EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

EF-hand domain pair, putative

Species:

Leishmania mexicana

UniProt:

E9B6K0_LEIMU

TriTrypDb:

LmxM.34.3210

Length:

664

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000159	protein phosphatase type 2A complex	5	1
GO:0008287	protein serine/threonine phosphatase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:1902494	catalytic complex	2	1
GO:1903293	phosphatase complex	3	1

Expansion

Sequence features

E9B6K0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6K0

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016311	dephosphorylation	5	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005509	calcium ion binding	5	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0019208	phosphatase regulator activity	3	1
GO:0019888	protein phosphatase regulator activity	4	1
GO:0030234	enzyme regulator activity	2	1
GO:0098772	molecular function regulator activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	328	332	PF00656	0.462
CLV_C14_Caspase3-7	567	571	PF00656	0.550
CLV_NRD_NRD_1	358	360	PF00675	0.297
CLV_NRD_NRD_1	596	598	PF00675	0.603
CLV_PCSK_KEX2_1	267	269	PF00082	0.571
CLV_PCSK_KEX2_1	358	360	PF00082	0.297
CLV_PCSK_KEX2_1	495	497	PF00082	0.313
CLV_PCSK_PC1ET2_1	267	269	PF00082	0.591
CLV_PCSK_PC1ET2_1	495	497	PF00082	0.313
CLV_PCSK_SKI1_1	254	258	PF00082	0.552
CLV_PCSK_SKI1_1	308	312	PF00082	0.365
CLV_PCSK_SKI1_1	317	321	PF00082	0.298
CLV_PCSK_SKI1_1	34	38	PF00082	0.592
CLV_PCSK_SKI1_1	39	43	PF00082	0.577
CLV_PCSK_SKI1_1	472	476	PF00082	0.417
CLV_PCSK_SKI1_1	624	628	PF00082	0.378
DEG_APCC_DBOX_1	33	41	PF00400	0.620
DOC_CKS1_1	165	170	PF01111	0.738
DOC_CYCLIN_RxL_1	34	47	PF00134	0.523
DOC_CYCLIN_RxL_1	561	571	PF00134	0.479
DOC_CYCLIN_RxL_1	621	632	PF00134	0.517
DOC_CYCLIN_yCln2_LP_2	217	223	PF00134	0.737
DOC_MAPK_gen_1	369	375	PF00069	0.522
DOC_MAPK_gen_1	595	603	PF00069	0.515
DOC_PP1_RVXF_1	421	427	PF00149	0.470
DOC_PP1_RVXF_1	562	569	PF00149	0.468
DOC_PP1_RVXF_1	622	629	PF00149	0.480
DOC_PP4_FxxP_1	310	313	PF00568	0.322
DOC_USP7_MATH_1	116	120	PF00917	0.689
DOC_USP7_MATH_1	231	235	PF00917	0.739
DOC_USP7_MATH_1	325	329	PF00917	0.394
DOC_USP7_MATH_1	504	508	PF00917	0.313
DOC_USP7_MATH_1	85	89	PF00917	0.751
DOC_WW_Pin1_4	107	112	PF00397	0.645
DOC_WW_Pin1_4	129	134	PF00397	0.657
DOC_WW_Pin1_4	138	143	PF00397	0.567
DOC_WW_Pin1_4	160	165	PF00397	0.612
DOC_WW_Pin1_4	167	172	PF00397	0.603
DOC_WW_Pin1_4	189	194	PF00397	0.670
DOC_WW_Pin1_4	198	203	PF00397	0.658
DOC_WW_Pin1_4	216	221	PF00397	0.547
DOC_WW_Pin1_4	245	250	PF00397	0.588
DOC_WW_Pin1_4	568	573	PF00397	0.533
DOC_WW_Pin1_4	608	613	PF00397	0.382
LIG_14-3-3_CanoR_1	237	247	PF00244	0.566
LIG_14-3-3_CanoR_1	39	44	PF00244	0.652
LIG_14-3-3_CanoR_1	503	510	PF00244	0.332
LIG_14-3-3_CanoR_1	86	90	PF00244	0.727
LIG_AP2alpha_2	632	634	PF02296	0.433
LIG_APCC_ABBA_1	299	304	PF00400	0.520
LIG_APCC_ABBAyCdc20_2	317	323	PF00400	0.459
LIG_BIR_II_1	1	5	PF00653	0.652
LIG_BRCT_BRCA1_1	241	245	PF00533	0.550
LIG_BRCT_BRCA1_1	306	310	PF00533	0.450
LIG_Clathr_ClatBox_1	475	479	PF01394	0.332
LIG_deltaCOP1_diTrp_1	647	651	PF00928	0.361
LIG_FHA_1	19	25	PF00498	0.612
LIG_FHA_1	216	222	PF00498	0.669
LIG_FHA_1	224	230	PF00498	0.678
LIG_FHA_1	234	240	PF00498	0.610
LIG_FHA_1	296	302	PF00498	0.465
LIG_FHA_1	405	411	PF00498	0.445
LIG_FHA_1	489	495	PF00498	0.384
LIG_FHA_2	255	261	PF00498	0.479
LIG_FHA_2	372	378	PF00498	0.469
LIG_FHA_2	468	474	PF00498	0.313
LIG_FHA_2	541	547	PF00498	0.417
LIG_FHA_2	600	606	PF00498	0.373
LIG_FHA_2	644	650	PF00498	0.383
LIG_FXI_DFP_1	426	430	PF00024	0.285
LIG_GBD_Chelix_1	408	416	PF00786	0.245
LIG_HCF-1_HBM_1	456	459	PF13415	0.311
LIG_LIR_Apic_2	307	313	PF02991	0.334
LIG_LIR_Apic_2	499	504	PF02991	0.417
LIG_LIR_Gen_1	371	378	PF02991	0.471
LIG_LIR_Gen_1	402	413	PF02991	0.531
LIG_LIR_Gen_1	454	462	PF02991	0.297
LIG_LIR_Gen_1	514	523	PF02991	0.297
LIG_LIR_Gen_1	550	558	PF02991	0.349
LIG_LIR_Gen_1	623	633	PF02991	0.431
LIG_LIR_Gen_1	646	656	PF02991	0.367
LIG_LIR_Nem_3	318	324	PF02991	0.336
LIG_LIR_Nem_3	349	354	PF02991	0.379
LIG_LIR_Nem_3	371	375	PF02991	0.471
LIG_LIR_Nem_3	399	403	PF02991	0.456
LIG_LIR_Nem_3	451	455	PF02991	0.328
LIG_LIR_Nem_3	456	462	PF02991	0.283
LIG_LIR_Nem_3	514	518	PF02991	0.297
LIG_LIR_Nem_3	623	628	PF02991	0.405
LIG_LIR_Nem_3	646	651	PF02991	0.365
LIG_MAD2	496	504	PF02301	0.313
LIG_NRBOX	284	290	PF00104	0.539
LIG_PALB2_WD40_1	533	541	PF16756	0.297
LIG_Pex14_2	616	620	PF04695	0.305
LIG_PTAP_UEV_1	178	183	PF05743	0.622
LIG_PTB_Apo_2	345	352	PF02174	0.428
LIG_PTB_Apo_2	614	621	PF02174	0.326
LIG_PTB_Phospho_1	345	351	PF10480	0.431
LIG_SH2_CRK	351	355	PF00017	0.430
LIG_SH2_CRK	501	505	PF00017	0.417
LIG_SH2_GRB2like	20	23	PF00017	0.557
LIG_SH2_NCK_1	347	351	PF00017	0.405
LIG_SH2_STAP1	20	24	PF00017	0.578
LIG_SH2_STAP1	455	459	PF00017	0.310
LIG_SH2_STAP1	578	582	PF00017	0.445
LIG_SH2_STAP1	656	660	PF00017	0.373
LIG_SH2_STAT5	125	128	PF00017	0.482
LIG_SH2_STAT5	20	23	PF00017	0.545
LIG_SH2_STAT5	384	387	PF00017	0.458
LIG_SH2_STAT5	452	455	PF00017	0.307
LIG_SH2_STAT5	459	462	PF00017	0.297
LIG_SH2_STAT5	520	523	PF00017	0.297
LIG_SH3_2	113	118	PF14604	0.710
LIG_SH3_3	110	116	PF00018	0.644
LIG_SH3_3	132	138	PF00018	0.699
LIG_SH3_3	162	168	PF00018	0.651
LIG_SH3_3	176	182	PF00018	0.521
LIG_SH3_3	208	214	PF00018	0.591
LIG_SH3_3	244	250	PF00018	0.628
LIG_SH3_3	347	353	PF00018	0.396
LIG_SUMO_SIM_par_1	352	357	PF11976	0.457
LIG_SUMO_SIM_par_1	39	44	PF11976	0.615
LIG_TYR_ITAM	348	364	PF00017	0.414
LIG_UBA3_1	438	444	PF00899	0.531
MOD_CDK_SPK_2	198	203	PF00069	0.738
MOD_CDK_SPxxK_3	111	118	PF00069	0.699
MOD_CDK_SPxxK_3	167	174	PF00069	0.735
MOD_CK1_1	119	125	PF00069	0.745
MOD_CK1_1	198	204	PF00069	0.675
MOD_CK1_1	488	494	PF00069	0.387
MOD_CK1_1	59	65	PF00069	0.689
MOD_CK1_1	608	614	PF00069	0.476
MOD_CK1_1	95	101	PF00069	0.722
MOD_CK2_1	22	28	PF00069	0.548
MOD_CK2_1	227	233	PF00069	0.694
MOD_CK2_1	263	269	PF00069	0.477
MOD_CK2_1	274	280	PF00069	0.404
MOD_CK2_1	373	379	PF00069	0.501
MOD_CK2_1	547	553	PF00069	0.297
MOD_CK2_1	94	100	PF00069	0.487
MOD_DYRK1A_RPxSP_1	107	111	PF00069	0.644
MOD_DYRK1A_RPxSP_1	160	164	PF00069	0.640
MOD_GlcNHglycan	1	4	PF01048	0.683
MOD_GlcNHglycan	121	124	PF01048	0.725
MOD_GlcNHglycan	178	182	PF01048	0.590
MOD_GlcNHglycan	187	190	PF01048	0.614
MOD_GlcNHglycan	229	232	PF01048	0.574
MOD_GlcNHglycan	241	244	PF01048	0.468
MOD_GlcNHglycan	327	330	PF01048	0.410
MOD_GlcNHglycan	43	46	PF01048	0.574
MOD_GlcNHglycan	506	509	PF01048	0.309
MOD_GlcNHglycan	549	552	PF01048	0.311
MOD_GlcNHglycan	97	100	PF01048	0.731
MOD_GSK3_1	107	114	PF00069	0.658
MOD_GSK3_1	136	143	PF00069	0.656
MOD_GSK3_1	160	167	PF00069	0.644
MOD_GSK3_1	18	25	PF00069	0.512
MOD_GSK3_1	185	192	PF00069	0.656
MOD_GSK3_1	223	230	PF00069	0.596
MOD_GSK3_1	241	248	PF00069	0.620
MOD_GSK3_1	263	270	PF00069	0.510
MOD_GSK3_1	39	46	PF00069	0.642
MOD_N-GLC_1	223	228	PF02516	0.489
MOD_N-GLC_1	620	625	PF02516	0.410
MOD_NEK2_1	204	209	PF00069	0.662
MOD_NEK2_1	227	232	PF00069	0.630
MOD_NEK2_1	238	243	PF00069	0.480
MOD_NEK2_1	354	359	PF00069	0.439
MOD_NEK2_1	363	368	PF00069	0.512
MOD_NEK2_1	41	46	PF00069	0.603
MOD_NEK2_1	620	625	PF00069	0.393
MOD_NEK2_1	94	99	PF00069	0.716
MOD_PKA_1	267	273	PF00069	0.526
MOD_PKA_2	231	237	PF00069	0.662
MOD_PKA_2	267	273	PF00069	0.522
MOD_PKA_2	85	91	PF00069	0.768
MOD_Plk_1	204	210	PF00069	0.640
MOD_Plk_1	223	229	PF00069	0.414
MOD_Plk_1	578	584	PF00069	0.425
MOD_Plk_2-3	371	377	PF00069	0.485
MOD_Plk_2-3	451	457	PF00069	0.408
MOD_Plk_2-3	467	473	PF00069	0.197
MOD_Plk_4	140	146	PF00069	0.689
MOD_Plk_4	295	301	PF00069	0.562
MOD_Plk_4	485	491	PF00069	0.327
MOD_ProDKin_1	107	113	PF00069	0.644
MOD_ProDKin_1	129	135	PF00069	0.655
MOD_ProDKin_1	138	144	PF00069	0.568
MOD_ProDKin_1	160	166	PF00069	0.611
MOD_ProDKin_1	167	173	PF00069	0.602
MOD_ProDKin_1	189	195	PF00069	0.668
MOD_ProDKin_1	198	204	PF00069	0.658
MOD_ProDKin_1	216	222	PF00069	0.549
MOD_ProDKin_1	245	251	PF00069	0.590
MOD_ProDKin_1	568	574	PF00069	0.531
MOD_ProDKin_1	608	614	PF00069	0.377
MOD_SUMO_for_1	368	371	PF00179	0.493
MOD_SUMO_rev_2	436	446	PF00179	0.456
MOD_SUMO_rev_2	524	530	PF00179	0.354
TRG_DiLeu_BaEn_1	284	289	PF01217	0.530
TRG_DiLeu_BaEn_4	280	286	PF01217	0.545
TRG_DiLeu_LyEn_5	284	289	PF01217	0.530
TRG_ENDOCYTIC_2	347	350	PF00928	0.401
TRG_ENDOCYTIC_2	351	354	PF00928	0.379
TRG_ENDOCYTIC_2	361	364	PF00928	0.456
TRG_ENDOCYTIC_2	455	458	PF00928	0.310
TRG_ENDOCYTIC_2	462	465	PF00928	0.297
TRG_ENDOCYTIC_2	520	523	PF00928	0.297
TRG_ENDOCYTIC_2	552	555	PF00928	0.390
TRG_ENDOCYTIC_2	656	659	PF00928	0.371
TRG_ER_diArg_1	358	360	PF00400	0.297
TRG_ER_diArg_1	639	642	PF00400	0.576
TRG_NES_CRM1_1	304	318	PF08389	0.482
TRG_NES_CRM1_1	31	47	PF08389	0.602
TRG_Pf-PMV_PEXEL_1	271	276	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	358	362	PF00026	0.297

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2Z7	Leptomonas seymouri	77%	100%
A0A0S4JHD9	Bodo saltans	40%	90%
A0A1X0P683	Trypanosomatidae	50%	100%
A0A3R7MAB5	Trypanosoma rangeli	52%	99%
A0A3S7X9I6	Leishmania donovani	95%	100%
A4HMY8	Leishmania braziliensis	84%	98%
A4IBL2	Leishmania infantum	95%	100%
C9ZZ28	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	98%
E9AFE5	Leishmania major	95%	100%
Q5QIT3	Arabidopsis thaliana	34%	100%
Q8VZQ4	Arabidopsis thaliana	34%	100%
Q9SLI8	Arabidopsis thaliana	34%	100%
Q9XGR4	Arabidopsis thaliana	35%	100%
Q9Y5P8	Homo sapiens	31%	100%
V5BY37	Trypanosoma cruzi	51%	99%