LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B6H9_LEIMU
TriTrypDb:
LmxM.34.3000
Length:
460

Annotations

LeishMANIAdb annotations

Possesses a conserved Fe2+ binding catalytic pocket. Might be involved in some unknown metabolic pathway.. Most similar to Chlamydomonas proteins A0A2K3DQH2 and A0A835WMM9.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

E9B6H9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6H9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 161 165 PF00656 0.547
CLV_C14_Caspase3-7 46 50 PF00656 0.642
CLV_MEL_PAP_1 284 290 PF00089 0.517
CLV_NRD_NRD_1 139 141 PF00675 0.409
CLV_NRD_NRD_1 24 26 PF00675 0.412
CLV_NRD_NRD_1 270 272 PF00675 0.353
CLV_NRD_NRD_1 56 58 PF00675 0.401
CLV_PCSK_KEX2_1 26 28 PF00082 0.420
CLV_PCSK_KEX2_1 270 272 PF00082 0.353
CLV_PCSK_KEX2_1 56 58 PF00082 0.401
CLV_PCSK_PC1ET2_1 26 28 PF00082 0.420
CLV_PCSK_SKI1_1 119 123 PF00082 0.390
CLV_PCSK_SKI1_1 155 159 PF00082 0.482
CLV_PCSK_SKI1_1 401 405 PF00082 0.412
CLV_PCSK_SKI1_1 407 411 PF00082 0.418
CLV_Separin_Metazoa 293 297 PF03568 0.568
DEG_APCC_DBOX_1 208 216 PF00400 0.610
DEG_APCC_DBOX_1 450 458 PF00400 0.656
DEG_APCC_KENBOX_2 101 105 PF00400 0.659
DEG_COP1_1 6 16 PF00400 0.408
DEG_Nend_Nbox_1 1 3 PF02207 0.417
DEG_SPOP_SBC_1 173 177 PF00917 0.758
DOC_CKS1_1 82 87 PF01111 0.708
DOC_CYCLIN_RxL_1 401 414 PF00134 0.615
DOC_MAPK_MEF2A_6 102 109 PF00069 0.590
DOC_MAPK_RevD_3 11 26 PF00069 0.369
DOC_PP2B_LxvP_1 11 14 PF13499 0.369
DOC_PP2B_PxIxI_1 13 19 PF00149 0.429
DOC_PP2B_PxIxI_1 412 418 PF00149 0.622
DOC_USP7_MATH_1 157 161 PF00917 0.679
DOC_USP7_MATH_1 173 177 PF00917 0.730
DOC_USP7_MATH_1 203 207 PF00917 0.651
DOC_USP7_MATH_1 382 386 PF00917 0.674
DOC_USP7_MATH_1 87 91 PF00917 0.601
DOC_WW_Pin1_4 174 179 PF00397 0.740
DOC_WW_Pin1_4 241 246 PF00397 0.527
DOC_WW_Pin1_4 278 283 PF00397 0.542
DOC_WW_Pin1_4 340 345 PF00397 0.669
DOC_WW_Pin1_4 377 382 PF00397 0.620
DOC_WW_Pin1_4 81 86 PF00397 0.731
LIG_14-3-3_CanoR_1 128 134 PF00244 0.569
LIG_14-3-3_CanoR_1 225 231 PF00244 0.650
LIG_14-3-3_CanoR_1 254 260 PF00244 0.487
LIG_14-3-3_CanoR_1 285 295 PF00244 0.594
LIG_14-3-3_CanoR_1 296 300 PF00244 0.581
LIG_APCC_ABBA_1 393 398 PF00400 0.521
LIG_BIR_III_4 438 442 PF00653 0.664
LIG_CaM_NSCaTE_8 129 136 PF13499 0.441
LIG_DCNL_PONY_1 1 4 PF03556 0.530
LIG_deltaCOP1_diTrp_1 323 326 PF00928 0.529
LIG_deltaCOP1_diTrp_1 414 418 PF00928 0.676
LIG_FHA_1 13 19 PF00498 0.358
LIG_FHA_1 134 140 PF00498 0.459
LIG_FHA_1 185 191 PF00498 0.617
LIG_FHA_2 175 181 PF00498 0.699
LIG_FHA_2 298 304 PF00498 0.539
LIG_FHA_2 427 433 PF00498 0.731
LIG_FHA_2 44 50 PF00498 0.586
LIG_FHA_2 98 104 PF00498 0.636
LIG_LIR_Gen_1 263 269 PF02991 0.519
LIG_LIR_Gen_1 6 16 PF02991 0.444
LIG_LIR_Nem_3 180 184 PF02991 0.655
LIG_LIR_Nem_3 229 233 PF02991 0.550
LIG_LIR_Nem_3 263 267 PF02991 0.537
LIG_LIR_Nem_3 53 58 PF02991 0.618
LIG_LIR_Nem_3 6 11 PF02991 0.344
LIG_LYPXL_yS_3 44 47 PF13949 0.565
LIG_REV1ctd_RIR_1 52 59 PF16727 0.585
LIG_SH2_CRK 250 254 PF00017 0.643
LIG_SH2_CRK 8 12 PF00017 0.444
LIG_SH2_PTP2 264 267 PF00017 0.520
LIG_SH2_SRC 264 267 PF00017 0.434
LIG_SH2_STAP1 8 12 PF00017 0.444
LIG_SH2_STAT5 221 224 PF00017 0.617
LIG_SH2_STAT5 240 243 PF00017 0.514
LIG_SH2_STAT5 264 267 PF00017 0.510
LIG_SH2_STAT5 369 372 PF00017 0.700
LIG_SH2_STAT5 453 456 PF00017 0.613
LIG_SH2_STAT5 8 11 PF00017 0.444
LIG_SH3_1 250 256 PF00018 0.652
LIG_SH3_1 338 344 PF00018 0.707
LIG_SH3_2 341 346 PF14604 0.743
LIG_SH3_3 110 116 PF00018 0.656
LIG_SH3_3 250 256 PF00018 0.617
LIG_SH3_3 262 268 PF00018 0.480
LIG_SH3_3 303 309 PF00018 0.576
LIG_SH3_3 338 344 PF00018 0.707
LIG_SH3_3 375 381 PF00018 0.629
LIG_SH3_3 67 73 PF00018 0.655
LIG_SUMO_SIM_anti_2 303 308 PF11976 0.567
LIG_SUMO_SIM_par_1 141 146 PF11976 0.512
LIG_SUMO_SIM_par_1 455 460 PF11976 0.692
LIG_UBA3_1 358 363 PF00899 0.593
LIG_WRC_WIRS_1 424 429 PF05994 0.656
MOD_CDC14_SPxK_1 343 346 PF00782 0.644
MOD_CDK_SPxK_1 340 346 PF00069 0.607
MOD_CDK_SPxxK_3 278 285 PF00069 0.465
MOD_CK1_1 168 174 PF00069 0.720
MOD_CK1_1 286 292 PF00069 0.488
MOD_CK1_1 380 386 PF00069 0.652
MOD_CK1_1 423 429 PF00069 0.660
MOD_CK1_1 6 12 PF00069 0.444
MOD_CK2_1 426 432 PF00069 0.714
MOD_CK2_1 97 103 PF00069 0.570
MOD_GlcNHglycan 171 174 PF01048 0.682
MOD_GlcNHglycan 205 208 PF01048 0.563
MOD_GlcNHglycan 309 312 PF01048 0.492
MOD_GlcNHglycan 384 387 PF01048 0.588
MOD_GlcNHglycan 61 64 PF01048 0.570
MOD_GSK3_1 129 136 PF00069 0.559
MOD_GSK3_1 164 171 PF00069 0.707
MOD_GSK3_1 330 337 PF00069 0.547
MOD_GSK3_1 373 380 PF00069 0.594
MOD_GSK3_1 401 408 PF00069 0.660
MOD_N-GLC_1 169 174 PF02516 0.625
MOD_NEK2_1 184 189 PF00069 0.527
MOD_NEK2_1 21 26 PF00069 0.529
MOD_NEK2_1 372 377 PF00069 0.502
MOD_PK_1 420 426 PF00069 0.637
MOD_PKA_2 127 133 PF00069 0.529
MOD_PKA_2 165 171 PF00069 0.716
MOD_PKA_2 226 232 PF00069 0.473
MOD_PKA_2 286 292 PF00069 0.575
MOD_PKA_2 295 301 PF00069 0.492
MOD_PKA_2 433 439 PF00069 0.554
MOD_Plk_1 145 151 PF00069 0.509
MOD_Plk_4 12 18 PF00069 0.352
MOD_Plk_4 273 279 PF00069 0.430
MOD_Plk_4 3 9 PF00069 0.340
MOD_Plk_4 330 336 PF00069 0.586
MOD_Plk_4 373 379 PF00069 0.644
MOD_ProDKin_1 174 180 PF00069 0.686
MOD_ProDKin_1 241 247 PF00069 0.397
MOD_ProDKin_1 278 284 PF00069 0.436
MOD_ProDKin_1 340 346 PF00069 0.606
MOD_ProDKin_1 377 383 PF00069 0.524
MOD_ProDKin_1 81 87 PF00069 0.672
TRG_DiLeu_BaEn_1 195 200 PF01217 0.544
TRG_ENDOCYTIC_2 264 267 PF00928 0.385
TRG_ENDOCYTIC_2 369 372 PF00928 0.637
TRG_ENDOCYTIC_2 44 47 PF00928 0.441
TRG_ENDOCYTIC_2 453 456 PF00928 0.492
TRG_ENDOCYTIC_2 8 11 PF00928 0.444
TRG_ER_diArg_1 209 212 PF00400 0.541
TRG_ER_diArg_1 25 28 PF00400 0.525
TRG_ER_diArg_1 269 271 PF00400 0.415
TRG_ER_diArg_1 284 287 PF00400 0.565
TRG_ER_diArg_1 55 57 PF00400 0.494
TRG_NES_CRM1_1 231 242 PF08389 0.510
TRG_Pf-PMV_PEXEL_1 188 192 PF00026 0.510
TRG_Pf-PMV_PEXEL_1 220 224 PF00026 0.518
TRG_Pf-PMV_PEXEL_1 401 406 PF00026 0.580
TRG_Pf-PMV_PEXEL_1 407 412 PF00026 0.572

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I3G4 Leptomonas seymouri 62% 95%
A0A1X0P5E8 Trypanosomatidae 48% 100%
A0A3S7X9P9 Leishmania donovani 89% 100%
A4HMW7 Leishmania braziliensis 82% 100%
A4IBI8 Leishmania infantum 90% 100%
C9ZZ52 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 100%
E9AFC4 Leishmania major 91% 100%
V5DUR9 Trypanosoma cruzi 45% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS