1-alkyl-2-acetylglycerophosphocholine esterase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phospholipase A2-like protein, putative

Species:

Leishmania mexicana

UniProt:

E9B6I1_LEIMU

TriTrypDb:

LmxM.34.3020

Length:

453

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9B6I1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6I1

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	13
GO:0008152	metabolic process	1	13
GO:0009056	catabolic process	2	13
GO:0016042	lipid catabolic process	4	13
GO:0044238	primary metabolic process	2	13
GO:0071704	organic substance metabolic process	2	13
GO:1901575	organic substance catabolic process	3	13

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity	5	13
GO:0016787	hydrolase activity	2	13
GO:0016788	hydrolase activity, acting on ester bonds	3	13
GO:0052689	carboxylic ester hydrolase activity	4	13
GO:0004620	phospholipase activity	5	1
GO:0008970	phospholipase A1 activity	5	1
GO:0016298	lipase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	185	189	PF00656	0.312
CLV_C14_Caspase3-7	279	283	PF00656	0.179
CLV_NRD_NRD_1	131	133	PF00675	0.417
CLV_NRD_NRD_1	246	248	PF00675	0.519
CLV_NRD_NRD_1	305	307	PF00675	0.551
CLV_PCSK_KEX2_1	131	133	PF00082	0.379
CLV_PCSK_KEX2_1	232	234	PF00082	0.470
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.465
CLV_PCSK_SKI1_1	307	311	PF00082	0.506
DEG_APCC_DBOX_1	106	114	PF00400	0.332
DEG_APCC_DBOX_1	224	232	PF00400	0.216
DEG_SCF_FBW7_1	87	94	PF00400	0.130
DOC_CKS1_1	323	328	PF01111	0.236
DOC_CKS1_1	88	93	PF01111	0.130
DOC_CYCLIN_yCln2_LP_2	398	404	PF00134	0.313
DOC_MAPK_gen_1	232	241	PF00069	0.281
DOC_MAPK_gen_1	317	323	PF00069	0.313
DOC_MAPK_MEF2A_6	216	224	PF00069	0.312
DOC_MAPK_MEF2A_6	235	243	PF00069	0.312
DOC_MAPK_MEF2A_6	77	86	PF00069	0.278
DOC_MAPK_RevD_3	120	133	PF00069	0.130
DOC_PP2B_LxvP_1	201	204	PF13499	0.130
DOC_PP4_FxxP_1	323	326	PF00568	0.312
DOC_PP4_MxPP_1	80	83	PF00568	0.312
DOC_USP7_MATH_1	15	19	PF00917	0.303
DOC_USP7_MATH_1	413	417	PF00917	0.202
DOC_USP7_MATH_1	89	93	PF00917	0.251
DOC_USP7_UBL2_3	313	317	PF12436	0.258
DOC_WW_Pin1_4	322	327	PF00397	0.236
DOC_WW_Pin1_4	397	402	PF00397	0.263
DOC_WW_Pin1_4	409	414	PF00397	0.264
DOC_WW_Pin1_4	447	452	PF00397	0.430
DOC_WW_Pin1_4	57	62	PF00397	0.375
DOC_WW_Pin1_4	87	92	PF00397	0.275
LIG_14-3-3_CanoR_1	247	251	PF00244	0.233
LIG_14-3-3_CanoR_1	286	296	PF00244	0.219
LIG_14-3-3_CanoR_1	306	310	PF00244	0.179
LIG_14-3-3_CanoR_1	357	365	PF00244	0.267
LIG_14-3-3_CanoR_1	376	380	PF00244	0.198
LIG_AP2alpha_2	299	301	PF02296	0.223
LIG_APCC_ABBA_1	328	333	PF00400	0.236
LIG_APCC_ABBAyCdc20_2	306	312	PF00400	0.179
LIG_BIR_III_2	353	357	PF00653	0.219
LIG_BRCT_BRCA1_1	319	323	PF00533	0.130
LIG_Clathr_ClatBox_1	425	429	PF01394	0.167
LIG_deltaCOP1_diTrp_1	32	37	PF00928	0.378
LIG_FHA_1	323	329	PF00498	0.225
LIG_FHA_1	33	39	PF00498	0.499
LIG_FHA_1	386	392	PF00498	0.294
LIG_FHA_1	437	443	PF00498	0.511
LIG_FHA_1	45	51	PF00498	0.443
LIG_FHA_1	68	74	PF00498	0.313
LIG_FHA_2	210	216	PF00498	0.319
LIG_FHA_2	356	362	PF00498	0.287
LIG_FHA_2	379	385	PF00498	0.355
LIG_LIR_Apic_2	299	304	PF02991	0.212
LIG_LIR_Apic_2	320	326	PF02991	0.198
LIG_LIR_Apic_2	85	91	PF02991	0.208
LIG_LIR_Gen_1	115	124	PF02991	0.245
LIG_LIR_Gen_1	251	260	PF02991	0.197
LIG_LIR_Gen_1	308	316	PF02991	0.251
LIG_LIR_Nem_3	115	119	PF02991	0.235
LIG_LIR_Nem_3	308	314	PF02991	0.312
LIG_LIR_Nem_3	397	402	PF02991	0.175
LIG_Pex14_1	33	37	PF04695	0.398
LIG_Pex14_2	331	335	PF04695	0.278
LIG_SH2_CRK	116	120	PF00017	0.278
LIG_SH2_CRK	167	171	PF00017	0.216
LIG_SH2_CRK	311	315	PF00017	0.284
LIG_SH2_NCK_1	116	120	PF00017	0.300
LIG_SH2_PTP2	121	124	PF00017	0.275
LIG_SH2_PTP2	52	55	PF00017	0.294
LIG_SH2_STAP1	167	171	PF00017	0.223
LIG_SH2_STAT5	101	104	PF00017	0.211
LIG_SH2_STAT5	109	112	PF00017	0.191
LIG_SH2_STAT5	116	119	PF00017	0.177
LIG_SH2_STAT5	121	124	PF00017	0.190
LIG_SH2_STAT5	13	16	PF00017	0.310
LIG_SH2_STAT5	193	196	PF00017	0.313
LIG_SH2_STAT5	253	256	PF00017	0.247
LIG_SH2_STAT5	380	383	PF00017	0.336
LIG_SH2_STAT5	52	55	PF00017	0.378
LIG_SH2_STAT5	7	10	PF00017	0.306
LIG_SH3_3	294	300	PF00018	0.277
LIG_SH3_3	428	434	PF00018	0.290
LIG_SH3_3	83	89	PF00018	0.163
LIG_SH3_5	3	7	PF00018	0.383
LIG_TRAF2_1	358	361	PF00917	0.251
LIG_TYR_ITIM	119	124	PF00017	0.312
LIG_UBA3_1	239	248	PF00899	0.300
LIG_UBA3_1	302	307	PF00899	0.246
LIG_UBA3_1	425	430	PF00899	0.170
MOD_CDK_SPK_2	409	414	PF00069	0.331
MOD_CDK_SPK_2	447	452	PF00069	0.313
MOD_CDK_SPK_2	91	96	PF00069	0.314
MOD_CK1_1	291	297	PF00069	0.239
MOD_CK1_1	378	384	PF00069	0.359
MOD_CK1_1	397	403	PF00069	0.195
MOD_CK1_1	44	50	PF00069	0.453
MOD_CK2_1	355	361	PF00069	0.228
MOD_GlcNHglycan	188	192	PF01048	0.418
MOD_GlcNHglycan	360	364	PF01048	0.458
MOD_GlcNHglycan	431	434	PF01048	0.578
MOD_GlcNHglycan	444	447	PF01048	0.621
MOD_GlcNHglycan	91	94	PF01048	0.451
MOD_GlcNHglycan	96	99	PF01048	0.521
MOD_GSK3_1	16	23	PF00069	0.348
MOD_GSK3_1	277	284	PF00069	0.278
MOD_GSK3_1	287	294	PF00069	0.223
MOD_GSK3_1	317	324	PF00069	0.201
MOD_GSK3_1	355	362	PF00069	0.227
MOD_GSK3_1	37	44	PF00069	0.425
MOD_GSK3_1	374	381	PF00069	0.195
MOD_GSK3_1	385	392	PF00069	0.245
MOD_GSK3_1	409	416	PF00069	0.279
MOD_GSK3_1	87	94	PF00069	0.251
MOD_N-GLC_1	277	282	PF02516	0.514
MOD_N-GLC_1	442	447	PF02516	0.661
MOD_NEK2_1	166	171	PF00069	0.269
MOD_NEK2_1	182	187	PF00069	0.326
MOD_NEK2_1	305	310	PF00069	0.346
MOD_NEK2_1	37	42	PF00069	0.300
MOD_NEK2_1	375	380	PF00069	0.317
MOD_NEK2_1	442	447	PF00069	0.447
MOD_NEK2_2	7	12	PF00069	0.318
MOD_OFUCOSY	36	41	PF10250	0.295
MOD_PIKK_1	204	210	PF00454	0.310
MOD_PIKK_1	277	283	PF00454	0.314
MOD_PK_1	317	323	PF00069	0.195
MOD_PKA_1	317	323	PF00069	0.198
MOD_PKA_2	224	230	PF00069	0.232
MOD_PKA_2	246	252	PF00069	0.233
MOD_PKA_2	305	311	PF00069	0.182
MOD_PKA_2	356	362	PF00069	0.300
MOD_PKA_2	375	381	PF00069	0.204
MOD_PKA_2	385	391	PF00069	0.351
MOD_PKA_2	413	419	PF00069	0.332
MOD_Plk_1	359	365	PF00069	0.291
MOD_Plk_1	394	400	PF00069	0.304
MOD_Plk_1	442	448	PF00069	0.506
MOD_Plk_2-3	246	252	PF00069	0.251
MOD_Plk_4	16	22	PF00069	0.343
MOD_Plk_4	166	172	PF00069	0.272
MOD_Plk_4	249	255	PF00069	0.287
MOD_Plk_4	292	298	PF00069	0.236
MOD_Plk_4	305	311	PF00069	0.284
MOD_Plk_4	375	381	PF00069	0.310
MOD_Plk_4	394	400	PF00069	0.159
MOD_Plk_4	41	47	PF00069	0.374
MOD_Plk_4	413	419	PF00069	0.218
MOD_Plk_4	421	427	PF00069	0.184
MOD_Plk_4	82	88	PF00069	0.323
MOD_ProDKin_1	322	328	PF00069	0.236
MOD_ProDKin_1	397	403	PF00069	0.270
MOD_ProDKin_1	409	415	PF00069	0.266
MOD_ProDKin_1	447	453	PF00069	0.318
MOD_ProDKin_1	57	63	PF00069	0.376
MOD_ProDKin_1	87	93	PF00069	0.275
MOD_SUMO_rev_2	312	320	PF00179	0.219
MOD_SUMO_rev_2	346	351	PF00179	0.341
MOD_SUMO_rev_2	432	442	PF00179	0.391
TRG_DiLeu_BaEn_1	360	365	PF01217	0.251
TRG_DiLeu_BaEn_3	346	352	PF01217	0.219
TRG_ENDOCYTIC_2	101	104	PF00928	0.225
TRG_ENDOCYTIC_2	116	119	PF00928	0.183
TRG_ENDOCYTIC_2	121	124	PF00928	0.236
TRG_ENDOCYTIC_2	167	170	PF00928	0.208
TRG_ENDOCYTIC_2	253	256	PF00928	0.254
TRG_ENDOCYTIC_2	311	314	PF00928	0.301
TRG_ER_diArg_1	130	132	PF00400	0.209
TRG_ER_diArg_1	222	225	PF00400	0.312
TRG_NLS_MonoExtN_4	131	136	PF00514	0.219

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4R1	Leptomonas seymouri	52%	100%
A0A0S4JLQ8	Bodo saltans	31%	95%
A0A1X0P5D8	Trypanosomatidae	36%	100%
A0A1X0P6A2	Trypanosomatidae	27%	100%
A0A3Q8IPQ3	Leishmania donovani	90%	100%
A0A3R7LD50	Trypanosoma rangeli	35%	100%
A0A3R7P367	Trypanosoma rangeli	27%	100%
A4HMW9	Leishmania braziliensis	75%	100%
A4IBJ0	Leishmania infantum	90%	100%
C9ZZ51	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AFC6	Leishmania major	87%	100%
Q13093	Homo sapiens	27%	100%
Q28017	Bos taurus	27%	100%
Q28262	Canis lupus familiaris	28%	100%
V5BD01	Trypanosoma cruzi	34%	100%
V5BTH3	Trypanosoma cruzi	29%	100%