3'-5' exonuclease domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3'-5' exonuclease, putative

Species:

Leishmania mexicana

UniProt:

E9B6H8_LEIMU

TriTrypDb:

LmxM.34.2990

Length:

413

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6H8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6H8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004518	nuclease activity	4	12
GO:0004527	exonuclease activity	5	12
GO:0005488	binding	1	12
GO:0008270	zinc ion binding	6	12
GO:0008408	3'-5' exonuclease activity	6	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	303	307	PF00656	0.456
CLV_MEL_PAP_1	63	69	PF00089	0.654
CLV_NRD_NRD_1	166	168	PF00675	0.275
CLV_NRD_NRD_1	174	176	PF00675	0.268
CLV_NRD_NRD_1	210	212	PF00675	0.276
CLV_NRD_NRD_1	341	343	PF00675	0.529
CLV_NRD_NRD_1	79	81	PF00675	0.265
CLV_PCSK_KEX2_1	174	176	PF00082	0.279
CLV_PCSK_KEX2_1	189	191	PF00082	0.276
CLV_PCSK_KEX2_1	210	212	PF00082	0.276
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.256
CLV_PCSK_PC7_1	206	212	PF00082	0.287
CLV_PCSK_SKI1_1	158	162	PF00082	0.287
CLV_PCSK_SKI1_1	167	171	PF00082	0.245
CLV_PCSK_SKI1_1	189	193	PF00082	0.381
CLV_PCSK_SKI1_1	9	13	PF00082	0.507
DEG_Nend_UBRbox_1	1	4	PF02207	0.727
DEG_SCF_FBW7_1	20	26	PF00400	0.639
DEG_SPOP_SBC_1	32	36	PF00917	0.760
DEG_SPOP_SBC_1	42	46	PF00917	0.693
DOC_ANK_TNKS_1	318	325	PF00023	0.405
DOC_CKS1_1	113	118	PF01111	0.553
DOC_CKS1_1	119	124	PF01111	0.553
DOC_CKS1_1	20	25	PF01111	0.724
DOC_CKS1_1	29	34	PF01111	0.693
DOC_CYCLIN_RxL_1	162	172	PF00134	0.497
DOC_CYCLIN_yCln2_LP_2	148	154	PF00134	0.524
DOC_MAPK_gen_1	102	110	PF00069	0.495
DOC_MAPK_gen_1	189	196	PF00069	0.581
DOC_MAPK_MEF2A_6	102	110	PF00069	0.501
DOC_MAPK_MEF2A_6	189	198	PF00069	0.492
DOC_MAPK_NFAT4_5	189	197	PF00069	0.581
DOC_PP1_RVXF_1	165	172	PF00149	0.487
DOC_PP2B_LxvP_1	148	151	PF13499	0.484
DOC_PP4_FxxP_1	113	116	PF00568	0.553
DOC_USP7_MATH_1	156	160	PF00917	0.476
DOC_USP7_MATH_1	32	36	PF00917	0.687
DOC_USP7_MATH_1	61	65	PF00917	0.634
DOC_USP7_UBL2_3	81	85	PF12436	0.482
DOC_WW_Pin1_4	112	117	PF00397	0.560
DOC_WW_Pin1_4	118	123	PF00397	0.565
DOC_WW_Pin1_4	184	189	PF00397	0.525
DOC_WW_Pin1_4	19	24	PF00397	0.724
DOC_WW_Pin1_4	28	33	PF00397	0.655
LIG_14-3-3_CanoR_1	126	130	PF00244	0.501
LIG_14-3-3_CanoR_1	211	217	PF00244	0.501
LIG_14-3-3_CanoR_1	25	33	PF00244	0.704
LIG_14-3-3_CanoR_1	286	292	PF00244	0.390
LIG_14-3-3_CanoR_1	349	353	PF00244	0.449
LIG_14-3-3_CanoR_1	57	61	PF00244	0.686
LIG_14-3-3_CanoR_1	66	71	PF00244	0.504
LIG_BIR_III_2	306	310	PF00653	0.494
LIG_BRCT_BRCA1_1	268	272	PF00533	0.508
LIG_BRCT_BRCA1_1	63	67	PF00533	0.658
LIG_FHA_1	119	125	PF00498	0.538
LIG_FHA_1	213	219	PF00498	0.517
LIG_FHA_1	245	251	PF00498	0.516
LIG_FHA_1	274	280	PF00498	0.547
LIG_FHA_1	312	318	PF00498	0.528
LIG_FHA_1	35	41	PF00498	0.713
LIG_FHA_2	130	136	PF00498	0.558
LIG_FHA_2	180	186	PF00498	0.525
LIG_FHA_2	334	340	PF00498	0.440
LIG_FHA_2	51	57	PF00498	0.752
LIG_FHA_2	87	93	PF00498	0.581
LIG_LIR_Apic_2	111	116	PF02991	0.553
LIG_LIR_Apic_2	318	323	PF02991	0.396
LIG_LIR_Nem_3	252	257	PF02991	0.476
LIG_LIR_Nem_3	269	275	PF02991	0.422
LIG_LIR_Nem_3	338	344	PF02991	0.552
LIG_LIR_Nem_3	58	63	PF02991	0.755
LIG_MLH1_MIPbox_1	268	272	PF16413	0.508
LIG_Pex14_1	316	320	PF04695	0.396
LIG_Rb_pABgroove_1	137	145	PF01858	0.487
LIG_REV1ctd_RIR_1	168	179	PF16727	0.537
LIG_SH2_CRK	7	11	PF00017	0.432
LIG_SH2_CRK	84	88	PF00017	0.537
LIG_SH2_NCK_1	7	11	PF00017	0.645
LIG_SH2_PTP2	320	323	PF00017	0.414
LIG_SH2_STAT5	216	219	PF00017	0.486
LIG_SH2_STAT5	271	274	PF00017	0.458
LIG_SH2_STAT5	291	294	PF00017	0.395
LIG_SH2_STAT5	320	323	PF00017	0.394
LIG_SH3_3	17	23	PF00018	0.650
LIG_SUMO_SIM_anti_2	95	101	PF11976	0.451
LIG_SUMO_SIM_par_1	144	149	PF11976	0.477
LIG_TRAF2_1	89	92	PF00917	0.525
LIG_WRC_WIRS_1	326	331	PF05994	0.558
MOD_CDK_SPK_2	184	189	PF00069	0.525
MOD_CDK_SPxK_1	184	190	PF00069	0.525
MOD_CDK_SPxK_1	19	25	PF00069	0.753
MOD_CK1_1	212	218	PF00069	0.501
MOD_CK1_1	28	34	PF00069	0.722
MOD_CK1_1	43	49	PF00069	0.550
MOD_CK1_1	52	58	PF00069	0.631
MOD_CK1_1	65	71	PF00069	0.584
MOD_CK2_1	333	339	PF00069	0.442
MOD_CK2_1	50	56	PF00069	0.670
MOD_CK2_1	86	92	PF00069	0.538
MOD_GlcNHglycan	17	20	PF01048	0.726
MOD_GlcNHglycan	211	214	PF01048	0.287
MOD_GlcNHglycan	230	233	PF01048	0.287
MOD_GlcNHglycan	46	49	PF01048	0.721
MOD_GSK3_1	125	132	PF00069	0.557
MOD_GSK3_1	15	22	PF00069	0.684
MOD_GSK3_1	228	235	PF00069	0.501
MOD_GSK3_1	23	30	PF00069	0.641
MOD_GSK3_1	267	274	PF00069	0.614
MOD_GSK3_1	325	332	PF00069	0.534
MOD_GSK3_1	40	47	PF00069	0.512
MOD_GSK3_1	52	59	PF00069	0.663
MOD_GSK3_1	61	68	PF00069	0.634
MOD_NEK2_1	100	105	PF00069	0.530
MOD_NEK2_1	129	134	PF00069	0.550
MOD_NEK2_1	146	151	PF00069	0.405
MOD_NEK2_1	15	20	PF00069	0.679
MOD_NEK2_1	196	201	PF00069	0.517
MOD_NEK2_1	267	272	PF00069	0.531
MOD_NEK2_1	329	334	PF00069	0.502
MOD_NEK2_1	33	38	PF00069	0.576
MOD_NEK2_1	348	353	PF00069	0.419
MOD_NEK2_1	356	361	PF00069	0.437
MOD_NEK2_1	379	384	PF00069	0.455
MOD_NEK2_2	156	161	PF00069	0.373
MOD_PIKK_1	179	185	PF00454	0.516
MOD_PIKK_1	25	31	PF00454	0.770
MOD_PIKK_1	273	279	PF00454	0.548
MOD_PK_1	204	210	PF00069	0.487
MOD_PKA_2	125	131	PF00069	0.501
MOD_PKA_2	209	215	PF00069	0.476
MOD_PKA_2	285	291	PF00069	0.388
MOD_PKA_2	348	354	PF00069	0.449
MOD_PKA_2	56	62	PF00069	0.688
MOD_PKA_2	65	71	PF00069	0.503
MOD_Plk_1	162	168	PF00069	0.581
MOD_Plk_1	55	61	PF00069	0.572
MOD_Plk_4	125	131	PF00069	0.537
MOD_Plk_4	212	218	PF00069	0.501
MOD_Plk_4	267	273	PF00069	0.589
MOD_ProDKin_1	112	118	PF00069	0.560
MOD_ProDKin_1	184	190	PF00069	0.525
MOD_ProDKin_1	19	25	PF00069	0.727
MOD_ProDKin_1	28	34	PF00069	0.656
MOD_SUMO_rev_2	88	96	PF00179	0.581
TRG_ENDOCYTIC_2	84	87	PF00928	0.476
TRG_Pf-PMV_PEXEL_1	167	172	PF00026	0.271
TRG_Pf-PMV_PEXEL_1	190	195	PF00026	0.362
TRG_Pf-PMV_PEXEL_1	248	252	PF00026	0.300
TRG_Pf-PMV_PEXEL_1	25	29	PF00026	0.769

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWS9	Leptomonas seymouri	77%	97%
A0A0S4JGY9	Bodo saltans	51%	100%
A0A1X0P5F6	Trypanosomatidae	68%	100%
A0A3R7KR79	Trypanosoma rangeli	68%	100%
A0A3S7X9G9	Leishmania donovani	93%	100%
A4HMW6	Leishmania braziliensis	87%	100%
A4IBI7	Leishmania infantum	93%	100%
C9ZZ53	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
E9AFC3	Leishmania major	93%	100%
V5BY58	Trypanosoma cruzi	68%	100%