Putative DNA-repair protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA-repair protein, putative

Species:

Leishmania mexicana

UniProt:

E9B6M4_LEIMU

TriTrypDb:

LmxM.34.3450

Length:

840

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	10
GO:0000109	nucleotide-excision repair complex	3	1
GO:0000111	nucleotide-excision repair factor 2 complex	4	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0071942	XPC complex	4	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9B6M4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6M4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006259	DNA metabolic process	4	10
GO:0006281	DNA repair	5	10
GO:0006289	nucleotide-excision repair	6	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0006950	response to stress	2	10
GO:0006974	DNA damage response	4	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0033554	cellular response to stress	3	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0046483	heterocycle metabolic process	3	10
GO:0050896	response to stimulus	1	10
GO:0051716	cellular response to stimulus	2	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:0006298	mismatch repair	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003677	DNA binding	4	10
GO:0003684	damaged DNA binding	5	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0003697	single-stranded DNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	400	404	PF00656	0.753
CLV_C14_Caspase3-7	460	464	PF00656	0.508
CLV_NRD_NRD_1	159	161	PF00675	0.560
CLV_NRD_NRD_1	217	219	PF00675	0.564
CLV_NRD_NRD_1	245	247	PF00675	0.658
CLV_NRD_NRD_1	415	417	PF00675	0.558
CLV_NRD_NRD_1	429	431	PF00675	0.487
CLV_NRD_NRD_1	434	436	PF00675	0.487
CLV_NRD_NRD_1	534	536	PF00675	0.330
CLV_NRD_NRD_1	741	743	PF00675	0.247
CLV_NRD_NRD_1	757	759	PF00675	0.247
CLV_NRD_NRD_1	763	765	PF00675	0.247
CLV_NRD_NRD_1	803	805	PF00675	0.327
CLV_PCSK_FUR_1	427	431	PF00082	0.532
CLV_PCSK_KEX2_1	158	160	PF00082	0.572
CLV_PCSK_KEX2_1	195	197	PF00082	0.569
CLV_PCSK_KEX2_1	209	211	PF00082	0.732
CLV_PCSK_KEX2_1	415	417	PF00082	0.560
CLV_PCSK_KEX2_1	429	431	PF00082	0.484
CLV_PCSK_KEX2_1	434	436	PF00082	0.491
CLV_PCSK_KEX2_1	449	451	PF00082	0.155
CLV_PCSK_KEX2_1	534	536	PF00082	0.314
CLV_PCSK_KEX2_1	641	643	PF00082	0.247
CLV_PCSK_KEX2_1	741	743	PF00082	0.247
CLV_PCSK_KEX2_1	756	758	PF00082	0.247
CLV_PCSK_KEX2_1	763	765	PF00082	0.250
CLV_PCSK_KEX2_1	802	804	PF00082	0.322
CLV_PCSK_KEX2_1	822	824	PF00082	0.234
CLV_PCSK_KEX2_1	90	92	PF00082	0.582
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.648
CLV_PCSK_PC1ET2_1	195	197	PF00082	0.642
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.731
CLV_PCSK_PC1ET2_1	429	431	PF00082	0.469
CLV_PCSK_PC1ET2_1	449	451	PF00082	0.155
CLV_PCSK_PC1ET2_1	641	643	PF00082	0.247
CLV_PCSK_PC1ET2_1	802	804	PF00082	0.314
CLV_PCSK_PC1ET2_1	822	824	PF00082	0.234
CLV_PCSK_PC1ET2_1	90	92	PF00082	0.582
CLV_PCSK_PC7_1	430	436	PF00082	0.385
CLV_PCSK_PC7_1	637	643	PF00082	0.267
CLV_PCSK_SKI1_1	152	156	PF00082	0.632
CLV_PCSK_SKI1_1	17	21	PF00082	0.688
CLV_PCSK_SKI1_1	195	199	PF00082	0.540
CLV_PCSK_SKI1_1	218	222	PF00082	0.591
CLV_PCSK_SKI1_1	373	377	PF00082	0.397
CLV_PCSK_SKI1_1	470	474	PF00082	0.300
CLV_PCSK_SKI1_1	60	64	PF00082	0.689
CLV_PCSK_SKI1_1	659	663	PF00082	0.405
CLV_PCSK_SKI1_1	741	745	PF00082	0.302
CLV_Separin_Metazoa	560	564	PF03568	0.502
DEG_APCC_DBOX_1	414	422	PF00400	0.732
DEG_APCC_DBOX_1	605	613	PF00400	0.444
DEG_SPOP_SBC_1	289	293	PF00917	0.500
DEG_SPOP_SBC_1	571	575	PF00917	0.467
DEG_SPOP_SBC_1	97	101	PF00917	0.457
DOC_CYCLIN_RxL_1	467	475	PF00134	0.372
DOC_CYCLIN_yCln2_LP_2	283	289	PF00134	0.371
DOC_CYCLIN_yCln2_LP_2	346	352	PF00134	0.367
DOC_MAPK_gen_1	195	202	PF00069	0.315
DOC_MAPK_gen_1	415	423	PF00069	0.705
DOC_MAPK_gen_1	641	648	PF00069	0.447
DOC_MAPK_gen_1	738	747	PF00069	0.447
DOC_MAPK_gen_1	90	97	PF00069	0.395
DOC_MAPK_MEF2A_6	195	202	PF00069	0.331
DOC_MAPK_MEF2A_6	738	747	PF00069	0.447
DOC_MAPK_NFAT4_5	195	203	PF00069	0.336
DOC_PP1_RVXF_1	180	186	PF00149	0.333
DOC_PP1_RVXF_1	742	748	PF00149	0.530
DOC_PP2B_LxvP_1	200	203	PF13499	0.362
DOC_PP2B_LxvP_1	283	286	PF13499	0.372
DOC_PP2B_LxvP_1	344	347	PF13499	0.333
DOC_PP4_FxxP_1	680	683	PF00568	0.599
DOC_PP4_MxPP_1	241	244	PF00568	0.300
DOC_USP7_MATH_1	132	136	PF00917	0.555
DOC_USP7_MATH_1	208	212	PF00917	0.515
DOC_USP7_MATH_1	289	293	PF00917	0.543
DOC_USP7_MATH_1	42	46	PF00917	0.412
DOC_USP7_MATH_1	494	498	PF00917	0.467
DOC_USP7_MATH_1	571	575	PF00917	0.530
DOC_USP7_MATH_1	644	648	PF00917	0.622
DOC_USP7_MATH_1	681	685	PF00917	0.585
DOC_WW_Pin1_4	516	521	PF00397	0.460
LIG_14-3-3_CanoR_1	159	167	PF00244	0.422
LIG_14-3-3_CanoR_1	218	227	PF00244	0.379
LIG_14-3-3_CanoR_1	295	300	PF00244	0.375
LIG_14-3-3_CanoR_1	337	344	PF00244	0.446
LIG_14-3-3_CanoR_1	434	442	PF00244	0.605
LIG_14-3-3_CanoR_1	563	567	PF00244	0.530
LIG_14-3-3_CanoR_1	586	592	PF00244	0.605
LIG_14-3-3_CanoR_1	659	669	PF00244	0.576
LIG_14-3-3_CanoR_1	689	694	PF00244	0.606
LIG_14-3-3_CanoR_1	713	717	PF00244	0.528
LIG_Actin_WH2_2	641	658	PF00022	0.495
LIG_BIR_II_1	1	5	PF00653	0.489
LIG_BIR_III_2	517	521	PF00653	0.530
LIG_BRCT_BRCA1_1	352	356	PF00533	0.353
LIG_BRCT_BRCA1_1	676	680	PF00533	0.572
LIG_Clathr_ClatBox_1	106	110	PF01394	0.538
LIG_deltaCOP1_diTrp_1	480	489	PF00928	0.465
LIG_eIF4E_1	788	794	PF01652	0.425
LIG_FHA_1	230	236	PF00498	0.396
LIG_FHA_1	505	511	PF00498	0.447
LIG_FHA_1	553	559	PF00498	0.541
LIG_FHA_1	563	569	PF00498	0.512
LIG_FHA_1	571	577	PF00498	0.465
LIG_FHA_1	74	80	PF00498	0.424
LIG_FHA_1	777	783	PF00498	0.504
LIG_FHA_2	18	24	PF00498	0.569
LIG_FHA_2	375	381	PF00498	0.696
LIG_FHA_2	699	705	PF00498	0.604
LIG_GBD_Chelix_1	175	183	PF00786	0.544
LIG_LIR_Apic_2	316	321	PF02991	0.375
LIG_LIR_Apic_2	677	683	PF02991	0.603
LIG_LIR_Gen_1	122	129	PF02991	0.521
LIG_LIR_Gen_1	142	149	PF02991	0.313
LIG_LIR_Gen_1	169	179	PF02991	0.342
LIG_LIR_Gen_1	221	231	PF02991	0.347
LIG_LIR_Gen_1	33	42	PF02991	0.474
LIG_LIR_Gen_1	353	363	PF02991	0.353
LIG_LIR_Gen_1	475	484	PF02991	0.454
LIG_LIR_Gen_1	487	494	PF02991	0.430
LIG_LIR_Gen_1	714	725	PF02991	0.447
LIG_LIR_Gen_1	789	795	PF02991	0.587
LIG_LIR_LC3C_4	366	371	PF02991	0.400
LIG_LIR_Nem_3	122	126	PF02991	0.525
LIG_LIR_Nem_3	169	175	PF02991	0.346
LIG_LIR_Nem_3	221	227	PF02991	0.379
LIG_LIR_Nem_3	33	37	PF02991	0.472
LIG_LIR_Nem_3	353	359	PF02991	0.353
LIG_LIR_Nem_3	475	481	PF02991	0.454
LIG_LIR_Nem_3	487	492	PF02991	0.447
LIG_LIR_Nem_3	692	698	PF02991	0.566
LIG_LIR_Nem_3	714	720	PF02991	0.447
LIG_LIR_Nem_3	789	794	PF02991	0.505
LIG_MYND_1	248	252	PF01753	0.359
LIG_NBox_RRM_1	226	236	PF00076	0.360
LIG_NRBOX	170	176	PF00104	0.352
LIG_Pex14_1	502	506	PF04695	0.465
LIG_Pex14_2	352	356	PF04695	0.344
LIG_PTB_Apo_2	275	282	PF02174	0.339
LIG_SH2_CRK	669	673	PF00017	0.558
LIG_SH2_NCK_1	304	308	PF00017	0.466
LIG_SH2_NCK_1	526	530	PF00017	0.447
LIG_SH2_PTP2	224	227	PF00017	0.368
LIG_SH2_PTP2	717	720	PF00017	0.447
LIG_SH2_SRC	530	533	PF00017	0.515
LIG_SH2_STAP1	145	149	PF00017	0.331
LIG_SH2_STAP1	506	510	PF00017	0.447
LIG_SH2_STAP1	526	530	PF00017	0.355
LIG_SH2_STAP1	593	597	PF00017	0.447
LIG_SH2_STAP1	788	792	PF00017	0.576
LIG_SH2_STAT5	224	227	PF00017	0.450
LIG_SH2_STAT5	351	354	PF00017	0.308
LIG_SH2_STAT5	506	509	PF00017	0.476
LIG_SH2_STAT5	522	525	PF00017	0.518
LIG_SH2_STAT5	610	613	PF00017	0.530
LIG_SH2_STAT5	717	720	PF00017	0.447
LIG_SH3_3	126	132	PF00018	0.473
LIG_SH3_3	283	289	PF00018	0.494
LIG_SH3_3	318	324	PF00018	0.436
LIG_SH3_3	34	40	PF00018	0.464
LIG_SH3_3	565	571	PF00018	0.502
LIG_SH3_3	668	674	PF00018	0.539
LIG_SH3_3	691	697	PF00018	0.535
LIG_SH3_3	7	13	PF00018	0.560
LIG_SH3_3	703	709	PF00018	0.577
LIG_SUMO_SIM_anti_2	778	786	PF11976	0.502
LIG_SUMO_SIM_anti_2	789	797	PF11976	0.482
LIG_SUMO_SIM_anti_2	93	101	PF11976	0.382
LIG_SUMO_SIM_par_1	419	425	PF11976	0.664
LIG_SUMO_SIM_par_1	505	511	PF11976	0.502
LIG_SUMO_SIM_par_1	643	650	PF11976	0.543
LIG_SUMO_SIM_par_1	789	797	PF11976	0.433
LIG_TRAF2_1	19	22	PF00917	0.478
LIG_TRAF2_1	787	790	PF00917	0.537
LIG_UBA3_1	273	282	PF00899	0.419
LIG_UBA3_1	818	822	PF00899	0.490
MOD_CDK_SPK_2	516	521	PF00069	0.284
MOD_CK1_1	316	322	PF00069	0.466
MOD_CK1_1	433	439	PF00069	0.722
MOD_CK1_1	454	460	PF00069	0.467
MOD_CK1_1	488	494	PF00069	0.386
MOD_CK1_1	497	503	PF00069	0.336
MOD_CK1_1	52	58	PF00069	0.513
MOD_CK1_1	524	530	PF00069	0.353
MOD_CK1_1	647	653	PF00069	0.420
MOD_CK1_1	660	666	PF00069	0.467
MOD_CK2_1	208	214	PF00069	0.723
MOD_CK2_1	306	312	PF00069	0.546
MOD_CK2_1	374	380	PF00069	0.550
MOD_CK2_1	419	425	PF00069	0.655
MOD_CK2_1	98	104	PF00069	0.681
MOD_Cter_Amidation	532	535	PF01082	0.400
MOD_GlcNHglycan	221	224	PF01048	0.474
MOD_GlcNHglycan	266	269	PF01048	0.388
MOD_GlcNHglycan	292	295	PF01048	0.772
MOD_GlcNHglycan	309	312	PF01048	0.697
MOD_GlcNHglycan	338	341	PF01048	0.624
MOD_GlcNHglycan	44	47	PF01048	0.695
MOD_GlcNHglycan	453	456	PF01048	0.428
MOD_GlcNHglycan	482	485	PF01048	0.360
MOD_GlcNHglycan	5	8	PF01048	0.708
MOD_GlcNHglycan	510	513	PF01048	0.346
MOD_GlcNHglycan	526	529	PF01048	0.308
MOD_GlcNHglycan	642	645	PF01048	0.284
MOD_GSK3_1	13	20	PF00069	0.638
MOD_GSK3_1	214	221	PF00069	0.673
MOD_GSK3_1	22	29	PF00069	0.786
MOD_GSK3_1	290	297	PF00069	0.627
MOD_GSK3_1	302	309	PF00069	0.503
MOD_GSK3_1	441	448	PF00069	0.690
MOD_GSK3_1	454	461	PF00069	0.479
MOD_GSK3_1	49	56	PF00069	0.622
MOD_GSK3_1	502	509	PF00069	0.318
MOD_GSK3_1	552	559	PF00069	0.413
MOD_GSK3_1	587	594	PF00069	0.600
MOD_GSK3_1	626	633	PF00069	0.284
MOD_GSK3_1	640	647	PF00069	0.284
MOD_GSK3_1	73	80	PF00069	0.752
MOD_GSK3_1	81	88	PF00069	0.702
MOD_GSK3_1	93	100	PF00069	0.695
MOD_N-GLC_1	17	22	PF02516	0.762
MOD_N-GLC_1	263	268	PF02516	0.373
MOD_N-GLC_1	395	400	PF02516	0.747
MOD_NEK2_1	3	8	PF00069	0.743
MOD_NEK2_1	326	331	PF00069	0.466
MOD_NEK2_1	350	355	PF00069	0.399
MOD_NEK2_1	374	379	PF00069	0.581
MOD_NEK2_1	472	477	PF00069	0.179
MOD_NEK2_1	508	513	PF00069	0.418
MOD_NEK2_1	562	567	PF00069	0.360
MOD_NEK2_2	185	190	PF00069	0.462
MOD_NEK2_2	363	368	PF00069	0.360
MOD_NEK2_2	644	649	PF00069	0.446
MOD_NEK2_2	78	83	PF00069	0.614
MOD_PIKK_1	374	380	PF00454	0.502
MOD_PIKK_1	689	695	PF00454	0.456
MOD_PIKK_1	729	735	PF00454	0.393
MOD_PK_1	295	301	PF00069	0.464
MOD_PK_1	419	425	PF00069	0.690
MOD_PKA_1	158	164	PF00069	0.550
MOD_PKA_1	218	224	PF00069	0.396
MOD_PKA_1	246	252	PF00069	0.515
MOD_PKA_1	430	436	PF00069	0.658
MOD_PKA_1	756	762	PF00069	0.346
MOD_PKA_2	132	138	PF00069	0.682
MOD_PKA_2	158	164	PF00069	0.439
MOD_PKA_2	185	191	PF00069	0.530
MOD_PKA_2	294	300	PF00069	0.462
MOD_PKA_2	336	342	PF00069	0.571
MOD_PKA_2	433	439	PF00069	0.508
MOD_PKA_2	451	457	PF00069	0.338
MOD_PKA_2	485	491	PF00069	0.344
MOD_PKA_2	562	568	PF00069	0.400
MOD_PKA_2	582	588	PF00069	0.155
MOD_PKA_2	712	718	PF00069	0.400
MOD_PKA_2	756	762	PF00069	0.319
MOD_Plk_1	316	322	PF00069	0.502
MOD_Plk_1	52	58	PF00069	0.565
MOD_Plk_1	73	79	PF00069	0.594
MOD_Plk_4	167	173	PF00069	0.424
MOD_Plk_4	419	425	PF00069	0.608
MOD_Plk_4	485	491	PF00069	0.314
MOD_Plk_4	497	503	PF00069	0.243
MOD_Plk_4	53	59	PF00069	0.643
MOD_Plk_4	587	593	PF00069	0.447
MOD_Plk_4	682	688	PF00069	0.487
MOD_Plk_4	712	718	PF00069	0.400
MOD_Plk_4	766	772	PF00069	0.331
MOD_Plk_4	93	99	PF00069	0.554
MOD_ProDKin_1	516	522	PF00069	0.302
MOD_SUMO_for_1	102	105	PF00179	0.430
MOD_SUMO_for_1	281	284	PF00179	0.335
MOD_SUMO_for_1	71	74	PF00179	0.686
MOD_SUMO_for_1	82	85	PF00179	0.703
MOD_SUMO_rev_2	454	464	PF00179	0.405
MOD_SUMO_rev_2	465	469	PF00179	0.392
TRG_DiLeu_BaEn_1	150	155	PF01217	0.431
TRG_DiLeu_BaEn_1	53	58	PF01217	0.553
TRG_DiLeu_BaEn_1	657	662	PF01217	0.504
TRG_DiLeu_BaEn_1	789	794	PF01217	0.480
TRG_DiLeu_BaEn_2	484	490	PF01217	0.400
TRG_DiLeu_BaLyEn_6	179	184	PF01217	0.430
TRG_DiLeu_BaLyEn_6	193	198	PF01217	0.389
TRG_DiLeu_BaLyEn_6	814	819	PF01217	0.424
TRG_ENDOCYTIC_2	145	148	PF00928	0.426
TRG_ENDOCYTIC_2	224	227	PF00928	0.449
TRG_ENDOCYTIC_2	351	354	PF00928	0.308
TRG_ENDOCYTIC_2	669	672	PF00928	0.407
TRG_ENDOCYTIC_2	717	720	PF00928	0.284
TRG_ER_diArg_1	138	141	PF00400	0.557
TRG_ER_diArg_1	179	182	PF00400	0.394
TRG_ER_diArg_1	203	206	PF00400	0.641
TRG_ER_diArg_1	415	417	PF00400	0.714
TRG_ER_diArg_1	450	453	PF00400	0.478
TRG_ER_diArg_1	534	536	PF00400	0.400
TRG_ER_diArg_1	648	651	PF00400	0.358
TRG_ER_diArg_1	741	743	PF00400	0.284
TRG_ER_diArg_1	756	758	PF00400	0.284
TRG_ER_diArg_1	803	806	PF00400	0.422
TRG_NES_CRM1_1	735	746	PF08389	0.400
TRG_NLS_Bipartite_1	195	213	PF00514	0.432
TRG_NLS_Bipartite_1	434	453	PF00514	0.502
TRG_NLS_MonoExtC_3	208	214	PF00514	0.702
TRG_NLS_MonoExtC_3	448	453	PF00514	0.379
TRG_NLS_MonoExtC_3	801	806	PF00514	0.377
TRG_NLS_MonoExtN_4	206	213	PF00514	0.645
TRG_NLS_MonoExtN_4	446	453	PF00514	0.393
TRG_Pf-PMV_PEXEL_1	118	122	PF00026	0.680
TRG_Pf-PMV_PEXEL_1	182	187	PF00026	0.381
TRG_Pf-PMV_PEXEL_1	543	548	PF00026	0.380
TRG_Pf-PMV_PEXEL_1	556	560	PF00026	0.433
TRG_Pf-PMV_PEXEL_1	659	664	PF00026	0.456

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4G5	Leptomonas seymouri	64%	95%
A0A1X0P5A4	Trypanosomatidae	40%	100%
A0A3Q8IJN2	Leishmania donovani	92%	100%
A0A3R7KHS6	Trypanosoma rangeli	42%	100%
A4HN12	Leishmania braziliensis	81%	100%
A4IBN5	Leishmania infantum	91%	100%
C9ZYZ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AFG9	Leishmania major	91%	100%