Dolichol kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Dolichol kinase

Gene product:

dolichol kinase, putative

Species:

Leishmania mexicana

UniProt:

E9B6H2_LEIMU

TriTrypDb:

LmxM.34.2930

Length:

554

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	10
GO:0016020	membrane	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9B6H2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6H2

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	11
GO:0006644	phospholipid metabolic process	4	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0008152	metabolic process	1	11
GO:0008610	lipid biosynthetic process	4	11
GO:0008654	phospholipid biosynthetic process	5	11
GO:0009058	biosynthetic process	2	11
GO:0009987	cellular process	1	11
GO:0019637	organophosphate metabolic process	3	11
GO:0043048	dolichyl monophosphate biosynthetic process	6	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044255	cellular lipid metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090407	organophosphate biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11
GO:0016310	phosphorylation	5	8

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004168	dolichol kinase activity	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	348	352	PF00656	0.569
CLV_C14_Caspase3-7	490	494	PF00656	0.299
CLV_NRD_NRD_1	207	209	PF00675	0.421
CLV_NRD_NRD_1	210	212	PF00675	0.384
CLV_NRD_NRD_1	285	287	PF00675	0.284
CLV_NRD_NRD_1	418	420	PF00675	0.351
CLV_NRD_NRD_1	66	68	PF00675	0.395
CLV_PCSK_KEX2_1	206	208	PF00082	0.441
CLV_PCSK_KEX2_1	212	214	PF00082	0.377
CLV_PCSK_KEX2_1	285	287	PF00082	0.277
CLV_PCSK_KEX2_1	418	420	PF00082	0.351
CLV_PCSK_KEX2_1	66	68	PF00082	0.387
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.377
CLV_PCSK_PC7_1	208	214	PF00082	0.305
CLV_PCSK_PC7_1	281	287	PF00082	0.306
CLV_PCSK_SKI1_1	212	216	PF00082	0.270
CLV_PCSK_SKI1_1	243	247	PF00082	0.549
CLV_PCSK_SKI1_1	286	290	PF00082	0.236
CLV_PCSK_SKI1_1	423	427	PF00082	0.387
CLV_PCSK_SKI1_1	522	526	PF00082	0.370
DEG_Nend_UBRbox_3	1	3	PF02207	0.361
DOC_CYCLIN_yCln2_LP_2	23	29	PF00134	0.320
DOC_CYCLIN_yCln2_LP_2	495	501	PF00134	0.236
DOC_MAPK_gen_1	206	218	PF00069	0.598
DOC_MAPK_gen_1	285	294	PF00069	0.436
DOC_MAPK_MEF2A_6	211	218	PF00069	0.524
DOC_MAPK_MEF2A_6	22	30	PF00069	0.279
DOC_MAPK_MEF2A_6	355	364	PF00069	0.404
DOC_MAPK_NFAT4_5	22	30	PF00069	0.321
DOC_MAPK_NFAT4_5	355	363	PF00069	0.384
DOC_PP1_RVXF_1	520	527	PF00149	0.492
DOC_PP2B_LxvP_1	159	162	PF13499	0.426
DOC_PP2B_LxvP_1	23	26	PF13499	0.302
DOC_PP2B_LxvP_1	495	498	PF13499	0.258
DOC_PP2B_LxvP_1	511	514	PF13499	0.271
DOC_PP2B_LxvP_1	539	542	PF13499	0.548
DOC_USP7_MATH_1	13	17	PF00917	0.413
DOC_USP7_MATH_1	434	438	PF00917	0.526
DOC_USP7_MATH_1	542	546	PF00917	0.673
DOC_WW_Pin1_4	295	300	PF00397	0.271
DOC_WW_Pin1_4	41	46	PF00397	0.301
DOC_WW_Pin1_4	545	550	PF00397	0.673
DOC_WW_Pin1_4	67	72	PF00397	0.597
LIG_14-3-3_CanoR_1	165	169	PF00244	0.292
LIG_14-3-3_CanoR_1	255	260	PF00244	0.306
LIG_14-3-3_CanoR_1	418	422	PF00244	0.636
LIG_14-3-3_CanoR_1	522	527	PF00244	0.511
LIG_14-3-3_CanoR_1	98	103	PF00244	0.251
LIG_APCC_ABBAyCdc20_2	426	432	PF00400	0.683
LIG_BRCT_BRCA1_1	233	237	PF00533	0.316
LIG_BRCT_BRCA1_1	250	254	PF00533	0.349
LIG_BRCT_BRCA1_1	276	280	PF00533	0.437
LIG_BRCT_BRCA1_1	410	414	PF00533	0.388
LIG_Clathr_ClatBox_1	512	516	PF01394	0.292
LIG_deltaCOP1_diTrp_1	516	526	PF00928	0.478
LIG_EH1_1	363	371	PF00400	0.281
LIG_eIF4E_1	424	430	PF01652	0.587
LIG_FHA_1	442	448	PF00498	0.453
LIG_FHA_1	9	15	PF00498	0.339
LIG_FHA_2	299	305	PF00498	0.335
LIG_FHA_2	481	487	PF00498	0.358
LIG_GBD_Chelix_1	224	232	PF00786	0.337
LIG_HP1_1	498	502	PF01393	0.404
LIG_IRF3_LxIS_1	227	234	PF10401	0.393
LIG_LIR_Gen_1	110	120	PF02991	0.349
LIG_LIR_Gen_1	166	176	PF02991	0.295
LIG_LIR_Gen_1	191	197	PF02991	0.567
LIG_LIR_Gen_1	304	315	PF02991	0.236
LIG_LIR_Gen_1	356	366	PF02991	0.404
LIG_LIR_Gen_1	475	484	PF02991	0.288
LIG_LIR_Gen_1	507	515	PF02991	0.233
LIG_LIR_Gen_1	55	64	PF02991	0.289
LIG_LIR_Gen_1	80	91	PF02991	0.335
LIG_LIR_Nem_3	110	115	PF02991	0.370
LIG_LIR_Nem_3	132	136	PF02991	0.171
LIG_LIR_Nem_3	166	171	PF02991	0.344
LIG_LIR_Nem_3	191	196	PF02991	0.531
LIG_LIR_Nem_3	304	310	PF02991	0.247
LIG_LIR_Nem_3	356	362	PF02991	0.271
LIG_LIR_Nem_3	475	479	PF02991	0.283
LIG_LIR_Nem_3	507	512	PF02991	0.233
LIG_LIR_Nem_3	540	546	PF02991	0.680
LIG_LIR_Nem_3	55	59	PF02991	0.289
LIG_LIR_Nem_3	80	86	PF02991	0.335
LIG_NRBOX	507	513	PF00104	0.404
LIG_PALB2_WD40_1	258	266	PF16756	0.292
LIG_PCNA_TLS_4	418	426	PF02747	0.639
LIG_Pex14_1	244	248	PF04695	0.286
LIG_PTB_Apo_2	424	431	PF02174	0.541
LIG_REV1ctd_RIR_1	112	119	PF16727	0.404
LIG_SH2_GRB2like	327	330	PF00017	0.594
LIG_SH2_NCK_1	168	172	PF00017	0.313
LIG_SH2_STAP1	168	172	PF00017	0.313
LIG_SH2_STAP1	474	478	PF00017	0.374
LIG_SH2_STAP1	49	53	PF00017	0.281
LIG_SH2_STAT5	107	110	PF00017	0.318
LIG_SH2_STAT5	112	115	PF00017	0.320
LIG_SH2_STAT5	137	140	PF00017	0.349
LIG_SH2_STAT5	168	171	PF00017	0.315
LIG_SH2_STAT5	182	185	PF00017	0.309
LIG_SH2_STAT5	248	251	PF00017	0.305
LIG_SH2_STAT5	271	274	PF00017	0.349
LIG_SH2_STAT5	359	362	PF00017	0.319
LIG_SH2_STAT5	424	427	PF00017	0.556
LIG_SH2_STAT5	56	59	PF00017	0.289
LIG_SH3_3	377	383	PF00018	0.420
LIG_SUMO_SIM_anti_2	5	11	PF11976	0.342
LIG_SUMO_SIM_anti_2	55	61	PF11976	0.289
LIG_SUMO_SIM_par_1	185	191	PF11976	0.389
LIG_SUMO_SIM_par_1	271	277	PF11976	0.364
LIG_SUMO_SIM_par_1	384	389	PF11976	0.336
LIG_SUMO_SIM_par_1	459	465	PF11976	0.343
LIG_SUMO_SIM_par_1	477	483	PF11976	0.206
LIG_SUMO_SIM_par_1	498	504	PF11976	0.184
LIG_SUMO_SIM_par_1	5	11	PF11976	0.335
LIG_TRFH_1	263	267	PF08558	0.292
LIG_TYR_ITIM	54	59	PF00017	0.289
LIG_TYR_ITSM	164	171	PF00017	0.368
LIG_UBA3_1	113	117	PF00899	0.292
LIG_WRC_WIRS_1	130	135	PF05994	0.171
LIG_WRC_WIRS_1	473	478	PF05994	0.301
MOD_CDK_SPK_2	67	72	PF00069	0.597
MOD_CDK_SPxxK_3	67	74	PF00069	0.597
MOD_CK1_1	155	161	PF00069	0.472
MOD_CK1_1	188	194	PF00069	0.393
MOD_CK1_1	202	208	PF00069	0.500
MOD_CK1_1	417	423	PF00069	0.603
MOD_CK1_1	545	551	PF00069	0.697
MOD_CK1_1	55	61	PF00069	0.283
MOD_CK2_1	480	486	PF00069	0.305
MOD_GlcNHglycan	109	112	PF01048	0.404
MOD_GlcNHglycan	87	90	PF01048	0.386
MOD_GSK3_1	166	173	PF00069	0.337
MOD_GSK3_1	195	202	PF00069	0.580
MOD_GSK3_1	310	317	PF00069	0.285
MOD_GSK3_1	330	337	PF00069	0.405
MOD_GSK3_1	409	416	PF00069	0.294
MOD_GSK3_1	436	443	PF00069	0.529
MOD_GSK3_1	48	55	PF00069	0.280
MOD_GSK3_1	527	534	PF00069	0.663
MOD_GSK3_1	8	15	PF00069	0.367
MOD_LATS_1	253	259	PF00433	0.165
MOD_N-GLC_1	434	439	PF02516	0.324
MOD_N-GLC_1	520	525	PF02516	0.293
MOD_N-GLC_1	527	532	PF02516	0.286
MOD_N-GLC_2	146	148	PF02516	0.490
MOD_NEK2_1	129	134	PF00069	0.284
MOD_NEK2_1	185	190	PF00069	0.188
MOD_NEK2_1	218	223	PF00069	0.291
MOD_NEK2_1	231	236	PF00069	0.342
MOD_NEK2_1	249	254	PF00069	0.387
MOD_NEK2_1	310	315	PF00069	0.276
MOD_NEK2_1	364	369	PF00069	0.304
MOD_NEK2_1	413	418	PF00069	0.439
MOD_NEK2_1	48	53	PF00069	0.298
MOD_PK_1	373	379	PF00069	0.363
MOD_PKA_1	207	213	PF00069	0.610
MOD_PKA_2	152	158	PF00069	0.451
MOD_PKA_2	164	170	PF00069	0.215
MOD_PKA_2	207	213	PF00069	0.522
MOD_PKA_2	280	286	PF00069	0.519
MOD_PKA_2	417	423	PF00069	0.638
MOD_PKB_1	371	379	PF00069	0.354
MOD_Plk_1	386	392	PF00069	0.298
MOD_Plk_1	434	440	PF00069	0.542
MOD_Plk_1	520	526	PF00069	0.493
MOD_Plk_4	129	135	PF00069	0.314
MOD_Plk_4	152	158	PF00069	0.416
MOD_Plk_4	185	191	PF00069	0.339
MOD_Plk_4	2	8	PF00069	0.332
MOD_Plk_4	298	304	PF00069	0.341
MOD_Plk_4	364	370	PF00069	0.200
MOD_Plk_4	409	415	PF00069	0.271
MOD_Plk_4	49	55	PF00069	0.288
MOD_Plk_4	504	510	PF00069	0.175
MOD_Plk_4	77	83	PF00069	0.341
MOD_ProDKin_1	295	301	PF00069	0.271
MOD_ProDKin_1	41	47	PF00069	0.297
MOD_ProDKin_1	545	551	PF00069	0.672
MOD_ProDKin_1	67	73	PF00069	0.595
MOD_SUMO_for_1	62	65	PF00179	0.558
TRG_DiLeu_BaEn_1	20	25	PF01217	0.290
TRG_DiLeu_BaLyEn_6	19	24	PF01217	0.323
TRG_ENDOCYTIC_2	112	115	PF00928	0.333
TRG_ENDOCYTIC_2	168	171	PF00928	0.355
TRG_ENDOCYTIC_2	182	185	PF00928	0.404
TRG_ENDOCYTIC_2	327	330	PF00928	0.533
TRG_ENDOCYTIC_2	359	362	PF00928	0.404
TRG_ENDOCYTIC_2	56	59	PF00928	0.289
TRG_ER_diArg_1	206	208	PF00400	0.652
TRG_ER_diArg_1	211	214	PF00400	0.566
TRG_ER_diArg_1	284	286	PF00400	0.512
TRG_ER_diArg_1	370	373	PF00400	0.355
TRG_NLS_MonoExtN_4	208	215	PF00514	0.501
TRG_Pf-PMV_PEXEL_1	342	346	PF00026	0.390
TRG_Pf-PMV_PEXEL_1	373	378	PF00026	0.610

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ90	Leptomonas seymouri	75%	91%
A0A1X0P5F5	Trypanosomatidae	49%	100%
A0A3Q8IJJ2	Leishmania donovani	92%	100%
A0A3R7KY54	Trypanosoma rangeli	49%	100%
A4HMW0	Leishmania braziliensis	85%	100%
A4IBI1	Leishmania infantum	93%	100%
C9ZZ59	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	99%
E9AFB7	Leishmania major	92%	100%
V5BTH9	Trypanosoma cruzi	50%	100%