Protein-S-isoprenylcysteine O-methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

prenyl protein specific carboxyl methyltransferase, putative

Species:

Leishmania mexicana

UniProt:

E9B6I2_LEIMU

TriTrypDb:

LmxM.34.3030

Length:

266

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	12
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9B6I2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6I2

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006481	C-terminal protein methylation	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0018410	C-terminal protein amino acid modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0043687	post-translational protein modification	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0003880	protein C-terminal carboxyl O-methyltransferase activity	5	12
GO:0004671	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity	6	12
GO:0008168	methyltransferase activity	4	12
GO:0008171	O-methyltransferase activity	5	12
GO:0008276	protein methyltransferase activity	3	12
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	12
GO:0010340	carboxyl-O-methyltransferase activity	6	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0051998	protein carboxyl O-methyltransferase activity	4	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	91	95	PF00656	0.555
CLV_NRD_NRD_1	18	20	PF00675	0.409
CLV_PCSK_KEX2_1	18	20	PF00082	0.394
CLV_PCSK_KEX2_1	253	255	PF00082	0.348
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.358
DOC_CYCLIN_RxL_1	22	32	PF00134	0.593
DOC_CYCLIN_yCln2_LP_2	195	201	PF00134	0.257
DOC_CYCLIN_yCln2_LP_2	214	220	PF00134	0.189
DOC_MAPK_gen_1	253	263	PF00069	0.483
DOC_MAPK_MEF2A_6	256	265	PF00069	0.496
DOC_PP4_FxxP_1	85	88	PF00568	0.609
DOC_WW_Pin1_4	99	104	PF00397	0.557
LIG_14-3-3_CanoR_1	161	166	PF00244	0.355
LIG_BIR_II_1	1	5	PF00653	0.715
LIG_CtBP_PxDLS_1	7	11	PF00389	0.486
LIG_eIF4E_1	144	150	PF01652	0.381
LIG_FHA_1	100	106	PF00498	0.549
LIG_FHA_1	108	114	PF00498	0.554
LIG_FHA_1	123	129	PF00498	0.448
LIG_FHA_1	149	155	PF00498	0.354
LIG_FHA_1	186	192	PF00498	0.272
LIG_FHA_1	30	36	PF00498	0.367
LIG_FHA_2	54	60	PF00498	0.401
LIG_FHA_2	89	95	PF00498	0.533
LIG_LIR_Apic_2	118	123	PF02991	0.546
LIG_LIR_Gen_1	114	123	PF02991	0.360
LIG_LIR_Gen_1	170	176	PF02991	0.296
LIG_LIR_Gen_1	94	104	PF02991	0.549
LIG_LIR_LC3C_4	151	155	PF02991	0.269
LIG_LIR_Nem_3	114	119	PF02991	0.348
LIG_LIR_Nem_3	227	231	PF02991	0.478
LIG_LIR_Nem_3	250	255	PF02991	0.487
LIG_LIR_Nem_3	94	99	PF02991	0.529
LIG_NRBOX	148	154	PF00104	0.232
LIG_Pex14_2	201	205	PF04695	0.247
LIG_REV1ctd_RIR_1	136	145	PF16727	0.533
LIG_REV1ctd_RIR_1	228	238	PF16727	0.447
LIG_SH2_CRK	192	196	PF00017	0.258
LIG_SH2_NCK_1	120	124	PF00017	0.618
LIG_SH2_NCK_1	237	241	PF00017	0.482
LIG_SH2_PTP2	67	70	PF00017	0.361
LIG_SH2_SRC	104	107	PF00017	0.531
LIG_SH2_SRC	120	123	PF00017	0.425
LIG_SH2_SRC	237	240	PF00017	0.463
LIG_SH2_STAP1	144	148	PF00017	0.369
LIG_SH2_STAT5	104	107	PF00017	0.517
LIG_SH2_STAT5	194	197	PF00017	0.261
LIG_SH2_STAT5	200	203	PF00017	0.231
LIG_SH2_STAT5	229	232	PF00017	0.533
LIG_SH2_STAT5	67	70	PF00017	0.342
LIG_SH3_3	258	264	PF00018	0.502
LIG_SUMO_SIM_anti_2	151	157	PF11976	0.378
LIG_TRAF2_1	236	239	PF00917	0.451
LIG_TRAF2_1	6	9	PF00917	0.498
MOD_CK1_1	170	176	PF00069	0.295
MOD_CK1_1	2	8	PF00069	0.719
MOD_CK2_1	2	8	PF00069	0.613
MOD_GlcNHglycan	107	110	PF01048	0.320
MOD_GlcNHglycan	145	148	PF01048	0.432
MOD_GlcNHglycan	218	221	PF01048	0.448
MOD_GlcNHglycan	4	7	PF01048	0.455
MOD_GSK3_1	53	60	PF00069	0.284
MOD_N-GLC_1	170	175	PF02516	0.447
MOD_NEK2_1	1	6	PF00069	0.728
MOD_NEK2_1	105	110	PF00069	0.515
MOD_NEK2_1	148	153	PF00069	0.362
MOD_NEK2_1	204	209	PF00069	0.270
MOD_NEK2_1	230	235	PF00069	0.515
MOD_PKA_2	179	185	PF00069	0.272
MOD_Plk_1	170	176	PF00069	0.247
MOD_Plk_1	238	244	PF00069	0.490
MOD_Plk_1	57	63	PF00069	0.336
MOD_Plk_4	161	167	PF00069	0.340
MOD_Plk_4	224	230	PF00069	0.378
MOD_Plk_4	57	63	PF00069	0.293
MOD_ProDKin_1	99	105	PF00069	0.555
TRG_ENDOCYTIC_2	192	195	PF00928	0.258
TRG_ENDOCYTIC_2	67	70	PF00928	0.361
TRG_ER_diArg_1	17	19	PF00400	0.637
TRG_ER_diArg_1	231	234	PF00400	0.529
TRG_Pf-PMV_PEXEL_1	26	31	PF00026	0.308

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P511	Leptomonas seymouri	67%	100%
A0A0S4JHW1	Bodo saltans	44%	100%
A0A1X0P5F1	Trypanosomatidae	51%	100%
A0A3S7X9G8	Leishmania donovani	91%	100%
A0A422P2Y4	Trypanosoma rangeli	51%	100%
A2XX73	Oryza sativa subsp. indica	30%	100%
A4HMX0	Leishmania braziliensis	83%	100%
A4IBJ1	Leishmania infantum	92%	100%
C9ZZ50	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
D6WJ77	Tribolium castaneum	33%	95%
E9AFC7	Leishmania major	88%	100%
O12947	Xenopus laevis	34%	92%
O60725	Homo sapiens	34%	94%
P32584	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
P87014	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
Q558K8	Dictyostelium discoideum	32%	100%
Q7XSR9	Oryza sativa subsp. japonica	30%	100%
Q9EQK7	Mus musculus	32%	94%
Q9WVM4	Rattus norvegicus	33%	94%
V5C2X9	Trypanosoma cruzi	47%	100%