UDENN domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

denn domain-containing protein

Species:

Leishmania mexicana

UniProt:

E9B6H5_LEIMU

TriTrypDb:

LmxM.34.2960

Length:

559

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6H5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6H5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	409	413	PF00656	0.475
CLV_NRD_NRD_1	21	23	PF00675	0.593
CLV_NRD_NRD_1	504	506	PF00675	0.587
CLV_PCSK_FUR_1	370	374	PF00082	0.590
CLV_PCSK_KEX2_1	365	367	PF00082	0.658
CLV_PCSK_KEX2_1	372	374	PF00082	0.558
CLV_PCSK_KEX2_1	399	401	PF00082	0.491
CLV_PCSK_KEX2_1	504	506	PF00082	0.587
CLV_PCSK_PC1ET2_1	365	367	PF00082	0.584
CLV_PCSK_PC1ET2_1	372	374	PF00082	0.503
CLV_PCSK_PC1ET2_1	399	401	PF00082	0.413
CLV_PCSK_SKI1_1	156	160	PF00082	0.415
CLV_PCSK_SKI1_1	372	376	PF00082	0.609
CLV_PCSK_SKI1_1	378	382	PF00082	0.460
CLV_PCSK_SKI1_1	399	403	PF00082	0.587
CLV_PCSK_SKI1_1	424	428	PF00082	0.547
DEG_APCC_DBOX_1	285	293	PF00400	0.462
DEG_APCC_DBOX_1	325	333	PF00400	0.495
DEG_SCF_FBW7_1	70	76	PF00400	0.539
DEG_SPOP_SBC_1	553	557	PF00917	0.611
DOC_CDC14_PxL_1	77	85	PF14671	0.493
DOC_CKS1_1	173	178	PF01111	0.420
DOC_CKS1_1	70	75	PF01111	0.505
DOC_MAPK_FxFP_2	203	206	PF00069	0.384
DOC_PP1_RVXF_1	376	383	PF00149	0.375
DOC_PP1_RVXF_1	62	68	PF00149	0.468
DOC_PP1_SILK_1	329	334	PF00149	0.555
DOC_PP2B_LxvP_1	244	247	PF13499	0.377
DOC_PP2B_LxvP_1	266	269	PF13499	0.321
DOC_PP4_FxxP_1	173	176	PF00568	0.348
DOC_PP4_FxxP_1	183	186	PF00568	0.297
DOC_PP4_FxxP_1	203	206	PF00568	0.384
DOC_USP7_MATH_1	27	31	PF00917	0.600
DOC_USP7_MATH_1	288	292	PF00917	0.377
DOC_USP7_MATH_1	553	557	PF00917	0.708
DOC_USP7_MATH_1	73	77	PF00917	0.504
DOC_USP7_MATH_1	91	95	PF00917	0.356
DOC_USP7_UBL2_3	159	163	PF12436	0.420
DOC_WW_Pin1_4	128	133	PF00397	0.345
DOC_WW_Pin1_4	163	168	PF00397	0.325
DOC_WW_Pin1_4	172	177	PF00397	0.329
DOC_WW_Pin1_4	401	406	PF00397	0.609
DOC_WW_Pin1_4	69	74	PF00397	0.498
LIG_14-3-3_CanoR_1	189	194	PF00244	0.321
LIG_14-3-3_CanoR_1	514	524	PF00244	0.678
LIG_BRCT_BRCA1_1	100	104	PF00533	0.387
LIG_BRCT_BRCA1_1	31	35	PF00533	0.646
LIG_BRCT_BRCA1_1	378	382	PF00533	0.500
LIG_BRCT_BRCA1_1	7	11	PF00533	0.431
LIG_BRCT_BRCA1_2	378	384	PF00533	0.474
LIG_Clathr_ClatBox_1	50	54	PF01394	0.229
LIG_CtBP_PxDLS_1	176	180	PF00389	0.420
LIG_deltaCOP1_diTrp_1	409	415	PF00928	0.475
LIG_eIF4E_1	140	146	PF01652	0.420
LIG_FHA_1	101	107	PF00498	0.386
LIG_FHA_1	117	123	PF00498	0.338
LIG_FHA_1	194	200	PF00498	0.304
LIG_FHA_1	258	264	PF00498	0.360
LIG_FHA_1	276	282	PF00498	0.201
LIG_FHA_1	460	466	PF00498	0.511
LIG_FHA_1	73	79	PF00498	0.512
LIG_FHA_2	1	7	PF00498	0.697
LIG_FHA_2	173	179	PF00498	0.418
LIG_FHA_2	339	345	PF00498	0.401
LIG_FHA_2	427	433	PF00498	0.465
LIG_GBD_Chelix_1	273	281	PF00786	0.323
LIG_HOMEOBOX	248	251	PF00046	0.345
LIG_LIR_Apic_2	182	186	PF02991	0.381
LIG_LIR_Apic_2	200	206	PF02991	0.384
LIG_LIR_Apic_2	66	70	PF02991	0.417
LIG_LIR_Gen_1	101	109	PF02991	0.472
LIG_LIR_Gen_1	209	220	PF02991	0.321
LIG_LIR_Gen_1	249	258	PF02991	0.328
LIG_LIR_Gen_1	351	361	PF02991	0.372
LIG_LIR_Gen_1	379	386	PF02991	0.418
LIG_LIR_Gen_1	388	398	PF02991	0.332
LIG_LIR_Gen_1	429	435	PF02991	0.551
LIG_LIR_Gen_1	456	465	PF02991	0.370
LIG_LIR_Gen_1	8	19	PF02991	0.678
LIG_LIR_Nem_3	101	105	PF02991	0.449
LIG_LIR_Nem_3	16	21	PF02991	0.579
LIG_LIR_Nem_3	209	215	PF02991	0.340
LIG_LIR_Nem_3	249	253	PF02991	0.303
LIG_LIR_Nem_3	347	352	PF02991	0.363
LIG_LIR_Nem_3	355	360	PF02991	0.477
LIG_LIR_Nem_3	379	385	PF02991	0.391
LIG_LIR_Nem_3	388	394	PF02991	0.337
LIG_LIR_Nem_3	429	434	PF02991	0.553
LIG_LIR_Nem_3	456	461	PF02991	0.502
LIG_LIR_Nem_3	8	14	PF02991	0.679
LIG_LYPXL_SIV_4	70	78	PF13949	0.542
LIG_LYPXL_yS_3	80	83	PF13949	0.406
LIG_MLH1_MIPbox_1	378	382	PF16413	0.476
LIG_Pex14_1	135	139	PF04695	0.321
LIG_Pex14_1	67	71	PF04695	0.521
LIG_REV1ctd_RIR_1	136	145	PF16727	0.377
LIG_REV1ctd_RIR_1	379	388	PF16727	0.491
LIG_REV1ctd_RIR_1	46	56	PF16727	0.312
LIG_SH2_CRK	102	106	PF00017	0.444
LIG_SH2_CRK	187	191	PF00017	0.301
LIG_SH2_CRK	353	357	PF00017	0.337
LIG_SH2_GRB2like	308	311	PF00017	0.484
LIG_SH2_NCK_1	71	75	PF00017	0.556
LIG_SH2_STAP1	102	106	PF00017	0.444
LIG_SH2_STAP1	353	357	PF00017	0.356
LIG_SH2_STAP1	431	435	PF00017	0.553
LIG_SH2_STAP1	448	452	PF00017	0.450
LIG_SH2_STAT5	102	105	PF00017	0.400
LIG_SH2_STAT5	144	147	PF00017	0.350
LIG_SH2_STAT5	272	275	PF00017	0.321
LIG_SH2_STAT5	71	74	PF00017	0.555
LIG_SH2_STAT5	95	98	PF00017	0.582
LIG_SH3_3	162	168	PF00018	0.280
LIG_SH3_3	253	259	PF00018	0.321
LIG_SH3_3	67	73	PF00018	0.485
LIG_SUMO_SIM_anti_2	260	267	PF11976	0.323
LIG_SUMO_SIM_anti_2	327	333	PF11976	0.500
LIG_SUMO_SIM_par_1	125	131	PF11976	0.345
LIG_TRAF2_1	58	61	PF00917	0.591
LIG_TYR_ITIM	100	105	PF00017	0.459
LIG_TYR_ITIM	142	147	PF00017	0.462
LIG_TYR_ITIM	78	83	PF00017	0.530
LIG_UBA3_1	331	338	PF00899	0.575
LIG_UBA3_1	356	365	PF00899	0.567
LIG_WRC_WIRS_1	190	195	PF05994	0.321
LIG_WRC_WIRS_1	458	463	PF05994	0.278
LIG_WW_1	269	272	PF00397	0.420
MOD_CK1_1	232	238	PF00069	0.408
MOD_CK1_1	404	410	PF00069	0.577
MOD_CK1_1	454	460	PF00069	0.530
MOD_CK1_1	490	496	PF00069	0.678
MOD_CK2_1	426	432	PF00069	0.462
MOD_CK2_1	515	521	PF00069	0.726
MOD_CK2_1	55	61	PF00069	0.559
MOD_Cter_Amidation	363	366	PF01082	0.564
MOD_Cter_Amidation	502	505	PF01082	0.626
MOD_GlcNHglycan	168	171	PF01048	0.321
MOD_GlcNHglycan	318	321	PF01048	0.451
MOD_GlcNHglycan	322	325	PF01048	0.378
MOD_GlcNHglycan	518	521	PF01048	0.672
MOD_GlcNHglycan	57	60	PF01048	0.611
MOD_GSK3_1	100	107	PF00069	0.398
MOD_GSK3_1	189	196	PF00069	0.311
MOD_GSK3_1	23	30	PF00069	0.584
MOD_GSK3_1	316	323	PF00069	0.433
MOD_GSK3_1	344	351	PF00069	0.366
MOD_GSK3_1	385	392	PF00069	0.395
MOD_GSK3_1	552	559	PF00069	0.671
MOD_GSK3_1	65	72	PF00069	0.430
MOD_LATS_1	336	342	PF00433	0.531
MOD_N-GLC_1	14	19	PF02516	0.585
MOD_N-GLC_1	229	234	PF02516	0.420
MOD_N-GLC_1	309	314	PF02516	0.531
MOD_NEK2_1	100	105	PF00069	0.371
MOD_NEK2_1	145	150	PF00069	0.323
MOD_NEK2_1	179	184	PF00069	0.369
MOD_NEK2_1	193	198	PF00069	0.237
MOD_NEK2_1	348	353	PF00069	0.341
MOD_NEK2_1	385	390	PF00069	0.349
MOD_NEK2_1	547	552	PF00069	0.701
MOD_NEK2_1	554	559	PF00069	0.751
MOD_NEK2_2	352	357	PF00069	0.455
MOD_NEK2_2	376	381	PF00069	0.513
MOD_PIKK_1	276	282	PF00454	0.321
MOD_PIKK_1	29	35	PF00454	0.640
MOD_PIKK_1	385	391	PF00454	0.377
MOD_PIKK_1	6	12	PF00454	0.677
MOD_Plk_1	14	20	PF00069	0.567
MOD_Plk_1	229	235	PF00069	0.395
MOD_Plk_1	23	29	PF00069	0.535
MOD_Plk_1	338	344	PF00069	0.474
MOD_Plk_1	40	46	PF00069	0.402
MOD_Plk_1	496	502	PF00069	0.630
MOD_Plk_1	547	553	PF00069	0.713
MOD_Plk_1	6	12	PF00069	0.529
MOD_Plk_4	100	106	PF00069	0.358
MOD_Plk_4	14	20	PF00069	0.625
MOD_Plk_4	189	195	PF00069	0.321
MOD_Plk_4	258	264	PF00069	0.279
MOD_Plk_4	288	294	PF00069	0.462
MOD_Plk_4	327	333	PF00069	0.542
MOD_Plk_4	344	350	PF00069	0.363
MOD_Plk_4	352	358	PF00069	0.387
MOD_Plk_4	376	382	PF00069	0.496
MOD_Plk_4	496	502	PF00069	0.687
MOD_Plk_4	73	79	PF00069	0.538
MOD_ProDKin_1	128	134	PF00069	0.345
MOD_ProDKin_1	163	169	PF00069	0.325
MOD_ProDKin_1	172	178	PF00069	0.329
MOD_ProDKin_1	401	407	PF00069	0.616
MOD_ProDKin_1	69	75	PF00069	0.500
MOD_SUMO_rev_2	395	401	PF00179	0.517
TRG_ENDOCYTIC_2	102	105	PF00928	0.443
TRG_ENDOCYTIC_2	144	147	PF00928	0.462
TRG_ENDOCYTIC_2	187	190	PF00928	0.301
TRG_ENDOCYTIC_2	353	356	PF00928	0.352
TRG_ENDOCYTIC_2	431	434	PF00928	0.460
TRG_ENDOCYTIC_2	80	83	PF00928	0.406
TRG_ER_diArg_1	332	335	PF00400	0.562
TRG_ER_diArg_1	504	506	PF00400	0.587
TRG_NES_CRM1_1	209	221	PF08389	0.377
TRG_NES_CRM1_1	280	290	PF08389	0.377

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV44	Leptomonas seymouri	73%	98%
A0A1X0P6A9	Trypanosomatidae	50%	98%
A0A3Q8IGE3	Leishmania donovani	97%	100%
A0A3R7NUK9	Trypanosoma rangeli	56%	100%
A4HMW3	Leishmania braziliensis	87%	100%
A4IBI4	Leishmania infantum	97%	100%
E9AFC0	Leishmania major	96%	100%
Q3U1T9	Mus musculus	25%	73%
Q6P3S1	Homo sapiens	23%	72%
V5DUS4	Trypanosoma cruzi	54%	100%