Putative DNA repair protein RAD2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA repair protein RAD2, putative

Species:

Leishmania mexicana

UniProt:

E9B6N8_LEIMU

TriTrypDb:

LmxM.34.3590

Length:

930

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9B6N8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6N8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006259	DNA metabolic process	4	7
GO:0006281	DNA repair	5	7
GO:0006289	nucleotide-excision repair	6	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0006950	response to stress	2	7
GO:0006974	DNA damage response	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0033554	cellular response to stress	3	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0046483	heterocycle metabolic process	3	7
GO:0050896	response to stimulus	1	7
GO:0051716	cellular response to stimulus	2	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003677	DNA binding	4	7
GO:0003697	single-stranded DNA binding	5	7
GO:0003824	catalytic activity	1	7
GO:0004518	nuclease activity	4	7
GO:0004519	endonuclease activity	5	7
GO:0005488	binding	1	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0004520	DNA endonuclease activity	5	1
GO:0004536	DNA nuclease activity	4	1
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	6	1
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0017108	5'-flap endonuclease activity	7	1
GO:0048256	flap endonuclease activity	6	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	317	321	PF00656	0.775
CLV_C14_Caspase3-7	470	474	PF00656	0.561
CLV_NRD_NRD_1	103	105	PF00675	0.606
CLV_NRD_NRD_1	208	210	PF00675	0.774
CLV_NRD_NRD_1	212	214	PF00675	0.571
CLV_NRD_NRD_1	215	217	PF00675	0.516
CLV_NRD_NRD_1	265	267	PF00675	0.699
CLV_NRD_NRD_1	485	487	PF00675	0.685
CLV_NRD_NRD_1	529	531	PF00675	0.561
CLV_NRD_NRD_1	772	774	PF00675	0.411
CLV_NRD_NRD_1	869	871	PF00675	0.411
CLV_NRD_NRD_1	875	877	PF00675	0.411
CLV_NRD_NRD_1	88	90	PF00675	0.335
CLV_NRD_NRD_1	892	894	PF00675	0.445
CLV_PCSK_FUR_1	213	217	PF00082	0.684
CLV_PCSK_KEX2_1	102	104	PF00082	0.611
CLV_PCSK_KEX2_1	190	192	PF00082	0.668
CLV_PCSK_KEX2_1	207	209	PF00082	0.684
CLV_PCSK_KEX2_1	214	216	PF00082	0.479
CLV_PCSK_KEX2_1	25	27	PF00082	0.346
CLV_PCSK_KEX2_1	265	267	PF00082	0.699
CLV_PCSK_KEX2_1	485	487	PF00082	0.685
CLV_PCSK_KEX2_1	772	774	PF00082	0.411
CLV_PCSK_KEX2_1	875	877	PF00082	0.411
CLV_PCSK_KEX2_1	88	90	PF00082	0.336
CLV_PCSK_KEX2_1	892	894	PF00082	0.597
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.579
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.707
CLV_PCSK_PC1ET2_1	214	216	PF00082	0.574
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.346
CLV_PCSK_PC7_1	204	210	PF00082	0.775
CLV_PCSK_SKI1_1	106	110	PF00082	0.561
CLV_PCSK_SKI1_1	135	139	PF00082	0.452
CLV_PCSK_SKI1_1	193	197	PF00082	0.582
CLV_PCSK_SKI1_1	277	281	PF00082	0.572
CLV_PCSK_SKI1_1	486	490	PF00082	0.663
CLV_PCSK_SKI1_1	59	63	PF00082	0.346
CLV_PCSK_SKI1_1	69	73	PF00082	0.290
CLV_PCSK_SKI1_1	693	697	PF00082	0.381
CLV_PCSK_SKI1_1	717	721	PF00082	0.411
CLV_PCSK_SKI1_1	773	777	PF00082	0.436
CLV_PCSK_SKI1_1	892	896	PF00082	0.592
CLV_PCSK_SKI1_1	906	910	PF00082	0.632
CLV_Separin_Metazoa	520	524	PF03568	0.535
DEG_APCC_DBOX_1	192	200	PF00400	0.523
DEG_APCC_DBOX_1	484	492	PF00400	0.758
DEG_COP1_1	141	151	PF00400	0.677
DEG_SCF_SKP2-CKS1_1	536	543	PF00560	0.554
DEG_SCF_TRCP1_1	437	442	PF00400	0.530
DEG_SPOP_SBC_1	418	422	PF00917	0.672
DEG_SPOP_SBC_1	606	610	PF00917	0.621
DEG_SPOP_SBC_1	761	765	PF00917	0.513
DEG_SPOP_SBC_1	77	81	PF00917	0.563
DOC_CYCLIN_RxL_1	56	67	PF00134	0.466
DOC_CYCLIN_yCln2_LP_2	857	863	PF00134	0.513
DOC_MAPK_DCC_7	550	560	PF00069	0.727
DOC_MAPK_gen_1	102	110	PF00069	0.582
DOC_MAPK_gen_1	204	212	PF00069	0.509
DOC_MAPK_gen_1	306	314	PF00069	0.522
DOC_MAPK_gen_1	550	558	PF00069	0.683
DOC_MAPK_gen_1	629	637	PF00069	0.709
DOC_MAPK_gen_1	772	778	PF00069	0.436
DOC_MAPK_MEF2A_6	552	560	PF00069	0.682
DOC_MAPK_MEF2A_6	629	637	PF00069	0.632
DOC_MAPK_RevD_3	13	26	PF00069	0.619
DOC_MAPK_RevD_3	200	216	PF00069	0.608
DOC_PP1_RVXF_1	60	66	PF00149	0.546
DOC_PP2B_LxvP_1	200	203	PF13499	0.803
DOC_PP4_FxxP_1	261	264	PF00568	0.711
DOC_PP4_FxxP_1	518	521	PF00568	0.638
DOC_PP4_FxxP_1	74	77	PF00568	0.563
DOC_USP7_MATH_1	125	129	PF00917	0.696
DOC_USP7_MATH_1	147	151	PF00917	0.676
DOC_USP7_MATH_1	159	163	PF00917	0.592
DOC_USP7_MATH_1	177	181	PF00917	0.819
DOC_USP7_MATH_1	323	327	PF00917	0.733
DOC_USP7_MATH_1	330	334	PF00917	0.672
DOC_USP7_MATH_1	351	355	PF00917	0.523
DOC_USP7_MATH_1	418	422	PF00917	0.670
DOC_USP7_MATH_1	435	439	PF00917	0.804
DOC_USP7_MATH_1	443	447	PF00917	0.599
DOC_USP7_MATH_1	450	454	PF00917	0.835
DOC_USP7_MATH_1	503	507	PF00917	0.813
DOC_USP7_MATH_1	722	726	PF00917	0.411
DOC_USP7_MATH_1	761	765	PF00917	0.465
DOC_USP7_MATH_1	77	81	PF00917	0.548
DOC_WW_Pin1_4	395	400	PF00397	0.756
DOC_WW_Pin1_4	445	450	PF00397	0.644
DOC_WW_Pin1_4	486	491	PF00397	0.556
DOC_WW_Pin1_4	537	542	PF00397	0.628
DOC_WW_Pin1_4	653	658	PF00397	0.411
DOC_WW_Pin1_4	832	837	PF00397	0.411
DOC_WW_Pin1_4	856	861	PF00397	0.513
LIG_14-3-3_CanoR_1	277	286	PF00244	0.615
LIG_14-3-3_CanoR_1	288	298	PF00244	0.517
LIG_14-3-3_CanoR_1	550	555	PF00244	0.803
LIG_14-3-3_CanoR_1	780	786	PF00244	0.411
LIG_14-3-3_CanoR_1	88	92	PF00244	0.563
LIG_14-3-3_CanoR_1	884	894	PF00244	0.588
LIG_Actin_WH2_2	219	234	PF00022	0.699
LIG_BRCT_BRCA1_1	447	451	PF00533	0.790
LIG_deltaCOP1_diTrp_1	476	482	PF00928	0.703
LIG_deltaCOP1_diTrp_1	843	850	PF00928	0.494
LIG_FHA_1	115	121	PF00498	0.446
LIG_FHA_1	290	296	PF00498	0.613
LIG_FHA_1	375	381	PF00498	0.697
LIG_FHA_1	384	390	PF00498	0.565
LIG_FHA_1	551	557	PF00498	0.717
LIG_FHA_1	574	580	PF00498	0.709
LIG_FHA_1	612	618	PF00498	0.545
LIG_FHA_1	628	634	PF00498	0.662
LIG_FHA_1	687	693	PF00498	0.372
LIG_FHA_1	714	720	PF00498	0.411
LIG_FHA_1	730	736	PF00498	0.411
LIG_FHA_2	240	246	PF00498	0.593
LIG_FHA_2	332	338	PF00498	0.696
LIG_FHA_2	750	756	PF00498	0.513
LIG_LIR_Apic_2	258	264	PF02991	0.706
LIG_LIR_Apic_2	515	521	PF02991	0.635
LIG_LIR_Gen_1	784	792	PF02991	0.411
LIG_LIR_Gen_1	843	851	PF02991	0.412
LIG_LIR_LC3C_4	745	749	PF02991	0.389
LIG_LIR_Nem_3	11	16	PF02991	0.516
LIG_LIR_Nem_3	476	482	PF02991	0.645
LIG_LIR_Nem_3	536	542	PF02991	0.716
LIG_LIR_Nem_3	784	788	PF02991	0.411
LIG_LIR_Nem_3	843	847	PF02991	0.412
LIG_MYND_1	285	289	PF01753	0.489
LIG_NRBOX	5	11	PF00104	0.546
LIG_NRBOX	722	728	PF00104	0.411
LIG_Pex14_1	34	38	PF04695	0.546
LIG_REV1ctd_RIR_1	823	833	PF16727	0.436
LIG_SH2_CRK	539	543	PF00017	0.820
LIG_SH2_STAT3	897	900	PF00017	0.539
LIG_SH2_STAT5	539	542	PF00017	0.603
LIG_SH2_STAT5	653	656	PF00017	0.411
LIG_SH2_STAT5	731	734	PF00017	0.389
LIG_SH3_3	13	19	PF00018	0.546
LIG_SH3_3	283	289	PF00018	0.676
LIG_SH3_3	446	452	PF00018	0.836
LIG_SH3_3	553	559	PF00018	0.696
LIG_SH3_3	576	582	PF00018	0.732
LIG_SH3_3	630	636	PF00018	0.720
LIG_SH3_3	651	657	PF00018	0.400
LIG_SH3_3	775	781	PF00018	0.411
LIG_SUMO_SIM_anti_2	343	349	PF11976	0.760
LIG_SUMO_SIM_par_1	116	122	PF11976	0.479
LIG_SUMO_SIM_par_1	294	302	PF11976	0.731
LIG_SUMO_SIM_par_1	343	349	PF11976	0.711
LIG_SUMO_SIM_par_1	641	647	PF11976	0.411
LIG_SUMO_SIM_par_1	718	725	PF11976	0.411
LIG_TRAF2_1	429	432	PF00917	0.606
LIG_TRAF2_1	456	459	PF00917	0.816
LIG_TRFH_1	653	657	PF08558	0.411
LIG_WRC_WIRS_1	10	15	PF05994	0.367
LIG_WW_3	520	524	PF00397	0.649
LIG_WW_3	620	624	PF00397	0.725
LIG_WW_3	780	784	PF00397	0.436
MOD_CDK_SPxK_1	537	543	PF00069	0.630
MOD_CDK_SPxxK_3	486	493	PF00069	0.559
MOD_CK1_1	299	305	PF00069	0.751
MOD_CK1_1	325	331	PF00069	0.664
MOD_CK1_1	365	371	PF00069	0.683
MOD_CK1_1	374	380	PF00069	0.597
MOD_CK1_1	393	399	PF00069	0.697
MOD_CK1_1	419	425	PF00069	0.728
MOD_CK1_1	438	444	PF00069	0.824
MOD_CK1_1	445	451	PF00069	0.759
MOD_CK1_1	453	459	PF00069	0.616
MOD_CK1_1	505	511	PF00069	0.774
MOD_CK1_1	563	569	PF00069	0.733
MOD_CK1_1	608	614	PF00069	0.695
MOD_CK2_1	151	157	PF00069	0.623
MOD_CK2_1	239	245	PF00069	0.543
MOD_CK2_1	312	318	PF00069	0.699
MOD_CK2_1	331	337	PF00069	0.740
MOD_CK2_1	426	432	PF00069	0.768
MOD_CK2_1	453	459	PF00069	0.815
MOD_CK2_1	563	569	PF00069	0.664
MOD_CK2_1	653	659	PF00069	0.411
MOD_CK2_1	749	755	PF00069	0.513
MOD_Cter_Amidation	188	191	PF01082	0.698
MOD_Cter_Amidation	23	26	PF01082	0.411
MOD_GlcNHglycan	128	131	PF01048	0.635
MOD_GlcNHglycan	175	178	PF01048	0.744
MOD_GlcNHglycan	183	186	PF01048	0.835
MOD_GlcNHglycan	222	225	PF01048	0.656
MOD_GlcNHglycan	280	283	PF01048	0.658
MOD_GlcNHglycan	325	328	PF01048	0.668
MOD_GlcNHglycan	368	371	PF01048	0.760
MOD_GlcNHglycan	373	376	PF01048	0.677
MOD_GlcNHglycan	381	384	PF01048	0.591
MOD_GlcNHglycan	422	425	PF01048	0.765
MOD_GlcNHglycan	428	431	PF01048	0.709
MOD_GlcNHglycan	437	440	PF01048	0.585
MOD_GlcNHglycan	441	444	PF01048	0.523
MOD_GlcNHglycan	566	569	PF01048	0.772
MOD_GlcNHglycan	579	582	PF01048	0.702
MOD_GlcNHglycan	602	605	PF01048	0.713
MOD_GlcNHglycan	710	713	PF01048	0.416
MOD_GlcNHglycan	764	767	PF01048	0.452
MOD_GSK3_1	147	154	PF00069	0.678
MOD_GSK3_1	173	180	PF00069	0.776
MOD_GSK3_1	220	227	PF00069	0.634
MOD_GSK3_1	362	369	PF00069	0.795
MOD_GSK3_1	379	386	PF00069	0.624
MOD_GSK3_1	412	419	PF00069	0.716
MOD_GSK3_1	420	427	PF00069	0.689
MOD_GSK3_1	433	440	PF00069	0.734
MOD_GSK3_1	441	448	PF00069	0.764
MOD_GSK3_1	450	457	PF00069	0.553
MOD_GSK3_1	498	505	PF00069	0.742
MOD_GSK3_1	521	528	PF00069	0.767
MOD_GSK3_1	546	553	PF00069	0.753
MOD_GSK3_1	560	567	PF00069	0.650
MOD_GSK3_1	573	580	PF00069	0.830
MOD_GSK3_1	607	614	PF00069	0.716
MOD_N-GLC_1	254	259	PF02516	0.589
MOD_N-GLC_1	289	294	PF02516	0.510
MOD_N-GLC_1	464	469	PF02516	0.670
MOD_NEK2_1	151	156	PF00069	0.616
MOD_NEK2_1	175	180	PF00069	0.826
MOD_NEK2_1	253	258	PF00069	0.628
MOD_NEK2_1	392	397	PF00069	0.574
MOD_NEK2_1	560	565	PF00069	0.821
MOD_NEK2_1	696	701	PF00069	0.411
MOD_NEK2_1	9	14	PF00069	0.367
MOD_PIKK_1	224	230	PF00454	0.735
MOD_PIKK_1	299	305	PF00454	0.754
MOD_PIKK_1	390	396	PF00454	0.759
MOD_PIKK_1	480	486	PF00454	0.655
MOD_PK_1	412	418	PF00069	0.628
MOD_PKA_1	892	898	PF00069	0.559
MOD_PKA_2	181	187	PF00069	0.759
MOD_PKA_2	87	93	PF00069	0.436
MOD_PKA_2	883	889	PF00069	0.580
MOD_PKA_2	892	898	PF00069	0.603
MOD_Plk_1	29	35	PF00069	0.411
MOD_Plk_1	362	368	PF00069	0.551
MOD_Plk_1	383	389	PF00069	0.622
MOD_Plk_1	573	579	PF00069	0.718
MOD_Plk_1	705	711	PF00069	0.513
MOD_Plk_2-3	269	275	PF00069	0.516
MOD_Plk_2-3	337	343	PF00069	0.804
MOD_Plk_2-3	454	460	PF00069	0.741
MOD_Plk_4	226	232	PF00069	0.612
MOD_Plk_4	256	262	PF00069	0.699
MOD_Plk_4	29	35	PF00069	0.411
MOD_Plk_4	412	418	PF00069	0.745
MOD_Plk_4	687	693	PF00069	0.383
MOD_Plk_4	715	721	PF00069	0.507
MOD_Plk_4	722	728	PF00069	0.411
MOD_Plk_4	790	796	PF00069	0.436
MOD_ProDKin_1	395	401	PF00069	0.758
MOD_ProDKin_1	445	451	PF00069	0.645
MOD_ProDKin_1	486	492	PF00069	0.555
MOD_ProDKin_1	537	543	PF00069	0.630
MOD_ProDKin_1	653	659	PF00069	0.411
MOD_ProDKin_1	832	838	PF00069	0.411
MOD_ProDKin_1	856	862	PF00069	0.513
MOD_SUMO_rev_2	119	126	PF00179	0.513
MOD_SUMO_rev_2	46	53	PF00179	0.389
MOD_SUMO_rev_2	823	830	PF00179	0.510
TRG_DiLeu_BaEn_1	343	348	PF01217	0.817
TRG_DiLeu_BaEn_4	197	203	PF01217	0.736
TRG_ENDOCYTIC_2	539	542	PF00928	0.817
TRG_ER_diArg_1	103	106	PF00400	0.644
TRG_ER_diArg_1	207	209	PF00400	0.785
TRG_ER_diArg_1	212	215	PF00400	0.629
TRG_ER_diArg_1	264	266	PF00400	0.695
TRG_ER_diArg_1	38	41	PF00400	0.411
TRG_ER_diArg_1	771	773	PF00400	0.411
TRG_ER_diArg_1	846	849	PF00400	0.513
TRG_ER_diArg_1	87	89	PF00400	0.312
TRG_ER_diArg_1	874	876	PF00400	0.515
TRG_ER_diArg_1	892	894	PF00400	0.424
TRG_ER_diArg_1	903	906	PF00400	0.626
TRG_NLS_Bipartite_1	88	106	PF00514	0.574
TRG_NLS_MonoCore_2	212	217	PF00514	0.514
TRG_NLS_MonoExtC_3	101	106	PF00514	0.571
TRG_NLS_MonoExtN_4	213	218	PF00514	0.567
TRG_Pf-PMV_PEXEL_1	215	220	PF00026	0.647
TRG_Pf-PMV_PEXEL_1	808	812	PF00026	0.389
TRG_Pf-PMV_PEXEL_1	892	896	PF00026	0.592

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Y4	Leptomonas seymouri	50%	99%
A0A3S5H802	Leishmania donovani	87%	100%
A4HN29	Leishmania braziliensis	71%	100%
A4IBP8	Leishmania infantum	87%	100%
E9AFI3	Leishmania major	87%	100%