LeishMANIAdb
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Thioredoxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Thioredoxin domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B6K1_LEIMU
TriTrypDb:
LmxM.34.3220
Length:
168

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005930 axoneme 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9B6K1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6K1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 12 14 PF00675 0.722
CLV_PCSK_SKI1_1 36 40 PF00082 0.573
CLV_PCSK_SKI1_1 72 76 PF00082 0.586
DOC_USP7_MATH_1 88 92 PF00917 0.490
DOC_USP7_UBL2_3 10 14 PF12436 0.666
DOC_WW_Pin1_4 48 53 PF00397 0.441
LIG_14-3-3_CanoR_1 36 46 PF00244 0.491
LIG_14-3-3_CanoR_1 67 76 PF00244 0.594
LIG_BIR_II_1 1 5 PF00653 0.753
LIG_FHA_1 56 62 PF00498 0.530
LIG_FHA_1 88 94 PF00498 0.469
LIG_FHA_2 28 34 PF00498 0.464
LIG_FHA_2 58 64 PF00498 0.560
LIG_FHA_2 87 93 PF00498 0.563
LIG_LIR_LC3C_4 44 49 PF02991 0.520
LIG_LIR_Nem_3 107 113 PF02991 0.458
LIG_SH2_CRK 85 89 PF00017 0.494
LIG_SH2_NCK_1 85 89 PF00017 0.494
LIG_SH3_1 15 21 PF00018 0.623
LIG_SH3_3 15 21 PF00018 0.597
LIG_SH3_3 46 52 PF00018 0.420
LIG_SUMO_SIM_anti_2 44 51 PF11976 0.511
LIG_SUMO_SIM_par_1 44 51 PF11976 0.424
LIG_TRAF2_1 144 147 PF00917 0.566
MOD_CK1_1 4 10 PF00069 0.676
MOD_CK1_1 70 76 PF00069 0.563
MOD_CK2_1 106 112 PF00069 0.201
MOD_CK2_1 57 63 PF00069 0.524
MOD_CK2_1 86 92 PF00069 0.553
MOD_GlcNHglycan 43 46 PF01048 0.524
MOD_GlcNHglycan 72 75 PF01048 0.590
MOD_GSK3_1 1 8 PF00069 0.691
MOD_GSK3_1 37 44 PF00069 0.503
MOD_GSK3_1 70 77 PF00069 0.513
MOD_GSK3_1 93 100 PF00069 0.541
MOD_N-GLC_1 68 73 PF02516 0.535
MOD_NEK2_1 1 6 PF00069 0.749
MOD_NEK2_1 104 109 PF00069 0.353
MOD_NEK2_1 131 136 PF00069 0.527
MOD_NEK2_1 68 73 PF00069 0.504
MOD_NEK2_1 97 102 PF00069 0.460
MOD_PIKK_1 131 137 PF00454 0.544
MOD_PKA_2 4 10 PF00069 0.662
MOD_Plk_4 57 63 PF00069 0.490
MOD_ProDKin_1 48 54 PF00069 0.447
TRG_DiLeu_BaEn_1 123 128 PF01217 0.449
TRG_ENDOCYTIC_2 110 113 PF00928 0.497
TRG_NLS_MonoExtC_3 9 14 PF00514 0.745
TRG_NLS_MonoExtN_4 10 17 PF00514 0.704

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PCS8 Leptomonas seymouri 53% 96%
A0A0S4JHS9 Bodo saltans 31% 100%
A0A1X0P5D6 Trypanosomatidae 44% 100%
A0A3S7X9I9 Leishmania donovani 93% 99%
A4HMY9 Leishmania braziliensis 81% 100%
A4IBL3 Leishmania infantum 92% 99%
C9ZZ27 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 98%
E9AFE6 Leishmania major 93% 100%
V5BD44 Trypanosoma cruzi 42% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS