tRNA N(3)-methylcytidine methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methyltransferase domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B6N9_LEIMU

TriTrypDb:

LmxM.34.3600

Length:

373

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6N9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6N9

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	13
GO:0006139	nucleobase-containing compound metabolic process	3	13
GO:0006725	cellular aromatic compound metabolic process	3	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009451	RNA modification	5	13
GO:0009987	cellular process	1	13
GO:0016070	RNA metabolic process	5	13
GO:0032259	methylation	2	13
GO:0034641	cellular nitrogen compound metabolic process	3	13
GO:0043170	macromolecule metabolic process	3	13
GO:0043412	macromolecule modification	4	13
GO:0043414	macromolecule methylation	3	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0044260	obsolete cellular macromolecule metabolic process	3	13
GO:0046483	heterocycle metabolic process	3	13
GO:0071704	organic substance metabolic process	2	13
GO:0090304	nucleic acid metabolic process	4	13
GO:1901360	organic cyclic compound metabolic process	3	13

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0008168	methyltransferase activity	4	13
GO:0016740	transferase activity	2	13
GO:0016741	transferase activity, transferring one-carbon groups	3	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	5	9	PF00656	0.475
CLV_NRD_NRD_1	263	265	PF00675	0.337
CLV_NRD_NRD_1	28	30	PF00675	0.647
CLV_NRD_NRD_1	289	291	PF00675	0.407
CLV_NRD_NRD_1	298	300	PF00675	0.382
CLV_NRD_NRD_1	353	355	PF00675	0.472
CLV_NRD_NRD_1	362	364	PF00675	0.369
CLV_PCSK_KEX2_1	172	174	PF00082	0.377
CLV_PCSK_KEX2_1	263	265	PF00082	0.323
CLV_PCSK_KEX2_1	289	291	PF00082	0.324
CLV_PCSK_KEX2_1	297	299	PF00082	0.334
CLV_PCSK_KEX2_1	30	32	PF00082	0.620
CLV_PCSK_KEX2_1	362	364	PF00082	0.473
CLV_PCSK_KEX2_1	65	67	PF00082	0.524
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.396
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.620
CLV_PCSK_PC1ET2_1	65	67	PF00082	0.544
CLV_PCSK_SKI1_1	154	158	PF00082	0.428
CLV_PCSK_SKI1_1	172	176	PF00082	0.428
CLV_PCSK_SKI1_1	331	335	PF00082	0.315
DEG_SPOP_SBC_1	16	20	PF00917	0.612
DEG_SPOP_SBC_1	211	215	PF00917	0.370
DOC_ANK_TNKS_1	296	303	PF00023	0.372
DOC_CKS1_1	201	206	PF01111	0.372
DOC_CYCLIN_RxL_1	149	160	PF00134	0.427
DOC_MAPK_DCC_7	172	180	PF00069	0.158
DOC_MAPK_gen_1	172	180	PF00069	0.158
DOC_MAPK_gen_1	354	360	PF00069	0.504
DOC_MAPK_MEF2A_6	172	180	PF00069	0.158
DOC_MAPK_NFAT4_5	173	181	PF00069	0.158
DOC_MAPK_RevD_3	159	173	PF00069	0.369
DOC_MAPK_RevD_3	248	264	PF00069	0.349
DOC_MAPK_RevD_3	339	355	PF00069	0.431
DOC_PP4_FxxP_1	201	204	PF00568	0.417
DOC_USP7_MATH_1	112	116	PF00917	0.431
DOC_USP7_MATH_1	119	123	PF00917	0.419
DOC_USP7_MATH_1	16	20	PF00917	0.543
DOC_USP7_MATH_1	191	195	PF00917	0.406
DOC_USP7_MATH_1	209	213	PF00917	0.119
DOC_USP7_MATH_1	254	258	PF00917	0.405
DOC_USP7_MATH_1	39	43	PF00917	0.696
DOC_USP7_MATH_1	4	8	PF00917	0.778
DOC_USP7_MATH_1	46	50	PF00917	0.654
DOC_WW_Pin1_4	200	205	PF00397	0.407
DOC_WW_Pin1_4	31	36	PF00397	0.660
LIG_14-3-3_CanoR_1	354	359	PF00244	0.578
LIG_14-3-3_CanoR_1	45	52	PF00244	0.584
LIG_14-3-3_CanoR_1	73	78	PF00244	0.516
LIG_14-3-3_CterR_2	370	373	PF00244	0.240
LIG_APCC_ABBA_1	141	146	PF00400	0.158
LIG_BIR_II_1	1	5	PF00653	0.749
LIG_BRCT_BRCA1_1	244	248	PF00533	0.326
LIG_BRCT_BRCA1_1	321	325	PF00533	0.314
LIG_BRCT_BRCA1_1	356	360	PF00533	0.558
LIG_Clathr_ClatBox_1	156	160	PF01394	0.369
LIG_FHA_1	227	233	PF00498	0.445
LIG_FHA_2	3	9	PF00498	0.770
LIG_FHA_2	330	336	PF00498	0.333
LIG_Integrin_RGD_1	299	301	PF01839	0.450
LIG_LIR_Apic_2	198	204	PF02991	0.379
LIG_LIR_Gen_1	126	132	PF02991	0.369
LIG_LIR_Gen_1	242	250	PF02991	0.323
LIG_LIR_Gen_1	89	97	PF02991	0.277
LIG_LIR_Nem_3	146	150	PF02991	0.166
LIG_LIR_Nem_3	242	246	PF02991	0.427
LIG_LIR_Nem_3	322	327	PF02991	0.310
LIG_LIR_Nem_3	34	40	PF02991	0.599
LIG_LIR_Nem_3	42	47	PF02991	0.548
LIG_LIR_Nem_3	89	93	PF02991	0.315
LIG_MLH1_MIPbox_1	321	325	PF16413	0.314
LIG_OCRL_FandH_1	79	91	PF00620	0.484
LIG_PCNA_yPIPBox_3	316	325	PF02747	0.314
LIG_Pex14_1	68	72	PF04695	0.390
LIG_Pex14_2	360	364	PF04695	0.519
LIG_SH2_STAT5	277	280	PF00017	0.426
LIG_SH2_STAT5	85	88	PF00017	0.390
LIG_SH3_1	33	39	PF00018	0.646
LIG_SH3_3	185	191	PF00018	0.305
LIG_SH3_3	229	235	PF00018	0.197
LIG_SH3_3	32	38	PF00018	0.645
LIG_SH3_3	7	13	PF00018	0.727
LIG_SUMO_SIM_anti_2	242	248	PF11976	0.396
LIG_SUMO_SIM_par_1	340	345	PF11976	0.354
LIG_TRAF2_1	326	329	PF00917	0.450
LIG_UBA3_1	175	183	PF00899	0.158
LIG_WRPW_2	44	47	PF00400	0.564
MOD_CK1_1	117	123	PF00069	0.382
MOD_CK1_1	19	25	PF00069	0.512
MOD_CK1_1	2	8	PF00069	0.652
MOD_CK1_1	212	218	PF00069	0.453
MOD_CK2_1	125	131	PF00069	0.377
MOD_CK2_1	323	329	PF00069	0.322
MOD_Cter_Amidation	27	30	PF01082	0.661
MOD_DYRK1A_RPxSP_1	31	35	PF00069	0.542
MOD_GlcNHglycan	106	109	PF01048	0.386
MOD_GlcNHglycan	116	119	PF01048	0.266
MOD_GlcNHglycan	19	22	PF01048	0.506
MOD_GlcNHglycan	214	217	PF01048	0.388
MOD_GlcNHglycan	229	232	PF01048	0.337
MOD_GlcNHglycan	48	51	PF01048	0.648
MOD_GSK3_1	119	126	PF00069	0.441
MOD_GSK3_1	15	22	PF00069	0.559
MOD_GSK3_1	207	214	PF00069	0.405
MOD_GSK3_1	249	256	PF00069	0.408
MOD_GSK3_1	306	313	PF00069	0.312
MOD_GSK3_1	319	326	PF00069	0.326
MOD_GSK3_1	349	356	PF00069	0.369
MOD_GSK3_1	4	11	PF00069	0.771
MOD_N-GLC_1	305	310	PF02516	0.328
MOD_N-GLC_1	317	322	PF02516	0.308
MOD_N-GLC_1	73	78	PF02516	0.493
MOD_NEK2_1	123	128	PF00069	0.293
MOD_NEK2_1	159	164	PF00069	0.291
MOD_PIKK_1	8	14	PF00454	0.712
MOD_PK_1	354	360	PF00069	0.572
MOD_PKA_1	354	360	PF00069	0.501
MOD_PKA_2	353	359	PF00069	0.575
MOD_Plk_1	159	165	PF00069	0.296
MOD_Plk_1	73	79	PF00069	0.494
MOD_Plk_2-3	329	335	PF00069	0.464
MOD_Plk_4	242	248	PF00069	0.321
MOD_ProDKin_1	200	206	PF00069	0.407
MOD_ProDKin_1	31	37	PF00069	0.659
TRG_DiLeu_BaEn_1	171	176	PF01217	0.275
TRG_DiLeu_BaEn_1	242	247	PF01217	0.408
TRG_DiLeu_BaEn_2	238	244	PF01217	0.450
TRG_ENDOCYTIC_2	147	150	PF00928	0.330
TRG_ENDOCYTIC_2	37	40	PF00928	0.713
TRG_ER_diArg_1	262	264	PF00400	0.338
TRG_ER_diArg_1	289	291	PF00400	0.405
TRG_ER_diArg_1	296	299	PF00400	0.381
TRG_ER_diArg_1	362	364	PF00400	0.467
TRG_ER_diArg_1	369	372	PF00400	0.442
TRG_NLS_MonoExtC_3	28	33	PF00514	0.642
TRG_NLS_MonoExtN_4	29	34	PF00514	0.716
TRG_Pf-PMV_PEXEL_1	331	335	PF00026	0.369

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4J3	Leptomonas seymouri	64%	100%
A0A0N1I1R8	Leptomonas seymouri	26%	100%
A0A0S4ISJ6	Bodo saltans	25%	84%
A0A0S4KFU5	Bodo saltans	34%	99%
A0A1X0NXB7	Trypanosomatidae	25%	100%
A0A1X0P5J2	Trypanosomatidae	45%	100%
A0A3Q8IDT0	Leishmania donovani	24%	100%
A0A3R7M2M3	Trypanosoma rangeli	45%	100%
A0A3S7X9Q3	Leishmania donovani	91%	96%
A4HBJ6	Leishmania braziliensis	26%	100%
A4HN30	Leishmania braziliensis	78%	100%
A4HZL8	Leishmania infantum	25%	100%
A4IBP9	Leishmania infantum	91%	96%
A8KBL7	Danio rerio	24%	100%
C9ZYX5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
D0A1J3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AFI4	Leishmania major	90%	100%
E9AUW5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
Q0P5B2	Bos taurus	22%	99%
Q4QCL7	Leishmania major	25%	100%
Q5RDV8	Pongo abelii	27%	100%
Q6AXU8	Rattus norvegicus	27%	100%
Q6P1Q9	Homo sapiens	23%	99%
Q86BS6	Drosophila melanogaster	26%	100%
Q8BMK1	Mus musculus	23%	96%
Q8BVH9	Mus musculus	27%	100%
Q8TCB7	Homo sapiens	26%	100%
Q96IZ6	Homo sapiens	22%	99%
V5BCV4	Trypanosoma cruzi	45%	100%
V5DGW7	Trypanosoma cruzi	28%	100%