Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B6P9_LEIMU

TriTrypDb:

LmxM.34.3710

Length:

341

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9B6P9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6P9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	56	60	PF00656	0.542
CLV_NRD_NRD_1	129	131	PF00675	0.643
CLV_NRD_NRD_1	77	79	PF00675	0.714
CLV_PCSK_KEX2_1	129	131	PF00082	0.619
CLV_PCSK_KEX2_1	77	79	PF00082	0.740
CLV_PCSK_SKI1_1	117	121	PF00082	0.707
CLV_PCSK_SKI1_1	274	278	PF00082	0.595
CLV_PCSK_SKI1_1	282	286	PF00082	0.364
DEG_MDM2_SWIB_1	235	243	PF02201	0.683
DEG_SCF_TRCP1_1	59	65	PF00400	0.545
DOC_ANK_TNKS_1	76	83	PF00023	0.553
DOC_CKS1_1	275	280	PF01111	0.400
DOC_MAPK_gen_1	139	147	PF00069	0.445
DOC_PP1_RVXF_1	144	150	PF00149	0.402
DOC_USP7_MATH_1	115	119	PF00917	0.537
DOC_USP7_MATH_1	21	25	PF00917	0.590
DOC_USP7_MATH_1	322	326	PF00917	0.750
DOC_USP7_MATH_1	331	335	PF00917	0.672
DOC_USP7_UBL2_3	189	193	PF12436	0.576
DOC_WW_Pin1_4	17	22	PF00397	0.631
DOC_WW_Pin1_4	242	247	PF00397	0.704
DOC_WW_Pin1_4	274	279	PF00397	0.387
LIG_14-3-3_CanoR_1	166	175	PF00244	0.346
LIG_14-3-3_CanoR_1	282	288	PF00244	0.445
LIG_14-3-3_CanoR_1	69	76	PF00244	0.428
LIG_14-3-3_CanoR_1	83	88	PF00244	0.508
LIG_BIR_III_2	330	334	PF00653	0.754
LIG_BRCT_BRCA1_1	200	204	PF00533	0.598
LIG_deltaCOP1_diTrp_1	317	323	PF00928	0.641
LIG_FHA_1	178	184	PF00498	0.612
LIG_FHA_1	206	212	PF00498	0.597
LIG_FHA_1	310	316	PF00498	0.648
LIG_FHA_1	84	90	PF00498	0.476
LIG_FHA_2	49	55	PF00498	0.567
LIG_LIR_Gen_1	188	199	PF02991	0.576
LIG_LIR_Gen_1	201	211	PF02991	0.540
LIG_LIR_Gen_1	232	243	PF02991	0.650
LIG_LIR_Gen_1	249	258	PF02991	0.397
LIG_LIR_Gen_1	43	50	PF02991	0.528
LIG_LIR_Gen_1	65	73	PF02991	0.545
LIG_LIR_Nem_3	188	194	PF02991	0.584
LIG_LIR_Nem_3	201	207	PF02991	0.546
LIG_LIR_Nem_3	232	238	PF02991	0.628
LIG_LIR_Nem_3	249	254	PF02991	0.434
LIG_LIR_Nem_3	3	7	PF02991	0.581
LIG_LIR_Nem_3	43	49	PF02991	0.565
LIG_NRBOX	233	239	PF00104	0.613
LIG_Pex14_2	235	239	PF04695	0.671
LIG_SH2_CRK	191	195	PF00017	0.601
LIG_SH2_CRK	273	277	PF00017	0.460
LIG_SH2_GRB2like	125	128	PF00017	0.502
LIG_SH2_GRB2like	99	102	PF00017	0.300
LIG_SH2_SRC	123	126	PF00017	0.493
LIG_SH2_SRC	316	319	PF00017	0.516
LIG_SH2_STAP1	99	103	PF00017	0.336
LIG_SH2_STAT3	307	310	PF00017	0.661
LIG_SH2_STAT5	163	166	PF00017	0.334
LIG_SH2_STAT5	268	271	PF00017	0.447
LIG_SH2_STAT5	298	301	PF00017	0.445
LIG_SH3_3	240	246	PF00018	0.612
LIG_SUMO_SIM_par_1	283	289	PF11976	0.480
LIG_WRPW_2	304	307	PF00400	0.578
LIG_WRPW_2	320	323	PF00400	0.629
MOD_CDC14_SPxK_1	245	248	PF00782	0.680
MOD_CDK_SPxK_1	242	248	PF00069	0.695
MOD_CK1_1	22	28	PF00069	0.578
MOD_CK1_1	257	263	PF00069	0.447
MOD_CK1_1	286	292	PF00069	0.422
MOD_CMANNOS	149	152	PF00535	0.591
MOD_CMANNOS	320	323	PF00535	0.450
MOD_GlcNHglycan	239	242	PF01048	0.427
MOD_GlcNHglycan	259	262	PF01048	0.238
MOD_GlcNHglycan	28	31	PF01048	0.697
MOD_GlcNHglycan	290	293	PF01048	0.491
MOD_GlcNHglycan	59	62	PF01048	0.771
MOD_GSK3_1	17	24	PF00069	0.573
MOD_GSK3_1	183	190	PF00069	0.644
MOD_GSK3_1	205	212	PF00069	0.547
MOD_GSK3_1	237	244	PF00069	0.609
MOD_GSK3_1	253	260	PF00069	0.323
MOD_GSK3_1	26	33	PF00069	0.584
MOD_GSK3_1	286	293	PF00069	0.211
MOD_GSK3_1	36	43	PF00069	0.350
MOD_N-GLC_1	254	259	PF02516	0.480
MOD_NEK2_1	187	192	PF00069	0.649
MOD_NEK2_1	219	224	PF00069	0.587
MOD_NEK2_1	285	290	PF00069	0.430
MOD_NEK2_1	36	41	PF00069	0.585
MOD_PIKK_1	62	68	PF00454	0.523
MOD_PKA_2	82	88	PF00069	0.529
MOD_Plk_1	187	193	PF00069	0.652
MOD_Plk_1	254	260	PF00069	0.400
MOD_Plk_1	30	36	PF00069	0.398
MOD_Plk_2-3	42	48	PF00069	0.583
MOD_Plk_2-3	88	94	PF00069	0.496
MOD_ProDKin_1	17	23	PF00069	0.628
MOD_ProDKin_1	242	248	PF00069	0.695
MOD_ProDKin_1	274	280	PF00069	0.383
MOD_SUMO_rev_2	68	76	PF00179	0.390
TRG_ENDOCYTIC_2	184	187	PF00928	0.556
TRG_ENDOCYTIC_2	191	194	PF00928	0.567
TRG_ENDOCYTIC_2	268	271	PF00928	0.447
TRG_ENDOCYTIC_2	273	276	PF00928	0.438
TRG_ENDOCYTIC_2	64	67	PF00928	0.549
TRG_ER_diArg_1	129	131	PF00400	0.435
TRG_ER_diArg_1	76	78	PF00400	0.529
TRG_Pf-PMV_PEXEL_1	38	42	PF00026	0.764

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB50	Leptomonas seymouri	58%	99%
A0A1X0P6A1	Trypanosomatidae	41%	100%
A0A3S7X9N6	Leishmania donovani	94%	100%
A0A422MTB0	Trypanosoma rangeli	39%	100%
A4HN42	Leishmania braziliensis	83%	100%
A4IBR0	Leishmania infantum	94%	100%
C9ZYW4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AFJ5	Leishmania major	93%	100%
V5C2T1	Trypanosoma cruzi	42%	100%