Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B6G2_LEIMU

TriTrypDb:

LmxM.34.2830

Length:

549

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6G2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6G2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	165	169	PF00656	0.508
CLV_NRD_NRD_1	149	151	PF00675	0.610
CLV_NRD_NRD_1	305	307	PF00675	0.648
CLV_NRD_NRD_1	410	412	PF00675	0.598
CLV_PCSK_FUR_1	408	412	PF00082	0.598
CLV_PCSK_KEX2_1	102	104	PF00082	0.592
CLV_PCSK_KEX2_1	149	151	PF00082	0.610
CLV_PCSK_KEX2_1	305	307	PF00082	0.642
CLV_PCSK_KEX2_1	322	324	PF00082	0.587
CLV_PCSK_KEX2_1	393	395	PF00082	0.716
CLV_PCSK_KEX2_1	410	412	PF00082	0.598
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.523
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.677
CLV_PCSK_PC1ET2_1	393	395	PF00082	0.716
CLV_PCSK_SKI1_1	103	107	PF00082	0.602
CLV_PCSK_SKI1_1	149	153	PF00082	0.712
CLV_PCSK_SKI1_1	213	217	PF00082	0.552
CLV_PCSK_SKI1_1	394	398	PF00082	0.741
CLV_PCSK_SKI1_1	492	496	PF00082	0.640
CLV_PCSK_SKI1_1	74	78	PF00082	0.529
DEG_COP1_1	458	469	PF00400	0.473
DEG_Nend_UBRbox_2	1	3	PF02207	0.465
DEG_SCF_FBW7_1	506	511	PF00400	0.659
DOC_CYCLIN_RxL_1	245	256	PF00134	0.612
DOC_CYCLIN_yCln2_LP_2	500	506	PF00134	0.508
DOC_MAPK_DCC_7	432	442	PF00069	0.518
DOC_MAPK_gen_1	246	254	PF00069	0.608
DOC_MAPK_gen_1	3	11	PF00069	0.471
DOC_MAPK_gen_1	408	418	PF00069	0.599
DOC_MAPK_JIP1_4	248	254	PF00069	0.598
DOC_MAPK_MEF2A_6	213	222	PF00069	0.549
DOC_MAPK_MEF2A_6	246	254	PF00069	0.495
DOC_PP2B_LxvP_1	221	224	PF13499	0.315
DOC_PP4_FxxP_1	105	108	PF00568	0.561
DOC_USP7_MATH_1	118	122	PF00917	0.588
DOC_USP7_MATH_1	237	241	PF00917	0.594
DOC_USP7_MATH_1	253	257	PF00917	0.458
DOC_USP7_MATH_1	367	371	PF00917	0.500
DOC_USP7_MATH_1	508	512	PF00917	0.652
DOC_USP7_MATH_1	519	523	PF00917	0.572
DOC_USP7_MATH_1	543	547	PF00917	0.586
DOC_WD40_RPTOR_TOS_1	50	56	PF00400	0.481
DOC_WW_Pin1_4	259	264	PF00397	0.556
DOC_WW_Pin1_4	277	282	PF00397	0.448
DOC_WW_Pin1_4	329	334	PF00397	0.692
DOC_WW_Pin1_4	459	464	PF00397	0.495
DOC_WW_Pin1_4	504	509	PF00397	0.723
LIG_14-3-3_CanoR_1	179	189	PF00244	0.577
LIG_14-3-3_CanoR_1	323	333	PF00244	0.532
LIG_14-3-3_CanoR_1	366	376	PF00244	0.672
LIG_14-3-3_CanoR_1	47	53	PF00244	0.342
LIG_Actin_WH2_2	530	547	PF00022	0.557
LIG_APCC_ABBA_1	120	125	PF00400	0.492
LIG_BIR_III_2	233	237	PF00653	0.704
LIG_BRCT_BRCA1_1	15	19	PF00533	0.551
LIG_BRCT_BRCA1_1	166	170	PF00533	0.485
LIG_deltaCOP1_diTrp_1	273	282	PF00928	0.440
LIG_eIF4E_1	147	153	PF01652	0.646
LIG_FHA_1	122	128	PF00498	0.410
LIG_FHA_1	245	251	PF00498	0.479
LIG_FHA_1	27	33	PF00498	0.394
LIG_FHA_1	325	331	PF00498	0.522
LIG_FHA_1	469	475	PF00498	0.520
LIG_FHA_2	205	211	PF00498	0.593
LIG_FHA_2	534	540	PF00498	0.561
LIG_HP1_1	217	221	PF01393	0.322
LIG_LIR_Apic_2	104	108	PF02991	0.556
LIG_LIR_Gen_1	167	178	PF02991	0.445
LIG_LIR_Gen_1	280	289	PF02991	0.471
LIG_LIR_Gen_1	484	494	PF02991	0.700
LIG_LIR_Nem_3	16	22	PF02991	0.567
LIG_LIR_Nem_3	167	173	PF02991	0.470
LIG_LIR_Nem_3	214	219	PF02991	0.435
LIG_LIR_Nem_3	280	285	PF02991	0.420
LIG_LIR_Nem_3	347	351	PF02991	0.340
LIG_LIR_Nem_3	484	490	PF02991	0.643
LIG_LIR_Nem_3	69	75	PF02991	0.641
LIG_MYND_1	463	467	PF01753	0.695
LIG_NRBOX	414	420	PF00104	0.564
LIG_Pex14_1	275	279	PF04695	0.391
LIG_Pex14_2	59	63	PF04695	0.458
LIG_SH2_SRC	231	234	PF00017	0.477
LIG_SH2_STAP1	123	127	PF00017	0.564
LIG_SH2_STAP1	147	151	PF00017	0.608
LIG_SH2_STAP1	351	355	PF00017	0.423
LIG_SH2_STAP1	60	64	PF00017	0.500
LIG_SH2_STAT3	135	138	PF00017	0.679
LIG_SH2_STAT5	10	13	PF00017	0.506
LIG_SH2_STAT5	123	126	PF00017	0.524
LIG_SH2_STAT5	172	175	PF00017	0.428
LIG_SH2_STAT5	231	234	PF00017	0.477
LIG_SH2_STAT5	279	282	PF00017	0.463
LIG_SH3_3	257	263	PF00018	0.512
LIG_SH3_3	393	399	PF00018	0.479
LIG_SH3_3	432	438	PF00018	0.664
LIG_Sin3_3	216	223	PF02671	0.541
LIG_SUMO_SIM_anti_2	292	298	PF11976	0.437
LIG_SUMO_SIM_anti_2	420	428	PF11976	0.634
LIG_SUMO_SIM_par_1	250	256	PF11976	0.473
LIG_SUMO_SIM_par_1	526	533	PF11976	0.580
LIG_TRAF2_1	137	140	PF00917	0.548
LIG_TRAF2_1	399	402	PF00917	0.705
LIG_TRAF2_1	456	459	PF00917	0.566
LIG_TRAF2_1	84	87	PF00917	0.639
LIG_UBA3_1	415	422	PF00899	0.608
MOD_CDK_SPK_2	459	464	PF00069	0.495
MOD_CK1_1	12	18	PF00069	0.511
MOD_CK1_1	121	127	PF00069	0.573
MOD_CK1_1	200	206	PF00069	0.639
MOD_CK1_1	240	246	PF00069	0.687
MOD_CK1_1	256	262	PF00069	0.425
MOD_CK1_1	318	324	PF00069	0.692
MOD_CK1_1	468	474	PF00069	0.648
MOD_CK1_1	48	54	PF00069	0.329
MOD_CK1_1	533	539	PF00069	0.631
MOD_CK2_1	261	267	PF00069	0.752
MOD_CK2_1	440	446	PF00069	0.538
MOD_CK2_1	81	87	PF00069	0.645
MOD_DYRK1A_RPxSP_1	545	549	PF00069	0.611
MOD_GlcNHglycan	108	111	PF01048	0.611
MOD_GlcNHglycan	174	177	PF01048	0.518
MOD_GlcNHglycan	239	242	PF01048	0.731
MOD_GlcNHglycan	317	320	PF01048	0.689
MOD_GlcNHglycan	323	326	PF01048	0.630
MOD_GlcNHglycan	510	513	PF01048	0.628
MOD_GlcNHglycan	83	86	PF01048	0.570
MOD_GlcNHglycan	92	95	PF01048	0.494
MOD_GSK3_1	112	119	PF00069	0.492
MOD_GSK3_1	200	207	PF00069	0.643
MOD_GSK3_1	22	29	PF00069	0.426
MOD_GSK3_1	240	247	PF00069	0.556
MOD_GSK3_1	314	321	PF00069	0.694
MOD_GSK3_1	346	353	PF00069	0.300
MOD_GSK3_1	424	431	PF00069	0.665
MOD_GSK3_1	436	443	PF00069	0.634
MOD_GSK3_1	504	511	PF00069	0.695
MOD_GSK3_1	529	536	PF00069	0.568
MOD_GSK3_1	9	16	PF00069	0.569
MOD_NEK2_1	101	106	PF00069	0.570
MOD_NEK2_1	180	185	PF00069	0.463
MOD_NEK2_1	297	302	PF00069	0.553
MOD_NEK2_1	344	349	PF00069	0.523
MOD_NEK2_1	376	381	PF00069	0.627
MOD_NEK2_1	440	445	PF00069	0.538
MOD_NEK2_2	118	123	PF00069	0.575
MOD_OFUCOSY	8	13	PF10250	0.495
MOD_PIKK_1	240	246	PF00454	0.687
MOD_PIKK_1	324	330	PF00454	0.642
MOD_PIKK_1	506	512	PF00454	0.505
MOD_PKA_2	197	203	PF00069	0.681
MOD_Plk_1	116	122	PF00069	0.453
MOD_Plk_1	529	535	PF00069	0.686
MOD_Plk_4	118	124	PF00069	0.514
MOD_Plk_4	13	19	PF00069	0.541
MOD_Plk_4	166	172	PF00069	0.446
MOD_Plk_4	292	298	PF00069	0.566
MOD_Plk_4	465	471	PF00069	0.425
MOD_Plk_4	495	501	PF00069	0.631
MOD_ProDKin_1	259	265	PF00069	0.561
MOD_ProDKin_1	277	283	PF00069	0.453
MOD_ProDKin_1	329	335	PF00069	0.690
MOD_ProDKin_1	459	465	PF00069	0.492
MOD_ProDKin_1	504	510	PF00069	0.725
MOD_SUMO_rev_2	51	59	PF00179	0.562
TRG_DiLeu_BaLyEn_6	414	419	PF01217	0.564
TRG_ENDOCYTIC_2	279	282	PF00928	0.438
TRG_ENDOCYTIC_2	60	63	PF00928	0.500
TRG_ER_diArg_1	304	306	PF00400	0.633
TRG_ER_diArg_1	408	411	PF00400	0.598
TRG_NES_CRM1_1	414	428	PF08389	0.623
TRG_Pf-PMV_PEXEL_1	150	155	PF00026	0.639
TRG_Pf-PMV_PEXEL_1	417	421	PF00026	0.680

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Q6	Leptomonas seymouri	39%	88%
A0A3S7X9F0	Leishmania donovani	82%	99%
A4HMV0	Leishmania braziliensis	68%	100%
A4IBH2	Leishmania infantum	82%	90%
E9AFA7	Leishmania major	81%	100%