LeishMANIAdb
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Envelope glycoprotein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Envelope glycoprotein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B6M7_LEIMU
TriTrypDb:
LmxM.34.3480
Length:
729

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6M7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6M7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 103 107 PF00656 0.428
CLV_C14_Caspase3-7 414 418 PF00656 0.541
CLV_NRD_NRD_1 190 192 PF00675 0.840
CLV_NRD_NRD_1 225 227 PF00675 0.703
CLV_NRD_NRD_1 437 439 PF00675 0.826
CLV_PCSK_FUR_1 188 192 PF00082 0.835
CLV_PCSK_FUR_1 440 444 PF00082 0.651
CLV_PCSK_KEX2_1 11 13 PF00082 0.488
CLV_PCSK_KEX2_1 190 192 PF00082 0.850
CLV_PCSK_KEX2_1 225 227 PF00082 0.703
CLV_PCSK_KEX2_1 439 441 PF00082 0.722
CLV_PCSK_KEX2_1 442 444 PF00082 0.729
CLV_PCSK_PC1ET2_1 11 13 PF00082 0.488
CLV_PCSK_PC1ET2_1 439 441 PF00082 0.722
CLV_PCSK_PC1ET2_1 442 444 PF00082 0.729
CLV_PCSK_PC7_1 438 444 PF00082 0.648
CLV_PCSK_SKI1_1 208 212 PF00082 0.543
CLV_PCSK_SKI1_1 325 329 PF00082 0.663
CLV_PCSK_SKI1_1 376 380 PF00082 0.606
DEG_Nend_UBRbox_3 1 3 PF02207 0.563
DEG_SCF_FBW7_1 578 585 PF00400 0.798
DEG_SCF_FBW7_1 685 690 PF00400 0.535
DEG_SIAH_1 145 153 PF03145 0.805
DEG_SPOP_SBC_1 482 486 PF00917 0.734
DOC_CKS1_1 446 451 PF01111 0.740
DOC_CKS1_1 561 566 PF01111 0.574
DOC_CKS1_1 583 588 PF01111 0.846
DOC_CYCLIN_yCln2_LP_2 719 725 PF00134 0.784
DOC_MAPK_HePTP_8 29 41 PF00069 0.623
DOC_MAPK_MEF2A_6 175 183 PF00069 0.688
DOC_MAPK_MEF2A_6 299 307 PF00069 0.501
DOC_MAPK_MEF2A_6 32 41 PF00069 0.537
DOC_MAPK_MEF2A_6 376 383 PF00069 0.390
DOC_PP1_RVXF_1 30 37 PF00149 0.635
DOC_PP2B_LxvP_1 141 144 PF13499 0.411
DOC_PP2B_LxvP_1 341 344 PF13499 0.531
DOC_PP2B_LxvP_1 379 382 PF13499 0.307
DOC_PP2B_LxvP_1 456 459 PF13499 0.611
DOC_PP2B_LxvP_1 670 673 PF13499 0.784
DOC_PP2B_LxvP_1 682 685 PF13499 0.651
DOC_PP2B_LxvP_1 700 703 PF13499 0.586
DOC_PP2B_LxvP_1 719 722 PF13499 0.756
DOC_PP4_FxxP_1 602 605 PF00568 0.743
DOC_USP7_MATH_1 100 104 PF00917 0.443
DOC_USP7_MATH_1 146 150 PF00917 0.755
DOC_USP7_MATH_1 163 167 PF00917 0.573
DOC_USP7_MATH_1 21 25 PF00917 0.457
DOC_USP7_MATH_1 213 217 PF00917 0.843
DOC_USP7_MATH_1 232 236 PF00917 0.541
DOC_USP7_MATH_1 275 279 PF00917 0.676
DOC_USP7_MATH_1 345 349 PF00917 0.621
DOC_USP7_MATH_1 382 386 PF00917 0.626
DOC_USP7_MATH_1 423 427 PF00917 0.704
DOC_USP7_MATH_1 482 486 PF00917 0.643
DOC_USP7_MATH_1 550 554 PF00917 0.709
DOC_USP7_MATH_1 572 576 PF00917 0.841
DOC_USP7_MATH_1 586 590 PF00917 0.676
DOC_USP7_MATH_1 595 599 PF00917 0.682
DOC_USP7_MATH_1 605 609 PF00917 0.759
DOC_USP7_UBL2_3 273 277 PF12436 0.748
DOC_WW_Pin1_4 148 153 PF00397 0.808
DOC_WW_Pin1_4 267 272 PF00397 0.582
DOC_WW_Pin1_4 312 317 PF00397 0.702
DOC_WW_Pin1_4 445 450 PF00397 0.741
DOC_WW_Pin1_4 501 506 PF00397 0.827
DOC_WW_Pin1_4 521 526 PF00397 0.543
DOC_WW_Pin1_4 551 556 PF00397 0.716
DOC_WW_Pin1_4 560 565 PF00397 0.745
DOC_WW_Pin1_4 578 583 PF00397 0.846
DOC_WW_Pin1_4 591 596 PF00397 0.737
DOC_WW_Pin1_4 632 637 PF00397 0.552
DOC_WW_Pin1_4 668 673 PF00397 0.612
DOC_WW_Pin1_4 683 688 PF00397 0.707
DOC_WW_Pin1_4 693 698 PF00397 0.638
LIG_14-3-3_CanoR_1 137 142 PF00244 0.500
LIG_14-3-3_CanoR_1 167 176 PF00244 0.622
LIG_14-3-3_CanoR_1 214 224 PF00244 0.770
LIG_14-3-3_CanoR_1 443 449 PF00244 0.642
LIG_14-3-3_CanoR_1 470 474 PF00244 0.703
LIG_14-3-3_CanoR_1 480 487 PF00244 0.735
LIG_14-3-3_CanoR_1 94 98 PF00244 0.607
LIG_EH1_1 291 299 PF00400 0.472
LIG_eIF4E_1 14 20 PF01652 0.633
LIG_EVH1_1 627 631 PF00568 0.508
LIG_FHA_1 24 30 PF00498 0.511
LIG_FHA_1 281 287 PF00498 0.668
LIG_FHA_1 403 409 PF00498 0.506
LIG_FHA_1 51 57 PF00498 0.512
LIG_FHA_1 632 638 PF00498 0.667
LIG_FHA_2 113 119 PF00498 0.481
LIG_FHA_2 167 173 PF00498 0.744
LIG_FHA_2 194 200 PF00498 0.664
LIG_FHA_2 321 327 PF00498 0.673
LIG_FXI_DFP_1 33 37 PF00024 0.571
LIG_LIR_Apic_2 544 548 PF02991 0.643
LIG_LIR_Apic_2 600 605 PF02991 0.772
LIG_LIR_Apic_2 624 630 PF02991 0.718
LIG_LIR_Gen_1 128 139 PF02991 0.507
LIG_LIR_Gen_1 30 41 PF02991 0.475
LIG_LIR_Gen_1 369 378 PF02991 0.489
LIG_LIR_Nem_3 115 119 PF02991 0.653
LIG_LIR_Nem_3 30 36 PF02991 0.479
LIG_LIR_Nem_3 369 373 PF02991 0.489
LIG_LIR_Nem_3 471 476 PF02991 0.746
LIG_MYND_1 454 458 PF01753 0.622
LIG_MYND_1 668 672 PF01753 0.818
LIG_NRBOX 236 242 PF00104 0.593
LIG_SH2_CRK 355 359 PF00017 0.486
LIG_SH2_CRK 370 374 PF00017 0.499
LIG_SH2_CRK 545 549 PF00017 0.647
LIG_SH2_NCK_1 243 247 PF00017 0.503
LIG_SH2_NCK_1 545 549 PF00017 0.850
LIG_SH2_NCK_1 569 573 PF00017 0.850
LIG_SH2_SRC 119 122 PF00017 0.607
LIG_SH2_SRC 46 49 PF00017 0.593
LIG_SH2_STAP1 116 120 PF00017 0.640
LIG_SH2_STAP1 243 247 PF00017 0.503
LIG_SH2_STAP1 355 359 PF00017 0.588
LIG_SH2_STAP1 569 573 PF00017 0.850
LIG_SH2_STAT3 239 242 PF00017 0.456
LIG_SH2_STAT3 247 250 PF00017 0.542
LIG_SH2_STAT3 359 362 PF00017 0.588
LIG_SH2_STAT5 119 122 PF00017 0.607
LIG_SH2_STAT5 177 180 PF00017 0.681
LIG_SH2_STAT5 239 242 PF00017 0.314
LIG_SH2_STAT5 352 355 PF00017 0.510
LIG_SH2_STAT5 393 396 PF00017 0.599
LIG_SH2_STAT5 569 572 PF00017 0.849
LIG_SH2_STAT5 674 677 PF00017 0.733
LIG_SH3_2 192 197 PF14604 0.752
LIG_SH3_3 152 158 PF00018 0.699
LIG_SH3_3 189 195 PF00018 0.749
LIG_SH3_3 313 319 PF00018 0.724
LIG_SH3_3 37 43 PF00018 0.520
LIG_SH3_3 425 431 PF00018 0.719
LIG_SH3_3 503 509 PF00018 0.768
LIG_SH3_3 512 518 PF00018 0.670
LIG_SH3_3 519 525 PF00018 0.624
LIG_SH3_3 535 541 PF00018 0.831
LIG_SH3_3 561 567 PF00018 0.751
LIG_SH3_3 568 574 PF00018 0.653
LIG_SH3_3 611 617 PF00018 0.733
LIG_SH3_3 625 631 PF00018 0.510
LIG_SH3_3 666 672 PF00018 0.722
LIG_SH3_3 675 681 PF00018 0.697
LIG_SH3_3 707 713 PF00018 0.646
LIG_SH3_3 722 728 PF00018 0.518
LIG_SH3_3 99 105 PF00018 0.594
LIG_SH3_CIN85_PxpxPR_1 724 729 PF14604 0.671
LIG_SUMO_SIM_par_1 137 142 PF11976 0.335
LIG_SUMO_SIM_par_1 24 30 PF11976 0.593
LIG_TRFH_1 14 18 PF08558 0.525
LIG_TYR_ITIM 353 358 PF00017 0.468
LIG_TYR_ITIM 368 373 PF00017 0.492
LIG_WRC_WIRS_1 473 478 PF05994 0.810
LIG_WRC_WIRS_1 599 604 PF05994 0.742
LIG_WW_1 542 545 PF00397 0.703
LIG_WW_1 566 569 PF00397 0.804
LIG_WW_3 222 226 PF00397 0.852
LIG_WW_3 317 321 PF00397 0.741
MOD_CDK_SPxK_1 267 273 PF00069 0.675
MOD_CDK_SPxK_1 582 588 PF00069 0.752
MOD_CK1_1 166 172 PF00069 0.753
MOD_CK1_1 193 199 PF00069 0.725
MOD_CK1_1 22 28 PF00069 0.643
MOD_CK1_1 284 290 PF00069 0.640
MOD_CK1_1 445 451 PF00069 0.829
MOD_CK1_1 469 475 PF00069 0.747
MOD_CK1_1 478 484 PF00069 0.654
MOD_CK1_1 485 491 PF00069 0.630
MOD_CK1_1 492 498 PF00069 0.730
MOD_CK1_1 554 560 PF00069 0.679
MOD_CK1_1 598 604 PF00069 0.741
MOD_CK1_1 635 641 PF00069 0.698
MOD_CK2_1 193 199 PF00069 0.753
MOD_CK2_1 248 254 PF00069 0.620
MOD_CK2_1 320 326 PF00069 0.687
MOD_CK2_1 80 86 PF00069 0.597
MOD_GlcNHglycan 169 172 PF01048 0.633
MOD_GlcNHglycan 21 24 PF01048 0.508
MOD_GlcNHglycan 276 280 PF01048 0.682
MOD_GlcNHglycan 480 483 PF01048 0.782
MOD_GlcNHglycan 574 577 PF01048 0.838
MOD_GlcNHglycan 602 605 PF01048 0.743
MOD_GlcNHglycan 691 694 PF01048 0.805
MOD_GlcNHglycan 82 85 PF01048 0.390
MOD_GSK3_1 163 170 PF00069 0.700
MOD_GSK3_1 19 26 PF00069 0.523
MOD_GSK3_1 228 235 PF00069 0.603
MOD_GSK3_1 248 255 PF00069 0.415
MOD_GSK3_1 275 282 PF00069 0.755
MOD_GSK3_1 412 419 PF00069 0.485
MOD_GSK3_1 438 445 PF00069 0.845
MOD_GSK3_1 464 471 PF00069 0.741
MOD_GSK3_1 472 479 PF00069 0.651
MOD_GSK3_1 481 488 PF00069 0.644
MOD_GSK3_1 550 557 PF00069 0.730
MOD_GSK3_1 572 579 PF00069 0.839
MOD_GSK3_1 582 589 PF00069 0.800
MOD_GSK3_1 591 598 PF00069 0.550
MOD_GSK3_1 631 638 PF00069 0.726
MOD_GSK3_1 648 655 PF00069 0.650
MOD_GSK3_1 683 690 PF00069 0.737
MOD_N-GLC_1 366 371 PF02516 0.494
MOD_N-GLC_1 532 537 PF02516 0.747
MOD_N-GLC_2 55 57 PF02516 0.638
MOD_NEK2_1 19 24 PF00069 0.503
MOD_NEK2_1 252 257 PF00069 0.537
MOD_NEK2_1 411 416 PF00069 0.554
MOD_NEK2_1 468 473 PF00069 0.759
MOD_NEK2_1 476 481 PF00069 0.697
MOD_NEK2_1 487 492 PF00069 0.628
MOD_NEK2_1 643 648 PF00069 0.726
MOD_PIKK_1 100 106 PF00454 0.387
MOD_PIKK_1 190 196 PF00454 0.843
MOD_PIKK_1 442 448 PF00454 0.824
MOD_PIKK_1 533 539 PF00454 0.681
MOD_PIKK_1 586 592 PF00454 0.734
MOD_PIKK_1 606 612 PF00454 0.785
MOD_PIKK_1 704 710 PF00454 0.736
MOD_PKA_1 190 196 PF00069 0.843
MOD_PKA_1 438 444 PF00069 0.759
MOD_PKA_2 166 172 PF00069 0.642
MOD_PKA_2 190 196 PF00069 0.762
MOD_PKA_2 213 219 PF00069 0.770
MOD_PKA_2 284 290 PF00069 0.621
MOD_PKA_2 442 448 PF00069 0.769
MOD_PKA_2 469 475 PF00069 0.762
MOD_PKA_2 62 68 PF00069 0.554
MOD_PKA_2 93 99 PF00069 0.598
MOD_PKB_1 188 196 PF00069 0.839
MOD_PKB_1 206 214 PF00069 0.590
MOD_Plk_1 232 238 PF00069 0.553
MOD_Plk_1 366 372 PF00069 0.489
MOD_Plk_4 233 239 PF00069 0.525
MOD_Plk_4 293 299 PF00069 0.579
MOD_Plk_4 366 372 PF00069 0.489
MOD_Plk_4 423 429 PF00069 0.783
MOD_Plk_4 507 513 PF00069 0.754
MOD_Plk_4 85 91 PF00069 0.433
MOD_ProDKin_1 148 154 PF00069 0.810
MOD_ProDKin_1 267 273 PF00069 0.594
MOD_ProDKin_1 312 318 PF00069 0.710
MOD_ProDKin_1 445 451 PF00069 0.742
MOD_ProDKin_1 501 507 PF00069 0.830
MOD_ProDKin_1 521 527 PF00069 0.546
MOD_ProDKin_1 551 557 PF00069 0.718
MOD_ProDKin_1 560 566 PF00069 0.740
MOD_ProDKin_1 578 584 PF00069 0.845
MOD_ProDKin_1 591 597 PF00069 0.737
MOD_ProDKin_1 632 638 PF00069 0.551
MOD_ProDKin_1 668 674 PF00069 0.614
MOD_ProDKin_1 683 689 PF00069 0.709
MOD_ProDKin_1 693 699 PF00069 0.637
MOD_SUMO_rev_2 324 330 PF00179 0.640
TRG_DiLeu_BaEn_1 233 238 PF01217 0.642
TRG_DiLeu_BaLyEn_6 15 20 PF01217 0.635
TRG_ENDOCYTIC_2 131 134 PF00928 0.490
TRG_ENDOCYTIC_2 355 358 PF00928 0.478
TRG_ENDOCYTIC_2 370 373 PF00928 0.502
TRG_ENDOCYTIC_2 473 476 PF00928 0.815
TRG_ER_diArg_1 188 191 PF00400 0.835
TRG_ER_diArg_1 224 226 PF00400 0.792
TRG_NLS_MonoExtC_3 437 442 PF00514 0.753
TRG_NLS_MonoExtN_4 436 443 PF00514 0.755
TRG_Pf-PMV_PEXEL_1 137 142 PF00026 0.630

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0P647 Trypanosomatidae 36% 100%
A0A3S5H801 Leishmania donovani 90% 100%
A4HN17 Leishmania braziliensis 74% 100%
A4IBN8 Leishmania infantum 90% 100%
E9AFH2 Leishmania major 89% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS