Lactoylglutathione lyase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

trypanothione-dependent glyoxalase I

Species:

Leishmania mexicana

UniProt:

E9B6I0_LEIMU

TriTrypDb:

LmxM.34.3010

Length:

141

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

E9B6I0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6I0

PDB structure(s): 2c21_A , 2c21_B , 2c21_C , 2c21_D , 2c21_E , 2c21_F

Function

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Biological processes
Term	Name	Level	Count
GO:0006081	cellular aldehyde metabolic process	3	1
GO:0006082	organic acid metabolic process	3	1
GO:0006089	lactate metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009438	methylglyoxal metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0019243	methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione	6	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0032787	monocarboxylic acid metabolic process	6	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004462	lactoylglutathione lyase activity	4	11
GO:0005488	binding	1	11
GO:0016829	lyase activity	2	11
GO:0016846	carbon-sulfur lyase activity	3	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	32	34	PF00675	0.257
CLV_NRD_NRD_1	4	6	PF00675	0.517
CLV_NRD_NRD_1	92	94	PF00675	0.267
CLV_PCSK_KEX2_1	4	6	PF00082	0.517
CLV_PCSK_SKI1_1	18	22	PF00082	0.264
CLV_PCSK_SKI1_1	4	8	PF00082	0.293
DEG_APCC_DBOX_1	3	11	PF00400	0.333
DOC_MAPK_gen_1	93	99	PF00069	0.268
DOC_PP1_RVXF_1	16	23	PF00149	0.239
DOC_USP7_MATH_1	51	55	PF00917	0.267

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4M0	Leptomonas seymouri	76%	100%
A0A0S4KKP2	Bodo saltans	64%	100%
A0A1X0P5K6	Trypanosomatidae	73%	100%
A0A3S7X9J4	Leishmania donovani	98%	100%
A0A422P2U3	Trypanosoma rangeli	73%	100%
A4HMW8	Leishmania braziliensis	93%	100%
A4IBI9	Leishmania infantum	98%	100%
O04885	Brassica juncea	31%	76%
O49818	Cicer arietinum	30%	76%
P0A0T2	Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491)	45%	100%

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