LeishMANIAdb
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Putative cystathione gamma lyase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative cystathione gamma lyase
Gene product:
cystathione gamma lyase, putative
Species:
Leishmania mexicana
UniProt:
E9B6K2_LEIMU
TriTrypDb:
LmxM.34.3230
Length:
410

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 2
Pissara et al. yes yes: 10
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 4
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 2
GO:0016020 membrane 2 1

Expansion

Sequence features

E9B6K2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6K2

Function

Biological processes
Term Name Level Count
GO:0000096 sulfur amino acid metabolic process 4 12
GO:0006082 organic acid metabolic process 3 12
GO:0006520 amino acid metabolic process 3 12
GO:0006534 cysteine metabolic process 5 12
GO:0006790 sulfur compound metabolic process 3 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009069 serine family amino acid metabolic process 5 12
GO:0009092 homoserine metabolic process 6 12
GO:0009987 cellular process 1 12
GO:0019346 transsulfuration 6 12
GO:0019752 carboxylic acid metabolic process 5 12
GO:0043436 oxoacid metabolic process 4 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0044281 small molecule metabolic process 2 12
GO:0050667 homocysteine metabolic process 5 12
GO:0071704 organic substance metabolic process 2 12
GO:1901564 organonitrogen compound metabolic process 3 12
GO:1901605 alpha-amino acid metabolic process 4 12
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006152 purine nucleoside catabolic process 6 1
GO:0006575 cellular modified amino acid metabolic process 3 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0009056 catabolic process 2 1
GO:0009063 amino acid catabolic process 4 1
GO:0009116 nucleoside metabolic process 4 1
GO:0009119 ribonucleoside metabolic process 5 1
GO:0009164 nucleoside catabolic process 5 1
GO:0016054 organic acid catabolic process 4 1
GO:0019439 aromatic compound catabolic process 4 1
GO:0019510 S-adenosylhomocysteine catabolic process 5 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0034655 nucleobase-containing compound catabolic process 4 1
GO:0034656 nucleobase-containing small molecule catabolic process 4 1
GO:0042219 cellular modified amino acid catabolic process 4 1
GO:0042278 purine nucleoside metabolic process 5 1
GO:0042454 ribonucleoside catabolic process 6 1
GO:0044248 cellular catabolic process 3 1
GO:0044270 cellular nitrogen compound catabolic process 4 1
GO:0044273 sulfur compound catabolic process 4 1
GO:0044282 small molecule catabolic process 3 1
GO:0046128 purine ribonucleoside metabolic process 6 1
GO:0046130 purine ribonucleoside catabolic process 7 1
GO:0046395 carboxylic acid catabolic process 5 1
GO:0046483 heterocycle metabolic process 3 1
GO:0046498 S-adenosylhomocysteine metabolic process 4 1
GO:0046700 heterocycle catabolic process 4 1
GO:0055086 nucleobase-containing small molecule metabolic process 3 1
GO:0072521 purine-containing compound metabolic process 4 1
GO:0072523 purine-containing compound catabolic process 5 1
GO:1901135 carbohydrate derivative metabolic process 3 1
GO:1901136 carbohydrate derivative catabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
GO:1901361 organic cyclic compound catabolic process 4 1
GO:1901565 organonitrogen compound catabolic process 4 1
GO:1901575 organic substance catabolic process 3 1
GO:1901606 alpha-amino acid catabolic process 5 1
GO:1901657 glycosyl compound metabolic process 4 1
GO:1901658 glycosyl compound catabolic process 5 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0005488 binding 1 12
GO:0016740 transferase activity 2 6
GO:0016829 lyase activity 2 12
GO:0019842 vitamin binding 3 12
GO:0030170 pyridoxal phosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0070279 vitamin B6 binding 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:1901363 heterocyclic compound binding 2 12
GO:0004123 cystathionine gamma-lyase activity 4 2
GO:0016846 carbon-sulfur lyase activity 3 2
GO:0044540 L-cystine L-cysteine-lyase (deaminating) 4 2
GO:0080146 L-cysteine desulfhydrase activity 4 2
GO:0003962 cystathionine gamma-synthase activity 4 1
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 3 1
GO:0102028 cystathionine gamma-synthase activity (acts on O-phosphohomoserine) 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 56 60 PF00656 0.270
CLV_NRD_NRD_1 336 338 PF00675 0.297
CLV_PCSK_KEX2_1 336 338 PF00082 0.339
CLV_PCSK_SKI1_1 131 135 PF00082 0.303
DEG_SPOP_SBC_1 100 104 PF00917 0.337
DOC_CKS1_1 43 48 PF01111 0.303
DOC_MAPK_MEF2A_6 70 78 PF00069 0.396
DOC_PP1_RVXF_1 129 135 PF00149 0.303
DOC_USP7_MATH_1 105 109 PF00917 0.337
DOC_USP7_MATH_1 179 183 PF00917 0.379
DOC_USP7_MATH_1 354 358 PF00917 0.303
DOC_USP7_UBL2_3 157 161 PF12436 0.339
DOC_WW_Pin1_4 164 169 PF00397 0.303
DOC_WW_Pin1_4 253 258 PF00397 0.318
DOC_WW_Pin1_4 42 47 PF00397 0.303
LIG_14-3-3_CanoR_1 245 251 PF00244 0.298
LIG_14-3-3_CanoR_1 344 349 PF00244 0.303
LIG_14-3-3_CanoR_1 386 394 PF00244 0.330
LIG_Actin_WH2_2 257 275 PF00022 0.295
LIG_Actin_WH2_2 387 404 PF00022 0.330
LIG_BIR_II_1 1 5 PF00653 0.514
LIG_BRCT_BRCA1_1 49 53 PF00533 0.318
LIG_Clathr_ClatBox_1 173 177 PF01394 0.379
LIG_FHA_1 101 107 PF00498 0.303
LIG_FHA_1 158 164 PF00498 0.303
LIG_FHA_1 170 176 PF00498 0.303
LIG_FHA_1 198 204 PF00498 0.321
LIG_FHA_1 217 223 PF00498 0.466
LIG_FHA_1 245 251 PF00498 0.330
LIG_FHA_1 25 31 PF00498 0.303
LIG_FHA_1 267 273 PF00498 0.303
LIG_FHA_1 38 44 PF00498 0.303
LIG_FHA_1 49 55 PF00498 0.303
LIG_FHA_1 73 79 PF00498 0.396
LIG_FHA_2 140 146 PF00498 0.303
LIG_FHA_2 369 375 PF00498 0.318
LIG_IRF3_LxIS_1 158 165 PF10401 0.396
LIG_LIR_Gen_1 140 149 PF02991 0.303
LIG_LIR_Gen_1 381 391 PF02991 0.303
LIG_LIR_Nem_3 140 144 PF02991 0.303
LIG_LIR_Nem_3 381 387 PF02991 0.303
LIG_LYPXL_S_1 298 302 PF13949 0.296
LIG_LYPXL_yS_3 299 302 PF13949 0.282
LIG_PCNA_yPIPBox_3 243 255 PF02747 0.379
LIG_PTB_Apo_2 117 124 PF02174 0.379
LIG_PTB_Apo_2 85 92 PF02174 0.339
LIG_PTB_Phospho_1 117 123 PF10480 0.379
LIG_PTB_Phospho_1 85 91 PF10480 0.339
LIG_REV1ctd_RIR_1 131 140 PF16727 0.318
LIG_SH2_CRK 91 95 PF00017 0.339
LIG_SH2_SRC 221 224 PF00017 0.446
LIG_SH2_STAP1 68 72 PF00017 0.318
LIG_SH2_STAT5 221 224 PF00017 0.375
LIG_SH2_STAT5 68 71 PF00017 0.314
LIG_SH2_STAT5 91 94 PF00017 0.428
LIG_SH3_3 165 171 PF00018 0.342
LIG_SH3_3 251 257 PF00018 0.330
LIG_SH3_3 294 300 PF00018 0.282
LIG_SH3_3 339 345 PF00018 0.303
LIG_SH3_4 157 164 PF00018 0.313
LIG_SUMO_SIM_anti_2 172 177 PF11976 0.396
LIG_SUMO_SIM_anti_2 212 219 PF11976 0.316
LIG_SUMO_SIM_anti_2 75 80 PF11976 0.396
LIG_SUMO_SIM_par_1 171 177 PF11976 0.303
LIG_SUMO_SIM_par_1 74 80 PF11976 0.364
LIG_TYR_ITIM 297 302 PF00017 0.303
LIG_UBA3_1 397 402 PF00899 0.337
LIG_WRC_WIRS_1 106 111 PF05994 0.337
MOD_CK1_1 108 114 PF00069 0.240
MOD_CK1_1 357 363 PF00069 0.303
MOD_CK1_1 57 63 PF00069 0.493
MOD_CK1_1 9 15 PF00069 0.499
MOD_CK2_1 344 350 PF00069 0.303
MOD_Cter_Amidation 334 337 PF01082 0.296
MOD_GlcNHglycan 110 113 PF01048 0.242
MOD_GlcNHglycan 14 17 PF01048 0.487
MOD_GlcNHglycan 70 73 PF01048 0.323
MOD_GSK3_1 100 107 PF00069 0.303
MOD_GSK3_1 211 218 PF00069 0.318
MOD_GSK3_1 268 275 PF00069 0.364
MOD_GSK3_1 64 71 PF00069 0.325
MOD_GSK3_1 90 97 PF00069 0.303
MOD_N-GLC_1 368 373 PF02516 0.318
MOD_N-GLC_2 120 122 PF02516 0.379
MOD_N-GLC_2 90 92 PF02516 0.318
MOD_NEK2_1 139 144 PF00069 0.330
MOD_NEK2_1 215 220 PF00069 0.330
MOD_NEK2_1 272 277 PF00069 0.357
MOD_NEK2_1 338 343 PF00069 0.303
MOD_NEK2_1 99 104 PF00069 0.306
MOD_PIKK_1 244 250 PF00454 0.303
MOD_PKA_2 244 250 PF00069 0.298
MOD_PKA_2 272 278 PF00069 0.321
MOD_PKA_2 385 391 PF00069 0.303
MOD_Plk_1 139 145 PF00069 0.379
MOD_Plk_1 194 200 PF00069 0.328
MOD_Plk_1 211 217 PF00069 0.303
MOD_Plk_1 225 231 PF00069 0.303
MOD_Plk_4 105 111 PF00069 0.272
MOD_Plk_4 14 20 PF00069 0.457
MOD_Plk_4 169 175 PF00069 0.405
MOD_Plk_4 211 217 PF00069 0.358
MOD_Plk_4 354 360 PF00069 0.303
MOD_Plk_4 49 55 PF00069 0.303
MOD_Plk_4 90 96 PF00069 0.370
MOD_ProDKin_1 164 170 PF00069 0.303
MOD_ProDKin_1 253 259 PF00069 0.318
MOD_ProDKin_1 42 48 PF00069 0.303
MOD_SUMO_rev_2 237 244 PF00179 0.325
TRG_ENDOCYTIC_2 299 302 PF00928 0.303
TRG_ENDOCYTIC_2 91 94 PF00928 0.339
TRG_ER_diArg_1 336 338 PF00400 0.339
TRG_ER_FFAT_2 107 114 PF00635 0.233
TRG_Pf-PMV_PEXEL_1 336 340 PF00026 0.303

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0C2WKN7 Amanita muscaria (strain Koide BX008) 21% 68%
A0A0D2YG02 Fusarium oxysporum f. sp. lycopersici (strain 4287 / CBS 123668 / FGSC 9935 / NRRL 34936) 29% 95%
A0A0J6G7P5 Pseudomonas deceptionensis 38% 100%
A0A0N0P3U0 Leptomonas seymouri 30% 80%
A0A0N0P8H0 Leptomonas seymouri 26% 100%
A0A0N1HW05 Leptomonas seymouri 86% 100%
A0A0N1PG90 Leptomonas seymouri 24% 93%
A0A0S4IZX4 Bodo saltans 76% 100%
A0A1X0NP01 Trypanosomatidae 31% 84%
A0A1X0P5N4 Trypanosomatidae 80% 100%
A0A3Q8ILD8 Leishmania donovani 25% 100%
A0A3R7R3B5 Trypanosoma rangeli 80% 100%
A0A3S7WSY5 Leishmania donovani 31% 89%
A0A3S7X9N0 Leishmania donovani 98% 100%
A2RM21 Lactococcus lactis subsp. cremoris (strain MG1363) 40% 100%
A4H7K6 Leishmania braziliensis 31% 100%
A4HKQ5 Leishmania braziliensis 24% 100%
A4HMZ0 Leishmania braziliensis 93% 100%
A4HVY9 Leishmania infantum 31% 79%
A4I885 Leishmania infantum 26% 100%
A4IBL4 Leishmania infantum 98% 100%
C9ZZ26 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 78% 92%
E9AFE7 Leishmania major 97% 100%
E9APP1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9B343 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
O05394 Bacillus subtilis (strain 168) 41% 100%
O13326 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 31% 96%
O31631 Bacillus subtilis (strain 168) 34% 100%
O31632 Bacillus subtilis (strain 168) 42% 100%
O42851 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 30% 100%
O94350 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 31% 100%
P00935 Escherichia coli (strain K12) 33% 100%
P06106 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 31% 92%
P06721 Escherichia coli (strain K12) 28% 100%
P0A4K2 Lactococcus lactis subsp. lactis (strain IL1403) 40% 100%
P0C2T9 Lactococcus lactis subsp. cremoris 39% 100%
P13254 Pseudomonas putida 38% 100%
P18757 Rattus norvegicus 41% 100%
P18949 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 27% 100%
P24601 Herpetosiphon aurantiacus 43% 100%
P31373 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 39% 100%
P32929 Homo sapiens 39% 100%
P38716 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 25% 100%
P43623 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 100%
P44502 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 35% 100%
P44527 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 26% 100%
P46807 Mycobacterium leprae (strain TN) 41% 100%
P50125 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 32% 94%
P53101 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 27% 88%
P53780 Arabidopsis thaliana 35% 88%
P55216 Caenorhabditis elegans 38% 100%
P55217 Arabidopsis thaliana 35% 73%
P55218 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 34% 100%
P56069 Helicobacter pylori (strain ATCC 700392 / 26695) 40% 100%
P66876 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) 42% 100%
P94890 Leptospira meyeri 33% 93%
P9WGB4 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 33% 100%
P9WGB5 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 33% 100%
P9WGB6 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 42% 100%
P9WGB7 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 42% 100%
Q07703 Bordetella avium 31% 100%
Q19QT7 Sus scrofa 40% 100%
Q1K8G0 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 37% 90%
Q1M0P5 Helicobacter pylori 40% 100%
Q4L332 Staphylococcus haemolyticus (strain JCSC1435) 34% 100%
Q4Q511 Leishmania major 26% 100%
Q4QFT8 Leishmania major 31% 100%
Q52811 Rhizobium leguminosarum bv. viciae (strain 3841) 29% 100%
Q55DV9 Dictyostelium discoideum 40% 100%
Q58DW2 Bos taurus 39% 100%
Q59829 Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) 31% 100%
Q5MNH8 Epichloe uncinata 30% 87%
Q5SJ58 Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) 31% 100%
Q5SK88 Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) 31% 97%
Q60HG7 Macaca fascicularis 40% 100%
Q73GL9 Wolbachia pipientis wMel 29% 100%
Q73KL7 Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104) 44% 100%
Q79VI4 Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) 33% 94%
Q7MX71 Porphyromonas gingivalis (strain ATCC BAA-308 / W83) 42% 100%
Q826W3 Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680) 32% 99%
Q83A83 Coxiella burnetii (strain RSA 493 / Nine Mile phase I) 40% 100%
Q8J0B2 Epichloe uncinata 29% 87%
Q8L0X4 Fusobacterium nucleatum subsp. polymorphum 38% 100%
Q8RDT4 Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355) 37% 100%
Q8VCN5 Mus musculus 41% 100%
Q92441 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 32% 92%
Q9C876 Arabidopsis thaliana 33% 100%
Q9SGU9 Arabidopsis thaliana 30% 93%
Q9WZY4 Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) 35% 95%
Q9X0Z7 Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) 27% 100%
Q9ZMW7 Helicobacter pylori (strain J99 / ATCC 700824) 38% 100%
S0DUX5 Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831) 29% 95%
V5DUQ5 Trypanosoma cruzi 80% 100%
W7MS09 Gibberella moniliformis (strain M3125 / FGSC 7600) 29% 95%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS