FYVE-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc finger protein, putative

Species:

Leishmania mexicana

UniProt:

E9B6M9_LEIMU

TriTrypDb:

LmxM.34.3500

Length:

298

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B6M9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6M9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	158	162	PF00656	0.704
CLV_NRD_NRD_1	141	143	PF00675	0.699
CLV_NRD_NRD_1	31	33	PF00675	0.293
CLV_PCSK_KEX2_1	31	33	PF00082	0.293
CLV_PCSK_SKI1_1	182	186	PF00082	0.549
CLV_PCSK_SKI1_1	193	197	PF00082	0.544
CLV_PCSK_SKI1_1	277	281	PF00082	0.640
CLV_PCSK_SKI1_1	56	60	PF00082	0.352
DEG_SPOP_SBC_1	25	29	PF00917	0.421
DOC_MAPK_MEF2A_6	193	201	PF00069	0.633
DOC_PP2B_LxvP_1	240	243	PF13499	0.724
DOC_WW_Pin1_4	173	178	PF00397	0.704
LIG_14-3-3_CanoR_1	117	124	PF00244	0.788
LIG_14-3-3_CanoR_1	188	193	PF00244	0.614
LIG_14-3-3_CanoR_1	56	61	PF00244	0.352
LIG_14-3-3_CanoR_1	73	78	PF00244	0.339
LIG_BIR_III_4	120	124	PF00653	0.699
LIG_EVH1_1	240	244	PF00568	0.667
LIG_FHA_1	194	200	PF00498	0.590
LIG_FHA_1	219	225	PF00498	0.739
LIG_FHA_1	235	241	PF00498	0.758
LIG_FHA_1	282	288	PF00498	0.694
LIG_FHA_1	85	91	PF00498	0.608
LIG_FHA_2	131	137	PF00498	0.715
LIG_FHA_2	211	217	PF00498	0.654
LIG_FHA_2	263	269	PF00498	0.677
LIG_FHA_2	57	63	PF00498	0.352
LIG_GBD_Chelix_1	270	278	PF00786	0.647
LIG_IRF3_LxIS_1	226	233	PF10401	0.449
LIG_LIR_Gen_1	145	156	PF02991	0.684
LIG_LIR_Gen_1	196	203	PF02991	0.655
LIG_LIR_Gen_1	66	77	PF02991	0.374
LIG_LIR_Nem_3	145	151	PF02991	0.654
LIG_LIR_Nem_3	196	201	PF02991	0.656
LIG_LIR_Nem_3	66	72	PF02991	0.340
LIG_SH2_CRK	148	152	PF00017	0.735
LIG_SH2_GRB2like	148	151	PF00017	0.730
LIG_SH2_PTP2	198	201	PF00017	0.690
LIG_SH2_SRC	198	201	PF00017	0.690
LIG_SH2_STAT5	198	201	PF00017	0.681
LIG_SH2_STAT5	252	255	PF00017	0.714
LIG_SH2_STAT5	40	43	PF00017	0.312
LIG_SH2_STAT5	69	72	PF00017	0.421
LIG_SH3_1	238	244	PF00018	0.743
LIG_SH3_3	225	231	PF00018	0.613
LIG_SH3_3	238	244	PF00018	0.583
LIG_SxIP_EBH_1	275	288	PF03271	0.525
LIG_TYR_ITSM	194	201	PF00017	0.674
MOD_CK1_1	113	119	PF00069	0.545
MOD_CK1_1	218	224	PF00069	0.715
MOD_CK1_1	80	86	PF00069	0.621
MOD_CK1_1	94	100	PF00069	0.590
MOD_CK2_1	130	136	PF00069	0.745
MOD_CK2_1	210	216	PF00069	0.674
MOD_CK2_1	262	268	PF00069	0.641
MOD_CK2_1	56	62	PF00069	0.472
MOD_GlcNHglycan	248	251	PF01048	0.674
MOD_GSK3_1	167	174	PF00069	0.701
MOD_GSK3_1	218	225	PF00069	0.722
MOD_GSK3_1	230	237	PF00069	0.591
MOD_GSK3_1	277	284	PF00069	0.697
MOD_GSK3_1	73	80	PF00069	0.513
MOD_N-GLC_1	161	166	PF02516	0.578
MOD_N-GLC_1	73	78	PF02516	0.617
MOD_N-GLC_2	20	22	PF02516	0.421
MOD_NEK2_1	26	31	PF00069	0.289
MOD_NEK2_1	72	77	PF00069	0.566
MOD_PIKK_1	230	236	PF00454	0.437
MOD_PKA_2	116	122	PF00069	0.783
MOD_PKA_2	218	224	PF00069	0.704
MOD_PKA_2	72	78	PF00069	0.517
MOD_Plk_1	73	79	PF00069	0.447
MOD_Plk_2-3	222	228	PF00069	0.666
MOD_Plk_4	193	199	PF00069	0.666
MOD_ProDKin_1	173	179	PF00069	0.699
TRG_DiLeu_BaEn_1	181	186	PF01217	0.549
TRG_ENDOCYTIC_2	148	151	PF00928	0.664
TRG_ENDOCYTIC_2	198	201	PF00928	0.690
TRG_ENDOCYTIC_2	69	72	PF00928	0.338
TRG_ER_diArg_1	30	32	PF00400	0.371
TRG_Pf-PMV_PEXEL_1	251	255	PF00026	0.691
TRG_Pf-PMV_PEXEL_1	56	60	PF00026	0.352

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9N1	Leptomonas seymouri	58%	98%
A0A1X0P5K3	Trypanosomatidae	33%	96%
A0A3Q8II84	Leishmania donovani	89%	100%
A0A3S5IRP0	Trypanosoma rangeli	34%	100%
A4HN19	Leishmania braziliensis	78%	100%
A4IBP0	Leishmania infantum	87%	100%
C9ZYZ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AFH4	Leishmania major	89%	100%
V5BTD8	Trypanosoma cruzi	37%	100%