Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B6M8_LEIMU

TriTrypDb:

LmxM.34.3490

Length:

426

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6M8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6M8

PDB structure(s): 7ane_q

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	187	191	PF00656	0.526
CLV_C14_Caspase3-7	207	211	PF00656	0.353
CLV_C14_Caspase3-7	246	250	PF00656	0.684
CLV_C14_Caspase3-7	337	341	PF00656	0.606
CLV_NRD_NRD_1	102	104	PF00675	0.532
CLV_NRD_NRD_1	26	28	PF00675	0.470
CLV_NRD_NRD_1	268	270	PF00675	0.667
CLV_NRD_NRD_1	286	288	PF00675	0.395
CLV_NRD_NRD_1	302	304	PF00675	0.596
CLV_NRD_NRD_1	324	326	PF00675	0.628
CLV_NRD_NRD_1	57	59	PF00675	0.418
CLV_NRD_NRD_1	9	11	PF00675	0.520
CLV_NRD_NRD_1	99	101	PF00675	0.543
CLV_PCSK_FUR_1	100	104	PF00082	0.635
CLV_PCSK_KEX2_1	101	103	PF00082	0.477
CLV_PCSK_KEX2_1	26	28	PF00082	0.553
CLV_PCSK_KEX2_1	286	288	PF00082	0.544
CLV_PCSK_KEX2_1	302	304	PF00082	0.596
CLV_PCSK_KEX2_1	323	325	PF00082	0.634
CLV_PCSK_KEX2_1	362	364	PF00082	0.670
CLV_PCSK_KEX2_1	369	371	PF00082	0.659
CLV_PCSK_KEX2_1	62	64	PF00082	0.412
CLV_PCSK_KEX2_1	9	11	PF00082	0.520
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.490
CLV_PCSK_PC1ET2_1	323	325	PF00082	0.669
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.670
CLV_PCSK_PC1ET2_1	369	371	PF00082	0.659
CLV_PCSK_PC1ET2_1	62	64	PF00082	0.423
CLV_PCSK_PC7_1	282	288	PF00082	0.537
CLV_PCSK_PC7_1	58	64	PF00082	0.420
CLV_PCSK_SKI1_1	112	116	PF00082	0.481
CLV_PCSK_SKI1_1	129	133	PF00082	0.361
CLV_PCSK_SKI1_1	26	30	PF00082	0.448
CLV_PCSK_SKI1_1	298	302	PF00082	0.637
CLV_PCSK_SKI1_1	349	353	PF00082	0.619
CLV_PCSK_SKI1_1	376	380	PF00082	0.641
DEG_SCF_FBW7_2	377	383	PF00400	0.549
DOC_CKS1_1	31	36	PF01111	0.428
DOC_CKS1_1	377	382	PF01111	0.550
DOC_CYCLIN_RxL_1	112	125	PF00134	0.458
DOC_MAPK_gen_1	116	122	PF00069	0.456
DOC_PP4_FxxP_1	301	304	PF00568	0.654
DOC_PP4_FxxP_1	31	34	PF00568	0.434
DOC_USP7_MATH_1	19	23	PF00917	0.496
DOC_USP7_MATH_1	245	249	PF00917	0.643
DOC_USP7_UBL2_3	294	298	PF12436	0.617
DOC_USP7_UBL2_3	345	349	PF12436	0.704
DOC_WW_Pin1_4	30	35	PF00397	0.435
DOC_WW_Pin1_4	309	314	PF00397	0.740
DOC_WW_Pin1_4	317	322	PF00397	0.508
DOC_WW_Pin1_4	376	381	PF00397	0.551
DOC_WW_Pin1_4	385	390	PF00397	0.696
LIG_14-3-3_CanoR_1	137	145	PF00244	0.410
LIG_14-3-3_CanoR_1	400	407	PF00244	0.672
LIG_APCC_ABBA_1	241	246	PF00400	0.526
LIG_FHA_1	27	33	PF00498	0.453
LIG_FHA_1	377	383	PF00498	0.551
LIG_FHA_1	401	407	PF00498	0.699
LIG_FHA_2	212	218	PF00498	0.663
LIG_FHA_2	276	282	PF00498	0.532
LIG_LIR_Apic_2	214	219	PF02991	0.637
LIG_LIR_Apic_2	29	34	PF02991	0.434
LIG_LIR_Apic_2	299	304	PF02991	0.693
LIG_LIR_Gen_1	51	61	PF02991	0.410
LIG_LIR_Nem_3	44	49	PF02991	0.409
LIG_LIR_Nem_3	51	57	PF02991	0.406
LIG_MYND_3	183	187	PF01753	0.495
LIG_PDZ_Class_3	421	426	PF00595	0.652
LIG_Pex14_1	65	69	PF04695	0.408
LIG_SH2_CRK	16	20	PF00017	0.473
LIG_SH2_GRB2like	15	18	PF00017	0.483
LIG_SH2_NCK_1	135	139	PF00017	0.400
LIG_SH2_NCK_1	16	20	PF00017	0.457
LIG_SH2_NCK_1	216	220	PF00017	0.674
LIG_SH2_SRC	216	219	PF00017	0.463
LIG_SH2_STAT3	150	153	PF00017	0.485
LIG_SH2_STAT3	61	64	PF00017	0.419
LIG_SH2_STAT5	150	153	PF00017	0.441
LIG_SH2_STAT5	167	170	PF00017	0.432
LIG_SH2_STAT5	289	292	PF00017	0.518
LIG_SH2_STAT5	405	408	PF00017	0.410
LIG_SH2_STAT5	76	79	PF00017	0.421
LIG_TRAF2_1	155	158	PF00917	0.586
LIG_TRAF2_1	235	238	PF00917	0.584
LIG_TRAF2_1	274	277	PF00917	0.633
LIG_TRAF2_1	278	281	PF00917	0.674
LIG_TRAF2_1	334	337	PF00917	0.608
LIG_WRC_WIRS_1	66	71	PF05994	0.410
MOD_CDK_SPxK_1	30	36	PF00069	0.430
MOD_CDK_SPxK_1	317	323	PF00069	0.693
MOD_CDK_SPxxK_3	317	324	PF00069	0.689
MOD_CK1_1	152	158	PF00069	0.488
MOD_CK1_1	312	318	PF00069	0.530
MOD_CK1_1	381	387	PF00069	0.711
MOD_CK2_1	152	158	PF00069	0.594
MOD_CK2_1	17	23	PF00069	0.528
MOD_CK2_1	211	217	PF00069	0.603
MOD_CK2_1	232	238	PF00069	0.575
MOD_CK2_1	271	277	PF00069	0.648
MOD_Cter_Amidation	24	27	PF01082	0.487
MOD_GlcNHglycan	234	237	PF01048	0.527
MOD_GlcNHglycan	262	265	PF01048	0.690
MOD_GlcNHglycan	4	7	PF01048	0.719
MOD_GlcNHglycan	84	87	PF01048	0.527
MOD_GSK3_1	199	206	PF00069	0.573
MOD_GSK3_1	245	252	PF00069	0.549
MOD_GSK3_1	26	33	PF00069	0.440
MOD_GSK3_1	271	278	PF00069	0.539
MOD_GSK3_1	292	299	PF00069	0.567
MOD_GSK3_1	353	360	PF00069	0.747
MOD_GSK3_1	381	388	PF00069	0.708
MOD_LATS_1	24	30	PF00433	0.480
MOD_N-GLC_1	80	85	PF02516	0.418
MOD_NEK2_1	1	6	PF00069	0.621
MOD_NEK2_1	232	237	PF00069	0.543
MOD_NEK2_2	211	216	PF00069	0.631
MOD_NEK2_2	296	301	PF00069	0.640
MOD_NEK2_2	65	70	PF00069	0.410
MOD_PIKK_1	102	108	PF00454	0.574
MOD_PIKK_1	149	155	PF00454	0.508
MOD_PKA_1	102	108	PF00069	0.574
MOD_PKA_1	26	32	PF00069	0.455
MOD_PKA_1	324	330	PF00069	0.696
MOD_PKA_2	102	108	PF00069	0.574
MOD_PKA_2	136	142	PF00069	0.404
MOD_PKA_2	2	8	PF00069	0.551
MOD_PKA_2	26	32	PF00069	0.567
MOD_PKA_2	324	330	PF00069	0.696
MOD_PKB_1	100	108	PF00069	0.636
MOD_Plk_4	211	217	PF00069	0.608
MOD_Plk_4	296	302	PF00069	0.677
MOD_ProDKin_1	30	36	PF00069	0.430
MOD_ProDKin_1	309	315	PF00069	0.743
MOD_ProDKin_1	317	323	PF00069	0.507
MOD_ProDKin_1	376	382	PF00069	0.551
MOD_ProDKin_1	385	391	PF00069	0.695
MOD_SUMO_rev_2	220	230	PF00179	0.661
TRG_ENDOCYTIC_2	15	18	PF00928	0.483
TRG_ER_diArg_1	100	103	PF00400	0.637
TRG_ER_diArg_1	26	28	PF00400	0.577
TRG_ER_diArg_1	301	303	PF00400	0.684
TRG_ER_diArg_1	370	373	PF00400	0.656
TRG_NLS_Bipartite_1	100	120	PF00514	0.488
TRG_NLS_MonoCore_2	322	327	PF00514	0.678
TRG_NLS_MonoExtC_3	115	121	PF00514	0.462
TRG_NLS_MonoExtC_3	324	330	PF00514	0.598
TRG_NLS_MonoExtN_4	321	327	PF00514	0.627

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2P6	Leptomonas seymouri	78%	100%
A0A0S4IKL5	Bodo saltans	52%	91%
A0A1X0P5A6	Trypanosomatidae	61%	96%
A0A3Q8IPV2	Leishmania donovani	96%	100%
A0A3R7NKQ1	Trypanosoma rangeli	61%	97%
A4HN18	Leishmania braziliensis	91%	100%
A4IBN9	Leishmania infantum	96%	100%
C9ZYZ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	97%
E9AFH3	Leishmania major	95%	100%
V5BY99	Trypanosoma cruzi	62%	96%