Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B6M2_LEIMU

TriTrypDb:

LmxM.34.3430

Length:

586

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6M2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6M2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	252	256	PF00656	0.501
CLV_C14_Caspase3-7	489	493	PF00656	0.636
CLV_C14_Caspase3-7	539	543	PF00656	0.547
CLV_C14_Caspase3-7	81	85	PF00656	0.605
CLV_NRD_NRD_1	516	518	PF00675	0.671
CLV_NRD_NRD_1	534	536	PF00675	0.479
CLV_PCSK_KEX2_1	164	166	PF00082	0.518
CLV_PCSK_KEX2_1	240	242	PF00082	0.582
CLV_PCSK_KEX2_1	516	518	PF00082	0.671
CLV_PCSK_KEX2_1	534	536	PF00082	0.479
CLV_PCSK_PC1ET2_1	164	166	PF00082	0.518
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.641
CLV_PCSK_SKI1_1	34	38	PF00082	0.499
CLV_PCSK_SKI1_1	353	357	PF00082	0.608
CLV_PCSK_SKI1_1	402	406	PF00082	0.595
CLV_PCSK_SKI1_1	486	490	PF00082	0.672
DEG_APCC_DBOX_1	362	370	PF00400	0.489
DEG_Nend_UBRbox_3	1	3	PF02207	0.656
DEG_SPOP_SBC_1	181	185	PF00917	0.544
DOC_CDC14_PxL_1	322	330	PF14671	0.481
DOC_CYCLIN_yCln2_LP_2	257	263	PF00134	0.541
DOC_MAPK_gen_1	133	141	PF00069	0.545
DOC_MAPK_gen_1	213	221	PF00069	0.612
DOC_MAPK_gen_1	534	540	PF00069	0.565
DOC_MAPK_gen_1	99	108	PF00069	0.466
DOC_MAPK_MEF2A_6	102	110	PF00069	0.479
DOC_MAPK_MEF2A_6	357	366	PF00069	0.583
DOC_MIT_MIM_1	152	161	PF04212	0.417
DOC_PP1_RVXF_1	218	224	PF00149	0.550
DOC_PP1_SILK_1	359	364	PF00149	0.579
DOC_PP2B_LxvP_1	434	437	PF13499	0.564
DOC_USP7_MATH_1	167	171	PF00917	0.630
DOC_USP7_MATH_1	181	185	PF00917	0.684
DOC_USP7_MATH_1	244	248	PF00917	0.596
DOC_USP7_MATH_1	39	43	PF00917	0.668
DOC_USP7_MATH_1	392	396	PF00917	0.585
DOC_USP7_MATH_1	409	413	PF00917	0.479
DOC_USP7_MATH_1	525	529	PF00917	0.584
DOC_USP7_MATH_1	553	557	PF00917	0.562
DOC_USP7_UBL2_3	34	38	PF12436	0.499
DOC_USP7_UBL2_3	390	394	PF12436	0.498
DOC_WW_Pin1_4	397	402	PF00397	0.589
DOC_WW_Pin1_4	509	514	PF00397	0.671
LIG_14-3-3_CanoR_1	220	224	PF00244	0.567
LIG_14-3-3_CanoR_1	248	257	PF00244	0.547
LIG_14-3-3_CanoR_1	314	318	PF00244	0.672
LIG_14-3-3_CanoR_1	363	367	PF00244	0.491
LIG_14-3-3_CanoR_1	446	454	PF00244	0.565
LIG_14-3-3_CanoR_1	486	491	PF00244	0.509
LIG_14-3-3_CanoR_1	527	533	PF00244	0.609
LIG_Actin_RPEL_3	104	123	PF02755	0.361
LIG_EH1_1	378	386	PF00400	0.478
LIG_eIF4E_1	323	329	PF01652	0.533
LIG_eIF4E_1	331	337	PF01652	0.442
LIG_FHA_1	209	215	PF00498	0.562
LIG_FHA_1	252	258	PF00498	0.607
LIG_FHA_1	263	269	PF00498	0.553
LIG_FHA_1	356	362	PF00498	0.558
LIG_FHA_1	398	404	PF00498	0.644
LIG_FHA_1	467	473	PF00498	0.507
LIG_FHA_1	483	489	PF00498	0.584
LIG_FHA_1	91	97	PF00498	0.571
LIG_FHA_1	99	105	PF00498	0.451
LIG_FHA_2	122	128	PF00498	0.466
LIG_FHA_2	487	493	PF00498	0.636
LIG_FHA_2	527	533	PF00498	0.613
LIG_FHA_2	6	12	PF00498	0.598
LIG_LIR_Gen_1	113	122	PF02991	0.367
LIG_LIR_Gen_1	222	231	PF02991	0.566
LIG_LIR_Gen_1	25	33	PF02991	0.519
LIG_LIR_Gen_1	291	302	PF02991	0.627
LIG_LIR_Gen_1	456	466	PF02991	0.552
LIG_LIR_Gen_1	479	488	PF02991	0.604
LIG_LIR_Nem_3	113	117	PF02991	0.356
LIG_LIR_Nem_3	222	226	PF02991	0.565
LIG_LIR_Nem_3	25	30	PF02991	0.608
LIG_LIR_Nem_3	291	297	PF02991	0.644
LIG_LIR_Nem_3	319	325	PF02991	0.517
LIG_LIR_Nem_3	4	9	PF02991	0.602
LIG_LIR_Nem_3	456	462	PF02991	0.553
LIG_LIR_Nem_3	479	483	PF02991	0.620
LIG_NRBOX	267	273	PF00104	0.589
LIG_NRBOX	365	371	PF00104	0.489
LIG_PDZ_Wminus1_1	584	586	PF00595	0.606
LIG_SH2_CRK	307	311	PF00017	0.513
LIG_SH2_SRC	323	326	PF00017	0.576
LIG_SH2_STAP1	15	19	PF00017	0.528
LIG_SH2_STAP1	331	335	PF00017	0.542
LIG_SH2_STAP1	426	430	PF00017	0.509
LIG_SH2_STAT5	114	117	PF00017	0.357
LIG_SH2_STAT5	137	140	PF00017	0.544
LIG_SH2_STAT5	323	326	PF00017	0.507
LIG_SH2_STAT5	572	575	PF00017	0.565
LIG_SH2_STAT5	577	580	PF00017	0.507
LIG_SH3_3	138	144	PF00018	0.394
LIG_SH3_3	18	24	PF00018	0.568
LIG_SH3_3	403	409	PF00018	0.592
LIG_SH3_3	430	436	PF00018	0.693
LIG_SH3_3	462	468	PF00018	0.515
LIG_SH3_3	55	61	PF00018	0.615
LIG_SUMO_SIM_anti_2	18	23	PF11976	0.604
LIG_SUMO_SIM_anti_2	183	191	PF11976	0.510
LIG_SUMO_SIM_anti_2	51	56	PF11976	0.431
LIG_SUMO_SIM_anti_2	84	90	PF11976	0.460
LIG_SUMO_SIM_par_1	121	128	PF11976	0.507
LIG_SUMO_SIM_par_1	258	265	PF11976	0.597
LIG_SUMO_SIM_par_1	460	467	PF11976	0.518
LIG_TRAF2_1	124	127	PF00917	0.489
LIG_TRFH_1	278	282	PF08558	0.586
LIG_TRFH_1	322	326	PF08558	0.505
LIG_TYR_ITIM	112	117	PF00017	0.349
LIG_TYR_ITIM	305	310	PF00017	0.511
LIG_WRC_WIRS_1	537	542	PF05994	0.570
MOD_CDK_SPK_2	397	402	PF00069	0.657
MOD_CDK_SPxxK_3	509	516	PF00069	0.653
MOD_CK1_1	175	181	PF00069	0.580
MOD_CK1_1	185	191	PF00069	0.519
MOD_CK1_1	25	31	PF00069	0.587
MOD_CK1_1	32	38	PF00069	0.619
MOD_CK1_1	396	402	PF00069	0.606
MOD_CK1_1	48	54	PF00069	0.557
MOD_CK1_1	512	518	PF00069	0.738
MOD_CK2_1	121	127	PF00069	0.487
MOD_CK2_1	188	194	PF00069	0.508
MOD_CK2_1	23	29	PF00069	0.622
MOD_CK2_1	313	319	PF00069	0.574
MOD_CK2_1	5	11	PF00069	0.530
MOD_GlcNHglycan	118	121	PF01048	0.472
MOD_GlcNHglycan	242	245	PF01048	0.708
MOD_GlcNHglycan	290	293	PF01048	0.591
MOD_GlcNHglycan	33	37	PF01048	0.607
MOD_GlcNHglycan	344	347	PF01048	0.585
MOD_GlcNHglycan	395	398	PF01048	0.565
MOD_GlcNHglycan	406	409	PF01048	0.576
MOD_GlcNHglycan	411	414	PF01048	0.705
MOD_GlcNHglycan	428	431	PF01048	0.590
MOD_GlcNHglycan	446	449	PF01048	0.634
MOD_GlcNHglycan	45	48	PF01048	0.480
MOD_GlcNHglycan	505	508	PF01048	0.595
MOD_GlcNHglycan	555	558	PF01048	0.593
MOD_GlcNHglycan	80	83	PF01048	0.575
MOD_GSK3_1	167	174	PF00069	0.667
MOD_GSK3_1	181	188	PF00069	0.583
MOD_GSK3_1	227	234	PF00069	0.622
MOD_GSK3_1	240	247	PF00069	0.508
MOD_GSK3_1	249	256	PF00069	0.583
MOD_GSK3_1	25	32	PF00069	0.448
MOD_GSK3_1	308	315	PF00069	0.560
MOD_GSK3_1	34	41	PF00069	0.692
MOD_GSK3_1	353	360	PF00069	0.696
MOD_GSK3_1	392	399	PF00069	0.600
MOD_GSK3_1	404	411	PF00069	0.503
MOD_GSK3_1	482	489	PF00069	0.616
MOD_GSK3_1	5	12	PF00069	0.614
MOD_GSK3_1	573	580	PF00069	0.539
MOD_GSK3_1	61	68	PF00069	0.421
MOD_GSK3_1	73	80	PF00069	0.560
MOD_LATS_1	249	255	PF00433	0.496
MOD_LATS_1	351	357	PF00433	0.612
MOD_N-GLC_2	391	393	PF02516	0.432
MOD_NEK2_1	115	120	PF00069	0.546
MOD_NEK2_1	171	176	PF00069	0.669
MOD_NEK2_1	180	185	PF00069	0.550
MOD_NEK2_1	208	213	PF00069	0.553
MOD_NEK2_1	295	300	PF00069	0.544
MOD_NEK2_1	342	347	PF00069	0.492
MOD_NEK2_1	355	360	PF00069	0.690
MOD_NEK2_1	362	367	PF00069	0.466
MOD_NEK2_1	573	578	PF00069	0.604
MOD_PIKK_1	165	171	PF00454	0.600
MOD_PIKK_1	208	214	PF00454	0.526
MOD_PIKK_1	355	361	PF00454	0.558
MOD_PIKK_1	519	525	PF00454	0.661
MOD_PIKK_1	61	67	PF00454	0.536
MOD_PK_1	357	363	PF00069	0.553
MOD_PKA_1	240	246	PF00069	0.637
MOD_PKA_2	219	225	PF00069	0.616
MOD_PKA_2	240	246	PF00069	0.670
MOD_PKA_2	313	319	PF00069	0.580
MOD_PKA_2	362	368	PF00069	0.493
MOD_PKA_2	452	458	PF00069	0.607
MOD_PKA_2	526	532	PF00069	0.629
MOD_PKA_2	9	15	PF00069	0.591
MOD_PKA_2	98	104	PF00069	0.475
MOD_PKB_1	151	159	PF00069	0.432
MOD_PKB_1	517	525	PF00069	0.587
MOD_Plk_2-3	5	11	PF00069	0.599
MOD_Plk_2-3	536	542	PF00069	0.578
MOD_Plk_4	185	191	PF00069	0.650
MOD_Plk_4	313	319	PF00069	0.574
MOD_Plk_4	357	363	PF00069	0.576
MOD_Plk_4	365	371	PF00069	0.497
MOD_Plk_4	536	542	PF00069	0.653
MOD_Plk_4	573	579	PF00069	0.603
MOD_Plk_4	9	15	PF00069	0.591
MOD_ProDKin_1	397	403	PF00069	0.588
MOD_ProDKin_1	509	515	PF00069	0.671
TRG_DiLeu_BaEn_1	18	23	PF01217	0.566
TRG_DiLeu_BaEn_1	332	337	PF01217	0.374
TRG_DiLeu_BaEn_2	535	541	PF01217	0.584
TRG_DiLeu_BaLyEn_6	483	488	PF01217	0.480
TRG_DiLeu_BaLyEn_6	58	63	PF01217	0.539
TRG_ENDOCYTIC_2	114	117	PF00928	0.357
TRG_ENDOCYTIC_2	307	310	PF00928	0.517
TRG_ENDOCYTIC_2	322	325	PF00928	0.511
TRG_ER_diArg_1	148	151	PF00400	0.389
TRG_ER_diArg_1	278	281	PF00400	0.628
TRG_ER_diArg_1	516	519	PF00400	0.604
TRG_ER_diArg_1	533	535	PF00400	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4V6	Leptomonas seymouri	31%	99%
A0A3Q8IVE9	Leishmania donovani	85%	100%
A4HN10	Leishmania braziliensis	68%	99%
A4IBN3	Leishmania infantum	87%	100%
E9AFG7	Leishmania major	86%	100%