Protein CUSTOS

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Protein CUSTOS

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B6K6_LEIMU

TriTrypDb:

LmxM.34.3270

Length:

187

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6K6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6K6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	8	12	PF00656	0.516
CLV_NRD_NRD_1	162	164	PF00675	0.487
CLV_NRD_NRD_1	166	168	PF00675	0.499
CLV_NRD_NRD_1	179	181	PF00675	0.549
CLV_NRD_NRD_1	182	184	PF00675	0.442
CLV_NRD_NRD_1	31	33	PF00675	0.508
CLV_NRD_NRD_1	51	53	PF00675	0.447
CLV_NRD_NRD_1	65	67	PF00675	0.671
CLV_PCSK_KEX2_1	153	155	PF00082	0.470
CLV_PCSK_KEX2_1	179	181	PF00082	0.549
CLV_PCSK_KEX2_1	31	33	PF00082	0.508
CLV_PCSK_KEX2_1	51	53	PF00082	0.447
CLV_PCSK_KEX2_1	64	66	PF00082	0.481
CLV_PCSK_PC1ET2_1	153	155	PF00082	0.470
CLV_PCSK_PC7_1	149	155	PF00082	0.515
CLV_PCSK_PC7_1	175	181	PF00082	0.539
CLV_PCSK_SKI1_1	179	183	PF00082	0.538
CLV_PCSK_SKI1_1	85	89	PF00082	0.440
DOC_USP7_MATH_1	143	147	PF00917	0.716
DOC_USP7_MATH_1	23	27	PF00917	0.401
DOC_USP7_UBL2_3	152	156	PF12436	0.513
DOC_USP7_UBL2_3	160	164	PF12436	0.577
DOC_USP7_UBL2_3	88	92	PF12436	0.518
DOC_WW_Pin1_4	125	130	PF00397	0.604
LIG_14-3-3_CanoR_1	74	80	PF00244	0.490
LIG_BIR_II_1	1	5	PF00653	0.636
LIG_deltaCOP1_diTrp_1	6	16	PF00928	0.507
LIG_FHA_2	1	7	PF00498	0.473
LIG_FHA_2	74	80	PF00498	0.530
LIG_LIR_Gen_1	14	24	PF02991	0.467
LIG_LIR_Nem_3	14	20	PF02991	0.461
LIG_NRP_CendR_1	184	187	PF00754	0.569
LIG_PCNA_PIPBox_1	10	19	PF02747	0.501
LIG_Pex14_2	16	20	PF04695	0.459
LIG_SH2_CRK	178	182	PF00017	0.552
LIG_Sin3_3	68	75	PF02671	0.403
LIG_TRAF2_1	59	62	PF00917	0.514
LIG_TYR_ITIM	176	181	PF00017	0.543
MOD_CDK_SPxxK_3	125	132	PF00069	0.593
MOD_CK1_1	104	110	PF00069	0.666
MOD_CK1_1	112	118	PF00069	0.654
MOD_CK1_1	26	32	PF00069	0.411
MOD_CK1_1	73	79	PF00069	0.489
MOD_CK2_1	110	116	PF00069	0.620
MOD_CK2_1	38	44	PF00069	0.606
MOD_CK2_1	56	62	PF00069	0.500
MOD_CK2_1	73	79	PF00069	0.467
MOD_GlcNHglycan	103	106	PF01048	0.572
MOD_GlcNHglycan	58	61	PF01048	0.499
MOD_GSK3_1	108	115	PF00069	0.542
MOD_GSK3_1	119	126	PF00069	0.594
MOD_GSK3_1	18	25	PF00069	0.493
MOD_GSK3_1	38	45	PF00069	0.373
MOD_GSK3_1	97	104	PF00069	0.653
MOD_NEK2_1	109	114	PF00069	0.582
MOD_PIKK_1	42	48	PF00454	0.561
MOD_PKA_2	133	139	PF00069	0.586
MOD_PKA_2	162	168	PF00069	0.620
MOD_PKA_2	73	79	PF00069	0.484
MOD_Plk_1	18	24	PF00069	0.531
MOD_ProDKin_1	125	131	PF00069	0.603
TRG_ENDOCYTIC_2	178	181	PF00928	0.550
TRG_ER_diArg_1	178	180	PF00400	0.552
TRG_ER_diArg_1	64	66	PF00400	0.475
TRG_NLS_MonoExtC_3	151	156	PF00514	0.462
TRG_NLS_MonoExtN_4	149	156	PF00514	0.477
TRG_Pf-PMV_PEXEL_1	180	185	PF00026	0.541

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDT8	Leptomonas seymouri	52%	100%
A0A3S7X9J2	Leishmania donovani	86%	99%
A4HMZ4	Leishmania braziliensis	70%	100%
A4IBL8	Leishmania infantum	85%	99%
E9AFF1	Leishmania major	88%	100%