LeishMANIAdb
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Multidrug and toxic compound extrusion protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Multidrug and toxic compound extrusion protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B6N7_LEIMU
TriTrypDb:
LmxM.34.3580
Length:
649

Annotations

LeishMANIAdb annotations

SLC47 family transporter, with potential detoxification functions

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 28
NetGPI no yes: 0, no: 28
Cellular components
Term Name Level Count
GO:0016020 membrane 2 29
GO:0110165 cellular anatomical entity 1 29

Expansion

Sequence features

E9B6N7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6N7

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 12
GO:0009987 cellular process 1 12
GO:0042908 xenobiotic transport 4 12
GO:0046618 xenobiotic export from cell 3 12
GO:0051179 localization 1 12
GO:0051234 establishment of localization 2 12
GO:0055085 transmembrane transport 2 12
GO:0140115 export across plasma membrane 3 12
GO:0140352 export from cell 2 12
GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane 4 12
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 29
GO:0015291 secondary active transmembrane transporter activity 4 29
GO:0015297 antiporter activity 5 29
GO:0022804 active transmembrane transporter activity 3 29
GO:0022857 transmembrane transporter activity 2 29
GO:0042910 xenobiotic transmembrane transporter activity 3 29

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 185 187 PF00675 0.213
CLV_NRD_NRD_1 334 336 PF00675 0.291
CLV_NRD_NRD_1 341 343 PF00675 0.282
CLV_NRD_NRD_1 383 385 PF00675 0.294
CLV_PCSK_KEX2_1 185 187 PF00082 0.213
CLV_PCSK_KEX2_1 341 343 PF00082 0.248
CLV_PCSK_SKI1_1 128 132 PF00082 0.198
CLV_PCSK_SKI1_1 269 273 PF00082 0.409
CLV_PCSK_SKI1_1 336 340 PF00082 0.252
CLV_PCSK_SKI1_1 342 346 PF00082 0.256
CLV_PCSK_SKI1_1 384 388 PF00082 0.281
CLV_Separin_Metazoa 182 186 PF03568 0.253
DEG_APCC_DBOX_1 127 135 PF00400 0.432
DEG_APCC_DBOX_1 168 176 PF00400 0.421
DEG_APCC_DBOX_1 341 349 PF00400 0.409
DEG_APCC_DBOX_1 506 514 PF00400 0.601
DEG_Nend_UBRbox_3 1 3 PF02207 0.748
DOC_CYCLIN_yClb5_NLxxxL_5 354 363 PF00134 0.247
DOC_CYCLIN_yCln2_LP_2 139 145 PF00134 0.179
DOC_CYCLIN_yCln2_LP_2 49 55 PF00134 0.406
DOC_MAPK_gen_1 341 348 PF00069 0.454
DOC_MAPK_HePTP_8 338 350 PF00069 0.489
DOC_MAPK_MEF2A_6 128 136 PF00069 0.425
DOC_MAPK_MEF2A_6 341 350 PF00069 0.492
DOC_MAPK_MEF2A_6 48 55 PF00069 0.455
DOC_MAPK_NFAT4_5 128 136 PF00069 0.445
DOC_MAPK_NFAT4_5 48 56 PF00069 0.484
DOC_PP1_RVXF_1 267 273 PF00149 0.421
DOC_PP1_RVXF_1 383 390 PF00149 0.400
DOC_PP2B_LxvP_1 49 52 PF13499 0.452
DOC_PP2B_LxvP_1 582 585 PF13499 0.770
DOC_USP7_MATH_1 271 275 PF00917 0.304
DOC_USP7_MATH_1 574 578 PF00917 0.716
DOC_USP7_MATH_1 59 63 PF00917 0.391
DOC_USP7_MATH_1 626 630 PF00917 0.745
DOC_USP7_MATH_2 585 591 PF00917 0.552
DOC_WW_Pin1_4 3 8 PF00397 0.584
DOC_WW_Pin1_4 534 539 PF00397 0.741
DOC_WW_Pin1_4 547 552 PF00397 0.763
DOC_WW_Pin1_4 632 637 PF00397 0.620
LIG_14-3-3_CanoR_1 169 173 PF00244 0.414
LIG_14-3-3_CanoR_1 499 504 PF00244 0.730
LIG_14-3-3_CanoR_1 576 584 PF00244 0.714
LIG_14-3-3_CanoR_1 603 609 PF00244 0.548
LIG_14-3-3_CanoR_1 628 636 PF00244 0.759
LIG_14-3-3_CanoR_1 640 644 PF00244 0.783
LIG_APCC_ABBA_1 475 480 PF00400 0.572
LIG_BRCT_BRCA1_1 206 210 PF00533 0.341
LIG_BRCT_BRCA1_1 317 321 PF00533 0.270
LIG_Clathr_ClatBox_1 178 182 PF01394 0.247
LIG_eIF4E_1 390 396 PF01652 0.435
LIG_FHA_1 116 122 PF00498 0.483
LIG_FHA_1 236 242 PF00498 0.337
LIG_FHA_1 360 366 PF00498 0.332
LIG_FHA_1 37 43 PF00498 0.528
LIG_FHA_1 498 504 PF00498 0.713
LIG_FHA_1 524 530 PF00498 0.644
LIG_FHA_1 535 541 PF00498 0.717
LIG_FHA_1 617 623 PF00498 0.724
LIG_IRF3_LxIS_1 146 153 PF10401 0.395
LIG_LIR_Apic_2 444 450 PF02991 0.232
LIG_LIR_Apic_2 609 614 PF02991 0.537
LIG_LIR_Gen_1 164 175 PF02991 0.233
LIG_LIR_Gen_1 301 309 PF02991 0.347
LIG_LIR_Gen_1 351 361 PF02991 0.380
LIG_LIR_Gen_1 41 52 PF02991 0.431
LIG_LIR_Gen_1 565 574 PF02991 0.735
LIG_LIR_Nem_3 164 170 PF02991 0.249
LIG_LIR_Nem_3 171 176 PF02991 0.233
LIG_LIR_Nem_3 207 211 PF02991 0.314
LIG_LIR_Nem_3 262 267 PF02991 0.432
LIG_LIR_Nem_3 301 306 PF02991 0.347
LIG_LIR_Nem_3 351 357 PF02991 0.371
LIG_LIR_Nem_3 41 47 PF02991 0.408
LIG_LIR_Nem_3 565 569 PF02991 0.736
LIG_PCNA_yPIPBox_3 376 388 PF02747 0.209
LIG_PCNA_yPIPBox_3 400 408 PF02747 0.305
LIG_Pex14_2 163 167 PF04695 0.256
LIG_SH2_CRK 294 298 PF00017 0.333
LIG_SH2_CRK 424 428 PF00017 0.290
LIG_SH2_CRK 462 466 PF00017 0.367
LIG_SH2_GRB2like 469 472 PF00017 0.368
LIG_SH2_NCK_1 294 298 PF00017 0.209
LIG_SH2_NCK_1 424 428 PF00017 0.292
LIG_SH2_NCK_1 593 597 PF00017 0.559
LIG_SH2_SRC 294 297 PF00017 0.331
LIG_SH2_STAP1 176 180 PF00017 0.448
LIG_SH2_STAP1 593 597 PF00017 0.559
LIG_SH2_STAT5 187 190 PF00017 0.425
LIG_SH2_STAT5 242 245 PF00017 0.316
LIG_SH2_STAT5 390 393 PF00017 0.321
LIG_SH2_STAT5 464 467 PF00017 0.349
LIG_SH2_STAT5 469 472 PF00017 0.487
LIG_SH3_3 1 7 PF00018 0.620
LIG_SH3_3 424 430 PF00018 0.298
LIG_SH3_3 454 460 PF00018 0.330
LIG_SH3_3 550 556 PF00018 0.604
LIG_SH3_3 568 574 PF00018 0.542
LIG_SUMO_SIM_anti_2 177 182 PF11976 0.247
LIG_SUMO_SIM_anti_2 360 365 PF11976 0.345
LIG_SUMO_SIM_anti_2 419 425 PF11976 0.369
LIG_SUMO_SIM_anti_2 509 519 PF11976 0.643
LIG_SUMO_SIM_anti_2 64 69 PF11976 0.262
LIG_SUMO_SIM_par_1 132 138 PF11976 0.223
LIG_TYR_ITIM 240 245 PF00017 0.156
LIG_TYR_ITIM 391 396 PF00017 0.348
LIG_TYR_ITIM 422 427 PF00017 0.361
LIG_UBA3_1 239 248 PF00899 0.361
LIG_UBA3_1 382 388 PF00899 0.422
LIG_WRC_WIRS_1 396 401 PF05994 0.283
LIG_WRC_WIRS_1 482 487 PF05994 0.496
LIG_WRC_WIRS_1 566 571 PF05994 0.742
MOD_CK1_1 17 23 PF00069 0.598
MOD_CK1_1 315 321 PF00069 0.335
MOD_CK1_1 374 380 PF00069 0.209
MOD_CK1_1 38 44 PF00069 0.435
MOD_CK1_1 398 404 PF00069 0.247
MOD_CK1_1 501 507 PF00069 0.619
MOD_CK1_1 565 571 PF00069 0.725
MOD_CK1_1 6 12 PF00069 0.624
MOD_CK1_1 629 635 PF00069 0.747
MOD_CK1_1 642 648 PF00069 0.781
MOD_CK1_1 96 102 PF00069 0.134
MOD_CK2_1 485 491 PF00069 0.674
MOD_CK2_1 512 518 PF00069 0.726
MOD_CK2_1 539 545 PF00069 0.780
MOD_CMANNOS 253 256 PF00535 0.307
MOD_GlcNHglycan 19 22 PF01048 0.535
MOD_GlcNHglycan 317 320 PF01048 0.311
MOD_GlcNHglycan 577 580 PF01048 0.432
MOD_GlcNHglycan 624 627 PF01048 0.560
MOD_GlcNHglycan 636 639 PF01048 0.532
MOD_GlcNHglycan 98 101 PF01048 0.240
MOD_GSK3_1 13 20 PF00069 0.756
MOD_GSK3_1 146 153 PF00069 0.431
MOD_GSK3_1 226 233 PF00069 0.439
MOD_GSK3_1 277 284 PF00069 0.341
MOD_GSK3_1 308 315 PF00069 0.374
MOD_GSK3_1 34 41 PF00069 0.570
MOD_GSK3_1 481 488 PF00069 0.664
MOD_GSK3_1 491 498 PF00069 0.695
MOD_GSK3_1 499 506 PF00069 0.652
MOD_GSK3_1 519 526 PF00069 0.687
MOD_GSK3_1 530 537 PF00069 0.645
MOD_GSK3_1 539 546 PF00069 0.565
MOD_GSK3_1 616 623 PF00069 0.736
MOD_GSK3_1 626 633 PF00069 0.731
MOD_N-GLC_1 35 40 PF02516 0.436
MOD_N-GLC_1 357 362 PF02516 0.421
MOD_N-GLC_1 374 379 PF02516 0.533
MOD_N-GLC_1 485 490 PF02516 0.480
MOD_N-GLC_1 562 567 PF02516 0.511
MOD_N-GLC_1 574 579 PF02516 0.403
MOD_N-GLC_1 587 592 PF02516 0.372
MOD_N-GLC_1 603 608 PF02516 0.429
MOD_N-GLC_1 90 95 PF02516 0.288
MOD_NEK2_1 109 114 PF00069 0.442
MOD_NEK2_1 146 151 PF00069 0.366
MOD_NEK2_1 230 235 PF00069 0.308
MOD_NEK2_1 243 248 PF00069 0.378
MOD_NEK2_1 348 353 PF00069 0.274
MOD_NEK2_1 359 364 PF00069 0.228
MOD_NEK2_1 395 400 PF00069 0.366
MOD_NEK2_1 422 427 PF00069 0.270
MOD_NEK2_1 436 441 PF00069 0.296
MOD_NEK2_1 452 457 PF00069 0.224
MOD_NEK2_1 47 52 PF00069 0.458
MOD_NEK2_1 485 490 PF00069 0.711
MOD_NEK2_1 497 502 PF00069 0.699
MOD_NEK2_1 503 508 PF00069 0.652
MOD_NEK2_1 543 548 PF00069 0.770
MOD_NEK2_1 80 85 PF00069 0.305
MOD_NEK2_1 90 95 PF00069 0.251
MOD_NEK2_2 168 173 PF00069 0.445
MOD_PIKK_1 107 113 PF00454 0.475
MOD_PIKK_1 192 198 PF00454 0.520
MOD_PIKK_1 281 287 PF00454 0.264
MOD_PKA_2 13 19 PF00069 0.710
MOD_PKA_2 168 174 PF00069 0.327
MOD_PKA_2 498 504 PF00069 0.678
MOD_PKA_2 530 536 PF00069 0.702
MOD_PKA_2 575 581 PF00069 0.620
MOD_PKA_2 627 633 PF00069 0.754
MOD_PKA_2 639 645 PF00069 0.747
MOD_PKB_1 12 20 PF00069 0.561
MOD_Plk_1 357 363 PF00069 0.361
MOD_Plk_1 374 380 PF00069 0.176
MOD_Plk_1 485 491 PF00069 0.685
MOD_Plk_1 562 568 PF00069 0.735
MOD_Plk_1 603 609 PF00069 0.754
MOD_Plk_1 90 96 PF00069 0.239
MOD_Plk_2-3 587 593 PF00069 0.554
MOD_Plk_4 104 110 PF00069 0.301
MOD_Plk_4 135 141 PF00069 0.340
MOD_Plk_4 146 152 PF00069 0.343
MOD_Plk_4 174 180 PF00069 0.359
MOD_Plk_4 235 241 PF00069 0.323
MOD_Plk_4 308 314 PF00069 0.320
MOD_Plk_4 348 354 PF00069 0.277
MOD_Plk_4 359 365 PF00069 0.328
MOD_Plk_4 368 374 PF00069 0.295
MOD_Plk_4 422 428 PF00069 0.319
MOD_Plk_4 452 458 PF00069 0.287
MOD_Plk_4 61 67 PF00069 0.163
MOD_Plk_4 80 86 PF00069 0.332
MOD_ProDKin_1 3 9 PF00069 0.587
MOD_ProDKin_1 534 540 PF00069 0.744
MOD_ProDKin_1 547 553 PF00069 0.759
MOD_ProDKin_1 632 638 PF00069 0.620
TRG_DiLeu_BaEn_1 323 328 PF01217 0.421
TRG_DiLeu_BaLyEn_6 263 268 PF01217 0.475
TRG_ENDOCYTIC_2 176 179 PF00928 0.382
TRG_ENDOCYTIC_2 242 245 PF00928 0.244
TRG_ENDOCYTIC_2 294 297 PF00928 0.347
TRG_ENDOCYTIC_2 393 396 PF00928 0.303
TRG_ENDOCYTIC_2 424 427 PF00928 0.286
TRG_ENDOCYTIC_2 462 465 PF00928 0.294
TRG_ER_diArg_1 12 15 PF00400 0.772
TRG_ER_diArg_1 184 186 PF00400 0.413
TRG_ER_diArg_1 27 30 PF00400 0.579

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P381 Leptomonas seymouri 23% 100%
A0A0N1I213 Leptomonas seymouri 37% 100%
A0A0N1I703 Leptomonas seymouri 25% 71%
A0A0N1IJ56 Leptomonas seymouri 58% 92%
A0A0S4INI5 Bodo saltans 39% 100%
A0A0S4JEP9 Bodo saltans 24% 100%
A0A0S4JTQ3 Bodo saltans 26% 100%
A0A0S4JV08 Bodo saltans 24% 100%
A0A0S4JVA6 Bodo saltans 24% 88%
A0A0S4JZ61 Bodo saltans 24% 96%
A0A1X0NM81 Trypanosomatidae 25% 100%
A0A1X0NU76 Trypanosomatidae 47% 100%
A0A1X0P579 Trypanosomatidae 42% 100%
A0A1X0P5F0 Trypanosomatidae 39% 100%
A0A1X0P8J4 Trypanosomatidae 23% 100%
A0A3Q8IGH9 Leishmania donovani 85% 93%
A0A3Q8II95 Leishmania donovani 38% 100%
A0A3R7M3E2 Trypanosoma rangeli 51% 100%
A0A3R7NUJ8 Trypanosoma rangeli 43% 100%
A0A422NR58 Trypanosoma rangeli 38% 100%
A1L1P9 Danio rerio 30% 100%
A4HN33 Leishmania braziliensis 37% 100%
A4HN34 Leishmania braziliensis 38% 100%
A4IBQ2 Leishmania infantum 38% 100%
A7KAU3 Oryctolagus cuniculus 30% 100%
A7MFC3 Cronobacter sakazakii (strain ATCC BAA-894) 24% 100%
A9MEJ6 Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980) 24% 100%
B4TH65 Salmonella heidelberg (strain SL476) 25% 100%
C9ZP79 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 100%
C9ZP80 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 49% 100%
C9ZQ36 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 49% 100%
C9ZYX8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 100%
C9ZYX9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 100%
C9ZYY0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 100%
C9ZYY1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
D0A551 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 22% 100%
E9AFI2 Leishmania major 83% 100%
E9AFI7 Leishmania major 39% 100%
E9AHW7 Leishmania infantum 86% 93%
E9AYY1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 73%
E9B6P2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 100%
F4HPH2 Arabidopsis thaliana 25% 100%
F4HQ05 Arabidopsis thaliana 28% 100%
F4HZH9 Arabidopsis thaliana 24% 100%
F4I4Q3 Arabidopsis thaliana 22% 100%
F4IHU9 Arabidopsis thaliana 28% 100%
F4J158 Arabidopsis thaliana 25% 100%
F4JH46 Arabidopsis thaliana 24% 100%
F4JTB3 Arabidopsis thaliana 23% 100%
O49660 Arabidopsis thaliana 22% 100%
O82752 Arabidopsis thaliana 27% 100%
Q05497 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 25% 93%
Q1PDX9 Arabidopsis thaliana 24% 100%
Q1PFG9 Arabidopsis thaliana 26% 100%
Q38956 Arabidopsis thaliana 23% 100%
Q3V050 Mus musculus 29% 100%
Q5E4Y6 Aliivibrio fischeri (strain ATCC 700601 / ES114) 23% 100%
Q5QWR6 Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR) 24% 100%
Q5R7E4 Pongo abelii 28% 100%
Q5RFD2 Pongo abelii 30% 100%
Q6LQ49 Photobacterium profundum (strain SS9) 24% 100%
Q6NB79 Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) 23% 100%
Q7MKP8 Vibrio vulnificus (strain YJ016) 24% 100%
Q86VL8 Homo sapiens 26% 100%
Q89W72 Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110) 22% 100%
Q8D9N8 Vibrio vulnificus (strain CMCP6) 24% 100%
Q8L616 Arabidopsis thaliana 24% 100%
Q8L731 Arabidopsis thaliana 25% 100%
Q8RWF5 Arabidopsis thaliana 25% 100%
Q8UDF5 Agrobacterium fabrum (strain C58 / ATCC 33970) 25% 100%
Q940N9 Arabidopsis thaliana 22% 100%
Q94AL1 Arabidopsis thaliana 25% 100%
Q96FL8 Homo sapiens 30% 100%
Q9C994 Arabidopsis thaliana 26% 100%
Q9C9M8 Arabidopsis thaliana 23% 100%
Q9C9U1 Arabidopsis thaliana 28% 100%
Q9F5N7 Burkholderia vietnamiensis 24% 100%
Q9FH21 Arabidopsis thaliana 23% 100%
Q9FHB6 Arabidopsis thaliana 27% 100%
Q9FJ87 Arabidopsis thaliana 24% 100%
Q9FNC1 Arabidopsis thaliana 23% 100%
Q9KRU4 Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) 25% 100%
Q9LPV4 Arabidopsis thaliana 23% 100%
Q9LUH2 Arabidopsis thaliana 25% 100%
Q9SIA4 Arabidopsis thaliana 25% 100%
Q9SIA5 Arabidopsis thaliana 26% 100%
Q9SX83 Arabidopsis thaliana 25% 100%
Q9SZE2 Arabidopsis thaliana 25% 100%
Q9UT92 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 23% 100%
V5BDE8 Trypanosoma cruzi 25% 100%
V5BJE3 Trypanosoma cruzi 52% 100%
V5C2T9 Trypanosoma cruzi 43% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS