RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein, putative

Species:

Leishmania mexicana

UniProt:

E9B6J9_LEIMU

TriTrypDb:

LmxM.34.3200

Length:

704

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B6J9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6J9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	243	247	PF00656	0.477
CLV_C14_Caspase3-7	624	628	PF00656	0.646
CLV_C14_Caspase3-7	643	647	PF00656	0.567
CLV_NRD_NRD_1	287	289	PF00675	0.611
CLV_NRD_NRD_1	350	352	PF00675	0.277
CLV_NRD_NRD_1	362	364	PF00675	0.277
CLV_NRD_NRD_1	391	393	PF00675	0.490
CLV_NRD_NRD_1	46	48	PF00675	0.494
CLV_NRD_NRD_1	571	573	PF00675	0.653
CLV_NRD_NRD_1	60	62	PF00675	0.446
CLV_PCSK_KEX2_1	349	351	PF00082	0.280
CLV_PCSK_KEX2_1	391	393	PF00082	0.490
CLV_PCSK_KEX2_1	46	48	PF00082	0.499
CLV_PCSK_KEX2_1	571	573	PF00082	0.791
CLV_PCSK_KEX2_1	69	71	PF00082	0.485
CLV_PCSK_PC1ET2_1	69	71	PF00082	0.423
CLV_PCSK_SKI1_1	106	110	PF00082	0.548
CLV_PCSK_SKI1_1	27	31	PF00082	0.474
CLV_PCSK_SKI1_1	350	354	PF00082	0.414
CLV_PCSK_SKI1_1	363	367	PF00082	0.277
CLV_PCSK_SKI1_1	61	65	PF00082	0.509
DEG_Nend_UBRbox_1	1	4	PF02207	0.621
DOC_CDC14_PxL_1	276	284	PF14671	0.615
DOC_CYCLIN_RxL_1	58	65	PF00134	0.451
DOC_CYCLIN_yClb1_LxF_4	48	53	PF00134	0.530
DOC_CYCLIN_yCln2_LP_2	51	57	PF00134	0.535
DOC_CYCLIN_yCln2_LP_2	677	683	PF00134	0.699
DOC_MAPK_gen_1	299	305	PF00069	0.395
DOC_MAPK_gen_1	349	356	PF00069	0.480
DOC_MAPK_gen_1	371	380	PF00069	0.477
DOC_MAPK_gen_1	46	53	PF00069	0.482
DOC_MAPK_gen_1	659	668	PF00069	0.520
DOC_MAPK_JIP1_4	47	53	PF00069	0.535
DOC_MAPK_MEF2A_6	271	279	PF00069	0.579
DOC_MAPK_MEF2A_6	374	382	PF00069	0.477
DOC_PP1_RVXF_1	48	54	PF00149	0.536
DOC_PP2B_LxvP_1	20	23	PF13499	0.498
DOC_PP2B_LxvP_1	303	306	PF13499	0.369
DOC_PP2B_LxvP_1	677	680	PF13499	0.699
DOC_PP2B_LxvP_1	697	700	PF13499	0.664
DOC_PP4_FxxP_1	329	332	PF00568	0.560
DOC_PP4_FxxP_1	631	634	PF00568	0.635
DOC_PP4_FxxP_1	692	695	PF00568	0.653
DOC_PP4_MxPP_1	691	694	PF00568	0.703
DOC_USP7_MATH_1	131	135	PF00917	0.692
DOC_USP7_MATH_1	150	154	PF00917	0.654
DOC_USP7_MATH_1	191	195	PF00917	0.477
DOC_USP7_MATH_1	278	282	PF00917	0.569
DOC_USP7_MATH_1	334	338	PF00917	0.535
DOC_USP7_MATH_1	417	421	PF00917	0.682
DOC_USP7_MATH_1	423	427	PF00917	0.637
DOC_USP7_MATH_1	543	547	PF00917	0.651
DOC_USP7_MATH_1	555	559	PF00917	0.584
DOC_USP7_MATH_1	562	566	PF00917	0.524
DOC_USP7_MATH_1	579	583	PF00917	0.626
DOC_USP7_MATH_1	658	662	PF00917	0.750
DOC_WW_Pin1_4	126	131	PF00397	0.633
DOC_WW_Pin1_4	271	276	PF00397	0.483
DOC_WW_Pin1_4	380	385	PF00397	0.513
DOC_WW_Pin1_4	428	433	PF00397	0.780
DOC_WW_Pin1_4	444	449	PF00397	0.611
DOC_WW_Pin1_4	492	497	PF00397	0.632
DOC_WW_Pin1_4	548	553	PF00397	0.612
DOC_WW_Pin1_4	575	580	PF00397	0.716
DOC_WW_Pin1_4	598	603	PF00397	0.604
DOC_WW_Pin1_4	604	609	PF00397	0.616
DOC_WW_Pin1_4	646	651	PF00397	0.710
DOC_WW_Pin1_4	666	671	PF00397	0.665
LIG_14-3-3_CanoR_1	351	357	PF00244	0.477
LIG_14-3-3_CanoR_1	374	379	PF00244	0.607
LIG_14-3-3_CanoR_1	490	496	PF00244	0.657
LIG_14-3-3_CanoR_1	61	67	PF00244	0.543
LIG_14-3-3_CanoR_1	662	670	PF00244	0.651
LIG_BIR_III_4	174	178	PF00653	0.470
LIG_BRCT_BRCA1_1	152	156	PF00533	0.620
LIG_BRCT_BRCA1_1	24	28	PF00533	0.483
LIG_BRCT_BRCA1_1	336	340	PF00533	0.535
LIG_Clathr_ClatBox_1	29	33	PF01394	0.450
LIG_Clathr_ClatBox_1	438	442	PF01394	0.605
LIG_deltaCOP1_diTrp_1	292	302	PF00928	0.500
LIG_EH_1	518	522	PF12763	0.496
LIG_EVH1_1	631	635	PF00568	0.705
LIG_EVH1_1	692	696	PF00568	0.703
LIG_FHA_1	309	315	PF00498	0.395
LIG_FHA_1	375	381	PF00498	0.477
LIG_FHA_1	464	470	PF00498	0.741
LIG_FHA_2	1	7	PF00498	0.653
LIG_FHA_2	150	156	PF00498	0.617
LIG_FHA_2	219	225	PF00498	0.341
LIG_FHA_2	320	326	PF00498	0.535
LIG_LIR_Apic_2	328	332	PF02991	0.535
LIG_LIR_Apic_2	383	389	PF02991	0.586
LIG_LIR_Apic_2	689	695	PF02991	0.651
LIG_LIR_Gen_1	13	22	PF02991	0.567
LIG_LIR_Gen_1	162	169	PF02991	0.630
LIG_LIR_Gen_1	218	227	PF02991	0.443
LIG_LIR_Gen_1	292	303	PF02991	0.403
LIG_LIR_Gen_1	33	40	PF02991	0.331
LIG_LIR_Gen_1	355	361	PF02991	0.535
LIG_LIR_Nem_3	13	17	PF02991	0.555
LIG_LIR_Nem_3	157	163	PF02991	0.551
LIG_LIR_Nem_3	213	217	PF02991	0.408
LIG_LIR_Nem_3	218	223	PF02991	0.437
LIG_LIR_Nem_3	292	298	PF02991	0.502
LIG_LIR_Nem_3	328	333	PF02991	0.535
LIG_LIR_Nem_3	33	37	PF02991	0.321
LIG_LIR_Nem_3	355	359	PF02991	0.535
LIG_LIR_Nem_3	59	63	PF02991	0.416
LIG_LIR_Nem_3	590	594	PF02991	0.499
LIG_LIR_Nem_3	613	619	PF02991	0.726
LIG_MYND_1	670	674	PF01753	0.634
LIG_MYND_1	695	699	PF01753	0.688
LIG_MYND_3	279	283	PF01753	0.627
LIG_NRBOX	25	31	PF00104	0.474
LIG_PAM2_1	62	74	PF00658	0.515
LIG_Pex14_2	156	160	PF04695	0.532
LIG_Pex14_2	201	205	PF04695	0.514
LIG_Pex14_2	49	53	PF04695	0.523
LIG_Pex14_2	56	60	PF04695	0.472
LIG_Pex14_2	591	595	PF04695	0.794
LIG_PROFILIN_1	632	638	PF00235	0.642
LIG_PTB_Apo_2	92	99	PF02174	0.402
LIG_PTB_Phospho_1	92	98	PF10480	0.405
LIG_RPA_C_Fungi	533	545	PF08784	0.636
LIG_SH2_CRK	34	38	PF00017	0.467
LIG_SH2_CRK	619	623	PF00017	0.654
LIG_SH2_CRK	675	679	PF00017	0.618
LIG_SH2_NCK_1	675	679	PF00017	0.618
LIG_SH2_PTP2	386	389	PF00017	0.603
LIG_SH2_SRC	644	647	PF00017	0.721
LIG_SH2_SRC	681	684	PF00017	0.509
LIG_SH2_SRC	98	101	PF00017	0.504
LIG_SH2_STAP1	34	38	PF00017	0.467
LIG_SH2_STAT3	500	503	PF00017	0.660
LIG_SH2_STAT5	181	184	PF00017	0.506
LIG_SH2_STAT5	386	389	PF00017	0.523
LIG_SH2_STAT5	500	503	PF00017	0.660
LIG_SH2_STAT5	594	597	PF00017	0.505
LIG_SH2_STAT5	644	647	PF00017	0.721
LIG_SH2_STAT5	681	684	PF00017	0.689
LIG_SH2_STAT5	701	704	PF00017	0.647
LIG_SH2_STAT5	98	101	PF00017	0.538
LIG_SH3_2	549	554	PF14604	0.702
LIG_SH3_2	680	685	PF14604	0.513
LIG_SH3_3	127	133	PF00018	0.664
LIG_SH3_3	269	275	PF00018	0.461
LIG_SH3_3	379	385	PF00018	0.507
LIG_SH3_3	493	499	PF00018	0.546
LIG_SH3_3	546	552	PF00018	0.610
LIG_SH3_3	626	632	PF00018	0.656
LIG_SH3_3	633	639	PF00018	0.585
LIG_SH3_3	667	673	PF00018	0.690
LIG_SH3_3	677	683	PF00018	0.653
LIG_SH3_3	690	696	PF00018	0.621
LIG_SUMO_SIM_par_1	437	442	PF11976	0.604
LIG_TRFH_1	268	272	PF08558	0.437
LIG_TRFH_1	675	679	PF08558	0.698
LIG_TYR_ITIM	32	37	PF00017	0.448
LIG_TYR_ITIM	592	597	PF00017	0.498
LIG_UBA3_1	63	69	PF00899	0.393
LIG_WRC_WIRS_1	326	331	PF05994	0.395
LIG_WRC_WIRS_1	353	358	PF05994	0.315
LIG_WW_1	641	644	PF00397	0.681
LIG_WW_1	678	681	PF00397	0.652
LIG_WW_1	698	701	PF00397	0.681
LIG_WW_2	695	698	PF00397	0.692
MOD_CDC14_SPxK_1	388	391	PF00782	0.609
MOD_CDC14_SPxK_1	551	554	PF00782	0.702
MOD_CDK_SPxK_1	385	391	PF00069	0.604
MOD_CDK_SPxK_1	548	554	PF00069	0.618
MOD_CDK_SPxxK_3	385	392	PF00069	0.598
MOD_CDK_SPxxK_3	444	451	PF00069	0.527
MOD_CDK_SPxxK_3	598	605	PF00069	0.661
MOD_CK1_1	136	142	PF00069	0.677
MOD_CK1_1	164	170	PF00069	0.640
MOD_CK1_1	189	195	PF00069	0.497
MOD_CK1_1	21	27	PF00069	0.497
MOD_CK1_1	218	224	PF00069	0.420
MOD_CK1_1	426	432	PF00069	0.709
MOD_CK1_1	434	440	PF00069	0.702
MOD_CK1_1	464	470	PF00069	0.677
MOD_CK1_1	478	484	PF00069	0.583
MOD_CK1_1	506	512	PF00069	0.587
MOD_CK1_1	598	604	PF00069	0.573
MOD_CK1_1	661	667	PF00069	0.644
MOD_CK1_1	82	88	PF00069	0.436
MOD_CK2_1	149	155	PF00069	0.658
MOD_CK2_1	256	262	PF00069	0.488
MOD_CK2_1	319	325	PF00069	0.327
MOD_CK2_1	562	568	PF00069	0.668
MOD_DYRK1A_RPxSP_1	271	275	PF00069	0.480
MOD_GlcNHglycan	133	136	PF01048	0.695
MOD_GlcNHglycan	216	220	PF01048	0.414
MOD_GlcNHglycan	414	417	PF01048	0.706
MOD_GlcNHglycan	428	431	PF01048	0.578
MOD_GlcNHglycan	508	511	PF01048	0.638
MOD_GlcNHglycan	545	548	PF01048	0.691
MOD_GlcNHglycan	557	560	PF01048	0.670
MOD_GlcNHglycan	564	567	PF01048	0.630
MOD_GlcNHglycan	597	600	PF01048	0.625
MOD_GSK3_1	136	143	PF00069	0.638
MOD_GSK3_1	146	153	PF00069	0.699
MOD_GSK3_1	161	168	PF00069	0.498
MOD_GSK3_1	18	25	PF00069	0.564
MOD_GSK3_1	370	377	PF00069	0.497
MOD_GSK3_1	426	433	PF00069	0.686
MOD_GSK3_1	437	444	PF00069	0.723
MOD_GSK3_1	461	468	PF00069	0.712
MOD_GSK3_1	575	582	PF00069	0.732
MOD_GSK3_1	657	664	PF00069	0.710
MOD_N-GLC_2	425	427	PF02516	0.649
MOD_NEK2_1	156	161	PF00069	0.552
MOD_NEK2_1	359	364	PF00069	0.395
MOD_NEK2_1	409	414	PF00069	0.678
MOD_NEK2_1	595	600	PF00069	0.625
MOD_NEK2_1	84	89	PF00069	0.504
MOD_NEK2_2	621	626	PF00069	0.557
MOD_PIKK_1	241	247	PF00454	0.552
MOD_PK_1	18	24	PF00069	0.489
MOD_PKA_2	658	664	PF00069	0.771
MOD_Plk_1	156	162	PF00069	0.619
MOD_Plk_1	168	174	PF00069	0.481
MOD_Plk_1	283	289	PF00069	0.513
MOD_Plk_1	464	470	PF00069	0.658
MOD_Plk_2-3	256	262	PF00069	0.510
MOD_Plk_2-3	319	325	PF00069	0.315
MOD_Plk_4	156	162	PF00069	0.556
MOD_Plk_4	308	314	PF00069	0.477
MOD_Plk_4	325	331	PF00069	0.205
MOD_Plk_4	434	440	PF00069	0.610
MOD_Plk_4	640	646	PF00069	0.701
MOD_Plk_4	79	85	PF00069	0.474
MOD_ProDKin_1	126	132	PF00069	0.636
MOD_ProDKin_1	271	277	PF00069	0.489
MOD_ProDKin_1	380	386	PF00069	0.513
MOD_ProDKin_1	428	434	PF00069	0.780
MOD_ProDKin_1	444	450	PF00069	0.611
MOD_ProDKin_1	492	498	PF00069	0.630
MOD_ProDKin_1	548	554	PF00069	0.615
MOD_ProDKin_1	575	581	PF00069	0.713
MOD_ProDKin_1	598	604	PF00069	0.606
MOD_ProDKin_1	646	652	PF00069	0.708
MOD_ProDKin_1	666	672	PF00069	0.664
MOD_SUMO_for_1	1	4	PF00179	0.483
MOD_SUMO_for_1	396	399	PF00179	0.630
MOD_SUMO_for_1	610	613	PF00179	0.687
MOD_SUMO_rev_2	13	20	PF00179	0.484
MOD_SUMO_rev_2	337	346	PF00179	0.395
MOD_SUMO_rev_2	367	373	PF00179	0.359
TRG_DiLeu_BaLyEn_6	88	93	PF01217	0.564
TRG_ENDOCYTIC_2	163	166	PF00928	0.626
TRG_ENDOCYTIC_2	181	184	PF00928	0.506
TRG_ENDOCYTIC_2	34	37	PF00928	0.460
TRG_ENDOCYTIC_2	594	597	PF00928	0.505
TRG_ENDOCYTIC_2	619	622	PF00928	0.744
TRG_ER_diArg_1	349	351	PF00400	0.318
TRG_ER_diArg_1	46	48	PF00400	0.575
TRG_ER_diArg_1	571	573	PF00400	0.653
TRG_NLS_MonoExtN_4	119	125	PF00514	0.447
TRG_Pf-PMV_PEXEL_1	288	292	PF00026	0.600

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IMJ6	Leishmania donovani	93%	100%
A4HMY7	Leishmania braziliensis	80%	100%
A4IBL1	Leishmania infantum	93%	100%
E9AFE4	Leishmania major	92%	100%
V5C2W3	Trypanosoma cruzi	42%	100%