Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania mexicana

UniProt:

E9B6G6_LEIMU

TriTrypDb:

LmxM.34.2870

Length:

740

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6G6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6G6

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0004674	protein serine/threonine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.573
CLV_C14_Caspase3-7	162	166	PF00656	0.544
CLV_C14_Caspase3-7	194	198	PF00656	0.435
CLV_C14_Caspase3-7	203	207	PF00656	0.427
CLV_NRD_NRD_1	102	104	PF00675	0.596
CLV_NRD_NRD_1	211	213	PF00675	0.477
CLV_NRD_NRD_1	444	446	PF00675	0.527
CLV_NRD_NRD_1	727	729	PF00675	0.554
CLV_NRD_NRD_1	730	732	PF00675	0.523
CLV_PCSK_FUR_1	100	104	PF00082	0.566
CLV_PCSK_KEX2_1	102	104	PF00082	0.567
CLV_PCSK_KEX2_1	210	212	PF00082	0.419
CLV_PCSK_KEX2_1	405	407	PF00082	0.386
CLV_PCSK_KEX2_1	444	446	PF00082	0.527
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.412
CLV_PCSK_PC1ET2_1	405	407	PF00082	0.366
CLV_PCSK_SKI1_1	211	215	PF00082	0.461
CLV_PCSK_SKI1_1	422	426	PF00082	0.533
CLV_PCSK_SKI1_1	496	500	PF00082	0.558
CLV_PCSK_SKI1_1	596	600	PF00082	0.612
CLV_PCSK_SKI1_1	733	737	PF00082	0.590
DEG_APCC_DBOX_1	265	273	PF00400	0.367
DEG_COP1_1	678	688	PF00400	0.509
DEG_SCF_FBW7_2	75	82	PF00400	0.470
DEG_SPOP_SBC_1	126	130	PF00917	0.626
DEG_SPOP_SBC_1	146	150	PF00917	0.510
DEG_SPOP_SBC_1	181	185	PF00917	0.485
DEG_SPOP_SBC_1	716	720	PF00917	0.551
DOC_CKS1_1	489	494	PF01111	0.619
DOC_CKS1_1	76	81	PF01111	0.475
DOC_CYCLIN_yCln2_LP_2	376	382	PF00134	0.455
DOC_MAPK_gen_1	210	220	PF00069	0.384
DOC_MAPK_gen_1	614	624	PF00069	0.378
DOC_MAPK_gen_1	9	19	PF00069	0.428
DOC_MAPK_MEF2A_6	260	269	PF00069	0.424
DOC_MAPK_MEF2A_6	617	624	PF00069	0.384
DOC_MAPK_RevD_3	90	103	PF00069	0.613
DOC_MIT_MIM_1	619	629	PF04212	0.554
DOC_PP1_RVXF_1	619	625	PF00149	0.495
DOC_PP2B_LxvP_1	328	331	PF13499	0.490
DOC_PP2B_LxvP_1	41	44	PF13499	0.499
DOC_USP7_MATH_1	146	150	PF00917	0.529
DOC_USP7_MATH_1	163	167	PF00917	0.675
DOC_USP7_MATH_1	179	183	PF00917	0.516
DOC_USP7_MATH_1	281	285	PF00917	0.477
DOC_USP7_MATH_1	293	297	PF00917	0.436
DOC_USP7_MATH_1	316	320	PF00917	0.399
DOC_USP7_MATH_1	516	520	PF00917	0.579
DOC_USP7_MATH_1	57	61	PF00917	0.596
DOC_USP7_MATH_1	572	576	PF00917	0.550
DOC_USP7_MATH_1	716	720	PF00917	0.644
DOC_USP7_UBL2_3	210	214	PF12436	0.513
DOC_USP7_UBL2_3	59	63	PF12436	0.480
DOC_USP7_UBL2_3	729	733	PF12436	0.562
DOC_WW_Pin1_4	122	127	PF00397	0.659
DOC_WW_Pin1_4	142	147	PF00397	0.626
DOC_WW_Pin1_4	289	294	PF00397	0.586
DOC_WW_Pin1_4	399	404	PF00397	0.408
DOC_WW_Pin1_4	446	451	PF00397	0.481
DOC_WW_Pin1_4	488	493	PF00397	0.564
DOC_WW_Pin1_4	75	80	PF00397	0.511
LIG_14-3-3_CanoR_1	266	275	PF00244	0.482
LIG_14-3-3_CanoR_1	422	427	PF00244	0.440
LIG_14-3-3_CanoR_1	448	454	PF00244	0.560
LIG_14-3-3_CanoR_1	461	466	PF00244	0.596
LIG_14-3-3_CanoR_1	714	723	PF00244	0.533
LIG_AP2alpha_1	495	499	PF02296	0.613
LIG_BIR_II_1	1	5	PF00653	0.548
LIG_BIR_III_2	667	671	PF00653	0.510
LIG_Clathr_ClatBox_1	189	193	PF01394	0.506
LIG_deltaCOP1_diTrp_1	486	495	PF00928	0.508
LIG_FHA_1	185	191	PF00498	0.539
LIG_FHA_1	293	299	PF00498	0.612
LIG_FHA_1	300	306	PF00498	0.700
LIG_FHA_1	364	370	PF00498	0.617
LIG_FHA_1	589	595	PF00498	0.591
LIG_FHA_1	599	605	PF00498	0.483
LIG_FHA_1	643	649	PF00498	0.428
LIG_FHA_1	696	702	PF00498	0.626
LIG_FHA_1	716	722	PF00498	0.408
LIG_FHA_1	75	81	PF00498	0.621
LIG_FHA_2	110	116	PF00498	0.570
LIG_FHA_2	160	166	PF00498	0.624
LIG_FHA_2	423	429	PF00498	0.504
LIG_FHA_2	83	89	PF00498	0.574
LIG_GBD_Chelix_1	227	235	PF00786	0.337
LIG_HCF-1_HBM_1	106	109	PF13415	0.581
LIG_LIR_Apic_2	486	492	PF02991	0.521
LIG_LIR_Gen_1	252	258	PF02991	0.286
LIG_LIR_Gen_1	322	331	PF02991	0.524
LIG_LIR_Gen_1	609	620	PF02991	0.413
LIG_LIR_LC3C_4	187	191	PF02991	0.547
LIG_LIR_Nem_3	25	29	PF02991	0.533
LIG_LIR_Nem_3	322	327	PF02991	0.523
LIG_LIR_Nem_3	494	498	PF02991	0.519
LIG_LIR_Nem_3	556	561	PF02991	0.506
LIG_LIR_Nem_3	609	615	PF02991	0.407
LIG_LIR_Nem_3	72	76	PF02991	0.531
LIG_PCNA_PIPBox_1	605	614	PF02747	0.553
LIG_Pex14_2	495	499	PF04695	0.613
LIG_PTAP_UEV_1	454	459	PF05743	0.538
LIG_SH2_CRK	26	30	PF00017	0.535
LIG_SH2_GRB2like	118	121	PF00017	0.584
LIG_SH2_PTP2	73	76	PF00017	0.529
LIG_SH2_SRC	195	198	PF00017	0.485
LIG_SH2_SRC	204	207	PF00017	0.323
LIG_SH2_STAP1	118	122	PF00017	0.565
LIG_SH2_STAP1	204	208	PF00017	0.366
LIG_SH2_STAT3	118	121	PF00017	0.561
LIG_SH2_STAT3	36	39	PF00017	0.572
LIG_SH2_STAT5	109	112	PF00017	0.591
LIG_SH2_STAT5	118	121	PF00017	0.530
LIG_SH2_STAT5	195	198	PF00017	0.502
LIG_SH2_STAT5	73	76	PF00017	0.529
LIG_SH3_1	700	706	PF00018	0.564
LIG_SH3_3	120	126	PF00018	0.714
LIG_SH3_3	262	268	PF00018	0.420
LIG_SH3_3	275	281	PF00018	0.550
LIG_SH3_3	310	316	PF00018	0.521
LIG_SH3_3	452	458	PF00018	0.602
LIG_SH3_3	495	501	PF00018	0.538
LIG_SH3_3	682	688	PF00018	0.662
LIG_SH3_3	700	706	PF00018	0.555
LIG_SUMO_SIM_anti_2	135	140	PF11976	0.564
LIG_SUMO_SIM_anti_2	187	194	PF11976	0.506
LIG_SUMO_SIM_par_1	187	194	PF11976	0.509
LIG_SUMO_SIM_par_1	47	54	PF11976	0.496
LIG_SUMO_SIM_par_1	478	483	PF11976	0.527
LIG_TRAF2_1	676	679	PF00917	0.569
LIG_TRAF2_1	79	82	PF00917	0.691
LIG_TRAF2_2	79	84	PF00917	0.494
LIG_TYR_ITIM	71	76	PF00017	0.525
MOD_CDC14_SPxK_1	402	405	PF00782	0.424
MOD_CDK_SPxK_1	399	405	PF00069	0.412
MOD_CDK_SPxxK_3	399	406	PF00069	0.405
MOD_CK1_1	124	130	PF00069	0.670
MOD_CK1_1	145	151	PF00069	0.576
MOD_CK1_1	166	172	PF00069	0.695
MOD_CK1_1	182	188	PF00069	0.523
MOD_CK1_1	292	298	PF00069	0.579
MOD_CK1_1	301	307	PF00069	0.524
MOD_CK1_1	319	325	PF00069	0.514
MOD_CK1_1	360	366	PF00069	0.532
MOD_CK1_1	408	414	PF00069	0.313
MOD_CK1_1	478	484	PF00069	0.574
MOD_CK1_1	64	70	PF00069	0.660
MOD_CK1_1	83	89	PF00069	0.462
MOD_CK2_1	422	428	PF00069	0.513
MOD_CK2_1	681	687	PF00069	0.612
MOD_CK2_1	82	88	PF00069	0.610
MOD_GlcNHglycan	1	4	PF01048	0.622
MOD_GlcNHglycan	129	132	PF01048	0.630
MOD_GlcNHglycan	165	168	PF01048	0.690
MOD_GlcNHglycan	269	272	PF01048	0.484
MOD_GlcNHglycan	283	286	PF01048	0.581
MOD_GlcNHglycan	328	331	PF01048	0.517
MOD_GlcNHglycan	359	362	PF01048	0.463
MOD_GlcNHglycan	415	418	PF01048	0.381
MOD_GlcNHglycan	518	521	PF01048	0.581
MOD_GlcNHglycan	570	573	PF01048	0.562
MOD_GlcNHglycan	574	577	PF01048	0.540
MOD_GlcNHglycan	59	62	PF01048	0.616
MOD_GlcNHglycan	66	69	PF01048	0.551
MOD_GSK3_1	121	128	PF00069	0.614
MOD_GSK3_1	142	149	PF00069	0.639
MOD_GSK3_1	159	166	PF00069	0.759
MOD_GSK3_1	180	187	PF00069	0.597
MOD_GSK3_1	289	296	PF00069	0.617
MOD_GSK3_1	401	408	PF00069	0.388
MOD_GSK3_1	449	456	PF00069	0.610
MOD_GSK3_1	457	464	PF00069	0.707
MOD_GSK3_1	487	494	PF00069	0.624
MOD_GSK3_1	518	525	PF00069	0.572
MOD_GSK3_1	563	570	PF00069	0.583
MOD_GSK3_1	57	64	PF00069	0.501
MOD_GSK3_1	572	579	PF00069	0.535
MOD_GSK3_1	596	603	PF00069	0.555
MOD_GSK3_1	655	662	PF00069	0.486
MOD_GSK3_1	80	87	PF00069	0.686
MOD_LATS_1	459	465	PF00433	0.656
MOD_N-GLC_1	357	362	PF02516	0.467
MOD_N-GLC_1	363	368	PF02516	0.439
MOD_N-GLC_1	429	434	PF02516	0.347
MOD_N-GLC_1	55	60	PF02516	0.609
MOD_N-GLC_1	716	721	PF02516	0.562
MOD_NEK2_1	180	185	PF00069	0.570
MOD_NEK2_1	412	417	PF00069	0.469
MOD_NEK2_1	487	492	PF00069	0.633
MOD_NEK2_1	5	10	PF00069	0.553
MOD_NEK2_1	655	660	PF00069	0.480
MOD_NEK2_1	722	727	PF00069	0.592
MOD_PIKK_1	563	569	PF00454	0.545
MOD_PIKK_1	678	684	PF00454	0.580
MOD_PK_1	405	411	PF00069	0.304
MOD_PKA_1	405	411	PF00069	0.405
MOD_PKA_2	22	28	PF00069	0.565
MOD_PKA_2	405	411	PF00069	0.405
MOD_Plk_1	429	435	PF00069	0.335
MOD_Plk_1	475	481	PF00069	0.559
MOD_Plk_1	716	722	PF00069	0.564
MOD_Plk_2-3	197	203	PF00069	0.381
MOD_Plk_4	132	138	PF00069	0.648
MOD_Plk_4	166	172	PF00069	0.487
MOD_Plk_4	293	299	PF00069	0.449
MOD_Plk_4	301	307	PF00069	0.446
MOD_Plk_4	408	414	PF00069	0.420
MOD_Plk_4	422	428	PF00069	0.425
MOD_Plk_4	461	467	PF00069	0.684
MOD_Plk_4	475	481	PF00069	0.552
MOD_Plk_4	600	606	PF00069	0.506
MOD_Plk_4	61	67	PF00069	0.552
MOD_Plk_4	69	75	PF00069	0.546
MOD_Plk_4	717	723	PF00069	0.590
MOD_ProDKin_1	122	128	PF00069	0.661
MOD_ProDKin_1	142	148	PF00069	0.629
MOD_ProDKin_1	289	295	PF00069	0.584
MOD_ProDKin_1	399	405	PF00069	0.412
MOD_ProDKin_1	446	452	PF00069	0.488
MOD_ProDKin_1	488	494	PF00069	0.556
MOD_ProDKin_1	75	81	PF00069	0.518
MOD_SUMO_rev_2	613	622	PF00179	0.487
MOD_SUMO_rev_2	684	691	PF00179	0.557
TRG_DiLeu_BaEn_2	307	313	PF01217	0.539
TRG_ENDOCYTIC_2	26	29	PF00928	0.538
TRG_ENDOCYTIC_2	558	561	PF00928	0.488
TRG_ENDOCYTIC_2	73	76	PF00928	0.529
TRG_ER_diArg_1	211	213	PF00400	0.360
TRG_ER_diArg_1	443	445	PF00400	0.490
TRG_ER_diArg_1	533	536	PF00400	0.630
TRG_ER_diArg_1	99	102	PF00400	0.555
TRG_NES_CRM1_1	640	652	PF08389	0.507
TRG_NLS_MonoExtC_3	209	214	PF00514	0.341
TRG_NLS_MonoExtC_3	727	732	PF00514	0.581
TRG_NLS_MonoExtN_4	728	735	PF00514	0.640
TRG_Pf-PMV_PEXEL_1	111	115	PF00026	0.743
TRG_Pf-PMV_PEXEL_1	211	215	PF00026	0.403
TRG_Pf-PMV_PEXEL_1	247	252	PF00026	0.396
TRG_Pf-PMV_PEXEL_1	592	597	PF00026	0.583

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFG5	Leptomonas seymouri	38%	98%
A0A3Q8IVC2	Leishmania donovani	81%	100%
A4HMV4	Leishmania braziliensis	61%	100%
A4IBH5	Leishmania infantum	81%	100%
E9AFB1	Leishmania major	82%	100%