FCP1 homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NLI interacting factor-like phosphatase, putative

Species:

Leishmania mexicana

UniProt:

E9B6N1_LEIMU

TriTrypDb:

LmxM.34.3520

Length:

547

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6N1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6N1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004721	phosphoprotein phosphatase activity	3	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	123	125	PF00675	0.756
CLV_NRD_NRD_1	424	426	PF00675	0.433
CLV_NRD_NRD_1	451	453	PF00675	0.573
CLV_NRD_NRD_1	471	473	PF00675	0.481
CLV_NRD_NRD_1	69	71	PF00675	0.666
CLV_PCSK_FUR_1	67	71	PF00082	0.539
CLV_PCSK_KEX2_1	110	112	PF00082	0.817
CLV_PCSK_KEX2_1	123	125	PF00082	0.580
CLV_PCSK_KEX2_1	424	426	PF00082	0.433
CLV_PCSK_KEX2_1	451	453	PF00082	0.680
CLV_PCSK_KEX2_1	69	71	PF00082	0.571
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.817
CLV_PCSK_SKI1_1	316	320	PF00082	0.252
CLV_PCSK_SKI1_1	425	429	PF00082	0.433
DOC_MAPK_gen_1	123	130	PF00069	0.599
DOC_MAPK_gen_1	32	40	PF00069	0.520
DOC_MAPK_gen_1	421	429	PF00069	0.530
DOC_MAPK_MEF2A_6	276	283	PF00069	0.512
DOC_MAPK_MEF2A_6	32	40	PF00069	0.520
DOC_MAPK_MEF2A_6	366	375	PF00069	0.522
DOC_MAPK_MEF2A_6	508	516	PF00069	0.608
DOC_PP1_RVXF_1	536	543	PF00149	0.650
DOC_PP2B_PxIxI_1	368	374	PF00149	0.620
DOC_USP7_MATH_1	115	119	PF00917	0.714
DOC_USP7_MATH_1	122	126	PF00917	0.723
DOC_USP7_MATH_1	42	46	PF00917	0.510
DOC_USP7_MATH_1	440	444	PF00917	0.433
DOC_USP7_MATH_1	487	491	PF00917	0.692
DOC_USP7_UBL2_3	324	328	PF12436	0.530
DOC_WW_Pin1_4	161	166	PF00397	0.630
DOC_WW_Pin1_4	175	180	PF00397	0.642
DOC_WW_Pin1_4	183	188	PF00397	0.640
DOC_WW_Pin1_4	208	213	PF00397	0.704
DOC_WW_Pin1_4	253	258	PF00397	0.481
DOC_WW_Pin1_4	265	270	PF00397	0.406
DOC_WW_Pin1_4	403	408	PF00397	0.437
DOC_WW_Pin1_4	473	478	PF00397	0.517
DOC_WW_Pin1_4	53	58	PF00397	0.624
LIG_14-3-3_CanoR_1	116	121	PF00244	0.755
LIG_14-3-3_CanoR_1	123	129	PF00244	0.682
LIG_14-3-3_CanoR_1	13	22	PF00244	0.621
LIG_14-3-3_CanoR_1	188	195	PF00244	0.684
LIG_14-3-3_CanoR_1	213	218	PF00244	0.627
LIG_14-3-3_CanoR_1	276	280	PF00244	0.478
LIG_14-3-3_CanoR_1	525	533	PF00244	0.582
LIG_BIR_III_2	192	196	PF00653	0.629
LIG_BIR_III_4	310	314	PF00653	0.238
LIG_DLG_GKlike_1	124	131	PF00625	0.732
LIG_FHA_1	21	27	PF00498	0.730
LIG_FHA_1	276	282	PF00498	0.501
LIG_FHA_1	288	294	PF00498	0.430
LIG_FHA_1	424	430	PF00498	0.467
LIG_FHA_1	487	493	PF00498	0.786
LIG_FHA_1	509	515	PF00498	0.601
LIG_FHA_1	54	60	PF00498	0.733
LIG_FHA_1	86	92	PF00498	0.674
LIG_FHA_2	100	106	PF00498	0.530
LIG_FHA_2	218	224	PF00498	0.775
LIG_FHA_2	480	486	PF00498	0.733
LIG_LIR_Gen_1	334	344	PF02991	0.530
LIG_LIR_Gen_1	500	510	PF02991	0.567
LIG_LIR_Nem_3	101	107	PF02991	0.659
LIG_LIR_Nem_3	203	209	PF02991	0.541
LIG_LIR_Nem_3	320	326	PF02991	0.462
LIG_LIR_Nem_3	334	339	PF02991	0.366
LIG_LIR_Nem_3	367	371	PF02991	0.368
LIG_LIR_Nem_3	500	506	PF02991	0.580
LIG_MYND_1	265	269	PF01753	0.526
LIG_PCNA_TLS_4	330	337	PF02747	0.530
LIG_PCNA_yPIPBox_3	424	438	PF02747	0.530
LIG_PTB_Apo_2	257	264	PF02174	0.644
LIG_RPA_C_Fungi	119	131	PF08784	0.605
LIG_RPA_C_Fungi	58	70	PF08784	0.539
LIG_SH2_CRK	22	26	PF00017	0.521
LIG_SH2_CRK	441	445	PF00017	0.530
LIG_SH2_STAP1	356	360	PF00017	0.530
LIG_SH2_STAP1	412	416	PF00017	0.433
LIG_SH2_STAP1	501	505	PF00017	0.378
LIG_SH2_STAT5	22	25	PF00017	0.522
LIG_SH2_STAT5	266	269	PF00017	0.482
LIG_SH2_STAT5	335	338	PF00017	0.275
LIG_SH2_STAT5	43	46	PF00017	0.611
LIG_SH2_STAT5	501	504	PF00017	0.395
LIG_SH3_1	22	28	PF00018	0.519
LIG_SH3_3	204	210	PF00018	0.609
LIG_SH3_3	22	28	PF00018	0.796
LIG_SH3_3	290	296	PF00018	0.396
LIG_SH3_3	434	440	PF00018	0.530
LIG_SUMO_SIM_anti_2	125	133	PF11976	0.694
LIG_SUMO_SIM_par_1	277	282	PF11976	0.530
LIG_SUMO_SIM_par_1	425	430	PF11976	0.530
LIG_TRAF2_1	219	222	PF00917	0.677
LIG_WRC_WIRS_1	532	537	PF05994	0.718
MOD_CDC14_SPxK_1	164	167	PF00782	0.721
MOD_CDK_SPK_2	183	188	PF00069	0.595
MOD_CDK_SPK_2	208	213	PF00069	0.611
MOD_CDK_SPxK_1	161	167	PF00069	0.629
MOD_CDK_SPxxK_3	175	182	PF00069	0.544
MOD_CDK_SPxxK_3	265	272	PF00069	0.442
MOD_CK1_1	15	21	PF00069	0.761
MOD_CK1_1	201	207	PF00069	0.717
MOD_CK1_1	317	323	PF00069	0.433
MOD_CK1_1	378	384	PF00069	0.788
MOD_CK1_1	479	485	PF00069	0.748
MOD_CK1_1	98	104	PF00069	0.702
MOD_CK2_1	217	223	PF00069	0.780
MOD_CK2_1	238	244	PF00069	0.424
MOD_CK2_1	479	485	PF00069	0.816
MOD_CK2_1	524	530	PF00069	0.665
MOD_CK2_1	99	105	PF00069	0.530
MOD_Cter_Amidation	108	111	PF01082	0.819
MOD_GlcNHglycan	107	110	PF01048	0.737
MOD_GlcNHglycan	17	20	PF01048	0.714
MOD_GlcNHglycan	319	322	PF01048	0.504
MOD_GlcNHglycan	380	383	PF01048	0.786
MOD_GlcNHglycan	44	47	PF01048	0.609
MOD_GlcNHglycan	478	481	PF01048	0.832
MOD_GlcNHglycan	517	520	PF01048	0.360
MOD_GSK3_1	156	163	PF00069	0.692
MOD_GSK3_1	171	178	PF00069	0.523
MOD_GSK3_1	201	208	PF00069	0.616
MOD_GSK3_1	213	220	PF00069	0.673
MOD_GSK3_1	283	290	PF00069	0.407
MOD_GSK3_1	3	10	PF00069	0.812
MOD_GSK3_1	376	383	PF00069	0.582
MOD_GSK3_1	472	479	PF00069	0.713
MOD_GSK3_1	85	92	PF00069	0.571
MOD_GSK3_1	94	101	PF00069	0.708
MOD_N-GLC_1	253	258	PF02516	0.604
MOD_N-GLC_1	430	435	PF02516	0.238
MOD_N-GLC_1	94	99	PF02516	0.783
MOD_NEK2_1	238	243	PF00069	0.513
MOD_NEK2_1	283	288	PF00069	0.530
MOD_NEK2_1	30	35	PF00069	0.714
MOD_NEK2_1	349	354	PF00069	0.530
MOD_NEK2_1	36	41	PF00069	0.643
MOD_NEK2_1	375	380	PF00069	0.642
MOD_NEK2_1	423	428	PF00069	0.530
MOD_NEK2_1	536	541	PF00069	0.742
MOD_NEK2_1	99	104	PF00069	0.704
MOD_NEK2_2	440	445	PF00069	0.433
MOD_PIKK_1	384	390	PF00454	0.702
MOD_PIKK_1	524	530	PF00454	0.568
MOD_PKA_1	123	129	PF00069	0.661
MOD_PKA_1	472	478	PF00069	0.516
MOD_PKA_1	69	75	PF00069	0.536
MOD_PKA_2	115	121	PF00069	0.685
MOD_PKA_2	12	18	PF00069	0.618
MOD_PKA_2	122	128	PF00069	0.722
MOD_PKA_2	275	281	PF00069	0.413
MOD_PKA_2	423	429	PF00069	0.530
MOD_PKA_2	524	530	PF00069	0.568
MOD_PKA_2	62	68	PF00069	0.537
MOD_PKA_2	69	75	PF00069	0.522
MOD_PKB_1	114	122	PF00069	0.715
MOD_PKB_1	67	75	PF00069	0.536
MOD_Plk_1	283	289	PF00069	0.407
MOD_Plk_1	430	436	PF00069	0.238
MOD_Plk_1	487	493	PF00069	0.714
MOD_Plk_1	508	514	PF00069	0.611
MOD_Plk_1	74	80	PF00069	0.821
MOD_Plk_1	94	100	PF00069	0.686
MOD_Plk_4	213	219	PF00069	0.752
MOD_Plk_4	275	281	PF00069	0.501
MOD_Plk_4	283	289	PF00069	0.362
MOD_Plk_4	508	514	PF00069	0.611
MOD_Plk_4	531	537	PF00069	0.720
MOD_Plk_4	74	80	PF00069	0.530
MOD_ProDKin_1	161	167	PF00069	0.629
MOD_ProDKin_1	175	181	PF00069	0.644
MOD_ProDKin_1	183	189	PF00069	0.639
MOD_ProDKin_1	208	214	PF00069	0.703
MOD_ProDKin_1	253	259	PF00069	0.485
MOD_ProDKin_1	265	271	PF00069	0.411
MOD_ProDKin_1	403	409	PF00069	0.437
MOD_ProDKin_1	473	479	PF00069	0.520
MOD_ProDKin_1	53	59	PF00069	0.625
MOD_SUMO_for_1	166	169	PF00179	0.632
TRG_DiLeu_BaEn_1	509	514	PF01217	0.598
TRG_DiLeu_BaLyEn_6	234	239	PF01217	0.658
TRG_DiLeu_BaLyEn_6	54	59	PF01217	0.636
TRG_ENDOCYTIC_2	104	107	PF00928	0.636
TRG_ENDOCYTIC_2	323	326	PF00928	0.530
TRG_ENDOCYTIC_2	441	444	PF00928	0.530
TRG_ENDOCYTIC_2	503	506	PF00928	0.548
TRG_ER_diArg_1	423	425	PF00400	0.433
TRG_ER_diArg_1	67	70	PF00400	0.575
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.736
TRG_Pf-PMV_PEXEL_1	362	367	PF00026	0.530
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.723

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IIK2	Leishmania donovani	79%	98%
A4HN21	Leishmania braziliensis	62%	93%
A4IBP7	Leishmania infantum	80%	98%
E9AFH6	Leishmania major	80%	100%