Dolichol kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Dolichol kinase

Gene product:

dolichol kinase, putative

Species:

Leishmania mexicana

UniProt:

E9B6H2_LEIMU

TriTrypDb:

LmxM.34.2930

Length:

554

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	10
GO:0016020	membrane	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10

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Expansion

Sequence features

E9B6H2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6H2

Function

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Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	11
GO:0006644	phospholipid metabolic process	4	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0008152	metabolic process	1	11
GO:0008610	lipid biosynthetic process	4	11
GO:0008654	phospholipid biosynthetic process	5	11
GO:0009058	biosynthetic process	2	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	8

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004168	dolichol kinase activity	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	348	352	PF00656	0.569
CLV_C14_Caspase3-7	490	494	PF00656	0.299
CLV_NRD_NRD_1	207	209	PF00675	0.421
CLV_NRD_NRD_1	210	212	PF00675	0.384
CLV_NRD_NRD_1	285	287	PF00675	0.284
CLV_NRD_NRD_1	418	420	PF00675	0.351
CLV_NRD_NRD_1	66	68	PF00675	0.395
CLV_PCSK_KEX2_1	206	208	PF00082	0.441
CLV_PCSK_KEX2_1	212	214	PF00082	0.377
CLV_PCSK_KEX2_1	285	287	PF00082	0.277

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ90	Leptomonas seymouri	75%	91%
A0A1X0P5F5	Trypanosomatidae	49%	100%
A0A3Q8IJJ2	Leishmania donovani	92%	100%
A0A3R7KY54	Trypanosoma rangeli	49%	100%
A4HMW0	Leishmania braziliensis	85%	100%
A4IBI1	Leishmania infantum	93%	100%
C9ZZ59	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	99%
E9AFB7	Leishmania major	92%	100%
V5BTH9	Trypanosoma cruzi	50%	100%

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