ATP-dependent RNA helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B6L6_LEIMU

TriTrypDb:

LmxM.34.3370

Length:

1084

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B6L6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6L6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2
GO:0003824	catalytic activity	1	3
GO:0004386	helicase activity	2	3
GO:0140640	catalytic activity, acting on a nucleic acid	2	3
GO:0140657	ATP-dependent activity	1	3
GO:0000166	nucleotide binding	3	1
GO:0005524	ATP binding	5	1
GO:0017076	purine nucleotide binding	4	1
GO:0030554	adenyl nucleotide binding	5	1
GO:0032553	ribonucleotide binding	3	1
GO:0032555	purine ribonucleotide binding	4	1
GO:0032559	adenyl ribonucleotide binding	5	1
GO:0035639	purine ribonucleoside triphosphate binding	4	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0097367	carbohydrate derivative binding	2	1
GO:1901265	nucleoside phosphate binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	443	447	PF00656	0.586
CLV_C14_Caspase3-7	995	999	PF00656	0.618
CLV_NRD_NRD_1	1005	1007	PF00675	0.498
CLV_NRD_NRD_1	229	231	PF00675	0.591
CLV_NRD_NRD_1	405	407	PF00675	0.610
CLV_NRD_NRD_1	505	507	PF00675	0.523
CLV_NRD_NRD_1	533	535	PF00675	0.527
CLV_NRD_NRD_1	63	65	PF00675	0.815
CLV_NRD_NRD_1	786	788	PF00675	0.403
CLV_NRD_NRD_1	8	10	PF00675	0.717
CLV_PCSK_KEX2_1	505	507	PF00082	0.505
CLV_PCSK_KEX2_1	533	535	PF00082	0.559
CLV_PCSK_KEX2_1	62	64	PF00082	0.821
CLV_PCSK_KEX2_1	786	788	PF00082	0.418
CLV_PCSK_KEX2_1	896	898	PF00082	0.430
CLV_PCSK_PC1ET2_1	62	64	PF00082	0.821
CLV_PCSK_PC1ET2_1	896	898	PF00082	0.433
CLV_PCSK_SKI1_1	223	227	PF00082	0.459
CLV_PCSK_SKI1_1	786	790	PF00082	0.425
CLV_PCSK_SKI1_1	893	897	PF00082	0.475
CLV_PCSK_SKI1_1	926	930	PF00082	0.544
DEG_MDM2_SWIB_1	911	919	PF02201	0.504
DOC_CKS1_1	124	129	PF01111	0.804
DOC_CKS1_1	363	368	PF01111	0.630
DOC_CYCLIN_RxL_1	783	793	PF00134	0.538
DOC_CYCLIN_yCln2_LP_2	1048	1054	PF00134	0.745
DOC_CYCLIN_yCln2_LP_2	215	221	PF00134	0.594
DOC_MAPK_gen_1	230	240	PF00069	0.572
DOC_MAPK_gen_1	800	809	PF00069	0.473
DOC_MAPK_gen_1	893	902	PF00069	0.451
DOC_MAPK_HePTP_8	214	226	PF00069	0.527
DOC_MAPK_HePTP_8	228	240	PF00069	0.514
DOC_MAPK_MEF2A_6	217	226	PF00069	0.528
DOC_MAPK_MEF2A_6	231	240	PF00069	0.515
DOC_MAPK_MEF2A_6	630	637	PF00069	0.431
DOC_PP1_RVXF_1	784	791	PF00149	0.519
DOC_PP1_RVXF_1	881	888	PF00149	0.512
DOC_PP2B_LxvP_1	125	128	PF13499	0.510
DOC_PP2B_LxvP_1	303	306	PF13499	0.517
DOC_PP2B_LxvP_1	548	551	PF13499	0.568
DOC_SPAK_OSR1_1	897	901	PF12202	0.454
DOC_USP7_MATH_1	103	107	PF00917	0.807
DOC_USP7_MATH_1	1030	1034	PF00917	0.807
DOC_USP7_MATH_1	169	173	PF00917	0.564
DOC_USP7_MATH_1	275	279	PF00917	0.319
DOC_USP7_MATH_1	313	317	PF00917	0.557
DOC_USP7_MATH_1	35	39	PF00917	0.706
DOC_USP7_MATH_1	370	374	PF00917	0.608
DOC_USP7_MATH_1	471	475	PF00917	0.690
DOC_USP7_MATH_1	57	61	PF00917	0.740
DOC_USP7_MATH_1	694	698	PF00917	0.462
DOC_USP7_MATH_1	75	79	PF00917	0.615
DOC_USP7_MATH_1	80	84	PF00917	0.777
DOC_USP7_MATH_1	820	824	PF00917	0.587
DOC_USP7_MATH_1	848	852	PF00917	0.531
DOC_USP7_MATH_2	594	600	PF00917	0.620
DOC_USP7_MATH_2	874	880	PF00917	0.653
DOC_USP7_UBL2_3	725	729	PF12436	0.579
DOC_WW_Pin1_4	1021	1026	PF00397	0.659
DOC_WW_Pin1_4	1042	1047	PF00397	0.709
DOC_WW_Pin1_4	123	128	PF00397	0.778
DOC_WW_Pin1_4	14	19	PF00397	0.697
DOC_WW_Pin1_4	22	27	PF00397	0.596
DOC_WW_Pin1_4	254	259	PF00397	0.665
DOC_WW_Pin1_4	309	314	PF00397	0.417
DOC_WW_Pin1_4	362	367	PF00397	0.603
DOC_WW_Pin1_4	469	474	PF00397	0.732
DOC_WW_Pin1_4	62	67	PF00397	0.784
DOC_WW_Pin1_4	818	823	PF00397	0.598
LIG_14-3-3_CanoR_1	422	431	PF00244	0.566
LIG_14-3-3_CanoR_1	737	743	PF00244	0.515
LIG_14-3-3_CanoR_1	744	753	PF00244	0.468
LIG_14-3-3_CanoR_1	849	857	PF00244	0.548
LIG_Actin_WH2_2	208	225	PF00022	0.567
LIG_APCC_ABBA_1	703	708	PF00400	0.510
LIG_BRCT_BRCA1_1	1004	1008	PF00533	0.530
LIG_BRCT_BRCA1_1	131	135	PF00533	0.736
LIG_BRCT_BRCA1_1	512	516	PF00533	0.507
LIG_BRCT_BRCA1_1	619	623	PF00533	0.538
LIG_Clathr_ClatBox_1	704	708	PF01394	0.413
LIG_Clathr_ClatBox_1	833	837	PF01394	0.524
LIG_deltaCOP1_diTrp_1	1012	1018	PF00928	0.625
LIG_EH1_1	52	60	PF00400	0.798
LIG_eIF4E_1	857	863	PF01652	0.425
LIG_FHA_1	284	290	PF00498	0.477
LIG_FHA_1	299	305	PF00498	0.428
LIG_FHA_1	494	500	PF00498	0.459
LIG_FHA_1	502	508	PF00498	0.474
LIG_FHA_1	622	628	PF00498	0.468
LIG_FHA_1	977	983	PF00498	0.594
LIG_FHA_2	280	286	PF00498	0.447
LIG_FHA_2	392	398	PF00498	0.702
LIG_FHA_2	564	570	PF00498	0.607
LIG_FHA_2	683	689	PF00498	0.586
LIG_FHA_2	775	781	PF00498	0.514
LIG_FHA_2	964	970	PF00498	0.551
LIG_LIR_Apic_2	398	404	PF02991	0.556
LIG_LIR_Apic_2	870	874	PF02991	0.461
LIG_LIR_Gen_1	741	750	PF02991	0.457
LIG_LIR_Gen_1	774	784	PF02991	0.463
LIG_LIR_Gen_1	856	867	PF02991	0.528
LIG_LIR_LC3C_4	234	239	PF02991	0.540
LIG_LIR_Nem_3	486	490	PF02991	0.636
LIG_LIR_Nem_3	708	712	PF02991	0.436
LIG_LIR_Nem_3	741	745	PF02991	0.453
LIG_LIR_Nem_3	748	753	PF02991	0.438
LIG_LIR_Nem_3	774	779	PF02991	0.525
LIG_LIR_Nem_3	856	862	PF02991	0.539
LIG_LYPXL_S_1	865	869	PF13949	0.422
LIG_LYPXL_yS_3	866	869	PF13949	0.425
LIG_MAD2	814	822	PF02301	0.558
LIG_NBox_RRM_1	778	788	PF00076	0.536
LIG_PCNA_PIPBox_1	311	320	PF02747	0.525
LIG_PCNA_yPIPBox_3	52	64	PF02747	0.804
LIG_PCNA_yPIPBox_3	772	786	PF02747	0.521
LIG_PCNA_yPIPBox_3	954	965	PF02747	0.573
LIG_Pex14_1	1014	1018	PF04695	0.726
LIG_Pex14_2	619	623	PF04695	0.558
LIG_Pex14_2	706	710	PF04695	0.508
LIG_Pex14_2	911	915	PF04695	0.500
LIG_REV1ctd_RIR_1	355	364	PF16727	0.604
LIG_REV1ctd_RIR_1	787	796	PF16727	0.587
LIG_SH2_CRK	219	223	PF00017	0.578
LIG_SH2_CRK	664	668	PF00017	0.546
LIG_SH2_CRK	871	875	PF00017	0.456
LIG_SH2_NCK_1	243	247	PF00017	0.577
LIG_SH2_NCK_1	379	383	PF00017	0.538
LIG_SH2_PTP2	545	548	PF00017	0.506
LIG_SH2_SRC	379	382	PF00017	0.542
LIG_SH2_STAT5	1072	1075	PF00017	0.641
LIG_SH2_STAT5	185	188	PF00017	0.605
LIG_SH2_STAT5	290	293	PF00017	0.471
LIG_SH2_STAT5	317	320	PF00017	0.513
LIG_SH2_STAT5	435	438	PF00017	0.508
LIG_SH2_STAT5	545	548	PF00017	0.412
LIG_SH2_STAT5	742	745	PF00017	0.465
LIG_SH2_STAT5	857	860	PF00017	0.436
LIG_SH2_STAT5	886	889	PF00017	0.424
LIG_SH2_STAT5	921	924	PF00017	0.558
LIG_SH3_3	235	241	PF00018	0.453
LIG_SH3_3	360	366	PF00018	0.585
LIG_SH3_3	41	47	PF00018	0.764
LIG_SH3_3	872	878	PF00018	0.596
LIG_SUMO_SIM_anti_2	1058	1070	PF11976	0.692
LIG_SUMO_SIM_anti_2	234	240	PF11976	0.503
LIG_SUMO_SIM_par_1	342	347	PF11976	0.576
LIG_SUMO_SIM_par_1	389	394	PF11976	0.623
LIG_SUMO_SIM_par_1	631	636	PF11976	0.434
LIG_SUMO_SIM_par_1	832	837	PF11976	0.523
LIG_SUMO_SIM_par_1	872	879	PF11976	0.606
LIG_TRAF2_1	587	590	PF00917	0.581
LIG_TRAF2_1	685	688	PF00917	0.513
LIG_TYR_ITIM	740	745	PF00017	0.517
LIG_TYR_ITIM	864	869	PF00017	0.420
LIG_TYR_ITIM	884	889	PF00017	0.473
LIG_TYR_ITIM	919	924	PF00017	0.577
LIG_UBA3_1	444	450	PF00899	0.598
LIG_WRC_WIRS_1	484	489	PF05994	0.638
LIG_WRC_WIRS_1	775	780	PF05994	0.514
MOD_CDC14_SPxK_1	65	68	PF00782	0.819
MOD_CDK_SPxK_1	469	475	PF00069	0.719
MOD_CDK_SPxK_1	62	68	PF00069	0.819
MOD_CK1_1	1017	1023	PF00069	0.705
MOD_CK1_1	123	129	PF00069	0.687
MOD_CK1_1	229	235	PF00069	0.558
MOD_CK1_1	244	250	PF00069	0.453
MOD_CK1_1	267	273	PF00069	0.564
MOD_CK1_1	27	33	PF00069	0.675
MOD_CK1_1	359	365	PF00069	0.478
MOD_CK1_1	483	489	PF00069	0.657
MOD_CK1_1	519	525	PF00069	0.544
MOD_CK1_1	617	623	PF00069	0.511
MOD_CK1_1	768	774	PF00069	0.549
MOD_CK1_1	78	84	PF00069	0.837
MOD_CK1_1	821	827	PF00069	0.558
MOD_CK1_1	843	849	PF00069	0.512
MOD_CK1_1	976	982	PF00069	0.518
MOD_CK2_1	370	376	PF00069	0.535
MOD_CK2_1	391	397	PF00069	0.579
MOD_CK2_1	517	523	PF00069	0.508
MOD_CK2_1	563	569	PF00069	0.615
MOD_CK2_1	603	609	PF00069	0.504
MOD_CK2_1	682	688	PF00069	0.542
MOD_CK2_1	774	780	PF00069	0.484
MOD_CK2_1	81	87	PF00069	0.838
MOD_CK2_1	898	904	PF00069	0.524
MOD_CK2_1	963	969	PF00069	0.556
MOD_Cter_Amidation	7	10	PF01082	0.706
MOD_DYRK1A_RPxSP_1	254	258	PF00069	0.658
MOD_GlcNHglycan	105	108	PF01048	0.642
MOD_GlcNHglycan	109	112	PF01048	0.740
MOD_GlcNHglycan	171	174	PF01048	0.543
MOD_GlcNHglycan	265	269	PF01048	0.552
MOD_GlcNHglycan	329	332	PF01048	0.608
MOD_GlcNHglycan	346	349	PF01048	0.334
MOD_GlcNHglycan	35	38	PF01048	0.776
MOD_GlcNHglycan	396	400	PF01048	0.631
MOD_GlcNHglycan	426	429	PF01048	0.510
MOD_GlcNHglycan	519	522	PF01048	0.590
MOD_GlcNHglycan	670	673	PF01048	0.635
MOD_GlcNHglycan	762	765	PF01048	0.533
MOD_GlcNHglycan	77	81	PF01048	0.817
MOD_GlcNHglycan	828	831	PF01048	0.559
MOD_GlcNHglycan	83	86	PF01048	0.811
MOD_GlcNHglycan	850	853	PF01048	0.529
MOD_GlcNHglycan	870	874	PF01048	0.552
MOD_GSK3_1	1013	1020	PF00069	0.584
MOD_GSK3_1	103	110	PF00069	0.662
MOD_GSK3_1	1038	1045	PF00069	0.806
MOD_GSK3_1	20	27	PF00069	0.778
MOD_GSK3_1	275	282	PF00069	0.487
MOD_GSK3_1	309	316	PF00069	0.295
MOD_GSK3_1	344	351	PF00069	0.479
MOD_GSK3_1	391	398	PF00069	0.660
MOD_GSK3_1	418	425	PF00069	0.451
MOD_GSK3_1	42	49	PF00069	0.753
MOD_GSK3_1	519	526	PF00069	0.487
MOD_GSK3_1	552	559	PF00069	0.510
MOD_GSK3_1	617	624	PF00069	0.492
MOD_GSK3_1	76	83	PF00069	0.758
MOD_GSK3_1	816	823	PF00069	0.503
MOD_GSK3_1	92	99	PF00069	0.756
MOD_N-GLC_1	120	125	PF02516	0.797
MOD_N-GLC_1	153	158	PF02516	0.748
MOD_N-GLC_1	306	311	PF02516	0.528
MOD_N-GLC_1	47	52	PF02516	0.798
MOD_N-GLC_1	510	515	PF02516	0.626
MOD_N-GLC_1	614	619	PF02516	0.600
MOD_N-GLC_1	694	699	PF02516	0.561
MOD_N-GLC_1	75	80	PF02516	0.760
MOD_N-GLC_1	771	776	PF02516	0.468
MOD_N-GLC_1	843	848	PF02516	0.484
MOD_N-GLC_1	853	858	PF02516	0.542
MOD_N-GLC_2	643	645	PF02516	0.538
MOD_NEK2_1	1013	1018	PF00069	0.670
MOD_NEK2_1	186	191	PF00069	0.598
MOD_NEK2_1	226	231	PF00069	0.417
MOD_NEK2_1	415	420	PF00069	0.540
MOD_NEK2_1	424	429	PF00069	0.578
MOD_NEK2_1	453	458	PF00069	0.619
MOD_NEK2_1	501	506	PF00069	0.512
MOD_NEK2_1	516	521	PF00069	0.384
MOD_NEK2_1	575	580	PF00069	0.480
MOD_NEK2_1	619	624	PF00069	0.475
MOD_NEK2_1	808	813	PF00069	0.470
MOD_NEK2_1	887	892	PF00069	0.435
MOD_NEK2_1	898	903	PF00069	0.464
MOD_NEK2_2	153	158	PF00069	0.748
MOD_PIKK_1	178	184	PF00454	0.567
MOD_PIKK_1	290	296	PF00454	0.531
MOD_PKA_2	229	235	PF00069	0.569
MOD_PKA_2	327	333	PF00069	0.635
MOD_PKA_2	809	815	PF00069	0.471
MOD_PKA_2	848	854	PF00069	0.529
MOD_PKA_2	898	904	PF00069	0.523
MOD_Plk_1	120	126	PF00069	0.608
MOD_Plk_1	153	159	PF00069	0.736
MOD_Plk_1	306	312	PF00069	0.533
MOD_Plk_1	375	381	PF00069	0.453
MOD_Plk_1	391	397	PF00069	0.544
MOD_Plk_1	409	415	PF00069	0.355
MOD_Plk_1	454	460	PF00069	0.574
MOD_Plk_1	47	53	PF00069	0.800
MOD_Plk_1	493	499	PF00069	0.473
MOD_Plk_1	617	623	PF00069	0.581
MOD_Plk_1	758	764	PF00069	0.508
MOD_Plk_1	771	777	PF00069	0.396
MOD_Plk_1	853	859	PF00069	0.564
MOD_Plk_2-3	195	201	PF00069	0.661
MOD_Plk_2-3	596	602	PF00069	0.611
MOD_Plk_4	1014	1020	PF00069	0.567
MOD_Plk_4	120	126	PF00069	0.822
MOD_Plk_4	24	30	PF00069	0.789
MOD_Plk_4	267	273	PF00069	0.615
MOD_Plk_4	275	281	PF00069	0.414
MOD_Plk_4	313	319	PF00069	0.485
MOD_Plk_4	370	376	PF00069	0.375
MOD_Plk_4	415	421	PF00069	0.515
MOD_Plk_4	454	460	PF00069	0.574
MOD_Plk_4	480	486	PF00069	0.576
MOD_Plk_4	493	499	PF00069	0.302
MOD_Plk_4	552	558	PF00069	0.588
MOD_Plk_4	563	569	PF00069	0.621
MOD_Plk_4	771	777	PF00069	0.429
MOD_Plk_4	821	827	PF00069	0.540
MOD_Plk_4	853	859	PF00069	0.477
MOD_ProDKin_1	1021	1027	PF00069	0.662
MOD_ProDKin_1	1042	1048	PF00069	0.706
MOD_ProDKin_1	123	129	PF00069	0.777
MOD_ProDKin_1	14	20	PF00069	0.697
MOD_ProDKin_1	22	28	PF00069	0.598
MOD_ProDKin_1	254	260	PF00069	0.669
MOD_ProDKin_1	309	315	PF00069	0.411
MOD_ProDKin_1	362	368	PF00069	0.613
MOD_ProDKin_1	469	475	PF00069	0.719
MOD_ProDKin_1	62	68	PF00069	0.787
MOD_ProDKin_1	818	824	PF00069	0.592
MOD_SUMO_for_1	941	944	PF00179	0.635
TRG_DiLeu_BaEn_1	960	965	PF01217	0.579
TRG_DiLeu_BaEn_2	492	498	PF01217	0.581
TRG_DiLeu_BaEn_4	531	537	PF01217	0.559
TRG_DiLeu_BaLyEn_6	449	454	PF01217	0.656
TRG_ENDOCYTIC_2	1072	1075	PF00928	0.669
TRG_ENDOCYTIC_2	219	222	PF00928	0.573
TRG_ENDOCYTIC_2	545	548	PF00928	0.412
TRG_ENDOCYTIC_2	742	745	PF00928	0.440
TRG_ENDOCYTIC_2	750	753	PF00928	0.377
TRG_ENDOCYTIC_2	866	869	PF00928	0.425
TRG_ENDOCYTIC_2	886	889	PF00928	0.424
TRG_ENDOCYTIC_2	921	924	PF00928	0.561
TRG_ER_diArg_1	505	507	PF00400	0.526
TRG_ER_diArg_1	786	788	PF00400	0.517
TRG_NLS_MonoCore_2	60	65	PF00514	0.810
TRG_NLS_MonoExtC_3	61	66	PF00514	0.837
TRG_NLS_MonoExtN_4	61	66	PF00514	0.837
TRG_NLS_MonoExtN_4	893	900	PF00514	0.555
TRG_Pf-PMV_PEXEL_1	406	410	PF00026	0.563
TRG_Pf-PMV_PEXEL_1	505	510	PF00026	0.625

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWI4	Leptomonas seymouri	74%	99%
A0A0N1IMH3	Leptomonas seymouri	20%	90%
A0A0S4JM26	Bodo saltans	27%	100%
A0A1X0P5G8	Trypanosomatidae	39%	100%
A0A3S5IQN1	Trypanosoma rangeli	36%	100%
A0A3S7X9K2	Leishmania donovani	96%	100%
A4HN04	Leishmania braziliensis	87%	100%
A4IBM7	Leishmania infantum	96%	100%
C9ZZ06	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AFG1	Leishmania major	96%	100%
V5BCW9	Trypanosoma cruzi	39%	100%