Phosphoglycerate mutase family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Histidine phosphatase superfamily (branch 1), putative

Species:

Leishmania mexicana

UniProt:

E9B6J8_LEIMU

TriTrypDb:

LmxM.34.3190

Length:

910

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9B6J8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6J8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.536
CLV_C14_Caspase3-7	228	232	PF00656	0.403
CLV_C14_Caspase3-7	23	27	PF00656	0.363
CLV_C14_Caspase3-7	280	284	PF00656	0.455
CLV_C14_Caspase3-7	325	329	PF00656	0.476
CLV_C14_Caspase3-7	536	540	PF00656	0.425
CLV_C14_Caspase3-7	590	594	PF00656	0.542
CLV_NRD_NRD_1	190	192	PF00675	0.739
CLV_NRD_NRD_1	24	26	PF00675	0.563
CLV_NRD_NRD_1	258	260	PF00675	0.557
CLV_NRD_NRD_1	366	368	PF00675	0.680
CLV_NRD_NRD_1	671	673	PF00675	0.448
CLV_NRD_NRD_1	740	742	PF00675	0.504
CLV_PCSK_FUR_1	343	347	PF00082	0.630
CLV_PCSK_FUR_1	738	742	PF00082	0.501
CLV_PCSK_KEX2_1	141	143	PF00082	0.509
CLV_PCSK_KEX2_1	190	192	PF00082	0.639
CLV_PCSK_KEX2_1	24	26	PF00082	0.563
CLV_PCSK_KEX2_1	258	260	PF00082	0.557
CLV_PCSK_KEX2_1	345	347	PF00082	0.666
CLV_PCSK_KEX2_1	366	368	PF00082	0.666
CLV_PCSK_KEX2_1	671	673	PF00082	0.448
CLV_PCSK_KEX2_1	740	742	PF00082	0.504
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.509
CLV_PCSK_PC1ET2_1	345	347	PF00082	0.666
CLV_PCSK_PC7_1	20	26	PF00082	0.563
CLV_PCSK_PC7_1	341	347	PF00082	0.650
CLV_PCSK_SKI1_1	142	146	PF00082	0.459
CLV_PCSK_SKI1_1	677	681	PF00082	0.218
DEG_MDM2_SWIB_1	716	723	PF02201	0.294
DEG_SCF_FBW7_1	475	482	PF00400	0.588
DEG_SPOP_SBC_1	360	364	PF00917	0.480
DEG_SPOP_SBC_1	480	484	PF00917	0.536
DOC_ANK_TNKS_1	297	304	PF00023	0.430
DOC_CKS1_1	408	413	PF01111	0.553
DOC_CYCLIN_yClb1_LxF_4	249	255	PF00134	0.246
DOC_MAPK_gen_1	110	119	PF00069	0.431
DOC_MAPK_HePTP_8	107	119	PF00069	0.395
DOC_MAPK_MEF2A_6	110	119	PF00069	0.431
DOC_MAPK_MEF2A_6	287	294	PF00069	0.404
DOC_MAPK_RevD_3	331	346	PF00069	0.426
DOC_PP2B_LxvP_1	117	120	PF13499	0.467
DOC_USP7_MATH_1	10	14	PF00917	0.396
DOC_USP7_MATH_1	118	122	PF00917	0.446
DOC_USP7_MATH_1	160	164	PF00917	0.498
DOC_USP7_MATH_1	167	171	PF00917	0.488
DOC_USP7_MATH_1	232	236	PF00917	0.384
DOC_USP7_MATH_1	32	36	PF00917	0.344
DOC_USP7_MATH_1	351	355	PF00917	0.517
DOC_USP7_MATH_1	370	374	PF00917	0.455
DOC_USP7_MATH_1	381	385	PF00917	0.469
DOC_USP7_MATH_1	448	452	PF00917	0.588
DOC_USP7_MATH_1	453	457	PF00917	0.549
DOC_USP7_MATH_1	479	483	PF00917	0.555
DOC_USP7_MATH_1	505	509	PF00917	0.496
DOC_USP7_MATH_1	556	560	PF00917	0.464
DOC_USP7_MATH_1	62	66	PF00917	0.332
DOC_USP7_MATH_1	624	628	PF00917	0.752
DOC_USP7_MATH_1	683	687	PF00917	0.428
DOC_USP7_MATH_1	90	94	PF00917	0.324
DOC_USP7_MATH_1	906	910	PF00917	0.657
DOC_USP7_UBL2_3	389	393	PF12436	0.435
DOC_WW_Pin1_4	175	180	PF00397	0.516
DOC_WW_Pin1_4	216	221	PF00397	0.415
DOC_WW_Pin1_4	407	412	PF00397	0.587
DOC_WW_Pin1_4	475	480	PF00397	0.589
DOC_WW_Pin1_4	517	522	PF00397	0.455
DOC_WW_Pin1_4	592	597	PF00397	0.525
DOC_WW_Pin1_4	606	611	PF00397	0.255
DOC_WW_Pin1_4	68	73	PF00397	0.363
DOC_WW_Pin1_4	785	790	PF00397	0.621
DOC_WW_Pin1_4	793	798	PF00397	0.587
LIG_14-3-3_CanoR_1	142	148	PF00244	0.362
LIG_14-3-3_CanoR_1	198	205	PF00244	0.550
LIG_14-3-3_CanoR_1	211	216	PF00244	0.476
LIG_14-3-3_CanoR_1	359	368	PF00244	0.549
LIG_14-3-3_CanoR_1	569	575	PF00244	0.561
LIG_14-3-3_CanoR_1	645	651	PF00244	0.741
LIG_14-3-3_CanoR_1	675	680	PF00244	0.679
LIG_14-3-3_CanoR_1	690	696	PF00244	0.257
LIG_14-3-3_CanoR_1	706	712	PF00244	0.333
LIG_14-3-3_CanoR_1	740	749	PF00244	0.699
LIG_14-3-3_CanoR_1	75	83	PF00244	0.361
LIG_14-3-3_CanoR_1	759	765	PF00244	0.586
LIG_APCC_ABBAyCdc20_2	346	352	PF00400	0.424
LIG_BIR_III_2	283	287	PF00653	0.444
LIG_BIR_III_4	231	235	PF00653	0.308
LIG_BIR_III_4	548	552	PF00653	0.425
LIG_BIR_III_4	660	664	PF00653	0.594
LIG_Clathr_ClatBox_1	291	295	PF01394	0.449
LIG_CtBP_PxDLS_1	135	139	PF00389	0.292
LIG_FHA_1	120	126	PF00498	0.319
LIG_FHA_1	143	149	PF00498	0.280
LIG_FHA_1	159	165	PF00498	0.482
LIG_FHA_1	200	206	PF00498	0.429
LIG_FHA_1	247	253	PF00498	0.365
LIG_FHA_1	381	387	PF00498	0.450
LIG_FHA_1	501	507	PF00498	0.545
LIG_FHA_1	587	593	PF00498	0.470
LIG_FHA_1	664	670	PF00498	0.716
LIG_FHA_1	692	698	PF00498	0.272
LIG_FHA_1	706	712	PF00498	0.284
LIG_FHA_1	820	826	PF00498	0.700
LIG_FHA_1	829	835	PF00498	0.572
LIG_FHA_1	877	883	PF00498	0.305
LIG_FHA_2	180	186	PF00498	0.474
LIG_FHA_2	226	232	PF00498	0.371
LIG_FHA_2	316	322	PF00498	0.423
LIG_FHA_2	518	524	PF00498	0.429
LIG_FHA_2	97	103	PF00498	0.363
LIG_GBD_Chelix_1	50	58	PF00786	0.563
LIG_HCF-1_HBM_1	238	241	PF13415	0.269
LIG_IRF3_LxIS_1	844	851	PF10401	0.226
LIG_LIR_Gen_1	678	689	PF02991	0.419
LIG_LIR_Gen_1	694	703	PF02991	0.205
LIG_LIR_Gen_1	721	730	PF02991	0.428
LIG_LIR_Nem_3	102	107	PF02991	0.413
LIG_LIR_Nem_3	152	157	PF02991	0.427
LIG_LIR_Nem_3	248	254	PF02991	0.396
LIG_LIR_Nem_3	678	684	PF02991	0.457
LIG_LIR_Nem_3	694	698	PF02991	0.245
LIG_LIR_Nem_3	710	716	PF02991	0.407
LIG_LIR_Nem_3	721	727	PF02991	0.302
LIG_LIR_Nem_3	885	891	PF02991	0.313
LIG_MAD2	389	397	PF02301	0.433
LIG_PDZ_Class_3	905	910	PF00595	0.691
LIG_Pex14_1	712	716	PF04695	0.428
LIG_Pex14_1	720	724	PF04695	0.337
LIG_Pex14_2	680	684	PF04695	0.277
LIG_Pex14_2	695	699	PF04695	0.408
LIG_Pex14_2	716	720	PF04695	0.428
LIG_PTB_Apo_2	147	154	PF02174	0.259
LIG_PTB_Apo_2	261	268	PF02174	0.422
LIG_PTB_Phospho_1	261	267	PF10480	0.424
LIG_SH2_CRK	154	158	PF00017	0.406
LIG_SH2_CRK	888	892	PF00017	0.428
LIG_SH2_STAP1	247	251	PF00017	0.442
LIG_SH2_STAP1	616	620	PF00017	0.482
LIG_SH2_STAP1	681	685	PF00017	0.226
LIG_SH2_STAT3	11	14	PF00017	0.421
LIG_SH2_STAT5	11	14	PF00017	0.277
LIG_SH2_STAT5	143	146	PF00017	0.377
LIG_SH2_STAT5	729	732	PF00017	0.280
LIG_SH2_STAT5	802	805	PF00017	0.653
LIG_SH3_1	409	415	PF00018	0.442
LIG_SH3_3	100	106	PF00018	0.363
LIG_SH3_3	112	118	PF00018	0.380
LIG_SH3_3	173	179	PF00018	0.433
LIG_SH3_3	26	32	PF00018	0.354
LIG_SH3_3	283	289	PF00018	0.439
LIG_SH3_3	405	411	PF00018	0.521
LIG_SH3_3	413	419	PF00018	0.507
LIG_SH3_3	424	430	PF00018	0.473
LIG_SH3_3	593	599	PF00018	0.423
LIG_SH3_3	604	610	PF00018	0.315
LIG_SH3_3	66	72	PF00018	0.324
LIG_SH3_4	413	420	PF00018	0.442
LIG_SUMO_SIM_anti_2	223	228	PF11976	0.405
LIG_SUMO_SIM_anti_2	288	295	PF11976	0.403
LIG_SUMO_SIM_par_1	223	228	PF11976	0.405
LIG_SUMO_SIM_par_1	288	295	PF11976	0.403
LIG_SUMO_SIM_par_1	378	384	PF11976	0.432
LIG_SUMO_SIM_par_1	846	851	PF11976	0.280
LIG_SUMO_SIM_par_1	882	887	PF11976	0.354
LIG_SxIP_EBH_1	572	585	PF03271	0.421
LIG_TRAF2_1	521	524	PF00917	0.461
LIG_TYR_ITIM	886	891	PF00017	0.428
LIG_UBA3_1	290	296	PF00899	0.449
LIG_UBA3_1	839	846	PF00899	0.375
LIG_WRC_WIRS_1	144	149	PF05994	0.368
LIG_WRC_WIRS_1	692	697	PF05994	0.259
LIG_WW_3	195	199	PF00397	0.571
LIG_WW_3	219	223	PF00397	0.366
MOD_CDC14_SPxK_1	219	222	PF00782	0.317
MOD_CDK_SPxK_1	216	222	PF00069	0.347
MOD_CDK_SPxK_1	407	413	PF00069	0.449
MOD_CDK_SPxxK_3	68	75	PF00069	0.363
MOD_CK1_1	168	174	PF00069	0.488
MOD_CK1_1	201	207	PF00069	0.554
MOD_CK1_1	214	220	PF00069	0.425
MOD_CK1_1	361	367	PF00069	0.509
MOD_CK1_1	403	409	PF00069	0.495
MOD_CK1_1	439	445	PF00069	0.553
MOD_CK1_1	483	489	PF00069	0.586
MOD_CK1_1	595	601	PF00069	0.493
MOD_CK1_1	615	621	PF00069	0.577
MOD_CK1_1	785	791	PF00069	0.636
MOD_CK1_1	851	857	PF00069	0.428
MOD_CK2_1	168	174	PF00069	0.542
MOD_CK2_1	179	185	PF00069	0.466
MOD_CK2_1	204	210	PF00069	0.503
MOD_CK2_1	232	238	PF00069	0.251
MOD_CK2_1	315	321	PF00069	0.422
MOD_CK2_1	326	332	PF00069	0.411
MOD_CK2_1	389	395	PF00069	0.495
MOD_CK2_1	517	523	PF00069	0.466
MOD_CK2_1	741	747	PF00069	0.695
MOD_CK2_1	801	807	PF00069	0.685
MOD_CK2_1	861	867	PF00069	0.309
MOD_CK2_1	96	102	PF00069	0.363
MOD_Cter_Amidation	364	367	PF01082	0.643
MOD_GlcNHglycan	170	173	PF01048	0.776
MOD_GlcNHglycan	206	209	PF01048	0.672
MOD_GlcNHglycan	306	309	PF01048	0.724
MOD_GlcNHglycan	328	331	PF01048	0.630
MOD_GlcNHglycan	420	423	PF01048	0.762
MOD_GlcNHglycan	431	434	PF01048	0.695
MOD_GlcNHglycan	438	441	PF01048	0.655
MOD_GlcNHglycan	450	453	PF01048	0.662
MOD_GlcNHglycan	507	510	PF01048	0.716
MOD_GlcNHglycan	576	579	PF01048	0.640
MOD_GlcNHglycan	584	587	PF01048	0.657
MOD_GlcNHglycan	64	67	PF01048	0.525
MOD_GlcNHglycan	660	664	PF01048	0.530
MOD_GlcNHglycan	743	746	PF01048	0.472
MOD_GlcNHglycan	784	787	PF01048	0.482
MOD_GlcNHglycan	803	806	PF01048	0.466
MOD_GlcNHglycan	850	853	PF01048	0.375
MOD_GlcNHglycan	856	859	PF01048	0.322
MOD_GlcNHglycan	863	866	PF01048	0.505
MOD_GSK3_1	156	163	PF00069	0.471
MOD_GSK3_1	175	182	PF00069	0.421
MOD_GSK3_1	197	204	PF00069	0.554
MOD_GSK3_1	210	217	PF00069	0.470
MOD_GSK3_1	269	276	PF00069	0.275
MOD_GSK3_1	381	388	PF00069	0.463
MOD_GSK3_1	399	406	PF00069	0.533
MOD_GSK3_1	431	438	PF00069	0.549
MOD_GSK3_1	475	482	PF00069	0.588
MOD_GSK3_1	570	577	PF00069	0.448
MOD_GSK3_1	582	589	PF00069	0.413
MOD_GSK3_1	612	619	PF00069	0.321
MOD_GSK3_1	659	666	PF00069	0.736
MOD_N-GLC_1	198	203	PF02516	0.694
MOD_N-GLC_1	435	440	PF02516	0.789
MOD_N-GLC_1	570	575	PF02516	0.736
MOD_NEK2_1	158	163	PF00069	0.525
MOD_NEK2_1	380	385	PF00069	0.440
MOD_NEK2_1	557	562	PF00069	0.535
MOD_NEK2_1	603	608	PF00069	0.348
MOD_NEK2_1	665	670	PF00069	0.675
MOD_NEK2_1	684	689	PF00069	0.208
MOD_NEK2_1	73	78	PF00069	0.363
MOD_NEK2_1	848	853	PF00069	0.375
MOD_NEK2_1	882	887	PF00069	0.351
MOD_NEK2_2	616	621	PF00069	0.484
MOD_PIKK_1	10	16	PF00454	0.419
MOD_PIKK_1	403	409	PF00454	0.560
MOD_PIKK_1	431	437	PF00454	0.515
MOD_PIKK_1	453	459	PF00454	0.501
MOD_PK_1	675	681	PF00069	0.679
MOD_PKA_1	24	30	PF00069	0.363
MOD_PKA_2	168	174	PF00069	0.451
MOD_PKA_2	197	203	PF00069	0.573
MOD_PKA_2	210	216	PF00069	0.545
MOD_PKA_2	24	30	PF00069	0.363
MOD_PKA_2	304	310	PF00069	0.394
MOD_PKA_2	358	364	PF00069	0.475
MOD_PKA_2	574	580	PF00069	0.419
MOD_PKA_2	705	711	PF00069	0.296
MOD_PKA_2	758	764	PF00069	0.683
MOD_PKB_1	471	479	PF00069	0.592
MOD_Plk_1	315	321	PF00069	0.422
MOD_Plk_1	551	557	PF00069	0.416
MOD_Plk_1	570	576	PF00069	0.512
MOD_Plk_1	634	640	PF00069	0.732
MOD_Plk_1	96	102	PF00069	0.363
MOD_Plk_2-3	316	322	PF00069	0.536
MOD_Plk_4	143	149	PF00069	0.365
MOD_Plk_4	211	217	PF00069	0.468
MOD_Plk_4	232	238	PF00069	0.359
MOD_Plk_4	273	279	PF00069	0.283
MOD_Plk_4	4	10	PF00069	0.388
MOD_Plk_4	579	585	PF00069	0.514
MOD_Plk_4	691	697	PF00069	0.267
MOD_Plk_4	707	713	PF00069	0.348
MOD_Plk_4	851	857	PF00069	0.399
MOD_Plk_4	90	96	PF00069	0.324
MOD_ProDKin_1	175	181	PF00069	0.517
MOD_ProDKin_1	216	222	PF00069	0.408
MOD_ProDKin_1	407	413	PF00069	0.586
MOD_ProDKin_1	475	481	PF00069	0.590
MOD_ProDKin_1	517	523	PF00069	0.454
MOD_ProDKin_1	592	598	PF00069	0.526
MOD_ProDKin_1	606	612	PF00069	0.255
MOD_ProDKin_1	68	74	PF00069	0.363
MOD_ProDKin_1	785	791	PF00069	0.620
MOD_ProDKin_1	793	799	PF00069	0.587
MOD_SUMO_rev_2	392	400	PF00179	0.438
MOD_SUMO_rev_2	598	606	PF00179	0.218
MOD_SUMO_rev_2	899	903	PF00179	0.614
TRG_AP2beta_CARGO_1	248	258	PF09066	0.353
TRG_ENDOCYTIC_2	154	157	PF00928	0.394
TRG_ENDOCYTIC_2	681	684	PF00928	0.280
TRG_ENDOCYTIC_2	888	891	PF00928	0.428
TRG_ER_diArg_1	190	192	PF00400	0.476
TRG_ER_diArg_1	257	259	PF00400	0.349
TRG_ER_diArg_1	366	368	PF00400	0.480
TRG_ER_diArg_1	471	474	PF00400	0.595
TRG_ER_diArg_1	671	673	PF00400	0.649
TRG_ER_diArg_1	737	740	PF00400	0.697
TRG_ER_FFAT_2	796	807	PF00635	0.653
TRG_Pf-PMV_PEXEL_1	494	498	PF00026	0.746
TRG_Pf-PMV_PEXEL_1	895	899	PF00026	0.426

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8II65	Leishmania donovani	76%	100%
A4HMY6	Leishmania braziliensis	52%	98%
A4IBL0	Leishmania infantum	76%	100%
E9AFE3	Leishmania major	76%	99%