CCHC-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleic acid binding protein, putative

Species:

Leishmania mexicana

UniProt:

E9B6I4_LEIMU

TriTrypDb:

LmxM.34.3050

Length:

407

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6I4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6I4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006397	mRNA processing	7	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016071	mRNA metabolic process	6	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004842	ubiquitin-protein transferase activity	4	12
GO:0005488	binding	1	12
GO:0008270	zinc ion binding	6	12
GO:0016740	transferase activity	2	12
GO:0019787	ubiquitin-like protein transferase activity	3	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	12
GO:0061630	ubiquitin protein ligase activity	5	12
GO:0061659	ubiquitin-like protein ligase activity	4	12
GO:0097159	organic cyclic compound binding	2	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	26	30	PF00656	0.442
CLV_C14_Caspase3-7	363	367	PF00656	0.506
CLV_NRD_NRD_1	142	144	PF00675	0.725
CLV_NRD_NRD_1	254	256	PF00675	0.474
CLV_NRD_NRD_1	399	401	PF00675	0.482
CLV_PCSK_FUR_1	140	144	PF00082	0.623
CLV_PCSK_KEX2_1	142	144	PF00082	0.725
CLV_PCSK_KEX2_1	253	255	PF00082	0.468
CLV_PCSK_KEX2_1	401	403	PF00082	0.453
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.425
CLV_PCSK_PC1ET2_1	401	403	PF00082	0.453
CLV_PCSK_PC7_1	250	256	PF00082	0.440
CLV_PCSK_SKI1_1	216	220	PF00082	0.492
CLV_PCSK_SKI1_1	243	247	PF00082	0.421
CLV_PCSK_SKI1_1	250	254	PF00082	0.447
CLV_PCSK_SKI1_1	394	398	PF00082	0.652
CLV_PCSK_SKI1_1	78	82	PF00082	0.694
DEG_SPOP_SBC_1	307	311	PF00917	0.647
DOC_CYCLIN_RxL_1	390	399	PF00134	0.632
DOC_CYCLIN_yCln2_LP_2	221	227	PF00134	0.544
DOC_MAPK_gen_1	213	223	PF00069	0.476
DOC_PP1_RVXF_1	217	224	PF00149	0.584
DOC_PP2B_LxvP_1	38	41	PF13499	0.547
DOC_PP4_FxxP_1	187	190	PF00568	0.470
DOC_USP7_MATH_1	307	311	PF00917	0.728
DOC_USP7_MATH_1	98	102	PF00917	0.642
LIG_14-3-3_CanoR_1	72	80	PF00244	0.574
LIG_14-3-3_CanoR_1	8	15	PF00244	0.427
LIG_BRCT_BRCA1_1	137	141	PF00533	0.593
LIG_BRCT_BRCA1_1	164	168	PF00533	0.568
LIG_BRCT_BRCA1_1	3	7	PF00533	0.451
LIG_FHA_1	294	300	PF00498	0.454
LIG_FHA_1	356	362	PF00498	0.676
LIG_FHA_1	4	10	PF00498	0.350
LIG_FHA_1	51	57	PF00498	0.596
LIG_FHA_2	114	120	PF00498	0.469
LIG_FHA_2	130	136	PF00498	0.479
LIG_FHA_2	234	240	PF00498	0.460
LIG_FHA_2	275	281	PF00498	0.626
LIG_FHA_2	303	309	PF00498	0.763
LIG_Integrin_RGD_1	175	177	PF01839	0.649
LIG_LIR_Apic_2	184	190	PF02991	0.498
LIG_LIR_Gen_1	259	269	PF02991	0.644
LIG_LIR_Gen_1	345	355	PF02991	0.507
LIG_SH2_NCK_1	65	69	PF00017	0.420
LIG_SH2_STAT5	194	197	PF00017	0.266
LIG_SH3_3	100	106	PF00018	0.451
LIG_SH3_3	222	228	PF00018	0.536
LIG_SH3_3	366	372	PF00018	0.561
LIG_TRAF2_1	116	119	PF00917	0.460
LIG_TRAF2_1	386	389	PF00917	0.430
LIG_TRAF2_1	41	44	PF00917	0.431
MOD_CK1_1	23	29	PF00069	0.543
MOD_CK1_1	259	265	PF00069	0.534
MOD_CK1_1	274	280	PF00069	0.547
MOD_CK1_1	310	316	PF00069	0.643
MOD_CK1_1	345	351	PF00069	0.479
MOD_CK1_1	93	99	PF00069	0.596
MOD_CK2_1	113	119	PF00069	0.483
MOD_CK2_1	302	308	PF00069	0.747
MOD_GlcNHglycan	100	103	PF01048	0.613
MOD_GlcNHglycan	210	213	PF01048	0.605
MOD_GlcNHglycan	272	276	PF01048	0.741
MOD_GlcNHglycan	75	78	PF01048	0.536
MOD_GSK3_1	298	305	PF00069	0.665
MOD_GSK3_1	306	313	PF00069	0.598
MOD_GSK3_1	93	100	PF00069	0.551
MOD_N-GLC_1	291	296	PF02516	0.729
MOD_N-GLC_1	299	304	PF02516	0.636
MOD_NEK2_1	1	6	PF00069	0.376
MOD_NEK2_1	20	25	PF00069	0.365
MOD_NEK2_1	342	347	PF00069	0.326
MOD_NEK2_1	355	360	PF00069	0.556
MOD_NEK2_1	49	54	PF00069	0.588
MOD_NEK2_1	80	85	PF00069	0.691
MOD_NEK2_1	9	14	PF00069	0.406
MOD_NEK2_2	3	8	PF00069	0.357
MOD_PKA_2	71	77	PF00069	0.585
MOD_Plk_1	233	239	PF00069	0.448
MOD_Plk_1	299	305	PF00069	0.456
MOD_Plk_1	316	322	PF00069	0.329
MOD_Plk_2-3	357	363	PF00069	0.663
MOD_Plk_4	20	26	PF00069	0.559
MOD_Plk_4	227	233	PF00069	0.405
MOD_Plk_4	256	262	PF00069	0.586
MOD_Plk_4	299	305	PF00069	0.456
TRG_DiLeu_BaEn_3	43	49	PF01217	0.415
TRG_DiLeu_BaLyEn_6	374	379	PF01217	0.510
TRG_ENDOCYTIC_2	65	68	PF00928	0.405
TRG_ER_diArg_1	141	143	PF00400	0.579
TRG_ER_diArg_1	254	256	PF00400	0.462
TRG_Pf-PMV_PEXEL_1	359	363	PF00026	0.738

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJT3	Leptomonas seymouri	66%	97%
A0A0S4JGE6	Bodo saltans	32%	100%
A0A1X0P6U9	Trypanosomatidae	43%	100%
A0A3Q8IMI0	Leishmania donovani	92%	100%
A0A3S5ISL5	Trypanosoma rangeli	45%	100%
A4HMX2	Leishmania braziliensis	83%	100%
A4IBJ3	Leishmania infantum	91%	100%
C9ZZ48	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AFC9	Leishmania major	90%	100%
V5DUR5	Trypanosoma cruzi	43%	100%