Membrane transporter protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B6P2_LEIMU

TriTrypDb:

LmxM.34.3630

Length:

620

Annotations

LeishMANIAdb annotations

SLC47 family transporter, with potential detoxification functions

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 29
NetGPI	no	yes: 0, no: 29

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	30
GO:0110165	cellular anatomical entity	1	30

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Expansion

Sequence features

E9B6P2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6P2

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0009987	cellular process	1	12
GO:0042908	xenobiotic transport	4	12
GO:0046618	xenobiotic export from cell	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0055085	transmembrane transport	2	12
GO:0140115	export across plasma membrane	3	12
GO:0140352	export from cell	2	12
GO:1990961	xenobiotic detoxification by transmembrane export across the plasma membrane	4	12

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Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	30
GO:0015291	secondary active transmembrane transporter activity	4	30
GO:0015297	antiporter activity	5	30
GO:0022804	active transmembrane transporter activity	3	30
GO:0022857	transmembrane transporter activity	2	30
GO:0042910	xenobiotic transmembrane transporter activity	3	30

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	437	441	PF00656	0.328
CLV_C14_Caspase3-7	5	9	PF00656	0.736
CLV_C14_Caspase3-7	55	59	PF00656	0.763
CLV_NRD_NRD_1	401	403	PF00675	0.260
CLV_NRD_NRD_1	47	49	PF00675	0.413
CLV_NRD_NRD_1	585	587	PF00675	0.539
CLV_PCSK_KEX2_1	155	157	PF00082	0.460
CLV_PCSK_KEX2_1	401	403	PF00082	0.243
CLV_PCSK_KEX2_1	47	49	PF00082	0.427
CLV_PCSK_KEX2_1	585	587	PF00082	0.545

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P381	Leptomonas seymouri	21%	100%
A0A0N1I213	Leptomonas seymouri	69%	99%
A0A0N1I703	Leptomonas seymouri	23%	68%
A0A0N1IJ56	Leptomonas seymouri	40%	88%
A0A0N1ILQ1	Leptomonas seymouri	23%	100%
A0A0S4IHH9	Bodo saltans	33%	100%
A0A0S4INI5	Bodo saltans	37%	100%
A0A0S4JEP9	Bodo saltans	21%	100%
A0A0S4JTQ3	Bodo saltans	24%	100%
A0A0S4JV01	Bodo saltans	21%	100%

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