DNA helicase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

DNA helicase

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B6G9_LEIMU

TriTrypDb:

LmxM.34.2900

Length:

605

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6G9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6G9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	315	319	PF00656	0.667
CLV_C14_Caspase3-7	433	437	PF00656	0.379
CLV_C14_Caspase3-7	529	533	PF00656	0.640
CLV_NRD_NRD_1	202	204	PF00675	0.527
CLV_NRD_NRD_1	291	293	PF00675	0.715
CLV_NRD_NRD_1	593	595	PF00675	0.680
CLV_PCSK_FUR_1	590	594	PF00082	0.521
CLV_PCSK_KEX2_1	201	203	PF00082	0.556
CLV_PCSK_KEX2_1	280	282	PF00082	0.675
CLV_PCSK_KEX2_1	291	293	PF00082	0.715
CLV_PCSK_KEX2_1	590	592	PF00082	0.778
CLV_PCSK_KEX2_1	593	595	PF00082	0.736
CLV_PCSK_PC1ET2_1	280	282	PF00082	0.675
CLV_PCSK_PC7_1	587	593	PF00082	0.526
CLV_PCSK_SKI1_1	225	229	PF00082	0.483
CLV_PCSK_SKI1_1	489	493	PF00082	0.505
CLV_PCSK_SKI1_1	552	556	PF00082	0.520
DEG_Nend_UBRbox_1	1	4	PF02207	0.660
DEG_SPOP_SBC_1	413	417	PF00917	0.646
DOC_CDC14_PxL_1	179	187	PF14671	0.604
DOC_CYCLIN_RxL_1	548	558	PF00134	0.502
DOC_CYCLIN_RxL_1	61	71	PF00134	0.390
DOC_CYCLIN_yCln2_LP_2	494	500	PF00134	0.536
DOC_CYCLIN_yCln2_LP_2	90	96	PF00134	0.422
DOC_MAPK_HePTP_8	490	502	PF00069	0.559
DOC_MAPK_MEF2A_6	493	502	PF00069	0.563
DOC_PP1_RVXF_1	350	356	PF00149	0.568
DOC_PP1_RVXF_1	374	380	PF00149	0.644
DOC_PP2B_LxvP_1	228	231	PF13499	0.476
DOC_PP4_FxxP_1	100	103	PF00568	0.506
DOC_PP4_FxxP_1	156	159	PF00568	0.576
DOC_PP4_FxxP_1	207	210	PF00568	0.482
DOC_PP4_FxxP_1	275	278	PF00568	0.689
DOC_PP4_FxxP_1	37	40	PF00568	0.530
DOC_PP4_FxxP_1	388	391	PF00568	0.565
DOC_PP4_FxxP_1	54	57	PF00568	0.549
DOC_USP7_MATH_1	309	313	PF00917	0.575
DOC_USP7_MATH_1	325	329	PF00917	0.665
DOC_USP7_MATH_1	344	348	PF00917	0.329
DOC_USP7_MATH_1	4	8	PF00917	0.676
DOC_USP7_MATH_1	479	483	PF00917	0.458
DOC_USP7_MATH_1	583	587	PF00917	0.519
DOC_USP7_MATH_2	322	328	PF00917	0.558
DOC_WW_Pin1_4	283	288	PF00397	0.521
DOC_WW_Pin1_4	358	363	PF00397	0.560
DOC_WW_Pin1_4	414	419	PF00397	0.669
DOC_WW_Pin1_4	43	48	PF00397	0.561
DOC_WW_Pin1_4	579	584	PF00397	0.650
LIG_14-3-3_CanoR_1	16	22	PF00244	0.535
LIG_14-3-3_CanoR_1	225	231	PF00244	0.493
LIG_14-3-3_CanoR_1	266	275	PF00244	0.649
LIG_14-3-3_CanoR_1	281	287	PF00244	0.719
LIG_14-3-3_CanoR_1	295	299	PF00244	0.720
LIG_14-3-3_CanoR_1	402	406	PF00244	0.572
LIG_14-3-3_CanoR_1	412	418	PF00244	0.576
LIG_14-3-3_CanoR_1	449	453	PF00244	0.518
LIG_14-3-3_CanoR_1	503	513	PF00244	0.580
LIG_14-3-3_CanoR_1	527	531	PF00244	0.596
LIG_14-3-3_CanoR_1	550	555	PF00244	0.513
LIG_14-3-3_CanoR_1	559	569	PF00244	0.461
LIG_Actin_WH2_2	499	514	PF00022	0.580
LIG_AP2alpha_1	366	370	PF02296	0.544
LIG_AP2alpha_1	37	41	PF02296	0.280
LIG_AP2alpha_2	273	275	PF02296	0.671
LIG_AP2alpha_2	39	41	PF02296	0.294
LIG_APCC_ABBA_1	355	360	PF00400	0.543
LIG_BRCT_BRCA1_1	120	124	PF00533	0.479
LIG_BRCT_BRCA1_1	228	232	PF00533	0.459
LIG_BRCT_BRCA1_1	402	406	PF00533	0.521
LIG_BRCT_BRCA1_1	482	486	PF00533	0.544
LIG_BRCT_BRCA1_1	562	566	PF00533	0.473
LIG_eIF4E_1	549	555	PF01652	0.510
LIG_FHA_1	106	112	PF00498	0.527
LIG_FHA_1	216	222	PF00498	0.561
LIG_FHA_1	284	290	PF00498	0.661
LIG_FHA_1	335	341	PF00498	0.673
LIG_FHA_1	4	10	PF00498	0.616
LIG_FHA_1	405	411	PF00498	0.554
LIG_FHA_1	475	481	PF00498	0.481
LIG_FHA_1	57	63	PF00498	0.575
LIG_FHA_2	373	379	PF00498	0.613
LIG_IBAR_NPY_1	382	384	PF08397	0.696
LIG_Integrin_isoDGR_2	223	225	PF01839	0.449
LIG_LIR_Apic_2	153	159	PF02991	0.555
LIG_LIR_Apic_2	205	210	PF02991	0.486
LIG_LIR_Apic_2	273	278	PF02991	0.680
LIG_LIR_Apic_2	35	40	PF02991	0.473
LIG_LIR_Apic_2	52	57	PF02991	0.527
LIG_LIR_Gen_1	118	126	PF02991	0.448
LIG_LIR_Gen_1	364	373	PF02991	0.497
LIG_LIR_Gen_1	563	572	PF02991	0.468
LIG_LIR_Nem_3	118	122	PF02991	0.458
LIG_LIR_Nem_3	364	369	PF02991	0.507
LIG_LIR_Nem_3	453	459	PF02991	0.650
LIG_LIR_Nem_3	52	56	PF02991	0.547
LIG_LIR_Nem_3	563	569	PF02991	0.470
LIG_LIR_Nem_3	89	94	PF02991	0.427
LIG_LYPXL_yS_3	384	387	PF13949	0.603
LIG_MAD2	489	497	PF02301	0.534
LIG_MLH1_MIPbox_1	402	406	PF16413	0.567
LIG_PCNA_TLS_4	201	208	PF02747	0.485
LIG_PCNA_yPIPBox_3	437	449	PF02747	0.358
LIG_PDZ_Class_1	600	605	PF00595	0.488
LIG_Pex14_2	146	150	PF04695	0.593
LIG_Pex14_2	232	236	PF04695	0.543
LIG_Pex14_2	366	370	PF04695	0.544
LIG_Pex14_2	37	41	PF04695	0.518
LIG_Pex14_2	469	473	PF04695	0.481
LIG_Pex14_2	84	88	PF04695	0.550
LIG_PTB_Apo_2	220	227	PF02174	0.438
LIG_PTB_Phospho_1	220	226	PF10480	0.440
LIG_REV1ctd_RIR_1	484	493	PF16727	0.556
LIG_SH2_CRK	456	460	PF00017	0.603
LIG_SH2_NCK_1	520	524	PF00017	0.547
LIG_SH2_STAP1	195	199	PF00017	0.616
LIG_SH2_STAT3	516	519	PF00017	0.709
LIG_SH2_STAT5	195	198	PF00017	0.637
LIG_SH2_STAT5	226	229	PF00017	0.513
LIG_SH2_STAT5	254	257	PF00017	0.540
LIG_SH2_STAT5	264	267	PF00017	0.573
LIG_SH2_STAT5	423	426	PF00017	0.525
LIG_SH3_2	287	292	PF14604	0.701
LIG_SH3_3	284	290	PF00018	0.738
LIG_SH3_3	338	344	PF00018	0.552
LIG_SH3_3	408	414	PF00018	0.551
LIG_SH3_3	577	583	PF00018	0.576
LIG_SUMO_SIM_anti_2	66	71	PF11976	0.603
LIG_SUMO_SIM_par_1	102	108	PF11976	0.527
LIG_TRFH_1	428	432	PF08558	0.372
LIG_WRC_WIRS_1	147	152	PF05994	0.606
LIG_WRC_WIRS_1	204	209	PF05994	0.561
LIG_WRC_WIRS_1	345	350	PF05994	0.552
LIG_WW_1	546	549	PF00397	0.465
MOD_CK1_1	118	124	PF00069	0.545
MOD_CK1_1	267	273	PF00069	0.579
MOD_CK1_1	283	289	PF00069	0.593
MOD_CK1_1	312	318	PF00069	0.747
MOD_CK1_1	327	333	PF00069	0.618
MOD_CK1_1	404	410	PF00069	0.632
MOD_CK1_1	468	474	PF00069	0.532
MOD_CK1_1	562	568	PF00069	0.470
MOD_CK1_1	581	587	PF00069	0.583
MOD_CK2_1	372	378	PF00069	0.609
MOD_CK2_1	502	508	PF00069	0.563
MOD_GlcNHglycan	228	231	PF01048	0.480
MOD_GlcNHglycan	242	246	PF01048	0.552
MOD_GlcNHglycan	270	273	PF01048	0.654
MOD_GlcNHglycan	363	366	PF01048	0.584
MOD_GlcNHglycan	378	382	PF01048	0.640
MOD_GlcNHglycan	583	586	PF01048	0.560
MOD_GSK3_1	142	149	PF00069	0.483
MOD_GSK3_1	193	200	PF00069	0.389
MOD_GSK3_1	237	244	PF00069	0.607
MOD_GSK3_1	264	271	PF00069	0.535
MOD_GSK3_1	304	311	PF00069	0.548
MOD_GSK3_1	400	407	PF00069	0.590
MOD_GSK3_1	412	419	PF00069	0.565
MOD_GSK3_1	465	472	PF00069	0.500
MOD_GSK3_1	52	59	PF00069	0.528
MOD_GSK3_1	555	562	PF00069	0.578
MOD_GSK3_1	579	586	PF00069	0.642
MOD_LATS_1	548	554	PF00433	0.499
MOD_N-GLC_1	268	273	PF02516	0.589
MOD_N-GLC_1	358	363	PF02516	0.500
MOD_NEK2_1	124	129	PF00069	0.481
MOD_NEK2_1	146	151	PF00069	0.519
MOD_NEK2_1	17	22	PF00069	0.565
MOD_NEK2_1	215	220	PF00069	0.537
MOD_NEK2_1	294	299	PF00069	0.600
MOD_NEK2_1	401	406	PF00069	0.582
MOD_NEK2_1	41	46	PF00069	0.561
MOD_NEK2_1	469	474	PF00069	0.531
MOD_NEK2_1	480	485	PF00069	0.476
MOD_NEK2_1	502	507	PF00069	0.520
MOD_NEK2_1	535	540	PF00069	0.662
MOD_NEK2_1	599	604	PF00069	0.492
MOD_NEK2_2	309	314	PF00069	0.455
MOD_NEK2_2	344	349	PF00069	0.477
MOD_OFUCOSY	38	45	PF10250	0.518
MOD_PIKK_1	264	270	PF00454	0.555
MOD_PKA_1	280	286	PF00069	0.681
MOD_PKA_2	280	286	PF00069	0.681
MOD_PKA_2	294	300	PF00069	0.719
MOD_PKA_2	304	310	PF00069	0.612
MOD_PKA_2	401	407	PF00069	0.574
MOD_PKA_2	448	454	PF00069	0.522
MOD_PKA_2	502	508	PF00069	0.547
MOD_PKA_2	526	532	PF00069	0.604
MOD_PKA_2	560	566	PF00069	0.479
MOD_PKB_1	201	209	PF00069	0.513
MOD_PKB_1	559	567	PF00069	0.481
MOD_Plk_1	142	148	PF00069	0.533
MOD_Plk_1	237	243	PF00069	0.586
MOD_Plk_1	469	475	PF00069	0.530
MOD_Plk_4	115	121	PF00069	0.498
MOD_Plk_4	181	187	PF00069	0.394
MOD_Plk_4	203	209	PF00069	0.490
MOD_Plk_4	294	300	PF00069	0.651
MOD_Plk_4	309	315	PF00069	0.565
MOD_Plk_4	401	407	PF00069	0.571
MOD_Plk_4	469	475	PF00069	0.512
MOD_Plk_4	49	55	PF00069	0.590
MOD_Plk_4	535	541	PF00069	0.621
MOD_ProDKin_1	283	289	PF00069	0.522
MOD_ProDKin_1	358	364	PF00069	0.562
MOD_ProDKin_1	414	420	PF00069	0.672
MOD_ProDKin_1	43	49	PF00069	0.563
MOD_ProDKin_1	579	585	PF00069	0.654
MOD_SUMO_rev_2	163	173	PF00179	0.477
MOD_SUMO_rev_2	256	263	PF00179	0.540
TRG_ENDOCYTIC_2	384	387	PF00928	0.592
TRG_ENDOCYTIC_2	456	459	PF00928	0.611
TRG_ENDOCYTIC_2	85	88	PF00928	0.484
TRG_ER_diArg_1	201	203	PF00400	0.560
TRG_ER_diArg_1	290	292	PF00400	0.783
TRG_ER_diArg_1	549	552	PF00400	0.503
TRG_ER_diArg_1	589	592	PF00400	0.752
TRG_ER_diArg_1	593	595	PF00400	0.672
TRG_NES_CRM1_1	169	181	PF08389	0.477
TRG_Pf-PMV_PEXEL_1	552	556	PF00026	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Q5	Leptomonas seymouri	74%	84%
A0A1X0P6X0	Trypanosomatidae	39%	96%
A0A3Q8IF92	Leishmania donovani	91%	77%
A0A3S5ISL4	Trypanosoma rangeli	40%	100%
A4HMV7	Leishmania braziliensis	80%	100%
A4IBH8	Leishmania infantum	91%	83%
E9AFB4	Leishmania major	92%	100%