Putative ubiquitin-activating enzyme e1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin-activating enzyme E1, putative

Species:

Leishmania mexicana

UniProt:

E9B6I5_LEIMU

TriTrypDb:

LmxM.34.3060

Length:

1154

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

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Expansion

Sequence features

E9B6I5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6I5

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	10
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0008152	metabolic process	1	10
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0016567	protein ubiquitination	7	10

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004839	ubiquitin activating enzyme activity	3	1
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0008641	ubiquitin-like modifier activating enzyme activity	2	11
GO:0016740	transferase activity	2	1
GO:0016746	acyltransferase activity	3	1
GO:0016874	ligase activity	2	11
GO:0016877	ligase activity, forming carbon-sulfur bonds	3	11
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0061631	ubiquitin conjugating enzyme activity	5	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1060	1064	PF00656	0.520
CLV_C14_Caspase3-7	118	122	PF00656	0.356
CLV_C14_Caspase3-7	635	639	PF00656	0.292
CLV_C14_Caspase3-7	794	798	PF00656	0.520
CLV_NRD_NRD_1	66	68	PF00675	0.313
CLV_NRD_NRD_1	709	711	PF00675	0.302
CLV_NRD_NRD_1	778	780	PF00675	0.269
CLV_PCSK_KEX2_1	709	711	PF00082	0.292
CLV_PCSK_KEX2_1	724	726	PF00082	0.288
CLV_PCSK_PC1ET2_1	724	726	PF00082	0.303

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0Q7	Leptomonas seymouri	28%	100%
A0A0N1IJ85	Leptomonas seymouri	79%	100%
A0A0S4IRG8	Bodo saltans	28%	100%
A0A0S4JDE8	Bodo saltans	59%	94%
A0A1X0P5N5	Trypanosomatidae	63%	95%
A0A3Q8IIG4	Leishmania donovani	95%	100%
A0A3R7MAM2	Trypanosoma rangeli	63%	95%
A0A3R7MK28	Trypanosoma rangeli	30%	100%
A0A3S7WXL3	Leishmania donovani	28%	100%
A0AVT1	Homo sapiens	29%	100%

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