Present in the outer mitochondrial membrane proteome 34

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 7

Species:

Leishmania mexicana

UniProt:

E9B6J0_LEIMU

TriTrypDb:

LmxM.34.3110

Length:

602

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5
GO:0005741	mitochondrial outer membrane	5	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

E9B6J0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6J0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	268	272	PF00656	0.562
CLV_C14_Caspase3-7	39	43	PF00656	0.675
CLV_NRD_NRD_1	194	196	PF00675	0.583
CLV_NRD_NRD_1	28	30	PF00675	0.407
CLV_NRD_NRD_1	319	321	PF00675	0.483
CLV_NRD_NRD_1	352	354	PF00675	0.496
CLV_NRD_NRD_1	554	556	PF00675	0.385
CLV_PCSK_FUR_1	317	321	PF00082	0.292
CLV_PCSK_KEX2_1	194	196	PF00082	0.583
CLV_PCSK_KEX2_1	253	255	PF00082	0.544
CLV_PCSK_KEX2_1	27	29	PF00082	0.421
CLV_PCSK_KEX2_1	319	321	PF00082	0.353
CLV_PCSK_KEX2_1	32	34	PF00082	0.431
CLV_PCSK_KEX2_1	352	354	PF00082	0.604
CLV_PCSK_KEX2_1	554	556	PF00082	0.385
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.493
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.438
CLV_PCSK_PC7_1	28	34	PF00082	0.442
CLV_PCSK_SKI1_1	146	150	PF00082	0.311
CLV_PCSK_SKI1_1	563	567	PF00082	0.384
DEG_Nend_UBRbox_2	1	3	PF02207	0.478
DEG_SPOP_SBC_1	531	535	PF00917	0.556
DOC_ANK_TNKS_1	112	119	PF00023	0.604
DOC_MAPK_DCC_7	278	288	PF00069	0.517
DOC_MAPK_DCC_7	53	61	PF00069	0.570
DOC_MAPK_gen_1	317	326	PF00069	0.665
DOC_MAPK_HePTP_8	314	326	PF00069	0.607
DOC_MAPK_MEF2A_6	278	285	PF00069	0.612
DOC_MAPK_MEF2A_6	317	326	PF00069	0.611
DOC_MAPK_MEF2A_6	365	373	PF00069	0.615
DOC_MAPK_MEF2A_6	53	61	PF00069	0.549
DOC_MAPK_NFAT4_5	319	327	PF00069	0.477
DOC_MAPK_RevD_3	16	30	PF00069	0.174
DOC_PP1_RVXF_1	164	171	PF00149	0.521
DOC_PP2B_LxvP_1	324	327	PF13499	0.639
DOC_PP2B_LxvP_1	87	90	PF13499	0.593
DOC_PP4_FxxP_1	297	300	PF00568	0.679
DOC_PP4_FxxP_1	397	400	PF00568	0.519
DOC_PP4_FxxP_1	77	80	PF00568	0.573
DOC_USP7_MATH_1	106	110	PF00917	0.673
DOC_USP7_MATH_1	300	304	PF00917	0.632
DOC_USP7_MATH_1	434	438	PF00917	0.699
DOC_WW_Pin1_4	119	124	PF00397	0.492
DOC_WW_Pin1_4	132	137	PF00397	0.587
DOC_WW_Pin1_4	168	173	PF00397	0.664
DOC_WW_Pin1_4	232	237	PF00397	0.602
DOC_WW_Pin1_4	256	261	PF00397	0.823
DOC_WW_Pin1_4	340	345	PF00397	0.733
DOC_WW_Pin1_4	488	493	PF00397	0.569
LIG_14-3-3_CanoR_1	104	111	PF00244	0.750
LIG_14-3-3_CanoR_1	554	560	PF00244	0.591
LIG_14-3-3_CanoR_1	563	568	PF00244	0.605
LIG_14-3-3_CanoR_1	9	18	PF00244	0.418
LIG_APCC_ABBAyCdc20_2	543	549	PF00400	0.547
LIG_BIR_III_4	99	103	PF00653	0.637
LIG_BRCT_BRCA1_1	393	397	PF00533	0.503
LIG_deltaCOP1_diTrp_1	577	586	PF00928	0.605
LIG_EVH1_2	374	378	PF00568	0.537
LIG_FHA_1	106	112	PF00498	0.781
LIG_FHA_1	120	126	PF00498	0.575
LIG_FHA_1	17	23	PF00498	0.320
LIG_FHA_1	227	233	PF00498	0.531
LIG_FHA_1	278	284	PF00498	0.594
LIG_FHA_1	439	445	PF00498	0.646
LIG_FHA_1	503	509	PF00498	0.641
LIG_FHA_1	556	562	PF00498	0.522
LIG_FHA_1	564	570	PF00498	0.510
LIG_FHA_1	590	596	PF00498	0.549
LIG_FHA_2	139	145	PF00498	0.690
LIG_FHA_2	260	266	PF00498	0.771
LIG_FHA_2	355	361	PF00498	0.697
LIG_FHA_2	37	43	PF00498	0.690
LIG_FHA_2	523	529	PF00498	0.588
LIG_FHA_2	572	578	PF00498	0.593
LIG_GBD_Chelix_1	48	56	PF00786	0.403
LIG_LIR_Apic_2	394	400	PF02991	0.603
LIG_LIR_Apic_2	445	451	PF02991	0.621
LIG_LIR_Apic_2	558	562	PF02991	0.493
LIG_LIR_Gen_1	202	208	PF02991	0.558
LIG_LIR_Gen_1	391	400	PF02991	0.677
LIG_LIR_Gen_1	505	510	PF02991	0.582
LIG_LIR_Nem_3	130	134	PF02991	0.646
LIG_LIR_Nem_3	202	206	PF02991	0.554
LIG_LIR_Nem_3	391	396	PF02991	0.677
LIG_LIR_Nem_3	476	482	PF02991	0.616
LIG_LIR_Nem_3	505	509	PF02991	0.560
LIG_Pex14_2	199	203	PF04695	0.648
LIG_Pex14_2	393	397	PF04695	0.503
LIG_Pex14_2	453	457	PF04695	0.594
LIG_PTB_Apo_2	516	523	PF02174	0.524
LIG_SH2_CRK	222	226	PF00017	0.553
LIG_SH2_CRK	311	315	PF00017	0.627
LIG_SH2_NCK_1	222	226	PF00017	0.517
LIG_SH2_PTP2	448	451	PF00017	0.582
LIG_SH2_PTP2	559	562	PF00017	0.493
LIG_SH2_STAP1	222	226	PF00017	0.517
LIG_SH2_STAP1	7	11	PF00017	0.167
LIG_SH2_STAT5	131	134	PF00017	0.627
LIG_SH2_STAT5	222	225	PF00017	0.489
LIG_SH2_STAT5	448	451	PF00017	0.628
LIG_SH2_STAT5	498	501	PF00017	0.591
LIG_SH2_STAT5	559	562	PF00017	0.493
LIG_SH2_STAT5	81	84	PF00017	0.592
LIG_SH3_3	413	419	PF00018	0.663
LIG_SH3_3	463	469	PF00018	0.562
LIG_SH3_3	486	492	PF00018	0.547
LIG_SH3_3	497	503	PF00018	0.636
LIG_SH3_3	69	75	PF00018	0.584
LIG_SUMO_SIM_anti_2	223	230	PF11976	0.645
LIG_SUMO_SIM_anti_2	566	571	PF11976	0.537
LIG_SUMO_SIM_par_1	223	230	PF11976	0.563
LIG_SUMO_SIM_par_1	284	292	PF11976	0.569
LIG_SUMO_SIM_par_1	367	372	PF11976	0.640
LIG_TYR_ITIM	477	482	PF00017	0.523
MOD_CDK_SPK_2	488	493	PF00069	0.569
MOD_CDK_SPxxK_3	232	239	PF00069	0.553
MOD_CK1_1	105	111	PF00069	0.673
MOD_CK1_1	235	241	PF00069	0.726
MOD_CK1_1	264	270	PF00069	0.620
MOD_CK1_1	340	346	PF00069	0.711
MOD_CK1_1	364	370	PF00069	0.582
MOD_CK1_1	377	383	PF00069	0.598
MOD_CK1_1	411	417	PF00069	0.737
MOD_CK2_1	259	265	PF00069	0.719
MOD_CK2_1	354	360	PF00069	0.789
MOD_CK2_1	522	528	PF00069	0.588
MOD_CK2_1	571	577	PF00069	0.549
MOD_Cter_Amidation	192	195	PF01082	0.472
MOD_Cter_Amidation	251	254	PF01082	0.536
MOD_GlcNHglycan	104	107	PF01048	0.593
MOD_GlcNHglycan	13	16	PF01048	0.414
MOD_GlcNHglycan	175	178	PF01048	0.522
MOD_GlcNHglycan	185	188	PF01048	0.571
MOD_GlcNHglycan	248	252	PF01048	0.578
MOD_GlcNHglycan	256	259	PF01048	0.510
MOD_GlcNHglycan	291	294	PF01048	0.478
MOD_GlcNHglycan	388	391	PF01048	0.448
MOD_GlcNHglycan	393	396	PF01048	0.440
MOD_GlcNHglycan	410	413	PF01048	0.459
MOD_GlcNHglycan	462	465	PF01048	0.408
MOD_GlcNHglycan	525	528	PF01048	0.432
MOD_GlcNHglycan	539	542	PF01048	0.321
MOD_GlcNHglycan	99	103	PF01048	0.586
MOD_GSK3_1	16	23	PF00069	0.335
MOD_GSK3_1	179	186	PF00069	0.767
MOD_GSK3_1	252	259	PF00069	0.829
MOD_GSK3_1	331	338	PF00069	0.660
MOD_GSK3_1	340	347	PF00069	0.708
MOD_GSK3_1	369	376	PF00069	0.634
MOD_GSK3_1	434	441	PF00069	0.713
MOD_GSK3_1	469	476	PF00069	0.640
MOD_GSK3_1	488	495	PF00069	0.477
MOD_GSK3_1	530	537	PF00069	0.598
MOD_GSK3_1	571	578	PF00069	0.587
MOD_GSK3_1	98	105	PF00069	0.659
MOD_N-GLC_1	5	10	PF02516	0.573
MOD_NEK2_1	237	242	PF00069	0.709
MOD_NEK2_1	369	374	PF00069	0.637
MOD_NEK2_1	52	57	PF00069	0.682
MOD_NEK2_1	522	527	PF00069	0.582
MOD_NEK2_2	277	282	PF00069	0.493
MOD_NEK2_2	328	333	PF00069	0.606
MOD_PKA_2	277	283	PF00069	0.482
MOD_PKA_2	492	498	PF00069	0.537
MOD_PKA_2	550	556	PF00069	0.652
MOD_Plk_1	328	334	PF00069	0.732
MOD_Plk_1	5	11	PF00069	0.373
MOD_Plk_4	121	127	PF00069	0.501
MOD_Plk_4	20	26	PF00069	0.355
MOD_Plk_4	220	226	PF00069	0.527
MOD_Plk_4	364	370	PF00069	0.653
MOD_Plk_4	374	380	PF00069	0.653
MOD_Plk_4	403	409	PF00069	0.662
MOD_Plk_4	442	448	PF00069	0.601
MOD_Plk_4	473	479	PF00069	0.646
MOD_Plk_4	52	58	PF00069	0.617
MOD_Plk_4	563	569	PF00069	0.589
MOD_ProDKin_1	119	125	PF00069	0.481
MOD_ProDKin_1	132	138	PF00069	0.593
MOD_ProDKin_1	168	174	PF00069	0.669
MOD_ProDKin_1	232	238	PF00069	0.605
MOD_ProDKin_1	256	262	PF00069	0.821
MOD_ProDKin_1	340	346	PF00069	0.735
MOD_ProDKin_1	488	494	PF00069	0.560
MOD_SUMO_rev_2	181	187	PF00179	0.643
TRG_ENDOCYTIC_2	222	225	PF00928	0.595
TRG_ENDOCYTIC_2	310	313	PF00928	0.616
TRG_ENDOCYTIC_2	479	482	PF00928	0.516
TRG_ENDOCYTIC_2	7	10	PF00928	0.306
TRG_ER_diArg_1	194	196	PF00400	0.568
TRG_ER_diArg_1	26	29	PF00400	0.617
TRG_ER_diArg_1	352	354	PF00400	0.603
TRG_ER_diArg_1	554	557	PF00400	0.582
TRG_NLS_MonoExtC_3	28	33	PF00514	0.588
TRG_NLS_MonoExtN_4	27	33	PF00514	0.592

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVZ7	Leptomonas seymouri	46%	94%
A0A1X0P5E3	Trypanosomatidae	27%	100%
A0A3R7NG87	Trypanosoma rangeli	27%	100%
A0A3S7X9K3	Leishmania donovani	87%	100%
A4HMX8	Leishmania braziliensis	67%	100%
A4IBK2	Leishmania infantum	87%	100%
C9ZZ42	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9AFD5	Leishmania major	84%	100%
V5DUQ9	Trypanosoma cruzi	25%	100%