LRRcap domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Leucine Rich repeats (2 copies), putative

Species:

Leishmania mexicana

UniProt:

E9B6L0_LEIMU

TriTrypDb:

LmxM.34.3310

Length:

303

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	13
GO:0042995	cell projection	2	13
GO:0043226	organelle	2	13
GO:0043227	membrane-bounded organelle	3	13
GO:0110165	cellular anatomical entity	1	13
GO:0120025	plasma membrane bounded cell projection	3	13

Expansion

Sequence features

E9B6L0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6L0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.525
CLV_NRD_NRD_1	108	110	PF00675	0.243
CLV_NRD_NRD_1	194	196	PF00675	0.697
CLV_NRD_NRD_1	20	22	PF00675	0.415
CLV_NRD_NRD_1	294	296	PF00675	0.423
CLV_NRD_NRD_1	64	66	PF00675	0.279
CLV_NRD_NRD_1	72	74	PF00675	0.230
CLV_PCSK_KEX2_1	108	110	PF00082	0.254
CLV_PCSK_KEX2_1	20	22	PF00082	0.496
CLV_PCSK_KEX2_1	294	296	PF00082	0.432
CLV_PCSK_KEX2_1	64	66	PF00082	0.320
CLV_PCSK_KEX2_1	72	74	PF00082	0.269
CLV_PCSK_SKI1_1	124	128	PF00082	0.327
CLV_PCSK_SKI1_1	195	199	PF00082	0.734
DEG_SPOP_SBC_1	170	174	PF00917	0.583
DOC_CDC14_PxL_1	85	93	PF14671	0.469
DOC_MAPK_gen_1	20	27	PF00069	0.499
DOC_MAPK_gen_1	64	71	PF00069	0.320
DOC_MAPK_MEF2A_6	39	46	PF00069	0.488
DOC_PP4_FxxP_1	144	147	PF00568	0.634
DOC_SPAK_OSR1_1	109	113	PF12202	0.454
DOC_USP7_MATH_1	114	118	PF00917	0.454
DOC_USP7_MATH_1	170	174	PF00917	0.607
DOC_USP7_MATH_1	182	186	PF00917	0.706
DOC_USP7_MATH_1	197	201	PF00917	0.733
DOC_USP7_MATH_1	244	248	PF00917	0.751
DOC_WW_Pin1_4	156	161	PF00397	0.637
LIG_14-3-3_CanoR_1	13	22	PF00244	0.399
LIG_14-3-3_CanoR_1	171	177	PF00244	0.665
LIG_BIR_II_1	1	5	PF00653	0.396
LIG_FHA_1	14	20	PF00498	0.450
LIG_FHA_1	4	10	PF00498	0.349
LIG_FHA_2	125	131	PF00498	0.512
LIG_FHA_2	160	166	PF00498	0.606
LIG_FHA_2	181	187	PF00498	0.628
LIG_Integrin_isoDGR_2	211	213	PF01839	0.745
LIG_LIR_Apic_2	143	147	PF02991	0.529
LIG_LIR_Apic_2	149	154	PF02991	0.536
LIG_LIR_Gen_1	258	266	PF02991	0.596
LIG_LIR_Nem_3	104	110	PF02991	0.463
LIG_LIR_Nem_3	258	262	PF02991	0.653
LIG_LRP6_Inhibitor_1	71	77	PF00058	0.288
LIG_MYND_3	88	92	PF01753	0.453
LIG_PTAP_UEV_1	227	232	PF05743	0.472
LIG_Rb_LxCxE_1	86	104	PF01857	0.453
LIG_SH2_CRK	151	155	PF00017	0.695
LIG_SH2_CRK	259	263	PF00017	0.647
LIG_SH2_SRC	233	236	PF00017	0.608
LIG_SH3_3	225	231	PF00018	0.719
LIG_SH3_3	263	269	PF00018	0.671
LIG_SUMO_SIM_par_1	45	50	PF11976	0.202
LIG_TRAF2_1	127	130	PF00917	0.509
LIG_TRAF2_1	162	165	PF00917	0.662
LIG_TRAF2_1	269	272	PF00917	0.597
LIG_WRC_WIRS_1	141	146	PF05994	0.642
MOD_CK1_1	180	186	PF00069	0.715
MOD_CK1_1	216	222	PF00069	0.630
MOD_CK1_1	247	253	PF00069	0.708
MOD_CK1_1	261	267	PF00069	0.669
MOD_CK1_1	283	289	PF00069	0.496
MOD_CK2_1	124	130	PF00069	0.367
MOD_CK2_1	159	165	PF00069	0.661
MOD_CK2_1	180	186	PF00069	0.742
MOD_GlcNHglycan	179	182	PF01048	0.756
MOD_GlcNHglycan	199	202	PF01048	0.669
MOD_GlcNHglycan	215	218	PF01048	0.665
MOD_GlcNHglycan	228	231	PF01048	0.543
MOD_GlcNHglycan	266	269	PF01048	0.657
MOD_GSK3_1	171	178	PF00069	0.684
MOD_GSK3_1	195	202	PF00069	0.675
MOD_GSK3_1	260	267	PF00069	0.744
MOD_LATS_1	193	199	PF00433	0.606
MOD_N-GLC_2	26	28	PF02516	0.353
MOD_NEK2_1	11	16	PF00069	0.369
MOD_NEK2_1	296	301	PF00069	0.600
MOD_NEK2_1	47	52	PF00069	0.343
MOD_NEK2_1	83	88	PF00069	0.366
MOD_PIKK_1	172	178	PF00454	0.468
MOD_PIKK_1	27	33	PF00454	0.420
MOD_PKA_1	195	201	PF00069	0.653
MOD_PKA_2	170	176	PF00069	0.504
MOD_Plk_1	283	289	PF00069	0.372
MOD_ProDKin_1	156	162	PF00069	0.633
TRG_ENDOCYTIC_2	107	110	PF00928	0.309
TRG_ENDOCYTIC_2	259	262	PF00928	0.650
TRG_ER_diArg_1	107	109	PF00400	0.299
TRG_ER_diArg_1	19	21	PF00400	0.532
TRG_ER_diArg_1	293	295	PF00400	0.432
TRG_ER_diArg_1	64	66	PF00400	0.320
TRG_ER_diArg_1	71	73	PF00400	0.320
TRG_NES_CRM1_1	17	31	PF08389	0.391
TRG_NES_CRM1_1	33	45	PF08389	0.359
TRG_Pf-PMV_PEXEL_1	124	128	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	64	68	PF00026	0.304
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.349

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7V8	Leptomonas seymouri	32%	100%
A0A0N1IJM3	Leptomonas seymouri	61%	99%
A0A0S4JGU9	Bodo saltans	41%	96%
A0A1X0P674	Trypanosomatidae	48%	96%
A0A3S7X9J5	Leishmania donovani	89%	100%
A0A422N788	Trypanosoma rangeli	48%	100%
A4HMZ8	Leishmania braziliensis	76%	100%
A4IBM1	Leishmania infantum	89%	100%
C9ZZ14	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AFF5	Leishmania major	89%	100%
V5DUQ3	Trypanosoma cruzi	49%	100%