167	173	PF00069	0.596
MOD_Plk_1	227	233	PF00069	0.620
MOD_Plk_1	386	392	PF00069	0.563
MOD_Plk_2-3	2	8	PF00069	0.628
MOD_Plk_2-3	34	40	PF00069	0.600
MOD_Plk_4	114	120	PF00069	0.576
MOD_Plk_4	144	150	PF00069	0.585
MOD_Plk_4	167	173	PF00069	0.521
MOD_Plk_4	227	233	PF00069	0.619
MOD_Plk_4	353	359	PF00069	0.600
MOD_SUMO_for_1	165	168	PF00179	0.477
MOD_SUMO_for_1	223	226	PF00179	0.601
MOD_SUMO_rev_2	150	160	PF00179	0.543
MOD_SUMO_rev_2	247	256	PF00179	0.542
MOD_SUMO_rev_2	398	405	PF00179	0.521
TRG_DiLeu_BaEn_1	400	405	PF01217	0.522
TRG_DiLeu_BaLyEn_6	328	333	PF01217	0.507
TRG_ENDOCYTIC_2	188	191	PF00928	0.487
TRG_ENDOCYTIC_2	324	327	PF00928	0.466
TRG_ER_diArg_1	184	187	PF00400	0.553
TRG_ER_diArg_1	276	278	PF00400	0.637
TRG_NES_CRM1_1	71	84	PF08389	0.538
TRG_Pf-PMV_PEXEL_1	19	23	PF00026	0.596
TRG_Pf-PMV_PEXEL_1	283	287	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	99	103	PF00026	0.581

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ51	Leptomonas seymouri	68%	100%
A0A0S4JDF0	Bodo saltans	42%	99%
A0A1X0P5H1	Trypanosomatidae	41%	100%
A0A3Q8IFE4	Leishmania donovani	91%	100%
A0A3R7N172	Trypanosoma rangeli	45%	100%
A4HN43	Leishmania braziliensis	79%	100%
A4IBR1	Leishmania infantum	91%	100%
C9ZYW3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AFJ6	Leishmania major	91%	100%
V5BXZ9	Trypanosoma cruzi	41%	100%