TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B6H6_LEIMU

TriTrypDb:

LmxM.34.2970

Length:

380

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6H6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6H6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.426
CLV_NRD_NRD_1	318	320	PF00675	0.297
CLV_PCSK_SKI1_1	353	357	PF00082	0.481
CLV_PCSK_SKI1_1	55	59	PF00082	0.439
CLV_PCSK_SKI1_1	93	97	PF00082	0.430
DEG_Nend_Nbox_1	1	3	PF02207	0.611
DEG_SPOP_SBC_1	115	119	PF00917	0.350
DEG_SPOP_SBC_1	210	214	PF00917	0.553
DEG_SPOP_SBC_1	360	364	PF00917	0.658
DOC_CYCLIN_RxL_1	350	361	PF00134	0.363
DOC_MAPK_gen_1	319	330	PF00069	0.441
DOC_PP2B_LxvP_1	357	360	PF13499	0.613
DOC_USP7_MATH_1	115	119	PF00917	0.543
DOC_USP7_MATH_1	168	172	PF00917	0.708
DOC_USP7_MATH_1	210	214	PF00917	0.611
DOC_USP7_MATH_1	358	362	PF00917	0.661
DOC_USP7_MATH_1	83	87	PF00917	0.359
DOC_WW_Pin1_4	201	206	PF00397	0.637
DOC_WW_Pin1_4	79	84	PF00397	0.404
LIG_14-3-3_CanoR_1	107	112	PF00244	0.336
LIG_14-3-3_CanoR_1	146	156	PF00244	0.482
LIG_Actin_WH2_2	341	358	PF00022	0.417
LIG_AP2alpha_1	133	137	PF02296	0.413
LIG_FHA_1	233	239	PF00498	0.369
LIG_FHA_1	82	88	PF00498	0.374
LIG_FHA_2	202	208	PF00498	0.724
LIG_FHA_2	32	38	PF00498	0.494
LIG_FHA_2	340	346	PF00498	0.556
LIG_FHA_2	60	66	PF00498	0.378
LIG_LIR_Apic_2	26	32	PF02991	0.525
LIG_LIR_Gen_1	22	32	PF02991	0.533
LIG_LIR_Gen_1	235	245	PF02991	0.318
LIG_LIR_Nem_3	110	114	PF02991	0.368
LIG_LIR_Nem_3	22	28	PF02991	0.549
LIG_LIR_Nem_3	235	240	PF02991	0.365
LIG_NRBOX	273	279	PF00104	0.381
LIG_NRBOX	90	96	PF00104	0.479
LIG_PCNA_yPIPBox_3	93	104	PF02747	0.351
LIG_Pex14_2	133	137	PF04695	0.369
LIG_Pex14_2	25	29	PF04695	0.523
LIG_SH2_NCK_1	156	160	PF00017	0.449
LIG_SH2_SRC	156	159	PF00017	0.450
LIG_SH2_SRC	311	314	PF00017	0.372
LIG_SH2_STAT5	111	114	PF00017	0.351
LIG_SH2_STAT5	311	314	PF00017	0.328
LIG_SH2_STAT5	42	45	PF00017	0.471
LIG_SH3_3	155	161	PF00018	0.626
LIG_SUMO_SIM_anti_2	325	332	PF11976	0.472
LIG_TRAF2_1	372	375	PF00917	0.746
LIG_TRFH_1	111	115	PF08558	0.360
LIG_UBA3_1	277	281	PF00899	0.348
LIG_UBA3_1	66	73	PF00899	0.404
LIG_UBA3_1	74	81	PF00899	0.384
MOD_CK1_1	118	124	PF00069	0.574
MOD_CK1_1	150	156	PF00069	0.565
MOD_CK1_1	211	217	PF00069	0.657
MOD_CK1_1	27	33	PF00069	0.533
MOD_CK1_1	361	367	PF00069	0.648
MOD_CK2_1	118	124	PF00069	0.653
MOD_CK2_1	222	228	PF00069	0.564
MOD_CK2_1	31	37	PF00069	0.515
MOD_CK2_1	339	345	PF00069	0.560
MOD_GlcNHglycan	120	123	PF01048	0.513
MOD_GlcNHglycan	149	152	PF01048	0.442
MOD_GlcNHglycan	191	194	PF01048	0.679
MOD_GlcNHglycan	303	307	PF01048	0.389
MOD_GlcNHglycan	366	369	PF01048	0.588
MOD_GSK3_1	114	121	PF00069	0.540
MOD_GSK3_1	185	192	PF00069	0.559
MOD_GSK3_1	19	26	PF00069	0.513
MOD_GSK3_1	27	34	PF00069	0.586
MOD_GSK3_1	358	365	PF00069	0.620
MOD_GSK3_1	77	84	PF00069	0.423
MOD_LATS_1	267	273	PF00433	0.432
MOD_N-GLC_1	115	120	PF02516	0.546
MOD_N-GLC_1	19	24	PF02516	0.600
MOD_N-GLC_2	147	149	PF02516	0.474
MOD_NEK2_1	129	134	PF00069	0.550
MOD_NEK2_1	2	7	PF00069	0.540
MOD_NEK2_1	232	237	PF00069	0.344
MOD_NEK2_1	24	29	PF00069	0.491
MOD_NEK2_1	58	63	PF00069	0.436
MOD_PIKK_1	211	217	PF00454	0.589
MOD_PIKK_1	339	345	PF00454	0.447
MOD_PK_1	217	223	PF00069	0.477
MOD_Plk_1	115	121	PF00069	0.611
MOD_Plk_1	232	238	PF00069	0.327
MOD_Plk_1	269	275	PF00069	0.437
MOD_Plk_1	47	53	PF00069	0.474
MOD_Plk_4	107	113	PF00069	0.384
MOD_Plk_4	217	223	PF00069	0.597
MOD_Plk_4	24	30	PF00069	0.479
MOD_ProDKin_1	201	207	PF00069	0.640
MOD_ProDKin_1	79	85	PF00069	0.405
MOD_SUMO_rev_2	77	83	PF00179	0.407
TRG_DiLeu_BaEn_1	326	331	PF01217	0.383
TRG_ENDOCYTIC_2	229	232	PF00928	0.520
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.369

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBE1	Leptomonas seymouri	68%	100%
A0A0S4JHH3	Bodo saltans	49%	100%
A0A1X0P5G2	Trypanosomatidae	55%	100%
A0A3S7X9G6	Leishmania donovani	89%	100%
A0A422P2T5	Trypanosoma rangeli	58%	100%
A4HMW4	Leishmania braziliensis	80%	100%
A4IBI5	Leishmania infantum	88%	100%
C9ZZ56	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9AFC1	Leishmania major	88%	100%
V5BD06	Trypanosoma cruzi	60%	100%