LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

LEM3 family/CDC50 family protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
LEM3 family/CDC50 family protein
Gene product:
LEM3 (ligand-effect modulator 3) family / CDC50 family, putative
Species:
Leishmania mexicana
UniProt:
E9B6L9_LEIMU
TriTrypDb:
LmxM.34.3400
Length:
421

Annotations

LeishMANIAdb annotations

Homologous to animal CDC50 family phospholipid flippase (ATPase) proteins.. This family has expanded in kinetoplastids

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 26
NetGPI no yes: 0, no: 26
Cellular components
Term Name Level Count
GO:0016020 membrane 2 27
GO:0110165 cellular anatomical entity 1 27
GO:0005783 endoplasmic reticulum 5 2
GO:0005794 Golgi apparatus 5 2
GO:0005886 plasma membrane 3 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0005737 cytoplasm 2 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1

Expansion

Sequence features

E9B6L9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6L9

Function

Biological processes
Term Name Level Count
GO:0033036 macromolecule localization 2 27
GO:0051179 localization 1 27
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 132 136 PF00656 0.258
CLV_C14_Caspase3-7 277 281 PF00656 0.308
CLV_NRD_NRD_1 127 129 PF00675 0.410
CLV_NRD_NRD_1 331 333 PF00675 0.445
CLV_PCSK_KEX2_1 127 129 PF00082 0.410
CLV_PCSK_KEX2_1 141 143 PF00082 0.395
CLV_PCSK_PC1ET2_1 141 143 PF00082 0.324
DEG_SCF_FBW7_1 28 35 PF00400 0.596
DOC_CKS1_1 2 7 PF01111 0.568
DOC_CKS1_1 29 34 PF01111 0.498
DOC_CYCLIN_yCln2_LP_2 109 115 PF00134 0.205
DOC_MAPK_gen_1 107 115 PF00069 0.246
DOC_PP1_RVXF_1 240 247 PF00149 0.219
DOC_PP2B_LxvP_1 109 112 PF13499 0.239
DOC_PP4_FxxP_1 259 262 PF00568 0.245
DOC_USP7_MATH_1 147 151 PF00917 0.315
DOC_USP7_MATH_1 245 249 PF00917 0.243
DOC_USP7_MATH_1 32 36 PF00917 0.499
DOC_USP7_MATH_1 56 60 PF00917 0.299
DOC_WW_Pin1_4 1 6 PF00397 0.539
DOC_WW_Pin1_4 150 155 PF00397 0.256
DOC_WW_Pin1_4 261 266 PF00397 0.343
DOC_WW_Pin1_4 28 33 PF00397 0.517
DOC_WW_Pin1_4 85 90 PF00397 0.333
LIG_14-3-3_CanoR_1 128 134 PF00244 0.308
LIG_14-3-3_CanoR_1 142 148 PF00244 0.352
LIG_14-3-3_CanoR_1 266 272 PF00244 0.278
LIG_14-3-3_CanoR_1 310 320 PF00244 0.271
LIG_14-3-3_CanoR_1 324 329 PF00244 0.240
LIG_14-3-3_CanoR_1 377 381 PF00244 0.327
LIG_AP2alpha_1 194 198 PF02296 0.236
LIG_CtBP_PxDLS_1 48 52 PF00389 0.412
LIG_EH1_1 411 419 PF00400 0.605
LIG_eIF4E_1 183 189 PF01652 0.211
LIG_FHA_1 150 156 PF00498 0.281
LIG_FHA_1 195 201 PF00498 0.248
LIG_FHA_1 245 251 PF00498 0.358
LIG_FHA_1 93 99 PF00498 0.242
LIG_FHA_2 202 208 PF00498 0.324
LIG_FHA_2 312 318 PF00498 0.228
LIG_LIR_Apic_2 251 257 PF02991 0.240
LIG_LIR_Gen_1 13 23 PF02991 0.543
LIG_LIR_Gen_1 179 189 PF02991 0.272
LIG_LIR_Gen_1 223 233 PF02991 0.299
LIG_LIR_Gen_1 398 406 PF02991 0.343
LIG_LIR_Nem_3 13 18 PF02991 0.511
LIG_LIR_Nem_3 174 178 PF02991 0.243
LIG_LIR_Nem_3 179 184 PF02991 0.241
LIG_LIR_Nem_3 196 201 PF02991 0.233
LIG_LIR_Nem_3 223 228 PF02991 0.278
LIG_LIR_Nem_3 398 402 PF02991 0.363
LIG_MYND_1 28 32 PF01753 0.516
LIG_OCRL_FandH_1 398 410 PF00620 0.210
LIG_Pex14_2 171 175 PF04695 0.124
LIG_Pex14_2 194 198 PF04695 0.236
LIG_Pex14_2 298 302 PF04695 0.248
LIG_PTB_Apo_2 192 199 PF02174 0.198
LIG_SH2_CRK 254 258 PF00017 0.261
LIG_SH2_GRB2like 123 126 PF00017 0.229
LIG_SH2_GRB2like 297 300 PF00017 0.261
LIG_SH2_NCK_1 276 280 PF00017 0.183
LIG_SH2_SRC 123 126 PF00017 0.251
LIG_SH2_SRC 183 186 PF00017 0.274
LIG_SH2_STAP1 178 182 PF00017 0.327
LIG_SH2_STAT3 67 70 PF00017 0.204
LIG_SH2_STAT5 114 117 PF00017 0.196
LIG_SH2_STAT5 183 186 PF00017 0.277
LIG_SH2_STAT5 258 261 PF00017 0.320
LIG_SH2_STAT5 297 300 PF00017 0.272
LIG_SH2_STAT5 347 350 PF00017 0.241
LIG_SH2_STAT5 385 388 PF00017 0.275
LIG_SH3_1 254 260 PF00018 0.300
LIG_SH3_3 179 185 PF00018 0.285
LIG_SH3_3 208 214 PF00018 0.286
LIG_SH3_3 254 260 PF00018 0.280
LIG_SH3_3 282 288 PF00018 0.341
LIG_SH3_3 42 48 PF00018 0.343
LIG_SH3_3 6 12 PF00018 0.561
LIG_SUMO_SIM_par_1 47 52 PF11976 0.278
LIG_WRC_WIRS_1 172 177 PF05994 0.204
MOD_CDK_SPK_2 261 266 PF00069 0.151
MOD_CK1_1 13 19 PF00069 0.612
MOD_CK1_1 150 156 PF00069 0.253
MOD_CK1_1 223 229 PF00069 0.251
MOD_CK1_1 293 299 PF00069 0.171
MOD_CK1_1 367 373 PF00069 0.249
MOD_CK1_1 392 398 PF00069 0.421
MOD_CK2_1 201 207 PF00069 0.321
MOD_CK2_1 245 251 PF00069 0.304
MOD_CK2_1 311 317 PF00069 0.228
MOD_Cter_Amidation 139 142 PF01082 0.324
MOD_GlcNHglycan 143 146 PF01048 0.447
MOD_GlcNHglycan 149 152 PF01048 0.435
MOD_GlcNHglycan 222 225 PF01048 0.485
MOD_GlcNHglycan 269 272 PF01048 0.454
MOD_GlcNHglycan 34 37 PF01048 0.354
MOD_GlcNHglycan 391 394 PF01048 0.360
MOD_GlcNHglycan 58 61 PF01048 0.527
MOD_GSK3_1 127 134 PF00069 0.221
MOD_GSK3_1 149 156 PF00069 0.233
MOD_GSK3_1 28 35 PF00069 0.559
MOD_GSK3_1 286 293 PF00069 0.288
MOD_GSK3_1 356 363 PF00069 0.210
MOD_GSK3_1 92 99 PF00069 0.224
MOD_N-GLC_1 194 199 PF02516 0.427
MOD_N-GLC_1 220 225 PF02516 0.454
MOD_N-GLC_1 56 61 PF02516 0.527
MOD_N-GLC_1 77 82 PF02516 0.517
MOD_NEK2_1 129 134 PF00069 0.268
MOD_NEK2_1 171 176 PF00069 0.286
MOD_NEK2_1 194 199 PF00069 0.229
MOD_NEK2_1 384 389 PF00069 0.291
MOD_NEK2_1 49 54 PF00069 0.332
MOD_PIKK_1 201 207 PF00454 0.264
MOD_PK_1 364 370 PF00069 0.215
MOD_PKA_1 127 133 PF00069 0.248
MOD_PKA_1 141 147 PF00069 0.248
MOD_PKA_2 10 16 PF00069 0.606
MOD_PKA_2 127 133 PF00069 0.242
MOD_PKA_2 141 147 PF00069 0.220
MOD_PKA_2 201 207 PF00069 0.266
MOD_PKA_2 226 232 PF00069 0.302
MOD_PKA_2 376 382 PF00069 0.340
MOD_Plk_1 194 200 PF00069 0.230
MOD_Plk_1 293 299 PF00069 0.157
MOD_Plk_1 56 62 PF00069 0.277
MOD_Plk_4 10 16 PF00069 0.616
MOD_Plk_4 171 177 PF00069 0.318
MOD_Plk_4 293 299 PF00069 0.160
MOD_Plk_4 343 349 PF00069 0.340
MOD_Plk_4 369 375 PF00069 0.244
MOD_Plk_4 376 382 PF00069 0.257
MOD_Plk_4 395 401 PF00069 0.306
MOD_Plk_4 49 55 PF00069 0.344
MOD_ProDKin_1 1 7 PF00069 0.535
MOD_ProDKin_1 150 156 PF00069 0.256
MOD_ProDKin_1 261 267 PF00069 0.343
MOD_ProDKin_1 28 34 PF00069 0.516
MOD_ProDKin_1 85 91 PF00069 0.333
TRG_DiLeu_BaLyEn_6 214 219 PF01217 0.204
TRG_ENDOCYTIC_2 116 119 PF00928 0.231
TRG_ENDOCYTIC_2 178 181 PF00928 0.211
TRG_ENDOCYTIC_2 335 338 PF00928 0.243
TRG_ENDOCYTIC_2 385 388 PF00928 0.301
TRG_ER_diArg_1 127 129 PF00400 0.212
TRG_Pf-PMV_PEXEL_1 336 340 PF00026 0.527

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I0U8 Leptomonas seymouri 34% 67%
A0A0N1PBG2 Leptomonas seymouri 70% 100%
A0A0N1PDQ9 Leptomonas seymouri 33% 100%
A0A0S4IMK4 Bodo saltans 42% 100%
A0A0S4J4T1 Bodo saltans 33% 100%
A0A0S4JB98 Bodo saltans 33% 100%
A0A0S4JJY0 Bodo saltans 33% 100%
A0A0S4JQR9 Bodo saltans 30% 80%
A0A1X0NHQ5 Trypanosomatidae 31% 88%
A0A1X0NV71 Trypanosomatidae 31% 100%
A0A1X0P5L3 Trypanosomatidae 50% 100%
A0A3Q8IBY5 Leishmania donovani 35% 71%
A0A3R7LIN7 Trypanosoma rangeli 34% 98%
A0A3R7MGX3 Trypanosoma rangeli 32% 100%
A0A3S7X551 Leishmania donovani 31% 100%
A0A3S7X9N4 Leishmania donovani 95% 100%
A0A422NR22 Trypanosoma rangeli 50% 100%
A4H5T1 Leishmania braziliensis 35% 69%
A4HK31 Leishmania braziliensis 29% 93%
A4HN07 Leishmania braziliensis 84% 100%
A4HU24 Leishmania infantum 35% 71%
A4I7N1 Leishmania infantum 31% 100%
A4IBN0 Leishmania infantum 95% 100%
C9ZZ02 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
D0A9K3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 90%
D0A9R9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
E9AFG4 Leishmania major 95% 100%
E9AMV4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 71%
E9B2H4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 91%
H2L0H3 Caenorhabditis elegans 27% 100%
P25656 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 100%
P42838 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 100%
P53740 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 27% 100%
Q17QL5 Bos taurus 31% 100%
Q1MTQ5 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 30% 100%
Q2T9P5 Bos taurus 25% 100%
Q3MIR4 Homo sapiens 27% 100%
Q4Q5N2 Leishmania major 30% 92%
Q4QHS2 Leishmania major 35% 71%
Q5F362 Gallus gallus 29% 100%
Q5R6C0 Pongo abelii 30% 100%
Q67YS6 Arabidopsis thaliana 29% 100%
Q6AY41 Rattus norvegicus 30% 100%
Q8BHG3 Mus musculus 29% 100%
Q8L8W0 Arabidopsis thaliana 31% 100%
Q8VEK0 Mus musculus 30% 100%
Q95JK4 Macaca fascicularis 24% 100%
Q96WW4 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 28% 100%
Q9D4D7 Mus musculus 25% 100%
Q9LTW0 Arabidopsis thaliana 31% 100%
Q9NV96 Homo sapiens 29% 100%
Q9SA35 Arabidopsis thaliana 30% 100%
Q9SLK2 Arabidopsis thaliana 32% 100%
V5AY40 Trypanosoma cruzi 35% 100%
V5B6A6 Trypanosoma cruzi 32% 100%
V5BY23 Trypanosoma cruzi 49% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS