J domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B6I8_LEIMU

TriTrypDb:

LmxM.34.3090

Length:

428

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0031207	Sec62/Sec63 complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1
GO:0140534	endoplasmic reticulum protein-containing complex	2	1

Expansion

Sequence features

E9B6I8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6I8

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006613	cotranslational protein targeting to membrane	6	1
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	7	1
GO:0006620	post-translational protein targeting to endoplasmic reticulum membrane	6	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0045047	protein targeting to ER	6	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0070972	protein localization to endoplasmic reticulum	6	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072599	establishment of protein localization to endoplasmic reticulum	5	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0008320	protein transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:0022884	macromolecule transmembrane transporter activity	3	1
GO:0140318	protein transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	313	317	PF00656	0.424
CLV_C14_Caspase3-7	347	351	PF00656	0.339
CLV_NRD_NRD_1	116	118	PF00675	0.463
CLV_NRD_NRD_1	135	137	PF00675	0.462
CLV_NRD_NRD_1	138	140	PF00675	0.436
CLV_NRD_NRD_1	187	189	PF00675	0.676
CLV_NRD_NRD_1	235	237	PF00675	0.557
CLV_NRD_NRD_1	239	241	PF00675	0.561
CLV_NRD_NRD_1	259	261	PF00675	0.407
CLV_NRD_NRD_1	3	5	PF00675	0.526
CLV_NRD_NRD_1	87	89	PF00675	0.571
CLV_PCSK_FUR_1	133	137	PF00082	0.458
CLV_PCSK_KEX2_1	135	137	PF00082	0.443
CLV_PCSK_KEX2_1	185	187	PF00082	0.607
CLV_PCSK_KEX2_1	235	237	PF00082	0.568
CLV_PCSK_KEX2_1	279	281	PF00082	0.608
CLV_PCSK_KEX2_1	3	5	PF00082	0.526
CLV_PCSK_KEX2_1	405	407	PF00082	0.622
CLV_PCSK_KEX2_1	45	47	PF00082	0.246
CLV_PCSK_KEX2_1	87	89	PF00082	0.564
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.607
CLV_PCSK_PC1ET2_1	279	281	PF00082	0.577
CLV_PCSK_PC1ET2_1	405	407	PF00082	0.603
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.246
CLV_PCSK_SKI1_1	142	146	PF00082	0.452
CLV_PCSK_SKI1_1	187	191	PF00082	0.624
CLV_PCSK_SKI1_1	235	239	PF00082	0.590
CLV_PCSK_SKI1_1	354	358	PF00082	0.499
CLV_PCSK_SKI1_1	424	428	PF00082	0.637
DEG_APCC_DBOX_1	141	149	PF00400	0.587
DEG_APCC_DBOX_1	185	193	PF00400	0.414
DEG_APCC_DBOX_1	2	10	PF00400	0.673
DEG_Nend_Nbox_1	1	3	PF02207	0.661
DOC_CKS1_1	29	34	PF01111	0.457
DOC_CKS1_1	308	313	PF01111	0.254
DOC_CYCLIN_RxL_1	362	372	PF00134	0.398
DOC_CYCLIN_yCln2_LP_2	196	202	PF00134	0.415
DOC_PP1_RVXF_1	363	370	PF00149	0.390
DOC_PP2B_LxvP_1	196	199	PF13499	0.416
DOC_PP2B_LxvP_1	419	422	PF13499	0.374
DOC_USP7_MATH_1	10	14	PF00917	0.772
DOC_USP7_MATH_1	256	260	PF00917	0.365
DOC_USP7_MATH_1	422	426	PF00917	0.502
DOC_WW_Pin1_4	25	30	PF00397	0.458
DOC_WW_Pin1_4	307	312	PF00397	0.289
DOC_WW_Pin1_4	332	337	PF00397	0.302
DOC_WW_Pin1_4	86	91	PF00397	0.661
DOC_WW_Pin1_4	99	104	PF00397	0.744
LIG_14-3-3_CanoR_1	139	145	PF00244	0.663
LIG_14-3-3_CanoR_1	174	179	PF00244	0.364
LIG_14-3-3_CanoR_1	235	242	PF00244	0.367
LIG_14-3-3_CanoR_1	260	269	PF00244	0.299
LIG_14-3-3_CanoR_1	3	7	PF00244	0.715
LIG_14-3-3_CanoR_1	309	315	PF00244	0.224
LIG_BRCT_BRCA1_1	263	267	PF00533	0.404
LIG_EH1_1	175	183	PF00400	0.421
LIG_FHA_1	161	167	PF00498	0.389
LIG_FHA_1	356	362	PF00498	0.363
LIG_FHA_2	205	211	PF00498	0.498
LIG_FHA_2	212	218	PF00498	0.325
LIG_FHA_2	29	35	PF00498	0.549
LIG_FHA_2	340	346	PF00498	0.273
LIG_FHA_2	408	414	PF00498	0.348
LIG_LIR_Apic_2	310	315	PF02991	0.298
LIG_LIR_Gen_1	173	183	PF02991	0.342
LIG_LIR_Gen_1	210	218	PF02991	0.476
LIG_LIR_Gen_1	247	256	PF02991	0.290
LIG_LIR_Gen_1	268	277	PF02991	0.226
LIG_LIR_Gen_1	31	41	PF02991	0.458
LIG_LIR_Gen_1	338	349	PF02991	0.292
LIG_LIR_Nem_3	173	178	PF02991	0.326
LIG_LIR_Nem_3	210	215	PF02991	0.496
LIG_LIR_Nem_3	243	248	PF02991	0.307
LIG_LIR_Nem_3	268	272	PF02991	0.226
LIG_LIR_Nem_3	293	299	PF02991	0.387
LIG_LIR_Nem_3	31	36	PF02991	0.469
LIG_LIR_Nem_3	338	344	PF02991	0.289
LIG_NRBOX	144	150	PF00104	0.446
LIG_PTB_Apo_2	363	370	PF02174	0.287
LIG_SH2_CRK	175	179	PF00017	0.351
LIG_SH2_CRK	212	216	PF00017	0.477
LIG_SH2_CRK	269	273	PF00017	0.282
LIG_SH2_CRK	296	300	PF00017	0.354
LIG_SH2_CRK	66	70	PF00017	0.431
LIG_SH2_SRC	269	272	PF00017	0.228
LIG_SH2_STAT5	271	274	PF00017	0.231
LIG_SH2_STAT5	346	349	PF00017	0.393
LIG_SH3_3	15	21	PF00018	0.612
LIG_SH3_3	195	201	PF00018	0.401
LIG_SH3_3	248	254	PF00018	0.314
LIG_SH3_3	26	32	PF00018	0.451
LIG_SUMO_SIM_anti_2	163	169	PF11976	0.321
LIG_SUMO_SIM_par_1	165	171	PF11976	0.336
LIG_SUMO_SIM_par_1	200	205	PF11976	0.436
LIG_TRAF2_1	129	132	PF00917	0.658
LIG_TRAF2_1	82	85	PF00917	0.546
MOD_CDK_SPxxK_3	28	35	PF00069	0.360
MOD_CDK_SPxxK_3	86	93	PF00069	0.666
MOD_CK1_1	13	19	PF00069	0.683
MOD_CK1_1	160	166	PF00069	0.411
MOD_CK1_1	28	34	PF00069	0.480
MOD_CK1_1	335	341	PF00069	0.310
MOD_CK1_1	78	84	PF00069	0.613
MOD_CK1_1	89	95	PF00069	0.727
MOD_CK2_1	211	217	PF00069	0.318
MOD_CK2_1	28	34	PF00069	0.540
MOD_CK2_1	339	345	PF00069	0.272
MOD_CK2_1	407	413	PF00069	0.354
MOD_CK2_1	74	80	PF00069	0.560
MOD_GlcNHglycan	14	18	PF01048	0.492
MOD_GlcNHglycan	263	266	PF01048	0.492
MOD_GlcNHglycan	312	315	PF01048	0.618
MOD_GlcNHglycan	80	83	PF01048	0.552
MOD_GSK3_1	261	268	PF00069	0.322
MOD_GSK3_1	286	293	PF00069	0.406
MOD_GSK3_1	332	339	PF00069	0.318
MOD_GSK3_1	74	81	PF00069	0.653
MOD_N-GLC_1	152	157	PF02516	0.457
MOD_N-GLC_1	336	341	PF02516	0.557
MOD_N-GLC_1	350	355	PF02516	0.517
MOD_NEK2_1	2	7	PF00069	0.754
MOD_NEK2_1	369	374	PF00069	0.418
MOD_NEK2_2	422	427	PF00069	0.525
MOD_PIKK_1	235	241	PF00454	0.360
MOD_PK_1	417	423	PF00069	0.336
MOD_PKA_1	135	141	PF00069	0.705
MOD_PKA_1	235	241	PF00069	0.360
MOD_PKA_2	135	141	PF00069	0.630
MOD_PKA_2	2	8	PF00069	0.714
MOD_PKA_2	235	241	PF00069	0.360
MOD_PKA_2	265	271	PF00069	0.320
MOD_PKA_2	73	79	PF00069	0.587
MOD_PKA_2	96	102	PF00069	0.660
MOD_PKB_1	133	141	PF00069	0.595
MOD_PKB_1	227	235	PF00069	0.434
MOD_Plk_1	204	210	PF00069	0.365
MOD_Plk_1	229	235	PF00069	0.436
MOD_Plk_1	417	423	PF00069	0.345
MOD_Plk_4	160	166	PF00069	0.356
MOD_Plk_4	204	210	PF00069	0.279
MOD_ProDKin_1	25	31	PF00069	0.458
MOD_ProDKin_1	307	313	PF00069	0.291
MOD_ProDKin_1	332	338	PF00069	0.305
MOD_ProDKin_1	86	92	PF00069	0.664
MOD_ProDKin_1	99	105	PF00069	0.740
MOD_SUMO_for_1	272	275	PF00179	0.231
TRG_DiLeu_BaEn_2	146	152	PF01217	0.451
TRG_ENDOCYTIC_2	175	178	PF00928	0.317
TRG_ENDOCYTIC_2	212	215	PF00928	0.499
TRG_ENDOCYTIC_2	269	272	PF00928	0.279
TRG_ENDOCYTIC_2	296	299	PF00928	0.316
TRG_ENDOCYTIC_2	346	349	PF00928	0.331
TRG_ENDOCYTIC_2	66	69	PF00928	0.431
TRG_ER_diArg_1	186	188	PF00400	0.377
TRG_ER_diArg_1	2	4	PF00400	0.667
TRG_ER_diArg_1	226	229	PF00400	0.388
TRG_ER_diArg_1	234	236	PF00400	0.341
TRG_ER_diArg_1	36	39	PF00400	0.522
TRG_NLS_MonoExtN_4	136	143	PF00514	0.507
TRG_Pf-PMV_PEXEL_1	180	184	PF00026	0.595
TRG_Pf-PMV_PEXEL_1	396	400	PF00026	0.653
TRG_Pf-PMV_PEXEL_1	67	72	PF00026	0.320

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P559	Leptomonas seymouri	66%	99%
A0A0S4JM78	Bodo saltans	29%	100%
A0A1X0P5J7	Trypanosomatidae	49%	97%
A0A3Q8IJK4	Leishmania donovani	92%	100%
A0A422MXB6	Trypanosoma rangeli	47%	100%
A4HMX6	Leishmania braziliensis	80%	100%
A4IBK0	Leishmania infantum	92%	100%
C9ZZ44	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AFD3	Leishmania major	90%	100%
V5DUR2	Trypanosoma cruzi	45%	100%