Protein-S-isoprenylcysteine O-methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

prenyl protein specific carboxyl methyltransferase, putative

Species:

Leishmania mexicana

UniProt:

E9B6I2_LEIMU

TriTrypDb:

LmxM.34.3030

Length:

266

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	1
GO:0005789	endoplasmic reticulum membrane	4	12
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	12
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	12

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Expansion

Sequence features

E9B6I2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6I2

Function

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Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006481	C-terminal protein methylation	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0018410	C-terminal protein amino acid modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0036211	protein modification process	4	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0003880	protein C-terminal carboxyl O-methyltransferase activity	5	12
GO:0004671	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity	6	12
GO:0008168	methyltransferase activity	4	12
GO:0008171	O-methyltransferase activity	5	12
GO:0008276	protein methyltransferase activity	3	12
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	12
GO:0010340	carboxyl-O-methyltransferase activity	6	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	91	95	PF00656	0.555
CLV_NRD_NRD_1	18	20	PF00675	0.409
CLV_PCSK_KEX2_1	18	20	PF00082	0.394
CLV_PCSK_KEX2_1	253	255	PF00082	0.348
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.358
DOC_CYCLIN_RxL_1	22	32	PF00134	0.593
DOC_CYCLIN_yCln2_LP_2	195	201	PF00134	0.257
DOC_CYCLIN_yCln2_LP_2	214	220	PF00134	0.189
DOC_MAPK_gen_1	253	263	PF00069	0.483
DOC_MAPK_MEF2A_6	256	265	PF00069	0.496

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P511	Leptomonas seymouri	67%	100%
A0A0S4JHW1	Bodo saltans	44%	100%
A0A1X0P5F1	Trypanosomatidae	51%	100%
A0A3S7X9G8	Leishmania donovani	91%	100%
A0A422P2Y4	Trypanosoma rangeli	51%	100%
A2XX73	Oryza sativa subsp. indica	30%	100%
A4HMX0	Leishmania braziliensis	83%	100%
A4IBJ1	Leishmania infantum	92%	100%
C9ZZ50	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
D6WJ77	Tribolium castaneum	33%	95%

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