Putative peptidyl-prolyl cis-trans isomerase (Cyclophilin)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peptidyl-prolyl cis-trans isomerase (cyclophilin), putative

Species:

Leishmania mexicana

UniProt:

E9B6P0_LEIMU

TriTrypDb:

LmxM.34.3610

Length:

247

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	1
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0032991	protein-containing complex	1	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990904	ribonucleoprotein complex	2	1
GO:0016020	membrane	2	1

Expansion

Sequence features

E9B6P0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6P0

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0018193	peptidyl-amino acid modification	5	13
GO:0018208	peptidyl-proline modification	6	13
GO:0019538	protein metabolic process	3	13
GO:0036211	protein modification process	4	13
GO:0043170	macromolecule metabolic process	3	13
GO:0043412	macromolecule modification	4	13
GO:0044238	primary metabolic process	2	13
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13
GO:0006457	protein folding	2	2
GO:0009987	cellular process	1	2

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	13
GO:0003824	catalytic activity	1	13
GO:0016853	isomerase activity	2	13
GO:0016859	cis-trans isomerase activity	3	13
GO:0140096	catalytic activity, acting on a protein	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	231	235	PF00082	0.418
DEG_SCF_FBW7_2	186	192	PF00400	0.424
DOC_CKS1_1	186	191	PF01111	0.422
DOC_MAPK_gen_1	227	235	PF00069	0.269
DOC_MAPK_MEF2A_6	44	51	PF00069	0.257
DOC_USP7_MATH_1	142	146	PF00917	0.238
DOC_USP7_MATH_1	22	26	PF00917	0.337
DOC_USP7_UBL2_3	215	219	PF12436	0.457
DOC_WW_Pin1_4	138	143	PF00397	0.382
DOC_WW_Pin1_4	185	190	PF00397	0.424
LIG_14-3-3_CanoR_1	117	123	PF00244	0.218
LIG_BIR_II_1	1	5	PF00653	0.205
LIG_BIR_III_2	196	200	PF00653	0.424
LIG_BRCT_BRCA1_1	133	137	PF00533	0.263
LIG_BRCT_BRCA1_1	24	28	PF00533	0.309
LIG_EH_1	237	241	PF12763	0.339
LIG_FHA_1	18	24	PF00498	0.326
LIG_FHA_2	125	131	PF00498	0.245
LIG_FHA_2	205	211	PF00498	0.313
LIG_FHA_2	6	12	PF00498	0.365
LIG_LIR_Gen_1	147	158	PF02991	0.334
LIG_LIR_Gen_1	218	228	PF02991	0.338
LIG_LIR_Gen_1	25	36	PF02991	0.309
LIG_LIR_Gen_1	64	74	PF02991	0.365
LIG_LIR_Nem_3	145	149	PF02991	0.325
LIG_LIR_Nem_3	151	156	PF02991	0.239
LIG_LIR_Nem_3	218	224	PF02991	0.367
LIG_LIR_Nem_3	234	240	PF02991	0.319
LIG_LIR_Nem_3	25	31	PF02991	0.354
LIG_LIR_Nem_3	41	46	PF02991	0.296
LIG_LIR_Nem_3	64	70	PF02991	0.309
LIG_MLH1_MIPbox_1	133	137	PF16413	0.263
LIG_Pex14_2	149	153	PF04695	0.225
LIG_Pex14_2	42	46	PF04695	0.345
LIG_SH2_STAT5	103	106	PF00017	0.218
LIG_SH2_STAT5	150	153	PF00017	0.314
LIG_SH2_STAT5	18	21	PF00017	0.162
LIG_WRC_WIRS_1	23	28	PF05994	0.257
MOD_CK1_1	185	191	PF00069	0.587
MOD_CK2_1	160	166	PF00069	0.493
MOD_CK2_1	172	178	PF00069	0.481
MOD_CK2_1	204	210	PF00069	0.309
MOD_GlcNHglycan	162	165	PF01048	0.553
MOD_GlcNHglycan	174	177	PF01048	0.609
MOD_GlcNHglycan	212	215	PF01048	0.568
MOD_GlcNHglycan	33	36	PF01048	0.286
MOD_GSK3_1	124	131	PF00069	0.323
MOD_GSK3_1	138	145	PF00069	0.242
MOD_GSK3_1	181	188	PF00069	0.677
MOD_GSK3_1	50	57	PF00069	0.266
MOD_GSK3_1	85	92	PF00069	0.331
MOD_N-GLC_1	131	136	PF02516	0.264
MOD_N-GLC_1	231	236	PF02516	0.311
MOD_NEK2_1	109	114	PF00069	0.320
MOD_NEK2_1	136	141	PF00069	0.354
MOD_NEK2_1	31	36	PF00069	0.231
MOD_NEK2_1	5	10	PF00069	0.255
MOD_NEK2_2	62	67	PF00069	0.263
MOD_PIKK_1	131	137	PF00454	0.278
MOD_PKA_2	116	122	PF00069	0.290
MOD_Plk_1	131	137	PF00069	0.218
MOD_Plk_1	182	188	PF00069	0.724
MOD_Plk_1	231	237	PF00069	0.437
MOD_Plk_4	231	237	PF00069	0.344
MOD_Plk_4	38	44	PF00069	0.325
MOD_Plk_4	62	68	PF00069	0.276
MOD_ProDKin_1	138	144	PF00069	0.382
MOD_ProDKin_1	185	191	PF00069	0.423
MOD_SUMO_rev_2	213	221	PF00179	0.484
TRG_ENDOCYTIC_2	150	153	PF00928	0.364
TRG_ENDOCYTIC_2	237	240	PF00928	0.326
TRG_ENDOCYTIC_2	43	46	PF00928	0.345
TRG_ER_diArg_1	227	230	PF00400	0.309

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P523	Leptomonas seymouri	30%	89%
A0A0N1HUZ6	Leptomonas seymouri	66%	100%
A0A0N1IAQ4	Leptomonas seymouri	32%	70%
A0A0S4KDV3	Bodo saltans	43%	100%
A0A1X0P6P3	Trypanosomatidae	43%	100%
A0A3Q8IPW3	Leishmania donovani	91%	100%
A0A3R7RE54	Trypanosoma rangeli	29%	96%
A0A422NR67	Trypanosoma rangeli	40%	100%
A4HE26	Leishmania braziliensis	32%	100%
A4HIW9	Leishmania braziliensis	30%	100%
A4HN31	Leishmania braziliensis	82%	100%
A4IBQ0	Leishmania infantum	91%	100%
C9ZUX8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	82%
C9ZYX4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AFI5	Leishmania major	93%	100%
Q4IPB8	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	32%	100%
Q4PCH8	Ustilago maydis (strain 521 / FGSC 9021)	30%	100%
Q4WMB6	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	30%	100%
Q5BAH7	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	31%	100%
Q6MWS8	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	31%	100%
V5BTK6	Trypanosoma cruzi	40%	100%