Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B6N4_LEIMU

TriTrypDb:

LmxM.34.3550

Length:

727

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6N4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6N4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.667
CLV_C14_Caspase3-7	655	659	PF00656	0.500
CLV_C14_Caspase3-7	714	718	PF00656	0.624
CLV_NRD_NRD_1	185	187	PF00675	0.578
CLV_NRD_NRD_1	299	301	PF00675	0.541
CLV_NRD_NRD_1	404	406	PF00675	0.643
CLV_NRD_NRD_1	411	413	PF00675	0.688
CLV_NRD_NRD_1	482	484	PF00675	0.643
CLV_NRD_NRD_1	586	588	PF00675	0.804
CLV_NRD_NRD_1	8	10	PF00675	0.562
CLV_PCSK_KEX2_1	174	176	PF00082	0.650
CLV_PCSK_KEX2_1	185	187	PF00082	0.547
CLV_PCSK_KEX2_1	299	301	PF00082	0.541
CLV_PCSK_KEX2_1	411	413	PF00082	0.701
CLV_PCSK_KEX2_1	482	484	PF00082	0.643
CLV_PCSK_KEX2_1	586	588	PF00082	0.804
CLV_PCSK_KEX2_1	650	652	PF00082	0.700
CLV_PCSK_KEX2_1	8	10	PF00082	0.562
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.650
CLV_PCSK_PC1ET2_1	650	652	PF00082	0.700
CLV_PCSK_SKI1_1	129	133	PF00082	0.677
CLV_PCSK_SKI1_1	171	175	PF00082	0.540
CLV_PCSK_SKI1_1	723	727	PF00082	0.632
DEG_APCC_DBOX_1	97	105	PF00400	0.678
DEG_SCF_FBW7_1	494	501	PF00400	0.819
DEG_SPOP_SBC_1	467	471	PF00917	0.567
DOC_CKS1_1	684	689	PF01111	0.700
DOC_CKS1_1	703	708	PF01111	0.599
DOC_CYCLIN_RxL_1	81	94	PF00134	0.624
DOC_CYCLIN_yCln2_LP_2	74	80	PF00134	0.636
DOC_MAPK_MEF2A_6	603	610	PF00069	0.682
DOC_PP2B_LxvP_1	562	565	PF13499	0.711
DOC_PP4_FxxP_1	433	436	PF00568	0.495
DOC_USP7_MATH_1	358	362	PF00917	0.340
DOC_USP7_MATH_1	450	454	PF00917	0.677
DOC_USP7_MATH_1	467	471	PF00917	0.672
DOC_USP7_MATH_1	498	502	PF00917	0.813
DOC_USP7_MATH_1	527	531	PF00917	0.735
DOC_USP7_MATH_1	595	599	PF00917	0.733
DOC_USP7_MATH_1	606	610	PF00917	0.626
DOC_USP7_MATH_1	620	624	PF00917	0.703
DOC_USP7_MATH_1	652	656	PF00917	0.553
DOC_USP7_MATH_1	690	694	PF00917	0.700
DOC_USP7_MATH_1	709	713	PF00917	0.524
DOC_WW_Pin1_4	432	437	PF00397	0.674
DOC_WW_Pin1_4	494	499	PF00397	0.784
DOC_WW_Pin1_4	500	505	PF00397	0.734
DOC_WW_Pin1_4	568	573	PF00397	0.662
DOC_WW_Pin1_4	678	683	PF00397	0.742
DOC_WW_Pin1_4	686	691	PF00397	0.663
DOC_WW_Pin1_4	702	707	PF00397	0.773
LIG_14-3-3_CanoR_1	13	21	PF00244	0.564
LIG_14-3-3_CanoR_1	233	242	PF00244	0.575
LIG_14-3-3_CanoR_1	291	297	PF00244	0.621
LIG_14-3-3_CanoR_1	344	352	PF00244	0.617
LIG_14-3-3_CanoR_1	405	415	PF00244	0.780
LIG_14-3-3_CanoR_1	513	523	PF00244	0.537
LIG_14-3-3_CanoR_1	628	638	PF00244	0.506
LIG_14-3-3_CanoR_1	651	657	PF00244	0.793
LIG_Actin_WH2_2	106	123	PF00022	0.669
LIG_Actin_WH2_2	170	187	PF00022	0.638
LIG_Actin_WH2_2	18	33	PF00022	0.559
LIG_BIR_II_1	1	5	PF00653	0.711
LIG_BRCT_BRCA1_1	429	433	PF00533	0.709
LIG_DLG_GKlike_1	411	418	PF00625	0.705
LIG_EVH1_2	436	440	PF00568	0.481
LIG_FHA_1	13	19	PF00498	0.659
LIG_FHA_1	469	475	PF00498	0.682
LIG_FHA_1	506	512	PF00498	0.677
LIG_FHA_1	583	589	PF00498	0.513
LIG_FHA_1	644	650	PF00498	0.740
LIG_FHA_1	69	75	PF00498	0.553
LIG_FHA_1	696	702	PF00498	0.764
LIG_FHA_2	33	39	PF00498	0.662
LIG_LIR_Apic_2	430	436	PF02991	0.499
LIG_LIR_Gen_1	222	231	PF02991	0.518
LIG_LIR_Gen_1	414	421	PF02991	0.709
LIG_LIR_Nem_3	222	227	PF02991	0.461
LIG_LIR_Nem_3	414	418	PF02991	0.708
LIG_MYND_1	494	498	PF01753	0.605
LIG_PCNA_yPIPBox_3	17	29	PF02747	0.521
LIG_SH2_NCK_1	704	708	PF00017	0.802
LIG_SH2_SRC	4	7	PF00017	0.618
LIG_SH2_STAT3	312	315	PF00017	0.409
LIG_SH2_STAT5	365	368	PF00017	0.339
LIG_SH2_STAT5	4	7	PF00017	0.673
LIG_SH2_STAT5	694	697	PF00017	0.710
LIG_SH2_STAT5	704	707	PF00017	0.713
LIG_SH3_3	433	439	PF00018	0.502
LIG_SH3_3	587	593	PF00018	0.629
LIG_SH3_3	64	70	PF00018	0.667
LIG_SH3_3	646	652	PF00018	0.795
LIG_SH3_3	681	687	PF00018	0.808
LIG_SUMO_SIM_par_1	116	123	PF11976	0.668
LIG_SUMO_SIM_par_1	574	580	PF11976	0.554
LIG_TRAF2_1	157	160	PF00917	0.648
LIG_TRAF2_1	165	168	PF00917	0.539
LIG_TRAF2_2	706	711	PF00917	0.791
MOD_CDK_SPxxK_3	502	509	PF00069	0.537
MOD_CK1_1	290	296	PF00069	0.559
MOD_CK1_1	332	338	PF00069	0.689
MOD_CK1_1	416	422	PF00069	0.772
MOD_CK1_1	435	441	PF00069	0.485
MOD_CK1_1	505	511	PF00069	0.802
MOD_CK1_1	514	520	PF00069	0.651
MOD_CK1_1	631	637	PF00069	0.802
MOD_CK1_1	68	74	PF00069	0.528
MOD_CK1_1	693	699	PF00069	0.776
MOD_CK1_1	94	100	PF00069	0.579
MOD_CK2_1	32	38	PF00069	0.657
MOD_CK2_1	39	45	PF00069	0.580
MOD_CK2_1	518	524	PF00069	0.634
MOD_CK2_1	660	666	PF00069	0.573
MOD_CK2_1	709	715	PF00069	0.652
MOD_Cter_Amidation	403	406	PF01082	0.508
MOD_Cter_Amidation	480	483	PF01082	0.621
MOD_GlcNHglycan	325	328	PF01048	0.597
MOD_GlcNHglycan	335	338	PF01048	0.476
MOD_GlcNHglycan	40	44	PF01048	0.599
MOD_GlcNHglycan	429	432	PF01048	0.738
MOD_GlcNHglycan	452	455	PF01048	0.752
MOD_GlcNHglycan	460	463	PF01048	0.685
MOD_GlcNHglycan	484	487	PF01048	0.679
MOD_GlcNHglycan	500	503	PF01048	0.620
MOD_GlcNHglycan	541	544	PF01048	0.737
MOD_GlcNHglycan	554	557	PF01048	0.654
MOD_GlcNHglycan	633	636	PF01048	0.795
MOD_GlcNHglycan	638	641	PF01048	0.747
MOD_GlcNHglycan	723	726	PF01048	0.622
MOD_GSK3_1	116	123	PF00069	0.429
MOD_GSK3_1	313	320	PF00069	0.595
MOD_GSK3_1	329	336	PF00069	0.487
MOD_GSK3_1	386	393	PF00069	0.753
MOD_GSK3_1	407	414	PF00069	0.698
MOD_GSK3_1	494	501	PF00069	0.819
MOD_GSK3_1	511	518	PF00069	0.602
MOD_GSK3_1	591	598	PF00069	0.769
MOD_GSK3_1	606	613	PF00069	0.794
MOD_GSK3_1	629	636	PF00069	0.711
MOD_GSK3_1	652	659	PF00069	0.674
MOD_GSK3_1	686	693	PF00069	0.747
MOD_GSK3_1	96	103	PF00069	0.545
MOD_LATS_1	626	632	PF00433	0.704
MOD_N-GLC_1	419	424	PF02516	0.647
MOD_N-GLC_1	628	633	PF02516	0.730
MOD_N-GLC_1	709	714	PF02516	0.581
MOD_NEK2_1	266	271	PF00069	0.548
MOD_NEK2_1	29	34	PF00069	0.557
MOD_NEK2_1	352	357	PF00069	0.658
MOD_NEK2_1	39	44	PF00069	0.587
MOD_NEK2_1	460	465	PF00069	0.641
MOD_NEK2_1	516	521	PF00069	0.802
MOD_NEK2_2	390	395	PF00069	0.741
MOD_PIKK_1	159	165	PF00454	0.641
MOD_PIKK_1	343	349	PF00454	0.600
MOD_PIKK_1	468	474	PF00454	0.721
MOD_PIKK_1	610	616	PF00454	0.795
MOD_PIKK_1	91	97	PF00454	0.580
MOD_PKA_1	405	411	PF00069	0.647
MOD_PKA_1	482	488	PF00069	0.647
MOD_PKA_2	12	18	PF00069	0.658
MOD_PKA_2	120	126	PF00069	0.604
MOD_PKA_2	207	213	PF00069	0.569
MOD_PKA_2	234	240	PF00069	0.566
MOD_PKA_2	290	296	PF00069	0.620
MOD_PKA_2	343	349	PF00069	0.606
MOD_PKA_2	350	356	PF00069	0.545
MOD_PKA_2	378	384	PF00069	0.619
MOD_PKA_2	411	417	PF00069	0.725
MOD_PKA_2	482	488	PF00069	0.647
MOD_PKA_2	514	520	PF00069	0.539
MOD_PKA_2	652	658	PF00069	0.582
MOD_PKB_1	233	241	PF00069	0.565
MOD_PKB_1	513	521	PF00069	0.541
MOD_Plk_1	398	404	PF00069	0.681
MOD_Plk_1	606	612	PF00069	0.698
MOD_Plk_1	643	649	PF00069	0.716
MOD_Plk_1	91	97	PF00069	0.580
MOD_Plk_2-3	660	666	PF00069	0.705
MOD_Plk_2-3	711	717	PF00069	0.724
MOD_Plk_4	100	106	PF00069	0.578
MOD_Plk_4	313	319	PF00069	0.530
MOD_Plk_4	398	404	PF00069	0.728
MOD_Plk_4	595	601	PF00069	0.585
MOD_Plk_4	643	649	PF00069	0.790
MOD_Plk_4	690	696	PF00069	0.703
MOD_ProDKin_1	432	438	PF00069	0.677
MOD_ProDKin_1	494	500	PF00069	0.786
MOD_ProDKin_1	502	508	PF00069	0.697
MOD_ProDKin_1	568	574	PF00069	0.663
MOD_ProDKin_1	678	684	PF00069	0.743
MOD_ProDKin_1	686	692	PF00069	0.665
MOD_ProDKin_1	702	708	PF00069	0.774
MOD_SUMO_for_1	131	134	PF00179	0.673
MOD_SUMO_rev_2	542	551	PF00179	0.506
TRG_DiLeu_BaEn_1	24	29	PF01217	0.548
TRG_DiLeu_BaEn_1	280	285	PF01217	0.645
TRG_DiLeu_BaEn_2	665	671	PF01217	0.509
TRG_DiLeu_BaEn_4	666	672	PF01217	0.512
TRG_ENDOCYTIC_2	415	418	PF00928	0.711
TRG_ER_diArg_1	126	129	PF00400	0.672
TRG_ER_diArg_1	184	186	PF00400	0.541
TRG_ER_diArg_1	411	413	PF00400	0.733
TRG_ER_diArg_1	512	515	PF00400	0.641
TRG_ER_diArg_1	586	588	PF00400	0.526
TRG_NLS_MonoCore_2	649	654	PF00514	0.503
TRG_Pf-PMV_PEXEL_1	603	607	PF00026	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I179	Leptomonas seymouri	40%	93%
A0A3Q8IFD3	Leishmania donovani	80%	97%
A4HN24	Leishmania braziliensis	63%	100%
A4IBP4	Leishmania infantum	80%	97%
E9AFH9	Leishmania major	80%	100%