WD domain, G-beta repeat family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B6K9_LEIMU

TriTrypDb:

LmxM.34.3300

Length:

636

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6K9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6K9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	301	303	PF00675	0.615
CLV_NRD_NRD_1	387	389	PF00675	0.479
CLV_NRD_NRD_1	532	534	PF00675	0.585
CLV_PCSK_KEX2_1	300	302	PF00082	0.617
CLV_PCSK_KEX2_1	386	388	PF00082	0.560
CLV_PCSK_KEX2_1	587	589	PF00082	0.815
CLV_PCSK_PC1ET2_1	386	388	PF00082	0.590
CLV_PCSK_PC1ET2_1	587	589	PF00082	0.815
CLV_PCSK_PC7_1	383	389	PF00082	0.580
CLV_PCSK_SKI1_1	113	117	PF00082	0.459
CLV_PCSK_SKI1_1	291	295	PF00082	0.699
CLV_PCSK_SKI1_1	355	359	PF00082	0.725
CLV_PCSK_SKI1_1	387	391	PF00082	0.480
CLV_PCSK_SKI1_1	434	438	PF00082	0.451
DEG_APCC_DBOX_1	422	430	PF00400	0.569
DEG_SPOP_SBC_1	577	581	PF00917	0.821
DOC_CKS1_1	234	239	PF01111	0.513
DOC_CYCLIN_yCln2_LP_2	234	240	PF00134	0.508
DOC_MAPK_DCC_7	423	431	PF00069	0.484
DOC_MAPK_MEF2A_6	423	432	PF00069	0.577
DOC_MAPK_NFAT4_5	423	431	PF00069	0.678
DOC_PP1_RVXF_1	432	439	PF00149	0.526
DOC_USP7_MATH_1	162	166	PF00917	0.788
DOC_USP7_MATH_1	230	234	PF00917	0.531
DOC_USP7_MATH_1	321	325	PF00917	0.641
DOC_USP7_MATH_1	333	337	PF00917	0.685
DOC_USP7_MATH_1	36	40	PF00917	0.569
DOC_USP7_MATH_1	398	402	PF00917	0.730
DOC_USP7_MATH_1	470	474	PF00917	0.548
DOC_USP7_MATH_1	577	581	PF00917	0.821
DOC_USP7_MATH_1	7	11	PF00917	0.624
DOC_USP7_MATH_1	75	79	PF00917	0.671
DOC_USP7_UBL2_3	468	472	PF12436	0.792
DOC_USP7_UBL2_3	630	634	PF12436	0.666
DOC_WW_Pin1_4	152	157	PF00397	0.605
DOC_WW_Pin1_4	233	238	PF00397	0.520
DOC_WW_Pin1_4	392	397	PF00397	0.597
DOC_WW_Pin1_4	492	497	PF00397	0.728
DOC_WW_Pin1_4	511	516	PF00397	0.616
DOC_WW_Pin1_4	86	91	PF00397	0.633
LIG_14-3-3_CanoR_1	142	152	PF00244	0.529
LIG_14-3-3_CanoR_1	202	210	PF00244	0.605
LIG_14-3-3_CanoR_1	291	297	PF00244	0.655
LIG_14-3-3_CanoR_1	387	396	PF00244	0.591
LIG_14-3-3_CanoR_1	487	496	PF00244	0.535
LIG_14-3-3_CanoR_1	56	66	PF00244	0.332
LIG_14-3-3_CanoR_1	597	603	PF00244	0.584
LIG_Actin_WH2_2	419	435	PF00022	0.654
LIG_BIR_II_1	1	5	PF00653	0.645
LIG_EVH1_1	81	85	PF00568	0.497
LIG_FHA_1	234	240	PF00498	0.604
LIG_FHA_1	245	251	PF00498	0.491
LIG_FHA_1	264	270	PF00498	0.408
LIG_FHA_1	411	417	PF00498	0.463
LIG_FHA_1	48	54	PF00498	0.522
LIG_FHA_1	508	514	PF00498	0.667
LIG_FHA_1	555	561	PF00498	0.531
LIG_FHA_1	621	627	PF00498	0.554
LIG_FHA_2	115	121	PF00498	0.468
LIG_FHA_2	486	492	PF00498	0.536
LIG_Integrin_isoDGR_2	572	574	PF01839	0.747
LIG_LIR_Apic_2	226	230	PF02991	0.594
LIG_LIR_Gen_1	532	543	PF02991	0.410
LIG_LIR_Gen_1	6	15	PF02991	0.517
LIG_LIR_LC3C_4	105	108	PF02991	0.675
LIG_LIR_LC3C_4	236	241	PF02991	0.592
LIG_LIR_Nem_3	324	330	PF02991	0.708
LIG_LIR_Nem_3	532	538	PF02991	0.425
LIG_LIR_Nem_3	6	11	PF02991	0.535
LIG_PTAP_UEV_1	375	380	PF05743	0.524
LIG_SH2_CRK	15	19	PF00017	0.467
LIG_SH2_CRK	327	331	PF00017	0.492
LIG_SH2_CRK	535	539	PF00017	0.435
LIG_SH2_NCK_1	499	503	PF00017	0.619
LIG_SH2_PTP2	227	230	PF00017	0.598
LIG_SH2_SRC	406	409	PF00017	0.628
LIG_SH2_STAT3	132	135	PF00017	0.499
LIG_SH2_STAT5	199	202	PF00017	0.488
LIG_SH2_STAT5	227	230	PF00017	0.598
LIG_SH2_STAT5	406	409	PF00017	0.628
LIG_SH2_STAT5	529	532	PF00017	0.578
LIG_SH2_STAT5	607	610	PF00017	0.494
LIG_SH3_2	156	161	PF14604	0.501
LIG_SH3_3	153	159	PF00018	0.500
LIG_SH3_3	279	285	PF00018	0.787
LIG_SH3_3	373	379	PF00018	0.747
LIG_SH3_3	79	85	PF00018	0.586
LIG_SUMO_SIM_anti_2	235	242	PF11976	0.603
LIG_SUMO_SIM_anti_2	338	344	PF11976	0.612
LIG_SUMO_SIM_anti_2	514	520	PF11976	0.627
LIG_SUMO_SIM_anti_2	623	632	PF11976	0.701
LIG_TRAF2_1	311	314	PF00917	0.686
LIG_TYR_ITSM	323	330	PF00017	0.495
LIG_UBA3_1	428	434	PF00899	0.535
LIG_WRC_WIRS_1	293	298	PF05994	0.577
LIG_WRC_WIRS_1	567	572	PF05994	0.736
LIG_WRC_WIRS_1	8	13	PF05994	0.657
MOD_CDK_SPxxK_3	392	399	PF00069	0.396
MOD_CK1_1	16	22	PF00069	0.480
MOD_CK1_1	233	239	PF00069	0.615
MOD_CK1_1	458	464	PF00069	0.627
MOD_CK1_1	554	560	PF00069	0.667
MOD_CK1_1	586	592	PF00069	0.723
MOD_CK1_1	600	606	PF00069	0.623
MOD_CK1_1	74	80	PF00069	0.646
MOD_CK2_1	114	120	PF00069	0.506
MOD_CK2_1	162	168	PF00069	0.720
MOD_CK2_1	278	284	PF00069	0.685
MOD_CK2_1	485	491	PF00069	0.586
MOD_CK2_1	511	517	PF00069	0.615
MOD_CK2_1	577	583	PF00069	0.706
MOD_Cter_Amidation	477	480	PF01082	0.522
MOD_GlcNHglycan	15	18	PF01048	0.417
MOD_GlcNHglycan	335	338	PF01048	0.616
MOD_GlcNHglycan	39	42	PF01048	0.460
MOD_GlcNHglycan	408	411	PF01048	0.543
MOD_GlcNHglycan	465	468	PF01048	0.634
MOD_GlcNHglycan	5	8	PF01048	0.570
MOD_GlcNHglycan	553	556	PF01048	0.629
MOD_GlcNHglycan	588	591	PF01048	0.745
MOD_GlcNHglycan	602	605	PF01048	0.575
MOD_GlcNHglycan	631	634	PF01048	0.772
MOD_GlcNHglycan	73	76	PF01048	0.711
MOD_GlcNHglycan	77	80	PF01048	0.693
MOD_GSK3_1	201	208	PF00069	0.548
MOD_GSK3_1	228	235	PF00069	0.612
MOD_GSK3_1	3	10	PF00069	0.594
MOD_GSK3_1	370	377	PF00069	0.585
MOD_GSK3_1	398	405	PF00069	0.621
MOD_GSK3_1	406	413	PF00069	0.462
MOD_GSK3_1	449	456	PF00069	0.695
MOD_GSK3_1	485	492	PF00069	0.771
MOD_GSK3_1	503	510	PF00069	0.618
MOD_GSK3_1	579	586	PF00069	0.699
MOD_GSK3_1	593	600	PF00069	0.775
MOD_GSK3_1	71	78	PF00069	0.632
MOD_N-GLC_1	162	167	PF02516	0.713
MOD_N-GLC_2	446	448	PF02516	0.521
MOD_NEK2_1	201	206	PF00069	0.491
MOD_NEK2_1	232	237	PF00069	0.638
MOD_NEK2_1	418	423	PF00069	0.640
MOD_NEK2_1	453	458	PF00069	0.671
MOD_NEK2_1	507	512	PF00069	0.726
MOD_NEK2_1	57	62	PF00069	0.426
MOD_NEK2_1	628	633	PF00069	0.678
MOD_NEK2_1	71	76	PF00069	0.665
MOD_NEK2_2	191	196	PF00069	0.474
MOD_NEK2_2	449	454	PF00069	0.586
MOD_NEK2_2	7	12	PF00069	0.669
MOD_PIKK_1	455	461	PF00454	0.730
MOD_PIKK_1	47	53	PF00454	0.563
MOD_PIKK_1	57	63	PF00454	0.442
MOD_PK_1	133	139	PF00069	0.525
MOD_PKA_1	387	393	PF00069	0.494
MOD_PKA_2	201	207	PF00069	0.596
MOD_PKA_2	387	393	PF00069	0.539
MOD_PKA_2	398	404	PF00069	0.604
MOD_PKA_2	463	469	PF00069	0.523
MOD_PKA_2	57	63	PF00069	0.336
MOD_PKA_2	593	599	PF00069	0.713
MOD_PKB_1	175	183	PF00069	0.713
MOD_PKB_1	485	493	PF00069	0.536
MOD_Plk_1	490	496	PF00069	0.553
MOD_Plk_2-3	278	284	PF00069	0.787
MOD_Plk_4	133	139	PF00069	0.409
MOD_Plk_4	223	229	PF00069	0.520
MOD_Plk_4	292	298	PF00069	0.701
MOD_Plk_4	402	408	PF00069	0.671
MOD_Plk_4	503	509	PF00069	0.525
MOD_ProDKin_1	152	158	PF00069	0.614
MOD_ProDKin_1	233	239	PF00069	0.514
MOD_ProDKin_1	392	398	PF00069	0.604
MOD_ProDKin_1	492	498	PF00069	0.728
MOD_ProDKin_1	511	517	PF00069	0.600
MOD_ProDKin_1	86	92	PF00069	0.633
TRG_DiLeu_BaEn_1	425	430	PF01217	0.675
TRG_DiLeu_BaEn_1	624	629	PF01217	0.683
TRG_DiLeu_BaLyEn_6	234	239	PF01217	0.513
TRG_DiLeu_BaLyEn_6	424	429	PF01217	0.559
TRG_ENDOCYTIC_2	15	18	PF00928	0.553
TRG_ENDOCYTIC_2	327	330	PF00928	0.707
TRG_ENDOCYTIC_2	535	538	PF00928	0.440
TRG_ENDOCYTIC_2	607	610	PF00928	0.436
TRG_ER_diArg_1	300	302	PF00400	0.595
TRG_ER_diArg_1	387	389	PF00400	0.498
TRG_ER_diArg_1	53	56	PF00400	0.527
TRG_NLS_MonoExtC_3	478	484	PF00514	0.596
TRG_NLS_MonoExtN_4	476	483	PF00514	0.596

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCD2	Leptomonas seymouri	44%	100%
A0A3Q8IJ91	Leishmania donovani	86%	100%
A4HMZ7	Leishmania braziliensis	69%	99%
A4IBM0	Leishmania infantum	86%	100%
E9AFF4	Leishmania major	87%	100%