PEROXIDASE_4 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peroxidase, putative

Species:

Leishmania mexicana

UniProt:

E9B6M5_LEIMU

TriTrypDb:

LmxM.34.3460

Length:

368

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	6
GO:0016020	membrane	2	5

Expansion

Sequence features

E9B6M5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6M5

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	10
GO:0006979	response to oxidative stress	3	10
GO:0009987	cellular process	1	10
GO:0033554	cellular response to stress	3	10
GO:0034599	cellular response to oxidative stress	4	10
GO:0042221	response to chemical	2	10
GO:0050896	response to stimulus	1	10
GO:0051716	cellular response to stimulus	2	10
GO:0062197	cellular response to chemical stress	4	10
GO:0070887	cellular response to chemical stimulus	3	10
GO:0000302	response to reactive oxygen species	4	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0042743	hydrogen peroxide metabolic process	4	1
GO:0042744	hydrogen peroxide catabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0072593	reactive oxygen species metabolic process	3	1
GO:1901700	response to oxygen-containing compound	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004601	peroxidase activity	2	10
GO:0005488	binding	1	10
GO:0016209	antioxidant activity	1	10
GO:0016491	oxidoreductase activity	2	10
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	3	10
GO:0020037	heme binding	4	10
GO:0046906	tetrapyrrole binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0140825	lactoperoxidase activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	239	243	PF00656	0.536
CLV_C14_Caspase3-7	256	260	PF00656	0.540
CLV_NRD_NRD_1	147	149	PF00675	0.344
CLV_NRD_NRD_1	197	199	PF00675	0.605
CLV_NRD_NRD_1	229	231	PF00675	0.541
CLV_PCSK_KEX2_1	104	106	PF00082	0.378
CLV_PCSK_KEX2_1	146	148	PF00082	0.343
CLV_PCSK_KEX2_1	229	231	PF00082	0.639
CLV_PCSK_KEX2_1	246	248	PF00082	0.591
CLV_PCSK_PC1ET2_1	104	106	PF00082	0.378
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.467
CLV_PCSK_PC1ET2_1	246	248	PF00082	0.674
CLV_PCSK_SKI1_1	104	108	PF00082	0.328
CLV_PCSK_SKI1_1	211	215	PF00082	0.562
CLV_PCSK_SKI1_1	229	233	PF00082	0.546
CLV_PCSK_SKI1_1	82	86	PF00082	0.440
CLV_PCSK_SKI1_1	98	102	PF00082	0.207
DEG_Nend_Nbox_1	1	3	PF02207	0.545
DOC_CYCLIN_yClb1_LxF_4	338	344	PF00134	0.518
DOC_MAPK_gen_1	207	215	PF00069	0.530
DOC_PP1_RVXF_1	123	130	PF00149	0.328
DOC_PP4_FxxP_1	14	17	PF00568	0.409
DOC_PP4_FxxP_1	159	162	PF00568	0.347
DOC_USP7_MATH_1	237	241	PF00917	0.616
DOC_USP7_MATH_1	284	288	PF00917	0.727
DOC_USP7_MATH_1	345	349	PF00917	0.502
DOC_USP7_MATH_2	310	316	PF00917	0.507
DOC_USP7_UBL2_3	142	146	PF12436	0.388
DOC_USP7_UBL2_3	232	236	PF12436	0.388
DOC_WW_Pin1_4	9	14	PF00397	0.434
LIG_14-3-3_CanoR_1	109	115	PF00244	0.440
LIG_14-3-3_CanoR_1	211	216	PF00244	0.644
LIG_14-3-3_CanoR_1	303	309	PF00244	0.697
LIG_AP2alpha_2	217	219	PF02296	0.566
LIG_APCC_ABBA_1	216	221	PF00400	0.552
LIG_BRCT_BRCA1_1	176	180	PF00533	0.440
LIG_deltaCOP1_diTrp_1	185	194	PF00928	0.371
LIG_deltaCOP1_diTrp_1	49	54	PF00928	0.371
LIG_FHA_1	79	85	PF00498	0.360
LIG_FHA_2	135	141	PF00498	0.326
LIG_FHA_2	166	172	PF00498	0.434
LIG_FHA_2	212	218	PF00498	0.595
LIG_FHA_2	44	50	PF00498	0.440
LIG_LIR_Apic_2	12	17	PF02991	0.417
LIG_LIR_Apic_2	156	162	PF02991	0.328
LIG_LIR_Apic_2	185	191	PF02991	0.467
LIG_LIR_Gen_1	177	186	PF02991	0.331
LIG_LIR_Gen_1	342	352	PF02991	0.496
LIG_LIR_Gen_1	49	59	PF02991	0.328
LIG_LIR_Nem_3	177	183	PF02991	0.329
LIG_LIR_Nem_3	342	347	PF02991	0.385
LIG_LIR_Nem_3	46	50	PF02991	0.339
LIG_MLH1_MIPbox_1	176	180	PF16413	0.440
LIG_Pex14_1	332	336	PF04695	0.384
LIG_Pex14_2	47	51	PF04695	0.440
LIG_SH2_CRK	344	348	PF00017	0.492
LIG_SH2_NCK_1	344	348	PF00017	0.492
LIG_SH2_STAT3	224	227	PF00017	0.662
LIG_SH2_STAT5	173	176	PF00017	0.328
LIG_SH2_STAT5	179	182	PF00017	0.328
LIG_SH2_STAT5	45	48	PF00017	0.431
LIG_SH3_4	142	149	PF00018	0.467
LIG_SUMO_SIM_anti_2	319	326	PF11976	0.466
LIG_TRAF2_1	137	140	PF00917	0.347
MOD_CK1_1	220	226	PF00069	0.666
MOD_CK2_1	134	140	PF00069	0.321
MOD_CK2_1	152	158	PF00069	0.440
MOD_CK2_1	284	290	PF00069	0.740
MOD_GlcNHglycan	255	258	PF01048	0.708
MOD_GlcNHglycan	264	268	PF01048	0.619
MOD_GlcNHglycan	276	279	PF01048	0.619
MOD_GSK3_1	161	168	PF00069	0.473
MOD_GSK3_1	274	281	PF00069	0.739
MOD_GSK3_1	312	319	PF00069	0.311
MOD_GSK3_1	5	12	PF00069	0.414
MOD_GSK3_1	84	91	PF00069	0.331
MOD_N-GLC_1	253	258	PF02516	0.756
MOD_N-GLC_1	278	283	PF02516	0.772
MOD_N-GLC_2	124	126	PF02516	0.467
MOD_NEK2_1	7	12	PF00069	0.468
MOD_NEK2_1	84	89	PF00069	0.316
MOD_PIKK_1	223	229	PF00454	0.682
MOD_PIKK_1	7	13	PF00454	0.454
MOD_PKA_2	237	243	PF00069	0.579
MOD_PKA_2	316	322	PF00069	0.487
MOD_PKB_1	209	217	PF00069	0.563
MOD_Plk_1	220	226	PF00069	0.613
MOD_Plk_4	211	217	PF00069	0.647
MOD_ProDKin_1	9	15	PF00069	0.428
MOD_SUMO_rev_2	139	143	PF00179	0.347
TRG_DiLeu_BaEn_1	178	183	PF01217	0.328
TRG_DiLeu_BaEn_3	26	32	PF01217	0.435
TRG_ENDOCYTIC_2	179	182	PF00928	0.326
TRG_ENDOCYTIC_2	344	347	PF00928	0.377
TRG_ER_diArg_1	147	149	PF00400	0.351
TRG_ER_diArg_1	229	231	PF00400	0.537
TRG_ER_diArg_1	70	73	PF00400	0.350
TRG_NLS_MonoExtN_4	143	150	PF00514	0.467
TRG_Pf-PMV_PEXEL_1	105	110	PF00026	0.328
TRG_Pf-PMV_PEXEL_1	90	95	PF00026	0.454

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCF6	Leptomonas seymouri	70%	78%
A0A1X0P5A0	Trypanosomatidae	48%	80%
A0A3Q8IJA1	Leishmania donovani	91%	100%
A0A422NR12	Trypanosoma rangeli	49%	81%
A4IBN6	Leishmania infantum	91%	100%
C9ZYZ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	81%
E9AFH0	Leishmania major	94%	100%
V5C2U7	Trypanosoma cruzi	49%	80%