TP_methylase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tetrapyrrole (Corrin/Porphyrin) Methylases, putative

Species:

Leishmania mexicana

UniProt:

E9B6L4_LEIMU

TriTrypDb:

LmxM.34.3350

Length:

462

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0016020	membrane	2	1

Expansion

Sequence features

E9B6L4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6L4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	12
GO:0032259	methylation	2	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008168	methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	16	18	PF00675	0.634
CLV_NRD_NRD_1	284	286	PF00675	0.256
CLV_NRD_NRD_1	299	301	PF00675	0.256
CLV_NRD_NRD_1	336	338	PF00675	0.397
CLV_NRD_NRD_1	365	367	PF00675	0.508
CLV_NRD_NRD_1	368	370	PF00675	0.505
CLV_NRD_NRD_1	414	416	PF00675	0.573
CLV_NRD_NRD_1	425	427	PF00675	0.434
CLV_NRD_NRD_1	429	431	PF00675	0.389
CLV_NRD_NRD_1	67	69	PF00675	0.655
CLV_PCSK_FUR_1	366	370	PF00082	0.484
CLV_PCSK_FUR_1	430	434	PF00082	0.494
CLV_PCSK_KEX2_1	16	18	PF00082	0.634
CLV_PCSK_KEX2_1	284	286	PF00082	0.256
CLV_PCSK_KEX2_1	299	301	PF00082	0.256
CLV_PCSK_KEX2_1	363	365	PF00082	0.495
CLV_PCSK_KEX2_1	368	370	PF00082	0.514
CLV_PCSK_KEX2_1	414	416	PF00082	0.573
CLV_PCSK_KEX2_1	425	427	PF00082	0.435
CLV_PCSK_KEX2_1	432	434	PF00082	0.349
CLV_PCSK_PC1ET2_1	363	365	PF00082	0.491
CLV_PCSK_PC1ET2_1	432	434	PF00082	0.500
CLV_PCSK_PC7_1	364	370	PF00082	0.490
CLV_PCSK_PC7_1	421	427	PF00082	0.557
CLV_PCSK_PC7_1	428	434	PF00082	0.498
CLV_PCSK_SKI1_1	124	128	PF00082	0.277
CLV_PCSK_SKI1_1	89	93	PF00082	0.493
CLV_Separin_Metazoa	281	285	PF03568	0.467
DEG_APCC_DBOX_1	153	161	PF00400	0.562
DEG_APCC_DBOX_1	420	428	PF00400	0.652
DEG_Nend_Nbox_1	1	3	PF02207	0.713
DEG_SPOP_SBC_1	39	43	PF00917	0.725
DEG_SPOP_SBC_1	398	402	PF00917	0.788
DOC_CDC14_PxL_1	9	17	PF14671	0.450
DOC_CYCLIN_RxL_1	124	132	PF00134	0.475
DOC_MAPK_gen_1	284	290	PF00069	0.499
DOC_MAPK_gen_1	337	345	PF00069	0.412
DOC_MAPK_gen_1	446	453	PF00069	0.511
DOC_MAPK_MEF2A_6	337	345	PF00069	0.397
DOC_MAPK_MEF2A_6	446	453	PF00069	0.611
DOC_MAPK_NFAT4_5	338	346	PF00069	0.405
DOC_PP1_RVXF_1	320	327	PF00149	0.536
DOC_USP7_MATH_1	200	204	PF00917	0.532
DOC_USP7_MATH_1	218	222	PF00917	0.402
DOC_USP7_MATH_1	232	236	PF00917	0.516
DOC_USP7_MATH_1	380	384	PF00917	0.707
DOC_USP7_MATH_1	39	43	PF00917	0.745
DOC_USP7_MATH_1	397	401	PF00917	0.759
DOC_USP7_MATH_1	439	443	PF00917	0.617
DOC_USP7_UBL2_3	359	363	PF12436	0.591
DOC_WW_Pin1_4	172	177	PF00397	0.475
DOC_WW_Pin1_4	237	242	PF00397	0.545
DOC_WW_Pin1_4	46	51	PF00397	0.649
DOC_WW_Pin1_4	70	75	PF00397	0.634
LIG_14-3-3_CanoR_1	147	157	PF00244	0.487
LIG_14-3-3_CanoR_1	16	20	PF00244	0.642
LIG_14-3-3_CanoR_1	23	30	PF00244	0.589
LIG_14-3-3_CanoR_1	33	39	PF00244	0.545
LIG_14-3-3_CanoR_1	366	372	PF00244	0.596
LIG_14-3-3_CanoR_1	446	452	PF00244	0.398
LIG_14-3-3_CanoR_1	52	61	PF00244	0.523
LIG_Actin_WH2_1	433	450	PF00022	0.561
LIG_BRCT_BRCA1_1	247	251	PF00533	0.487
LIG_BRCT_BRCA1_1	61	65	PF00533	0.669
LIG_FHA_1	125	131	PF00498	0.487
LIG_FHA_1	173	179	PF00498	0.475
LIG_FHA_1	303	309	PF00498	0.536
LIG_FHA_1	448	454	PF00498	0.488
LIG_FHA_2	127	133	PF00498	0.487
LIG_FHA_2	150	156	PF00498	0.555
LIG_FHA_2	241	247	PF00498	0.577
LIG_FHA_2	368	374	PF00498	0.629
LIG_FHA_2	407	413	PF00498	0.589
LIG_FHA_2	71	77	PF00498	0.580
LIG_FHA_2	83	89	PF00498	0.519
LIG_IRF3_LxIS_1	205	212	PF10401	0.532
LIG_LIR_Nem_3	248	254	PF02991	0.536
LIG_LIR_Nem_3	274	278	PF02991	0.562
LIG_MAD2	264	272	PF02301	0.579
LIG_MLH1_MIPbox_1	247	251	PF16413	0.487
LIG_NRBOX	156	162	PF00104	0.487
LIG_Pex14_2	275	279	PF04695	0.562
LIG_Pex14_2	61	65	PF04695	0.710
LIG_SH2_STAT3	327	330	PF00017	0.458
LIG_SH2_STAT5	118	121	PF00017	0.475
LIG_SH2_STAT5	303	306	PF00017	0.562
LIG_SH2_STAT5	327	330	PF00017	0.544
LIG_SH3_3	131	137	PF00018	0.562
LIG_SH3_3	92	98	PF00018	0.475
LIG_SUMO_SIM_anti_2	129	135	PF11976	0.487
LIG_TRAF2_1	410	413	PF00917	0.683
LIG_TRAF2_1	442	445	PF00917	0.587
MOD_CDC14_SPxK_1	49	52	PF00782	0.442
MOD_CDK_SPxK_1	46	52	PF00069	0.514
MOD_CK1_1	18	24	PF00069	0.707
MOD_CK1_1	212	218	PF00069	0.360
MOD_CK1_1	221	227	PF00069	0.343
MOD_CK1_1	240	246	PF00069	0.448
MOD_CK1_1	400	406	PF00069	0.745
MOD_CK2_1	149	155	PF00069	0.448
MOD_CK2_1	214	220	PF00069	0.328
MOD_CK2_1	381	387	PF00069	0.685
MOD_CK2_1	398	404	PF00069	0.807
MOD_CK2_1	406	412	PF00069	0.701
MOD_CK2_1	439	445	PF00069	0.598
MOD_GlcNHglycan	172	175	PF01048	0.328
MOD_GlcNHglycan	191	194	PF01048	0.328
MOD_GlcNHglycan	202	205	PF01048	0.339
MOD_GlcNHglycan	206	209	PF01048	0.320
MOD_GlcNHglycan	211	214	PF01048	0.253
MOD_GlcNHglycan	216	219	PF01048	0.349
MOD_GlcNHglycan	220	223	PF01048	0.222
MOD_GlcNHglycan	387	390	PF01048	0.778
MOD_GlcNHglycan	4	7	PF01048	0.724
MOD_GlcNHglycan	61	64	PF01048	0.633
MOD_GSK3_1	168	175	PF00069	0.448
MOD_GSK3_1	18	25	PF00069	0.531
MOD_GSK3_1	200	207	PF00069	0.383
MOD_GSK3_1	209	216	PF00069	0.312
MOD_GSK3_1	302	309	PF00069	0.413
MOD_GSK3_1	34	41	PF00069	0.620
MOD_GSK3_1	381	388	PF00069	0.745
MOD_GSK3_1	399	406	PF00069	0.684
MOD_N-GLC_1	148	153	PF02516	0.343
MOD_N-GLC_1	311	316	PF02516	0.343
MOD_NEK2_1	15	20	PF00069	0.634
MOD_NEK2_1	169	174	PF00069	0.343
MOD_NEK2_1	2	7	PF00069	0.654
MOD_NEK2_1	209	214	PF00069	0.292
MOD_NEK2_1	22	27	PF00069	0.574
MOD_NEK2_1	311	316	PF00069	0.362
MOD_NEK2_1	367	372	PF00069	0.542
MOD_NEK2_1	447	452	PF00069	0.362
MOD_NEK2_1	54	59	PF00069	0.570
MOD_NEK2_1	61	66	PF00069	0.530
MOD_PIKK_1	24	30	PF00454	0.712
MOD_PKA_2	149	155	PF00069	0.439
MOD_PKA_2	15	21	PF00069	0.713
MOD_PKA_2	194	200	PF00069	0.362
MOD_PKA_2	22	28	PF00069	0.530
MOD_PKA_2	367	373	PF00069	0.571
MOD_PKA_2	447	453	PF00069	0.399
MOD_PKA_2	59	65	PF00069	0.593
MOD_Plk_1	103	109	PF00069	0.328
MOD_Plk_1	311	317	PF00069	0.343
MOD_Plk_1	403	409	PF00069	0.698
MOD_Plk_1	456	462	PF00069	0.713
MOD_Plk_4	126	132	PF00069	0.343
MOD_Plk_4	245	251	PF00069	0.343
MOD_Plk_4	292	298	PF00069	0.439
MOD_ProDKin_1	172	178	PF00069	0.328
MOD_ProDKin_1	237	243	PF00069	0.425
MOD_ProDKin_1	46	52	PF00069	0.650
MOD_ProDKin_1	70	76	PF00069	0.628
TRG_DiLeu_BaEn_1	331	336	PF01217	0.458
TRG_DiLeu_BaLyEn_6	138	143	PF01217	0.343
TRG_DiLeu_BaLyEn_6	432	437	PF01217	0.541
TRG_ER_diArg_1	15	17	PF00400	0.631
TRG_ER_diArg_1	262	265	PF00400	0.343
TRG_ER_diArg_1	283	285	PF00400	0.301
TRG_ER_diArg_1	298	300	PF00400	0.301
TRG_ER_diArg_1	364	366	PF00400	0.500
TRG_ER_diArg_1	367	369	PF00400	0.516
TRG_ER_diArg_1	414	417	PF00400	0.569
TRG_ER_diArg_1	424	426	PF00400	0.487
TRG_ER_diArg_1	427	430	PF00400	0.456
TRG_ER_diArg_1	446	449	PF00400	0.352
TRG_NLS_MonoCore_2	362	367	PF00514	0.617
TRG_NLS_MonoExtC_3	416	421	PF00514	0.654
TRG_NLS_MonoExtN_4	414	421	PF00514	0.627
TRG_Pf-PMV_PEXEL_1	425	429	PF00026	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4G3	Leptomonas seymouri	70%	100%
A0A0S4IXW1	Bodo saltans	44%	100%
A0A1X0P5K8	Trypanosomatidae	55%	100%
A0A3R7N6Y9	Trypanosoma rangeli	55%	100%
A0A3S7X9K0	Leishmania donovani	91%	100%
A4HN02	Leishmania braziliensis	83%	100%
A4IBM5	Leishmania infantum	91%	100%
C9ZZ09	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9AFF9	Leishmania major	90%	100%
V5BY28	Trypanosoma cruzi	54%	100%