Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B6K3_LEIMU

TriTrypDb:

LmxM.34.3240

Length:

799

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6K3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6K3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	597	601	PF00656	0.787
CLV_NRD_NRD_1	121	123	PF00675	0.666
CLV_NRD_NRD_1	23	25	PF00675	0.515
CLV_NRD_NRD_1	251	253	PF00675	0.466
CLV_NRD_NRD_1	260	262	PF00675	0.483
CLV_NRD_NRD_1	353	355	PF00675	0.547
CLV_NRD_NRD_1	436	438	PF00675	0.441
CLV_NRD_NRD_1	501	503	PF00675	0.582
CLV_NRD_NRD_1	616	618	PF00675	0.653
CLV_NRD_NRD_1	640	642	PF00675	0.598
CLV_NRD_NRD_1	704	706	PF00675	0.754
CLV_NRD_NRD_1	730	732	PF00675	0.683
CLV_PCSK_KEX2_1	121	123	PF00082	0.621
CLV_PCSK_KEX2_1	213	215	PF00082	0.574
CLV_PCSK_KEX2_1	23	25	PF00082	0.515
CLV_PCSK_KEX2_1	251	253	PF00082	0.481
CLV_PCSK_KEX2_1	260	262	PF00082	0.530
CLV_PCSK_KEX2_1	353	355	PF00082	0.559
CLV_PCSK_KEX2_1	425	427	PF00082	0.533
CLV_PCSK_KEX2_1	436	438	PF00082	0.374
CLV_PCSK_KEX2_1	500	502	PF00082	0.567
CLV_PCSK_KEX2_1	616	618	PF00082	0.651
CLV_PCSK_KEX2_1	640	642	PF00082	0.603
CLV_PCSK_KEX2_1	703	705	PF00082	0.791
CLV_PCSK_KEX2_1	730	732	PF00082	0.681
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.574
CLV_PCSK_PC1ET2_1	425	427	PF00082	0.614
CLV_PCSK_PC7_1	612	618	PF00082	0.607
CLV_PCSK_SKI1_1	109	113	PF00082	0.621
CLV_PCSK_SKI1_1	192	196	PF00082	0.540
CLV_PCSK_SKI1_1	389	393	PF00082	0.551
CLV_PCSK_SKI1_1	674	678	PF00082	0.736
CLV_PCSK_SKI1_1	88	92	PF00082	0.617
CLV_Separin_Metazoa	577	581	PF03568	0.775
DEG_APCC_DBOX_1	140	148	PF00400	0.631
DEG_APCC_DBOX_1	189	197	PF00400	0.574
DEG_Nend_UBRbox_2	1	3	PF02207	0.631
DOC_CYCLIN_yClb5_NLxxxL_5	401	410	PF00134	0.593
DOC_MAPK_gen_1	260	268	PF00069	0.477
DOC_MAPK_gen_1	730	738	PF00069	0.716
DOC_MIT_MIM_1	369	377	PF04212	0.443
DOC_USP7_MATH_1	100	104	PF00917	0.585
DOC_USP7_MATH_1	114	118	PF00917	0.583
DOC_USP7_MATH_1	139	143	PF00917	0.459
DOC_USP7_MATH_1	54	58	PF00917	0.582
DOC_USP7_MATH_1	570	574	PF00917	0.414
DOC_USP7_MATH_1	598	602	PF00917	0.724
DOC_USP7_MATH_1	719	723	PF00917	0.595
DOC_USP7_MATH_1	724	728	PF00917	0.589
DOC_USP7_MATH_1	752	756	PF00917	0.662
DOC_USP7_MATH_1	758	762	PF00917	0.606
DOC_USP7_UBL2_3	105	109	PF12436	0.631
DOC_WW_Pin1_4	601	606	PF00397	0.476
LIG_14-3-3_CanoR_1	261	267	PF00244	0.609
LIG_14-3-3_CanoR_1	55	59	PF00244	0.577
LIG_14-3-3_CanoR_1	563	571	PF00244	0.616
LIG_14-3-3_CanoR_1	572	577	PF00244	0.643
LIG_14-3-3_CanoR_1	696	702	PF00244	0.815
LIG_APCC_ABBAyCdc20_2	263	269	PF00400	0.494
LIG_BRCT_BRCA1_1	721	725	PF00533	0.486
LIG_Clathr_ClatBox_1	193	197	PF01394	0.577
LIG_deltaCOP1_diTrp_1	429	438	PF00928	0.448
LIG_deltaCOP1_diTrp_1	772	782	PF00928	0.718
LIG_DLG_GKlike_1	572	579	PF00625	0.430
LIG_FHA_1	111	117	PF00498	0.580
LIG_FHA_1	323	329	PF00498	0.660
LIG_FHA_1	594	600	PF00498	0.735
LIG_FHA_1	781	787	PF00498	0.600
LIG_FHA_2	206	212	PF00498	0.550
LIG_FHA_2	332	338	PF00498	0.698
LIG_FHA_2	383	389	PF00498	0.579
LIG_FHA_2	595	601	PF00498	0.745
LIG_KLC1_Yacidic_2	223	228	PF13176	0.502
LIG_LIR_Gen_1	170	179	PF02991	0.532
LIG_LIR_Gen_1	781	788	PF02991	0.643
LIG_LIR_Nem_3	170	174	PF02991	0.511
LIG_LIR_Nem_3	484	488	PF02991	0.426
LIG_LIR_Nem_3	781	785	PF02991	0.642
LIG_NRBOX	86	92	PF00104	0.633
LIG_PCNA_PIPBox_1	293	302	PF02747	0.612
LIG_Pex14_1	431	435	PF04695	0.444
LIG_RPA_C_Fungi	50	62	PF08784	0.551
LIG_SH2_SRC	226	229	PF00017	0.481
LIG_SH2_STAP1	171	175	PF00017	0.567
LIG_SH2_STAP1	345	349	PF00017	0.634
LIG_SH2_STAP1	574	578	PF00017	0.439
LIG_SH2_STAP1	66	70	PF00017	0.507
LIG_SH2_STAT3	440	443	PF00017	0.297
LIG_SH2_STAT5	226	229	PF00017	0.481
LIG_SH2_STAT5	299	302	PF00017	0.617
LIG_SH2_STAT5	440	443	PF00017	0.297
LIG_SH3_3	581	587	PF00018	0.785
LIG_SH3_3	713	719	PF00018	0.692
LIG_TRAF2_1	208	211	PF00917	0.577
LIG_TRAF2_1	283	286	PF00917	0.540
LIG_TRAF2_1	301	304	PF00917	0.363
LIG_TRAF2_1	316	319	PF00917	0.515
LIG_TRAF2_1	418	421	PF00917	0.597
LIG_TRAF2_1	448	451	PF00917	0.522
LIG_TRAF2_1	80	83	PF00917	0.461
MOD_CK1_1	601	607	PF00069	0.555
MOD_CK1_1	765	771	PF00069	0.658
MOD_CK1_1	778	784	PF00069	0.739
MOD_CK2_1	159	165	PF00069	0.539
MOD_CK2_1	205	211	PF00069	0.563
MOD_CK2_1	31	37	PF00069	0.547
MOD_CK2_1	380	386	PF00069	0.478
MOD_CK2_1	40	46	PF00069	0.570
MOD_CK2_1	424	430	PF00069	0.517
MOD_CK2_1	768	774	PF00069	0.761
MOD_Cter_Amidation	351	354	PF01082	0.460
MOD_GlcNHglycan	102	105	PF01048	0.478
MOD_GlcNHglycan	116	119	PF01048	0.537
MOD_GlcNHglycan	183	186	PF01048	0.550
MOD_GlcNHglycan	30	36	PF01048	0.505
MOD_GlcNHglycan	613	616	PF01048	0.788
MOD_GlcNHglycan	635	638	PF01048	0.761
MOD_GlcNHglycan	667	670	PF01048	0.676
MOD_GlcNHglycan	721	724	PF01048	0.645
MOD_GlcNHglycan	777	780	PF01048	0.716
MOD_GlcNHglycan	92	96	PF01048	0.714
MOD_GSK3_1	110	117	PF00069	0.513
MOD_GSK3_1	139	146	PF00069	0.594
MOD_GSK3_1	420	427	PF00069	0.551
MOD_GSK3_1	594	601	PF00069	0.790
MOD_GSK3_1	719	726	PF00069	0.498
MOD_GSK3_1	753	760	PF00069	0.650
MOD_GSK3_1	786	793	PF00069	0.642
MOD_N-GLC_1	601	606	PF02516	0.618
MOD_N-GLC_1	762	767	PF02516	0.742
MOD_NEK2_1	196	201	PF00069	0.586
MOD_NEK2_1	245	250	PF00069	0.601
MOD_NEK2_1	377	382	PF00069	0.549
MOD_NEK2_1	460	465	PF00069	0.561
MOD_NEK2_1	631	636	PF00069	0.490
MOD_NEK2_1	665	670	PF00069	0.658
MOD_NEK2_1	677	682	PF00069	0.717
MOD_NEK2_1	791	796	PF00069	0.678
MOD_PIKK_1	205	211	PF00454	0.575
MOD_PIKK_1	377	383	PF00454	0.584
MOD_PIKK_1	394	400	PF00454	0.448
MOD_PIKK_1	40	46	PF00454	0.630
MOD_PIKK_1	518	524	PF00454	0.581
MOD_PIKK_1	564	570	PF00454	0.634
MOD_PIKK_1	762	768	PF00454	0.670
MOD_PIKK_1	792	798	PF00454	0.651
MOD_PKA_2	262	268	PF00069	0.588
MOD_PKA_2	40	46	PF00069	0.607
MOD_PKA_2	54	60	PF00069	0.429
MOD_PKA_2	611	617	PF00069	0.781
MOD_PKA_2	697	703	PF00069	0.777
MOD_PKA_2	729	735	PF00069	0.754
MOD_Plk_1	196	202	PF00069	0.600
MOD_Plk_1	245	251	PF00069	0.601
MOD_Plk_1	411	417	PF00069	0.568
MOD_Plk_1	708	714	PF00069	0.724
MOD_Plk_1	762	768	PF00069	0.694
MOD_Plk_4	143	149	PF00069	0.627
MOD_Plk_4	196	202	PF00069	0.495
MOD_Plk_4	412	418	PF00069	0.327
MOD_ProDKin_1	601	607	PF00069	0.481
MOD_SUMO_for_1	62	65	PF00179	0.537
MOD_SUMO_rev_2	30	35	PF00179	0.541
MOD_SUMO_rev_2	65	71	PF00179	0.546
TRG_DiLeu_BaEn_1	143	148	PF01217	0.536
TRG_DiLeu_BaEn_1	189	194	PF01217	0.572
TRG_DiLeu_BaEn_1	236	241	PF01217	0.565
TRG_DiLeu_BaEn_1	366	371	PF01217	0.442
TRG_DiLeu_BaEn_4	82	88	PF01217	0.340
TRG_DiLeu_LyEn_5	189	194	PF01217	0.572
TRG_DiLeu_LyEn_5	236	241	PF01217	0.591
TRG_ENDOCYTIC_2	171	174	PF00928	0.568
TRG_ER_diArg_1	120	122	PF00400	0.661
TRG_ER_diArg_1	22	24	PF00400	0.528
TRG_ER_diArg_1	260	263	PF00400	0.610
TRG_ER_diArg_1	435	437	PF00400	0.442
TRG_ER_diArg_1	499	502	PF00400	0.534
TRG_ER_diArg_1	616	618	PF00400	0.643
TRG_ER_diArg_1	702	705	PF00400	0.782
TRG_ER_diArg_1	730	733	PF00400	0.693
TRG_ER_diArg_1	738	741	PF00400	0.728
TRG_NES_CRM1_1	455	470	PF08389	0.547
TRG_NES_CRM1_1	553	568	PF08389	0.616
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.625
TRG_Pf-PMV_PEXEL_1	192	197	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	239	244	PF00026	0.571
TRG_Pf-PMV_PEXEL_1	408	412	PF00026	0.539
TRG_Pf-PMV_PEXEL_1	472	477	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	652	656	PF00026	0.619
TRG_Pf-PMV_PEXEL_1	88	92	PF00026	0.645

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJW5	Leptomonas seymouri	58%	82%
A0A0S4IKJ1	Bodo saltans	33%	100%
A0A1X0P6F2	Trypanosomatidae	36%	92%
A0A3Q8IIH8	Leishmania donovani	90%	100%
A0A422MWV3	Trypanosoma rangeli	33%	95%
A4HMZ1	Leishmania braziliensis	77%	100%
A4IBL5	Leishmania infantum	89%	100%
C9ZZ25	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	92%
E9AFE8	Leishmania major	88%	100%
V5BCX8	Trypanosoma cruzi	32%	95%