Dynein light chain

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Dynein light chain

Gene product:

dynein light chain, putative

Species:

Leishmania mexicana

UniProt:

E9B6H0_LEIMU

TriTrypDb:

LmxM.34.2910

Length:

123

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005868	cytoplasmic dynein complex	4	1
GO:0005875	microtubule associated complex	2	1
GO:0030286	dynein complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1

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Expansion

Sequence features

E9B6H0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6H0

Function

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Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045505	dynein intermediate chain binding	3	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	96	100	PF00656	0.443
CLV_PCSK_SKI1_1	109	113	PF00082	0.443
CLV_PCSK_SKI1_1	30	34	PF00082	0.415
DEG_Nend_UBRbox_3	1	3	PF02207	0.689
DOC_CYCLIN_RxL_1	106	116	PF00134	0.443
DOC_USP7_UBL2_3	26	30	PF12436	0.505
DOC_USP7_UBL2_3	61	65	PF12436	0.505
LIG_eIF4E_1	106	112	PF01652	0.358
LIG_FHA_1	7	13	PF00498	0.594
LIG_FHA_2	55	61	PF00498	0.374

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3B2	Leptomonas seymouri	85%	100%
A0A0N1PFP4	Leptomonas seymouri	33%	98%
A0A0S4IQE7	Bodo saltans	26%	100%
A0A0S4JDH6	Bodo saltans	72%	88%
A0A1X0NYC6	Trypanosomatidae	28%	98%
A0A1X0P6I3	Trypanosomatidae	69%	99%
A0A3R7LJS7	Trypanosoma rangeli	25%	98%
A0A3S5H7J0	Leishmania donovani	31%	98%
A0A3S7X9I4	Leishmania donovani	98%	100%
A0A422P2R8	Trypanosoma rangeli	76%	99%

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