Putative replication factor C, subunit 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

replication factor C, subunit 3, putative

Species:

Leishmania mexicana

UniProt:

E9B6K4_LEIMU

TriTrypDb:

LmxM.34.3250

Length:

364

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005663	DNA replication factor C complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B6K4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6K4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006260	DNA replication	5	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0006261	DNA-templated DNA replication	6	1
GO:0006281	DNA repair	5	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0033554	cellular response to stress	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0016887	ATP hydrolysis activity	7	12
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	152	154	PF00675	0.293
CLV_NRD_NRD_1	227	229	PF00675	0.341
CLV_NRD_NRD_1	351	353	PF00675	0.488
CLV_PCSK_KEX2_1	152	154	PF00082	0.293
CLV_PCSK_KEX2_1	227	229	PF00082	0.341
CLV_PCSK_PC7_1	223	229	PF00082	0.224
CLV_PCSK_SKI1_1	311	315	PF00082	0.278
CLV_PCSK_SKI1_1	353	357	PF00082	0.401
DEG_APCC_DBOX_1	226	234	PF00400	0.333
DEG_MDM2_SWIB_1	272	279	PF02201	0.244
DEG_Nend_Nbox_1	1	3	PF02207	0.630
DEG_SPOP_SBC_1	106	110	PF00917	0.298
DOC_PP1_RVXF_1	158	165	PF00149	0.263
DOC_SPAK_OSR1_1	163	167	PF12202	0.241
DOC_USP7_MATH_1	106	110	PF00917	0.299
DOC_USP7_MATH_1	12	16	PF00917	0.510
DOC_USP7_MATH_1	177	181	PF00917	0.266
DOC_USP7_MATH_1	262	266	PF00917	0.387
DOC_USP7_MATH_1	329	333	PF00917	0.356
DOC_WW_Pin1_4	253	258	PF00397	0.263
LIG_14-3-3_CanoR_1	228	234	PF00244	0.345
LIG_14-3-3_CanoR_1	24	29	PF00244	0.380
LIG_BRCT_BRCA1_1	108	112	PF00533	0.248
LIG_BRCT_BRCA1_1	268	272	PF00533	0.356
LIG_Clathr_ClatBox_1	134	138	PF01394	0.263
LIG_CORNRBOX	167	175	PF00104	0.323
LIG_FHA_1	106	112	PF00498	0.278
LIG_FHA_1	157	163	PF00498	0.263
LIG_FHA_1	210	216	PF00498	0.480
LIG_FHA_1	259	265	PF00498	0.403
LIG_FHA_1	272	278	PF00498	0.327
LIG_FHA_1	292	298	PF00498	0.125
LIG_FHA_1	62	68	PF00498	0.263
LIG_FHA_2	254	260	PF00498	0.263
LIG_Integrin_RGD_1	223	225	PF01839	0.221
LIG_LIR_Gen_1	274	284	PF02991	0.229
LIG_LIR_Nem_3	274	279	PF02991	0.229
LIG_NRBOX	334	340	PF00104	0.403
LIG_PCNA_yPIPBox_3	148	160	PF02747	0.356
LIG_Pex14_1	19	23	PF04695	0.352
LIG_Pex14_2	272	276	PF04695	0.298
LIG_SH2_CRK	56	60	PF00017	0.263
LIG_SH2_SRC	73	76	PF00017	0.356
LIG_SH2_STAP1	145	149	PF00017	0.296
LIG_SH2_STAP1	158	162	PF00017	0.272
LIG_SH2_STAT3	145	148	PF00017	0.151
LIG_SH2_STAT5	158	161	PF00017	0.278
LIG_SH2_STAT5	201	204	PF00017	0.472
LIG_SH2_STAT5	210	213	PF00017	0.527
LIG_SH2_STAT5	73	76	PF00017	0.298
LIG_SUMO_SIM_par_1	133	139	PF11976	0.263
LIG_TRAF2_1	203	206	PF00917	0.352
MOD_CK1_1	107	113	PF00069	0.264
MOD_CK1_1	117	123	PF00069	0.298
MOD_CK1_1	180	186	PF00069	0.263
MOD_CK1_1	236	242	PF00069	0.389
MOD_CK2_1	23	29	PF00069	0.412
MOD_CK2_1	236	242	PF00069	0.389
MOD_CK2_1	316	322	PF00069	0.403
MOD_GlcNHglycan	116	119	PF01048	0.326
MOD_GlcNHglycan	122	125	PF01048	0.386
MOD_GlcNHglycan	192	195	PF01048	0.358
MOD_GlcNHglycan	235	238	PF01048	0.403
MOD_GlcNHglycan	331	334	PF01048	0.313
MOD_GlcNHglycan	46	49	PF01048	0.411
MOD_GSK3_1	106	113	PF00069	0.327
MOD_GSK3_1	114	121	PF00069	0.243
MOD_GSK3_1	229	236	PF00069	0.340
MOD_GSK3_1	23	30	PF00069	0.498
MOD_GSK3_1	249	256	PF00069	0.453
MOD_GSK3_1	258	265	PF00069	0.316
MOD_GSK3_1	267	274	PF00069	0.262
MOD_GSK3_1	58	65	PF00069	0.263
MOD_N-GLC_1	87	92	PF02516	0.271
MOD_NEK2_1	105	110	PF00069	0.263
MOD_NEK2_1	114	119	PF00069	0.263
MOD_NEK2_1	219	224	PF00069	0.342
MOD_NEK2_1	233	238	PF00069	0.365
MOD_NEK2_1	272	277	PF00069	0.403
MOD_NEK2_1	44	49	PF00069	0.395
MOD_PIKK_1	347	353	PF00454	0.415
MOD_PKA_2	180	186	PF00069	0.263
MOD_PKA_2	219	225	PF00069	0.374
MOD_PKA_2	23	29	PF00069	0.444
MOD_PKA_2	249	255	PF00069	0.387
MOD_PKA_2	329	335	PF00069	0.393
MOD_Plk_1	244	250	PF00069	0.377
MOD_Plk_1	258	264	PF00069	0.318
MOD_Plk_2-3	141	147	PF00069	0.151
MOD_Plk_4	107	113	PF00069	0.263
MOD_Plk_4	244	250	PF00069	0.370
MOD_Plk_4	27	33	PF00069	0.515
MOD_Plk_4	272	278	PF00069	0.441
MOD_ProDKin_1	253	259	PF00069	0.263
MOD_SUMO_for_1	277	280	PF00179	0.403
MOD_SUMO_rev_2	305	313	PF00179	0.278
MOD_SUMO_rev_2	8	13	PF00179	0.588
TRG_ER_diArg_1	151	153	PF00400	0.293
TRG_ER_diArg_1	197	200	PF00400	0.494
TRG_ER_diArg_1	226	228	PF00400	0.349
TRG_NES_CRM1_1	296	309	PF08389	0.348
TRG_Pf-PMV_PEXEL_1	42	46	PF00026	0.401

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P564	Leptomonas seymouri	86%	99%
A0A0N0P777	Leptomonas seymouri	38%	100%
A0A0N1IAI3	Leptomonas seymouri	30%	100%
A0A0N1PCT2	Leptomonas seymouri	41%	100%
A0A0S4IM83	Bodo saltans	35%	100%
A0A0S4JFI8	Bodo saltans	37%	100%
A0A0S4JGB9	Bodo saltans	61%	96%
A0A1X0NN25	Trypanosomatidae	32%	100%
A0A1X0P333	Trypanosomatidae	42%	100%
A0A1X0P3R4	Trypanosomatidae	38%	100%
A0A1X0P5L7	Trypanosomatidae	73%	100%
A0A3Q8IDA5	Leishmania donovani	38%	100%
A0A3Q8IVD9	Leishmania donovani	97%	100%
A0A3R7KCC2	Trypanosoma rangeli	70%	100%
A0A3R7KEM0	Trypanosoma rangeli	41%	100%
A0A3R7KKZ5	Trypanosoma rangeli	32%	100%
A0A3R7LYZ3	Trypanosoma rangeli	38%	100%
A0A3S7X3R0	Leishmania donovani	39%	100%
A0A3S7XCG1	Leishmania donovani	31%	100%
A0B6D7	Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)	28%	78%
A1RSA2	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	39%	100%
A1RSA3	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	25%	86%
A1RV38	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	41%	100%
A1RWU7	Thermofilum pendens (strain DSM 2475 / Hrk 5)	39%	100%
A2SQR6	Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)	24%	76%
A2SQT3	Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)	35%	100%
A3CUX9	Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)	35%	100%
A3DNV8	Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)	26%	86%
A3DNV9	Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)	38%	100%
A3MS28	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	40%	100%
A4FZ74	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	35%	100%
A4FZL6	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	29%	75%
A4HFI1	Leishmania braziliensis	39%	100%
A4HIJ5	Leishmania braziliensis	39%	100%
A4HMZ2	Leishmania braziliensis	93%	100%
A4HQJ4	Leishmania braziliensis	32%	100%
A4I5T9	Leishmania infantum	39%	100%
A4IBL6	Leishmania infantum	97%	100%
A4WGV2	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	39%	100%
A4WGV3	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	26%	86%
A4WLY0	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	40%	100%
A5UMF3	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	34%	100%
A6US36	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	34%	100%
A6VIW1	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	29%	76%
A6VJ61	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	36%	100%
A7I8Y0	Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)	35%	100%
A9A6K6	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	36%	100%
A9A6N2	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	29%	75%
B0R7H7	Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)	38%	100%
B1YC69	Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta)	24%	86%
B9LPV1	Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34)	29%	73%
C9ZR59	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
C9ZZ23	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	100%
D0A3P3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
D0A8F2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AD32	Leishmania major	38%	100%
E9AFE9	Leishmania major	96%	100%
E9AHC5	Leishmania infantum	38%	100%
E9AI03	Leishmania infantum	31%	100%
E9AUA7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AYV6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9B134	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
O14003	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	100%
O26343	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	35%	100%
O28219	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	39%	100%
O74111	Blastobotrys adeninivorans	43%	100%
O94449	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	100%
P34429	Caenorhabditis elegans	44%	99%
P35249	Homo sapiens	37%	100%
P35250	Homo sapiens	36%	100%
P38251	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
P38629	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	43%	100%
P40339	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	100%
P40348	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	100%
P40937	Homo sapiens	47%	100%
P53033	Gallus gallus	36%	100%
P53034	Drosophila melanogaster	34%	100%
P60373	Nanoarchaeum equitans (strain Kin4-M)	26%	85%
P60374	Nanoarchaeum equitans (strain Kin4-M)	35%	100%
Q05B83	Bos taurus	37%	100%
Q09843	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	100%
Q0W037	Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)	37%	100%
Q12TX1	Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)	27%	73%
Q2FQT9	Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)	33%	100%
Q2NH89	Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)	35%	100%
Q3ITJ2	Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara)	36%	100%
Q46C63	Methanosarcina barkeri (strain Fusaro / DSM 804)	34%	100%
Q4JAB0	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	37%	100%
Q4Q084	Leishmania major	32%	100%
Q4Q732	Leishmania major	39%	100%
Q54BN3	Dictyostelium discoideum	30%	100%
Q54E21	Dictyostelium discoideum	36%	100%
Q54MD4	Dictyostelium discoideum	39%	100%
Q54ST4	Dictyostelium discoideum	47%	100%
Q5JHP1	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	27%	73%
Q5UP47	Acanthamoeba polyphaga mimivirus	37%	100%
Q5UQ47	Acanthamoeba polyphaga mimivirus	26%	100%
Q5UZE5	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	35%	100%
Q641W4	Rattus norvegicus	35%	100%
Q6L0P4	Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)	24%	89%
Q6L1I0	Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)	33%	100%
Q6M044	Methanococcus maripaludis (strain S2 / LL)	36%	100%
Q6YZ54	Oryza sativa subsp. japonica	46%	100%
Q7XRX1	Oryza sativa subsp. japonica	35%	100%
Q852K3	Oryza sativa subsp. japonica	28%	100%
Q89A95	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	23%	98%
Q8K983	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	20%	100%
Q8PVY4	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	34%	100%
Q8SQM0	Encephalitozoon cuniculi (strain GB-M1)	35%	100%
Q8TSX5	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	33%	100%
Q8VXX4	Arabidopsis thaliana	27%	100%
Q8X082	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	31%	100%
Q8ZWS2	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	39%	100%
Q8ZYK3	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	25%	86%
Q8ZYK4	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	40%	100%
Q93ZX1	Arabidopsis thaliana	37%	100%
Q975D3	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	39%	100%
Q977Z9	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	32%	100%
Q99J62	Mus musculus	37%	100%
Q9CAM7	Arabidopsis thaliana	37%	100%
Q9CAQ8	Arabidopsis thaliana	48%	99%
Q9D0F6	Mus musculus	47%	100%
Q9FXM3	Oryza sativa subsp. japonica	38%	100%
Q9HI47	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	31%	100%
Q9HIP7	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	23%	87%
Q9HN27	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	38%	100%
Q9UXF5	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	37%	100%
Q9WUK4	Mus musculus	35%	100%
Q9YBS5	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	28%	76%
Q9YBS7	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	37%	100%
V5BM57	Trypanosoma cruzi	32%	100%
V5BMW7	Trypanosoma cruzi	37%	100%
V5C2V9	Trypanosoma cruzi	74%	100%