Membrane transporter protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B6P2_LEIMU

TriTrypDb:

LmxM.34.3630

Length:

620

Annotations

LeishMANIAdb annotations

SLC47 family transporter, with potential detoxification functions

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 29
NetGPI	no	yes: 0, no: 29

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	30
GO:0110165	cellular anatomical entity	1	30

Expansion

Sequence features

E9B6P2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6P2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0009987	cellular process	1	12
GO:0042908	xenobiotic transport	4	12
GO:0046618	xenobiotic export from cell	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0055085	transmembrane transport	2	12
GO:0140115	export across plasma membrane	3	12
GO:0140352	export from cell	2	12
GO:1990961	xenobiotic detoxification by transmembrane export across the plasma membrane	4	12

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	30
GO:0015291	secondary active transmembrane transporter activity	4	30
GO:0015297	antiporter activity	5	30
GO:0022804	active transmembrane transporter activity	3	30
GO:0022857	transmembrane transporter activity	2	30
GO:0042910	xenobiotic transmembrane transporter activity	3	30

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	437	441	PF00656	0.328
CLV_C14_Caspase3-7	5	9	PF00656	0.736
CLV_C14_Caspase3-7	55	59	PF00656	0.763
CLV_NRD_NRD_1	401	403	PF00675	0.260
CLV_NRD_NRD_1	47	49	PF00675	0.413
CLV_NRD_NRD_1	585	587	PF00675	0.539
CLV_PCSK_KEX2_1	155	157	PF00082	0.460
CLV_PCSK_KEX2_1	401	403	PF00082	0.243
CLV_PCSK_KEX2_1	47	49	PF00082	0.427
CLV_PCSK_KEX2_1	585	587	PF00082	0.545
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.460
CLV_PCSK_SKI1_1	329	333	PF00082	0.399
CLV_PCSK_SKI1_1	396	400	PF00082	0.250
CLV_PCSK_SKI1_1	402	406	PF00082	0.255
CLV_PCSK_SKI1_1	531	535	PF00082	0.306
CLV_PCSK_SKI1_1	77	81	PF00082	0.263
DEG_COP1_1	592	602	PF00400	0.578
DEG_SPOP_SBC_1	53	57	PF00917	0.559
DEG_SPOP_SBC_1	560	564	PF00917	0.700
DOC_CKS1_1	520	525	PF01111	0.424
DOC_CYCLIN_yCln2_LP_2	253	259	PF00134	0.464
DOC_CYCLIN_yCln2_LP_2	424	430	PF00134	0.245
DOC_MAPK_gen_1	401	408	PF00069	0.438
DOC_MAPK_HePTP_8	398	410	PF00069	0.462
DOC_MAPK_MEF2A_6	188	195	PF00069	0.405
DOC_MAPK_MEF2A_6	401	410	PF00069	0.469
DOC_MAPK_MEF2A_6	447	454	PF00069	0.309
DOC_MAPK_MEF2A_6	477	485	PF00069	0.424
DOC_MAPK_NFAT4_5	188	196	PF00069	0.427
DOC_PP1_RVXF_1	308	314	PF00149	0.631
DOC_PP1_RVXF_1	399	406	PF00149	0.535
DOC_PP1_RVXF_1	529	536	PF00149	0.482
DOC_PP4_FxxP_1	233	236	PF00568	0.313
DOC_USP7_MATH_1	173	177	PF00917	0.483
DOC_USP7_MATH_1	331	335	PF00917	0.279
DOC_USP7_MATH_1	375	379	PF00917	0.291
DOC_USP7_MATH_1	41	45	PF00917	0.693
DOC_USP7_MATH_1	606	610	PF00917	0.719
DOC_USP7_UBL2_3	503	507	PF12436	0.364
DOC_WW_Pin1_4	281	286	PF00397	0.247
DOC_WW_Pin1_4	519	524	PF00397	0.430
DOC_WW_Pin1_4	575	580	PF00397	0.704
DOC_WW_Pin1_4	589	594	PF00397	0.717
LIG_14-3-3_CanoR_1	246	253	PF00244	0.483
LIG_14-3-3_CanoR_1	559	569	PF00244	0.708
LIG_Actin_WH2_2	288	306	PF00022	0.346
LIG_AP2alpha_1	458	462	PF02296	0.424
LIG_APCC_ABBA_1	538	543	PF00400	0.579
LIG_BIR_II_1	1	5	PF00653	0.767
LIG_BRCT_BRCA1_1	142	146	PF00533	0.463
LIG_Clathr_ClatBox_1	107	111	PF01394	0.219
LIG_FHA_1	13	19	PF00498	0.702
LIG_FHA_1	167	173	PF00498	0.594
LIG_FHA_1	252	258	PF00498	0.432
LIG_FHA_1	291	297	PF00498	0.316
LIG_FHA_1	362	368	PF00498	0.216
LIG_FHA_1	414	420	PF00498	0.282
LIG_FHA_1	434	440	PF00498	0.213
LIG_FHA_1	543	549	PF00498	0.710
LIG_FHA_1	556	562	PF00498	0.712
LIG_FHA_1	70	76	PF00498	0.503
LIG_FHA_2	304	310	PF00498	0.589
LIG_FHA_2	354	360	PF00498	0.238
LIG_FHA_2	55	61	PF00498	0.694
LIG_FHA_2	561	567	PF00498	0.688
LIG_GBD_Chelix_1	295	303	PF00786	0.214
LIG_LIR_Gen_1	340	350	PF02991	0.219
LIG_LIR_Gen_1	448	459	PF02991	0.327
LIG_LIR_Gen_1	484	494	PF02991	0.408
LIG_LIR_Gen_1	495	504	PF02991	0.399
LIG_LIR_Gen_1	522	533	PF02991	0.311
LIG_LIR_Nem_3	143	149	PF02991	0.469
LIG_LIR_Nem_3	340	345	PF02991	0.238
LIG_LIR_Nem_3	484	490	PF02991	0.408
LIG_LIR_Nem_3	495	499	PF02991	0.363
LIG_LIR_Nem_3	522	528	PF02991	0.334
LIG_NRBOX	420	426	PF00104	0.329
LIG_PCNA_PIPBox_1	73	82	PF02747	0.474
LIG_Pex14_1	510	514	PF04695	0.346
LIG_Pex14_2	202	206	PF04695	0.393
LIG_Pex14_2	275	279	PF04695	0.334
LIG_Pex14_2	370	374	PF04695	0.287
LIG_Pex14_2	428	432	PF04695	0.315
LIG_Pex14_2	458	462	PF04695	0.403
LIG_Pex14_2	496	500	PF04695	0.263
LIG_REV1ctd_RIR_1	497	507	PF16727	0.371
LIG_SH2_CRK	241	245	PF00017	0.282
LIG_SH2_PTP2	525	528	PF00017	0.269
LIG_SH2_SRC	525	528	PF00017	0.367
LIG_SH2_SRC	6	9	PF00017	0.594
LIG_SH2_STAP1	185	189	PF00017	0.389
LIG_SH2_STAP1	363	367	PF00017	0.335
LIG_SH2_STAT3	248	251	PF00017	0.431
LIG_SH2_STAT5	223	226	PF00017	0.257
LIG_SH2_STAT5	302	305	PF00017	0.363
LIG_SH2_STAT5	363	366	PF00017	0.310
LIG_SH2_STAT5	451	454	PF00017	0.295
LIG_SH2_STAT5	501	504	PF00017	0.294
LIG_SH2_STAT5	525	528	PF00017	0.288
LIG_SH2_STAT5	532	535	PF00017	0.491
LIG_SH3_3	424	430	PF00018	0.284
LIG_SH3_3	449	455	PF00018	0.241
LIG_SH3_3	487	493	PF00018	0.273
LIG_SH3_3	517	523	PF00018	0.306
LIG_SH3_3	562	568	PF00018	0.661
LIG_SH3_3	573	579	PF00018	0.564
LIG_SH3_3	594	600	PF00018	0.559
LIG_SH3_3	613	619	PF00018	0.554
LIG_SUMO_SIM_anti_2	190	195	PF11976	0.365
LIG_SUMO_SIM_anti_2	378	385	PF11976	0.350
LIG_SUMO_SIM_anti_2	515	522	PF11976	0.409
LIG_SUMO_SIM_anti_2	592	598	PF11976	0.547
LIG_SUMO_SIM_par_1	257	263	PF11976	0.416
LIG_SUMO_SIM_par_1	543	551	PF11976	0.580
LIG_SUMO_SIM_par_1	84	90	PF11976	0.274
LIG_TRAF2_1	609	612	PF00917	0.720
LIG_UBA3_1	270	277	PF00899	0.349
LIG_UBA3_1	529	534	PF00899	0.498
LIG_Vh1_VBS_1	405	423	PF01044	0.128
LIG_WRC_WIRS_1	429	434	PF05994	0.317
MOD_CK1_1	19	25	PF00069	0.551
MOD_CK1_1	2	8	PF00069	0.747
MOD_CK1_1	67	73	PF00069	0.430
MOD_CK2_1	353	359	PF00069	0.236
MOD_CK2_1	54	60	PF00069	0.725
MOD_CK2_1	560	566	PF00069	0.720
MOD_CK2_1	606	612	PF00069	0.724
MOD_CMANNOS	227	230	PF00535	0.424
MOD_CMANNOS	313	316	PF00535	0.303
MOD_GlcNHglycan	216	219	PF01048	0.410
MOD_GlcNHglycan	26	29	PF01048	0.390
MOD_GlcNHglycan	262	265	PF01048	0.373
MOD_GlcNHglycan	377	380	PF01048	0.286
MOD_GlcNHglycan	589	592	PF01048	0.515
MOD_GlcNHglycan	612	615	PF01048	0.451
MOD_GSK3_1	12	19	PF00069	0.747
MOD_GSK3_1	2	9	PF00069	0.752
MOD_GSK3_1	555	562	PF00069	0.716
MOD_GSK3_1	606	613	PF00069	0.733
MOD_GSK3_1	64	71	PF00069	0.573
MOD_N-GLC_1	123	128	PF02516	0.258
MOD_N-GLC_1	16	21	PF02516	0.529
MOD_NEK2_1	142	147	PF00069	0.404
MOD_NEK2_1	18	23	PF00069	0.563
MOD_NEK2_1	303	308	PF00069	0.363
MOD_NEK2_1	381	386	PF00069	0.323
MOD_NEK2_1	462	467	PF00069	0.323
MOD_NEK2_1	548	553	PF00069	0.724
MOD_NEK2_1	587	592	PF00069	0.693
MOD_NEK2_1	86	91	PF00069	0.287
MOD_PIKK_1	606	612	PF00454	0.751
MOD_PKA_2	187	193	PF00069	0.495
MOD_PKA_2	303	309	PF00069	0.419
MOD_PKB_1	557	565	PF00069	0.578
MOD_Plk_1	16	22	PF00069	0.719
MOD_Plk_1	542	548	PF00069	0.683
MOD_Plk_1	68	74	PF00069	0.548
MOD_Plk_2-3	69	75	PF00069	0.553
MOD_Plk_4	137	143	PF00069	0.268
MOD_Plk_4	187	193	PF00069	0.472
MOD_Plk_4	209	215	PF00069	0.264
MOD_Plk_4	216	222	PF00069	0.250
MOD_Plk_4	323	329	PF00069	0.505
MOD_Plk_4	382	388	PF00069	0.257
MOD_Plk_4	428	434	PF00069	0.261
MOD_Plk_4	462	468	PF00069	0.299
MOD_Plk_4	492	498	PF00069	0.332
MOD_Plk_4	542	548	PF00069	0.576
MOD_ProDKin_1	281	287	PF00069	0.247
MOD_ProDKin_1	519	525	PF00069	0.430
MOD_ProDKin_1	575	581	PF00069	0.705
MOD_ProDKin_1	589	595	PF00069	0.718
MOD_SUMO_for_1	160	163	PF00179	0.478
MOD_SUMO_for_1	533	536	PF00179	0.561
MOD_SUMO_rev_2	152	157	PF00179	0.660
TRG_DiLeu_BaEn_4	152	158	PF01217	0.512
TRG_DiLeu_LyEn_5	394	399	PF01217	0.438
TRG_ENDOCYTIC_2	241	244	PF00928	0.372
TRG_ENDOCYTIC_2	446	449	PF00928	0.232
TRG_ENDOCYTIC_2	451	454	PF00928	0.262
TRG_ENDOCYTIC_2	456	459	PF00928	0.278
TRG_ENDOCYTIC_2	501	504	PF00928	0.288
TRG_ENDOCYTIC_2	525	528	PF00928	0.273
TRG_ER_diArg_1	401	403	PF00400	0.437
TRG_ER_diArg_1	47	49	PF00400	0.629
TRG_ER_diArg_1	584	586	PF00400	0.753
TRG_NES_CRM1_1	536	550	PF08389	0.689

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P381	Leptomonas seymouri	21%	100%
A0A0N1I213	Leptomonas seymouri	69%	99%
A0A0N1I703	Leptomonas seymouri	23%	68%
A0A0N1IJ56	Leptomonas seymouri	40%	88%
A0A0N1ILQ1	Leptomonas seymouri	23%	100%
A0A0S4IHH9	Bodo saltans	33%	100%
A0A0S4INI5	Bodo saltans	37%	100%
A0A0S4JEP9	Bodo saltans	21%	100%
A0A0S4JTQ3	Bodo saltans	24%	100%
A0A0S4JV01	Bodo saltans	21%	100%
A0A0S4JV08	Bodo saltans	21%	100%
A0A0S4JVA6	Bodo saltans	24%	84%
A0A0S4JZ61	Bodo saltans	23%	91%
A0A1X0NM81	Trypanosomatidae	21%	100%
A0A1X0NU76	Trypanosomatidae	44%	100%
A0A1X0P579	Trypanosomatidae	50%	100%
A0A1X0P5F0	Trypanosomatidae	38%	100%
A0A1X0P8J4	Trypanosomatidae	23%	100%
A0A3Q8IGH9	Leishmania donovani	39%	89%
A0A3Q8II95	Leishmania donovani	92%	100%
A0A3R7M3E2	Trypanosoma rangeli	43%	100%
A0A3R7NUJ8	Trypanosoma rangeli	50%	100%
A0A422NN08	Trypanosoma rangeli	22%	74%
A0A422NR58	Trypanosoma rangeli	38%	100%
A1L1P9	Danio rerio	29%	100%
A4HN33	Leishmania braziliensis	74%	100%
A4HN34	Leishmania braziliensis	77%	100%
A4IBQ2	Leishmania infantum	91%	100%
A4IIS8	Xenopus tropicalis	26%	100%
A7KAU2	Oryctolagus cuniculus	26%	100%
A7KAU3	Oryctolagus cuniculus	24%	100%
C9ZP79	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
C9ZP80	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
C9ZQ36	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
C9ZYX8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
C9ZYX9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
C9ZYY0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
C9ZYY1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AD56	Leishmania major	21%	70%
E9AFI2	Leishmania major	39%	100%
E9AFI7	Leishmania major	90%	100%
E9AHW7	Leishmania infantum	39%	89%
E9B6N7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
F4HPH2	Arabidopsis thaliana	24%	100%
F4HQ05	Arabidopsis thaliana	25%	100%
F4HZH9	Arabidopsis thaliana	24%	100%
F4I4Q3	Arabidopsis thaliana	24%	100%
F4IHU9	Arabidopsis thaliana	26%	100%
F4JH46	Arabidopsis thaliana	23%	100%
F4JTB3	Arabidopsis thaliana	22%	100%
O49660	Arabidopsis thaliana	21%	100%
O82752	Arabidopsis thaliana	24%	100%
P38767	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P45272	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	23%	100%
Q05497	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	89%
Q10085	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
Q1PDX9	Arabidopsis thaliana	24%	100%
Q1PFG9	Arabidopsis thaliana	24%	100%
Q38956	Arabidopsis thaliana	25%	100%
Q3V050	Mus musculus	26%	100%
Q4PSF4	Arabidopsis thaliana	23%	100%
Q5I0E9	Rattus norvegicus	25%	100%
Q5R7E4	Pongo abelii	24%	100%
Q5RFD2	Pongo abelii	27%	100%
Q86VL8	Homo sapiens	23%	100%
Q89W72	Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)	24%	100%
Q8GXM8	Arabidopsis thaliana	24%	100%
Q8K0H1	Mus musculus	25%	100%
Q8L731	Arabidopsis thaliana	26%	100%
Q8RWF5	Arabidopsis thaliana	23%	100%
Q8RXK1	Arabidopsis thaliana	23%	100%
Q8VYL8	Arabidopsis thaliana	23%	100%
Q8W488	Arabidopsis thaliana	23%	100%
Q94AL1	Arabidopsis thaliana	24%	100%
Q96FL8	Homo sapiens	26%	100%
Q98D15	Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)	24%	100%
Q9C994	Arabidopsis thaliana	24%	100%
Q9C9M8	Arabidopsis thaliana	23%	100%
Q9C9U1	Arabidopsis thaliana	27%	100%
Q9FH21	Arabidopsis thaliana	23%	100%
Q9FHB6	Arabidopsis thaliana	28%	100%
Q9FJ87	Arabidopsis thaliana	24%	100%
Q9FKQ1	Arabidopsis thaliana	25%	100%
Q9FNC1	Arabidopsis thaliana	23%	100%
Q9LE20	Arabidopsis thaliana	24%	100%
Q9LPV4	Arabidopsis thaliana	24%	100%
Q9LS19	Arabidopsis thaliana	25%	100%
Q9LUH2	Arabidopsis thaliana	22%	100%
Q9LUH3	Arabidopsis thaliana	24%	100%
Q9LYT3	Arabidopsis thaliana	23%	100%
Q9SIA1	Arabidopsis thaliana	24%	100%
Q9SIA3	Arabidopsis thaliana	24%	100%
Q9SIA4	Arabidopsis thaliana	24%	100%
Q9SIA5	Arabidopsis thaliana	23%	100%
Q9SLV0	Arabidopsis thaliana	23%	100%
Q9SX83	Arabidopsis thaliana	24%	100%
Q9SZE2	Arabidopsis thaliana	23%	100%
Q9USK3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
Q9UT92	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
Q9ZVH5	Arabidopsis thaliana	23%	100%
V5BE59	Trypanosoma cruzi	22%	76%
V5BJE3	Trypanosoma cruzi	44%	100%
V5C2T9	Trypanosoma cruzi	51%	100%