SpoU_methylase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SpoU rRNA Methylase family, putative

Species:

Leishmania mexicana

UniProt:

E9B6G8_LEIMU

TriTrypDb:

LmxM.34.2890

Length:

607

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6G8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6G8

PDB structure(s): 7am2_BX , 7am2_BY

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	9
GO:0006396	RNA processing	6	9
GO:0006725	cellular aromatic compound metabolic process	3	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	9
GO:0016070	RNA metabolic process	5	9
GO:0034641	cellular nitrogen compound metabolic process	3	9
GO:0043170	macromolecule metabolic process	3	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0046483	heterocycle metabolic process	3	9
GO:0071704	organic substance metabolic process	2	9
GO:0090304	nucleic acid metabolic process	4	9
GO:1901360	organic cyclic compound metabolic process	3	9
GO:0032259	methylation	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003723	RNA binding	4	9
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	9
GO:0008168	methyltransferase activity	4	10
GO:0008173	RNA methyltransferase activity	4	9
GO:0016740	transferase activity	2	10
GO:0016741	transferase activity, transferring one-carbon groups	3	10
GO:0097159	organic cyclic compound binding	2	9
GO:0140098	catalytic activity, acting on RNA	3	9
GO:0140640	catalytic activity, acting on a nucleic acid	2	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	180	182	PF00675	0.519
CLV_NRD_NRD_1	19	21	PF00675	0.648
CLV_NRD_NRD_1	33	35	PF00675	0.497
CLV_NRD_NRD_1	361	363	PF00675	0.484
CLV_NRD_NRD_1	422	424	PF00675	0.424
CLV_NRD_NRD_1	426	428	PF00675	0.434
CLV_NRD_NRD_1	430	432	PF00675	0.423
CLV_NRD_NRD_1	525	527	PF00675	0.463
CLV_NRD_NRD_1	530	532	PF00675	0.470
CLV_NRD_NRD_1	544	546	PF00675	0.411
CLV_NRD_NRD_1	551	553	PF00675	0.430
CLV_NRD_NRD_1	556	558	PF00675	0.424
CLV_PCSK_FUR_1	523	527	PF00082	0.418
CLV_PCSK_FUR_1	554	558	PF00082	0.582
CLV_PCSK_KEX2_1	180	182	PF00082	0.613
CLV_PCSK_KEX2_1	19	21	PF00082	0.648
CLV_PCSK_KEX2_1	2	4	PF00082	0.618
CLV_PCSK_KEX2_1	33	35	PF00082	0.497
CLV_PCSK_KEX2_1	361	363	PF00082	0.484
CLV_PCSK_KEX2_1	417	419	PF00082	0.421
CLV_PCSK_KEX2_1	422	424	PF00082	0.400
CLV_PCSK_KEX2_1	426	428	PF00082	0.410
CLV_PCSK_KEX2_1	430	432	PF00082	0.399
CLV_PCSK_KEX2_1	525	527	PF00082	0.418
CLV_PCSK_KEX2_1	529	531	PF00082	0.436
CLV_PCSK_KEX2_1	544	546	PF00082	0.427
CLV_PCSK_KEX2_1	551	553	PF00082	0.429
CLV_PCSK_KEX2_1	556	558	PF00082	0.426
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.555
CLV_PCSK_PC1ET2_1	417	419	PF00082	0.421
CLV_PCSK_PC7_1	418	424	PF00082	0.420
CLV_PCSK_PC7_1	426	432	PF00082	0.430
CLV_PCSK_PC7_1	525	531	PF00082	0.526
CLV_PCSK_PC7_1	547	553	PF00082	0.464
CLV_PCSK_SKI1_1	100	104	PF00082	0.401
CLV_PCSK_SKI1_1	141	145	PF00082	0.376
CLV_PCSK_SKI1_1	418	422	PF00082	0.597
CLV_PCSK_SKI1_1	434	438	PF00082	0.386
CLV_PCSK_SKI1_1	547	551	PF00082	0.416
CLV_PCSK_SKI1_1	565	569	PF00082	0.717
CLV_PCSK_SKI1_1	589	593	PF00082	0.477
CLV_PCSK_SKI1_1	65	69	PF00082	0.511
DEG_APCC_DBOX_1	304	312	PF00400	0.369
DEG_APCC_DBOX_1	417	425	PF00400	0.597
DEG_APCC_DBOX_1	433	441	PF00400	0.412
DEG_Nend_UBRbox_1	1	4	PF02207	0.770
DEG_ODPH_VHL_1	57	69	PF01847	0.470
DEG_SPOP_SBC_1	368	372	PF00917	0.528
DEG_SPOP_SBC_1	80	84	PF00917	0.644
DOC_CKS1_1	209	214	PF01111	0.518
DOC_CYCLIN_RxL_1	222	235	PF00134	0.398
DOC_MAPK_gen_1	136	145	PF00069	0.360
DOC_MAPK_gen_1	180	188	PF00069	0.406
DOC_MAPK_gen_1	19	26	PF00069	0.505
DOC_MAPK_gen_1	426	437	PF00069	0.464
DOC_MAPK_gen_1	554	564	PF00069	0.469
DOC_MAPK_JIP1_4	161	167	PF00069	0.489
DOC_MAPK_MEF2A_6	486	494	PF00069	0.536
DOC_MAPK_MEF2A_6	556	564	PF00069	0.361
DOC_PP2B_LxvP_1	357	360	PF13499	0.593
DOC_PP4_FxxP_1	207	210	PF00568	0.377
DOC_PP4_FxxP_1	411	414	PF00568	0.479
DOC_USP7_MATH_1	363	367	PF00917	0.634
DOC_USP7_MATH_1	368	372	PF00917	0.603
DOC_USP7_MATH_1	376	380	PF00917	0.443
DOC_USP7_MATH_1	441	445	PF00917	0.567
DOC_USP7_MATH_1	46	50	PF00917	0.545
DOC_USP7_MATH_1	76	80	PF00917	0.561
DOC_USP7_MATH_2	443	449	PF00917	0.562
DOC_USP7_UBL2_3	96	100	PF12436	0.378
DOC_WW_Pin1_4	208	213	PF00397	0.431
DOC_WW_Pin1_4	439	444	PF00397	0.557
LIG_14-3-3_CanoR_1	180	188	PF00244	0.473
LIG_14-3-3_CanoR_1	19	24	PF00244	0.480
LIG_14-3-3_CanoR_1	190	198	PF00244	0.390
LIG_14-3-3_CanoR_1	28	35	PF00244	0.472
LIG_14-3-3_CanoR_1	3	9	PF00244	0.766
LIG_14-3-3_CanoR_1	346	350	PF00244	0.583
LIG_14-3-3_CanoR_1	430	437	PF00244	0.414
LIG_14-3-3_CanoR_1	47	57	PF00244	0.651
LIG_14-3-3_CanoR_1	496	506	PF00244	0.606
LIG_14-3-3_CanoR_1	584	588	PF00244	0.614
LIG_CSL_BTD_1	560	563	PF09270	0.678
LIG_FHA_1	181	187	PF00498	0.433
LIG_FHA_1	329	335	PF00498	0.638
LIG_FHA_1	431	437	PF00498	0.392
LIG_FHA_1	478	484	PF00498	0.520
LIG_FHA_1	66	72	PF00498	0.541
LIG_FHA_2	113	119	PF00498	0.398
LIG_FHA_2	284	290	PF00498	0.533
LIG_FHA_2	444	450	PF00498	0.518
LIG_FHA_2	472	478	PF00498	0.623
LIG_IRF3_LxIS_1	447	453	PF10401	0.451
LIG_LIR_Apic_2	206	210	PF02991	0.373
LIG_LIR_Apic_2	51	56	PF02991	0.638
LIG_LIR_Apic_2	599	605	PF02991	0.567
LIG_LIR_Gen_1	406	414	PF02991	0.486
LIG_LIR_Nem_3	293	299	PF02991	0.368
LIG_LIR_Nem_3	406	411	PF02991	0.485
LIG_LIR_Nem_3	468	472	PF02991	0.493
LIG_NRBOX	239	245	PF00104	0.446
LIG_NRP_CendR_1	604	607	PF00754	0.585
LIG_PCNA_yPIPBox_3	543	557	PF02747	0.550
LIG_RPA_C_Fungi	540	552	PF08784	0.446
LIG_SH2_CRK	252	256	PF00017	0.282
LIG_SH2_CRK	296	300	PF00017	0.360
LIG_SH2_CRK	602	606	PF00017	0.685
LIG_SH2_SRC	4	7	PF00017	0.573
LIG_SH2_SRC	469	472	PF00017	0.573
LIG_SH2_STAP1	252	256	PF00017	0.282
LIG_SH2_STAP1	265	269	PF00017	0.282
LIG_SH2_STAP1	313	317	PF00017	0.397
LIG_SH2_STAP1	4	8	PF00017	0.576
LIG_SH2_STAP1	535	539	PF00017	0.417
LIG_SH2_STAT3	313	316	PF00017	0.447
LIG_SH2_STAT5	203	206	PF00017	0.417
LIG_SH2_STAT5	285	288	PF00017	0.364
LIG_SH2_STAT5	313	316	PF00017	0.468
LIG_SH2_STAT5	408	411	PF00017	0.470
LIG_SH2_STAT5	459	462	PF00017	0.402
LIG_SH2_STAT5	469	472	PF00017	0.418
LIG_SH3_1	53	59	PF00018	0.524
LIG_SH3_1	557	563	PF00018	0.485
LIG_SH3_2	210	215	PF14604	0.409
LIG_SH3_2	560	565	PF14604	0.515
LIG_SH3_3	207	213	PF00018	0.478
LIG_SH3_3	231	237	PF00018	0.254
LIG_SH3_3	352	358	PF00018	0.674
LIG_SH3_3	53	59	PF00018	0.529
LIG_SH3_3	557	563	PF00018	0.606
LIG_SH3_3	64	70	PF00018	0.519
LIG_SH3_CIN85_PxpxPR_1	356	361	PF14604	0.644
LIG_SUMO_SIM_anti_2	183	189	PF11976	0.474
LIG_SUMO_SIM_par_1	183	189	PF11976	0.394
LIG_SUMO_SIM_par_1	227	232	PF11976	0.320
LIG_TRAF2_1	381	384	PF00917	0.580
LIG_TRAF2_1	474	477	PF00917	0.503
LIG_TRFH_1	459	463	PF08558	0.420
MOD_CDK_SPxxK_3	208	215	PF00069	0.463
MOD_CK1_1	337	343	PF00069	0.501
MOD_CK1_1	429	435	PF00069	0.417
MOD_CK1_1	439	445	PF00069	0.506
MOD_CK1_1	79	85	PF00069	0.620
MOD_CK2_1	129	135	PF00069	0.422
MOD_CK2_1	283	289	PF00069	0.399
MOD_CK2_1	332	338	PF00069	0.594
MOD_CK2_1	35	41	PF00069	0.618
MOD_CK2_1	395	401	PF00069	0.553
MOD_CK2_1	439	445	PF00069	0.586
MOD_CK2_1	471	477	PF00069	0.625
MOD_GlcNHglycan	192	195	PF01048	0.411
MOD_GlcNHglycan	247	250	PF01048	0.342
MOD_GlcNHglycan	325	328	PF01048	0.535
MOD_GlcNHglycan	398	401	PF01048	0.701
MOD_GlcNHglycan	405	408	PF01048	0.491
MOD_GlcNHglycan	499	502	PF01048	0.426
MOD_GlcNHglycan	50	53	PF01048	0.607
MOD_GlcNHglycan	78	81	PF01048	0.652
MOD_GlcNHglycan	85	88	PF01048	0.590
MOD_GlcNHglycan	89	92	PF01048	0.570
MOD_GSK3_1	239	246	PF00069	0.282
MOD_GSK3_1	24	31	PF00069	0.585
MOD_GSK3_1	328	335	PF00069	0.674
MOD_GSK3_1	363	370	PF00069	0.657
MOD_GSK3_1	392	399	PF00069	0.638
MOD_GSK3_1	426	433	PF00069	0.517
MOD_GSK3_1	439	446	PF00069	0.562
MOD_GSK3_1	76	83	PF00069	0.607
MOD_LATS_1	17	23	PF00433	0.488
MOD_LATS_1	178	184	PF00433	0.403
MOD_LATS_1	594	600	PF00433	0.560
MOD_N-GLC_1	65	70	PF02516	0.513
MOD_N-GLC_2	259	261	PF02516	0.282
MOD_NEK2_1	243	248	PF00069	0.315
MOD_NEK2_1	278	283	PF00069	0.316
MOD_NEK2_1	311	316	PF00069	0.321
MOD_NEK2_1	345	350	PF00069	0.647
MOD_NEK2_1	35	40	PF00069	0.719
MOD_NEK2_1	436	441	PF00069	0.562
MOD_NEK2_1	450	455	PF00069	0.541
MOD_NEK2_1	48	53	PF00069	0.564
MOD_NEK2_2	283	288	PF00069	0.390
MOD_PIKK_1	10	16	PF00454	0.723
MOD_PIKK_1	60	66	PF00454	0.591
MOD_PK_1	486	492	PF00069	0.477
MOD_PKA_1	180	186	PF00069	0.484
MOD_PKA_1	19	25	PF00069	0.655
MOD_PKA_1	426	432	PF00069	0.449
MOD_PKA_1	530	536	PF00069	0.488
MOD_PKA_2	180	186	PF00069	0.596
MOD_PKA_2	19	25	PF00069	0.545
MOD_PKA_2	345	351	PF00069	0.587
MOD_PKA_2	392	398	PF00069	0.494
MOD_PKA_2	426	432	PF00069	0.437
MOD_PKA_2	46	52	PF00069	0.635
MOD_PKA_2	497	503	PF00069	0.556
MOD_PKA_2	530	536	PF00069	0.563
MOD_PKA_2	583	589	PF00069	0.617
MOD_PKA_2	71	77	PF00069	0.646
MOD_Plk_1	188	194	PF00069	0.408
MOD_Plk_1	337	343	PF00069	0.532
MOD_Plk_1	363	369	PF00069	0.607
MOD_Plk_1	476	482	PF00069	0.595
MOD_Plk_1	65	71	PF00069	0.515
MOD_Plk_2-3	477	483	PF00069	0.548
MOD_Plk_4	112	118	PF00069	0.379
MOD_Plk_4	19	25	PF00069	0.555
MOD_Plk_4	239	245	PF00069	0.282
MOD_Plk_4	345	351	PF00069	0.620
MOD_Plk_4	452	458	PF00069	0.448
MOD_ProDKin_1	208	214	PF00069	0.433
MOD_ProDKin_1	439	445	PF00069	0.561
MOD_SUMO_for_1	287	290	PF00179	0.413
TRG_DiLeu_BaEn_1	304	309	PF01217	0.468
TRG_DiLeu_BaEn_2	516	522	PF01217	0.383
TRG_DiLeu_BaLyEn_6	431	436	PF01217	0.499
TRG_ENDOCYTIC_2	252	255	PF00928	0.282
TRG_ENDOCYTIC_2	296	299	PF00928	0.362
TRG_ENDOCYTIC_2	408	411	PF00928	0.489
TRG_ENDOCYTIC_2	469	472	PF00928	0.491
TRG_ER_diArg_1	18	20	PF00400	0.653
TRG_ER_diArg_1	33	35	PF00400	0.480
TRG_ER_diArg_1	360	362	PF00400	0.567
TRG_ER_diArg_1	421	423	PF00400	0.426
TRG_ER_diArg_1	426	428	PF00400	0.434
TRG_ER_diArg_1	461	464	PF00400	0.472
TRG_ER_diArg_1	496	499	PF00400	0.505
TRG_ER_diArg_1	524	526	PF00400	0.449
TRG_ER_diArg_1	529	531	PF00400	0.461
TRG_ER_diArg_1	544	547	PF00400	0.303
TRG_ER_diArg_1	550	552	PF00400	0.435
TRG_ER_diArg_1	554	557	PF00400	0.428
TRG_Pf-PMV_PEXEL_1	163	168	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	227	232	PF00026	0.282
TRG_Pf-PMV_PEXEL_1	434	438	PF00026	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEE8	Leptomonas seymouri	72%	99%
A0A1X0P5S3	Trypanosomatidae	50%	100%
A0A3S7X9F7	Leishmania donovani	93%	100%
A0A422P2S4	Trypanosoma rangeli	51%	100%
A4HMV6	Leishmania braziliensis	80%	100%
A4IBH7	Leishmania infantum	93%	100%
C9ZZ65	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9AFB3	Leishmania major	92%	100%