Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B6M0_LEIMU

TriTrypDb:

LmxM.34.3410

Length:

639

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6M0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6M0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.700
CLV_NRD_NRD_1	11	13	PF00675	0.750
CLV_NRD_NRD_1	397	399	PF00675	0.469
CLV_NRD_NRD_1	590	592	PF00675	0.524
CLV_NRD_NRD_1	634	636	PF00675	0.727
CLV_PCSK_FUR_1	394	398	PF00082	0.485
CLV_PCSK_FUR_1	588	592	PF00082	0.571
CLV_PCSK_KEX2_1	109	111	PF00082	0.702
CLV_PCSK_KEX2_1	11	13	PF00082	0.750
CLV_PCSK_KEX2_1	396	398	PF00082	0.483
CLV_PCSK_KEX2_1	399	401	PF00082	0.444
CLV_PCSK_KEX2_1	590	592	PF00082	0.498
CLV_PCSK_KEX2_1	634	636	PF00082	0.701
CLV_PCSK_PC1ET2_1	399	401	PF00082	0.454
CLV_PCSK_SKI1_1	151	155	PF00082	0.301
CLV_PCSK_SKI1_1	591	595	PF00082	0.504
CLV_PCSK_SKI1_1	74	78	PF00082	0.395
DEG_APCC_DBOX_1	462	470	PF00400	0.493
DEG_APCC_DBOX_1	530	538	PF00400	0.433
DEG_MDM2_SWIB_1	599	607	PF02201	0.522
DEG_SPOP_SBC_1	122	126	PF00917	0.551
DEG_SPOP_SBC_1	136	140	PF00917	0.434
DEG_SPOP_SBC_1	327	331	PF00917	0.465
DOC_CDC14_PxL_1	296	304	PF14671	0.389
DOC_CDC14_PxL_1	523	531	PF14671	0.555
DOC_CYCLIN_yCln2_LP_2	285	288	PF00134	0.575
DOC_CYCLIN_yCln2_LP_2	297	303	PF00134	0.338
DOC_MAPK_gen_1	588	597	PF00069	0.484
DOC_PP1_RVXF_1	10	17	PF00149	0.631
DOC_PP2B_LxvP_1	284	287	PF13499	0.509
DOC_PP2B_LxvP_1	297	300	PF13499	0.367
DOC_PP4_FxxP_1	360	363	PF00568	0.510
DOC_PP4_FxxP_1	593	596	PF00568	0.464
DOC_USP7_MATH_1	117	121	PF00917	0.683
DOC_USP7_MATH_1	122	126	PF00917	0.682
DOC_USP7_MATH_1	136	140	PF00917	0.722
DOC_USP7_MATH_1	2	6	PF00917	0.532
DOC_USP7_MATH_1	322	326	PF00917	0.767
DOC_USP7_MATH_1	327	331	PF00917	0.764
DOC_USP7_MATH_1	487	491	PF00917	0.638
DOC_USP7_MATH_1	571	575	PF00917	0.664
DOC_USP7_MATH_1	619	623	PF00917	0.624
DOC_USP7_UBL2_3	606	610	PF12436	0.551
DOC_USP7_UBL2_3	613	617	PF12436	0.591
DOC_WW_Pin1_4	123	128	PF00397	0.705
DOC_WW_Pin1_4	16	21	PF00397	0.647
DOC_WW_Pin1_4	183	188	PF00397	0.559
DOC_WW_Pin1_4	24	29	PF00397	0.635
DOC_WW_Pin1_4	240	245	PF00397	0.660
DOC_WW_Pin1_4	320	325	PF00397	0.575
DOC_WW_Pin1_4	410	415	PF00397	0.429
DOC_WW_Pin1_4	556	561	PF00397	0.656
DOC_WW_Pin1_4	567	572	PF00397	0.754
LIG_14-3-3_CanoR_1	205	209	PF00244	0.634
LIG_14-3-3_CanoR_1	384	391	PF00244	0.590
LIG_Actin_WH2_2	418	434	PF00022	0.546
LIG_APCC_ABBA_1	545	550	PF00400	0.538
LIG_BIR_II_1	1	5	PF00653	0.434
LIG_CtBP_PxDLS_1	362	366	PF00389	0.491
LIG_EH1_1	534	542	PF00400	0.554
LIG_FHA_1	213	219	PF00498	0.531
LIG_FHA_1	268	274	PF00498	0.582
LIG_FHA_1	281	287	PF00498	0.472
LIG_FHA_1	377	383	PF00498	0.335
LIG_FHA_2	165	171	PF00498	0.567
LIG_FHA_2	205	211	PF00498	0.671
LIG_FHA_2	266	272	PF00498	0.522
LIG_FHA_2	493	499	PF00498	0.517
LIG_FHA_2	578	584	PF00498	0.554
LIG_GBD_Chelix_1	421	429	PF00786	0.452
LIG_HCF-1_HBM_1	219	222	PF13415	0.559
LIG_LIR_Apic_2	156	160	PF02991	0.380
LIG_LIR_Apic_2	304	310	PF02991	0.595
LIG_LIR_Apic_2	357	363	PF02991	0.461
LIG_LIR_Apic_2	592	596	PF02991	0.496
LIG_LIR_Gen_1	219	229	PF02991	0.528
LIG_LIR_Gen_1	291	301	PF02991	0.499
LIG_LIR_Gen_1	349	356	PF02991	0.536
LIG_LIR_Gen_1	46	53	PF02991	0.454
LIG_LIR_Nem_3	219	225	PF02991	0.486
LIG_LIR_Nem_3	257	261	PF02991	0.417
LIG_LIR_Nem_3	291	296	PF02991	0.459
LIG_LIR_Nem_3	349	354	PF02991	0.533
LIG_LIR_Nem_3	46	50	PF02991	0.472
LIG_PCNA_yPIPBox_3	531	545	PF02747	0.553
LIG_Pex14_2	593	597	PF04695	0.491
LIG_Pex14_2	599	603	PF04695	0.515
LIG_SH2_CRK	222	226	PF00017	0.277
LIG_SH2_PTP2	307	310	PF00017	0.405
LIG_SH2_SRC	42	45	PF00017	0.271
LIG_SH2_STAP1	338	342	PF00017	0.509
LIG_SH2_STAP1	80	84	PF00017	0.532
LIG_SH2_STAT3	611	614	PF00017	0.567
LIG_SH2_STAT5	157	160	PF00017	0.473
LIG_SH2_STAT5	307	310	PF00017	0.405
LIG_SH2_STAT5	351	354	PF00017	0.525
LIG_SH2_STAT5	415	418	PF00017	0.371
LIG_SH2_STAT5	42	45	PF00017	0.348
LIG_SH2_STAT5	611	614	PF00017	0.567
LIG_SH3_1	521	527	PF00018	0.599
LIG_SH3_3	25	31	PF00018	0.594
LIG_SH3_3	521	527	PF00018	0.566
LIG_SH3_3	62	68	PF00018	0.603
LIG_SUMO_SIM_anti_2	543	548	PF11976	0.460
LIG_SUMO_SIM_anti_2	550	557	PF11976	0.424
LIG_SUMO_SIM_par_1	378	383	PF11976	0.293
LIG_SxIP_EBH_1	43	55	PF03271	0.503
LIG_TRAF2_1	368	371	PF00917	0.518
LIG_TRAF2_1	495	498	PF00917	0.484
LIG_TRFH_1	426	430	PF08558	0.473
MOD_CDK_SPxxK_3	183	190	PF00069	0.572
MOD_CDK_SPxxK_3	240	247	PF00069	0.665
MOD_CK1_1	125	131	PF00069	0.730
MOD_CK1_1	18	24	PF00069	0.699
MOD_CK1_1	204	210	PF00069	0.681
MOD_CK1_1	243	249	PF00069	0.619
MOD_CK1_1	27	33	PF00069	0.569
MOD_CK1_1	490	496	PF00069	0.485
MOD_CK1_1	505	511	PF00069	0.399
MOD_CK1_1	566	572	PF00069	0.721
MOD_CK1_1	6	12	PF00069	0.720
MOD_CK1_1	629	635	PF00069	0.739
MOD_CK2_1	164	170	PF00069	0.552
MOD_CK2_1	265	271	PF00069	0.512
MOD_CK2_1	492	498	PF00069	0.498
MOD_CK2_1	577	583	PF00069	0.363
MOD_Cter_Amidation	588	591	PF01082	0.559
MOD_GlcNHglycan	103	106	PF01048	0.635
MOD_GlcNHglycan	127	130	PF01048	0.765
MOD_GlcNHglycan	228	232	PF01048	0.418
MOD_GlcNHglycan	233	237	PF01048	0.580
MOD_GlcNHglycan	274	277	PF01048	0.480
MOD_GlcNHglycan	297	300	PF01048	0.407
MOD_GlcNHglycan	314	317	PF01048	0.546
MOD_GlcNHglycan	324	327	PF01048	0.690
MOD_GlcNHglycan	330	333	PF01048	0.663
MOD_GlcNHglycan	386	389	PF01048	0.572
MOD_GlcNHglycan	437	440	PF01048	0.499
MOD_GlcNHglycan	5	8	PF01048	0.608
MOD_GSK3_1	117	124	PF00069	0.623
MOD_GSK3_1	131	138	PF00069	0.676
MOD_GSK3_1	14	21	PF00069	0.603
MOD_GSK3_1	2	9	PF00069	0.715
MOD_GSK3_1	200	207	PF00069	0.598
MOD_GSK3_1	308	315	PF00069	0.584
MOD_GSK3_1	322	329	PF00069	0.672
MOD_GSK3_1	338	345	PF00069	0.713
MOD_GSK3_1	515	522	PF00069	0.586
MOD_GSK3_1	561	568	PF00069	0.676
MOD_GSK3_1	605	612	PF00069	0.509
MOD_NEK2_1	121	126	PF00069	0.726
MOD_NEK2_1	164	169	PF00069	0.542
MOD_NEK2_1	3	8	PF00069	0.735
MOD_NEK2_1	346	351	PF00069	0.571
MOD_NEK2_1	440	445	PF00069	0.542
MOD_NEK2_1	565	570	PF00069	0.720
MOD_NEK2_2	619	624	PF00069	0.627
MOD_PK_1	137	143	PF00069	0.614
MOD_PKA_2	101	107	PF00069	0.649
MOD_PKA_2	204	210	PF00069	0.696
MOD_PKB_1	624	632	PF00069	0.682
MOD_Plk_1	212	218	PF00069	0.571
MOD_Plk_1	338	344	PF00069	0.559
MOD_Plk_1	369	375	PF00069	0.583
MOD_Plk_1	37	43	PF00069	0.380
MOD_Plk_1	577	583	PF00069	0.533
MOD_Plk_2-3	378	384	PF00069	0.297
MOD_Plk_2-3	577	583	PF00069	0.363
MOD_Plk_4	153	159	PF00069	0.372
MOD_Plk_4	280	286	PF00069	0.498
MOD_Plk_4	346	352	PF00069	0.575
MOD_Plk_4	369	375	PF00069	0.600
MOD_Plk_4	38	44	PF00069	0.389
MOD_ProDKin_1	123	129	PF00069	0.705
MOD_ProDKin_1	16	22	PF00069	0.648
MOD_ProDKin_1	183	189	PF00069	0.556
MOD_ProDKin_1	24	30	PF00069	0.619
MOD_ProDKin_1	240	246	PF00069	0.654
MOD_ProDKin_1	320	326	PF00069	0.572
MOD_ProDKin_1	410	416	PF00069	0.424
MOD_ProDKin_1	556	562	PF00069	0.650
MOD_ProDKin_1	567	573	PF00069	0.749
MOD_SUMO_rev_2	82	89	PF00179	0.554
TRG_DiLeu_BaEn_1	280	285	PF01217	0.486
TRG_DiLeu_BaLyEn_6	72	77	PF01217	0.453
TRG_ENDOCYTIC_2	222	225	PF00928	0.454
TRG_ENDOCYTIC_2	351	354	PF00928	0.525
TRG_ER_diArg_1	10	12	PF00400	0.747
TRG_ER_diArg_1	394	397	PF00400	0.555
TRG_ER_diArg_1	587	590	PF00400	0.551
TRG_ER_diArg_1	623	626	PF00400	0.668
TRG_ER_diArg_1	634	636	PF00400	0.689
TRG_ER_diArg_1	95	98	PF00400	0.434
TRG_ER_diArg_1	99	102	PF00400	0.520
TRG_NES_CRM1_1	371	383	PF08389	0.395
TRG_NLS_MonoCore_2	397	402	PF00514	0.478
TRG_NLS_MonoExtN_4	396	403	PF00514	0.462
TRG_Pf-PMV_PEXEL_1	400	405	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	419	423	PF00026	0.371
TRG_Pf-PMV_PEXEL_1	55	60	PF00026	0.615
TRG_Pf-PMV_PEXEL_1	579	583	PF00026	0.632

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUU2	Leptomonas seymouri	52%	100%
A0A1X0P6R1	Trypanosomatidae	28%	100%
A0A3Q8IMM0	Leishmania donovani	90%	89%
A0A3R7L599	Trypanosoma rangeli	31%	100%
A4HN08	Leishmania braziliensis	80%	100%
A4IBN1	Leishmania infantum	91%	89%
C9ZZ00	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AFG5	Leishmania major	90%	100%
V5BY91	Trypanosoma cruzi	30%	100%